BR0108771A - Processos para a preparação de um triéster de fosforotioato, e de oligonucleotìdeo desprotegido, fosforotioato de oligonucleotìdeo, ou oligonucleotìdeo/fosforotioato de oligonucleotìdeo mistos - Google Patents

Processos para a preparação de um triéster de fosforotioato, e de oligonucleotìdeo desprotegido, fosforotioato de oligonucleotìdeo, ou oligonucleotìdeo/fosforotioato de oligonucleotìdeo mistos

Info

Publication number
BR0108771A
BR0108771A BR0108771-1A BR0108771A BR0108771A BR 0108771 A BR0108771 A BR 0108771A BR 0108771 A BR0108771 A BR 0108771A BR 0108771 A BR0108771 A BR 0108771A
Authority
BR
Brazil
Prior art keywords
oligonucleotide
phosphorothioate
triester
processes
preparation
Prior art date
Application number
BR0108771-1A
Other languages
English (en)
Inventor
Colin Bernard Reese
Original Assignee
Avecia Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avecia Ltd filed Critical Avecia Ltd
Publication of BR0108771A publication Critical patent/BR0108771A/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06Pyrimidine radicals
    • C07H19/10Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/16Esters of thiophosphoric acids or thiophosphorous acids
    • C07F9/165Esters of thiophosphoric acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16Purine radicals
    • C07H19/20Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Luminescent Compositions (AREA)

Abstract

"PROCESSOS PARA A PREPARAçãO DE UM TRIéSTER DE FOSFOROTIOATO, E DE OLIGONUCLEOTìDEO DESPROTEGIDO, FOSFOROTIOATO DE OLIGONUCLEOTìDEO, OU OLIGONUCLEOTìDEO/FOSFOROTIOATO DE OLIGONUCLEOTìDEO MISTOS". é provido um processo para a síntese de um triéster de fosforotioato. O processo compreende o acoplamento de um H-fosfonato com um álcool, na presença de uma solução, que compreende tanto um agente de acoplamento como um agente de transferência de enxofre. Preferivelmente, o H-fosfonato e o álcool são oligonucleotídeos ou nucleosídeos protegidos.
BR0108771-1A 2000-03-01 2001-02-23 Processos para a preparação de um triéster de fosforotioato, e de oligonucleotìdeo desprotegido, fosforotioato de oligonucleotìdeo, ou oligonucleotìdeo/fosforotioato de oligonucleotìdeo mistos BR0108771A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0004889.2A GB0004889D0 (en) 2000-03-01 2000-03-01 Synthesis of oligonucleotides
PCT/GB2001/000764 WO2001064702A1 (en) 2000-03-01 2001-02-23 Process for the preparation of phosphorothioate triesters

Publications (1)

Publication Number Publication Date
BR0108771A true BR0108771A (pt) 2002-11-26

Family

ID=9886705

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0108771-1A BR0108771A (pt) 2000-03-01 2001-02-23 Processos para a preparação de um triéster de fosforotioato, e de oligonucleotìdeo desprotegido, fosforotioato de oligonucleotìdeo, ou oligonucleotìdeo/fosforotioato de oligonucleotìdeo mistos

Country Status (21)

Country Link
US (1) US7022833B2 (pt)
EP (1) EP1272501B1 (pt)
JP (1) JP2003525305A (pt)
KR (1) KR20030032924A (pt)
CN (1) CN1262557C (pt)
AT (1) ATE266037T1 (pt)
AU (2) AU3576601A (pt)
BR (1) BR0108771A (pt)
CA (1) CA2401083A1 (pt)
CZ (1) CZ20022930A3 (pt)
DE (1) DE60103145T2 (pt)
DK (1) DK1272501T3 (pt)
ES (1) ES2220721T3 (pt)
GB (1) GB0004889D0 (pt)
HU (1) HUP0204249A3 (pt)
IL (1) IL151238A0 (pt)
MX (1) MXPA02008530A (pt)
NO (1) NO20024155L (pt)
NZ (1) NZ520778A (pt)
PL (1) PL362067A1 (pt)
WO (1) WO2001064702A1 (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9717158D0 (en) * 1997-08-13 1997-10-22 King S College London Solution synthesis of oligonucleotides and their phosphorothioate analogues
WO2003045969A1 (en) * 2001-11-21 2003-06-05 Avecia Biotechnology Inc. Coupling reagent for h-phosphonate chemistry
EP1386925A1 (en) 2002-07-31 2004-02-04 Girindus AG Method for preparing oligonucleotides
GB0229423D0 (en) * 2002-12-18 2003-01-22 Avecia Ltd Process
BRPI0923225A2 (pt) 2008-12-02 2016-10-04 Chiralgen Ltd metodo para sintese de acidos nucleicos modificados no atomo de fosforo
KR101885383B1 (ko) 2009-07-06 2018-08-03 웨이브 라이프 사이언시스 리미티드 신규한 핵산 프로드러그 및 그의 사용 방법
JP5868324B2 (ja) 2010-09-24 2016-02-24 株式会社Wave Life Sciences Japan 不斉補助基
CN103796657B (zh) 2011-07-19 2017-07-11 波涛生命科学有限公司 合成官能化核酸的方法
EP4219516A3 (en) 2012-07-13 2024-01-10 Wave Life Sciences Ltd. Chiral control
SG11201500239VA (en) 2012-07-13 2015-03-30 Wave Life Sciences Japan Asymmetric auxiliary group
EP2873674B1 (en) 2012-07-13 2020-05-06 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant
WO2015108047A1 (ja) 2014-01-15 2015-07-23 株式会社新日本科学 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤
JPWO2015108048A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
US10322173B2 (en) 2014-01-15 2019-06-18 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent
KR102423317B1 (ko) 2014-01-16 2022-07-22 웨이브 라이프 사이언시스 리미티드 키랄 디자인

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9501465D0 (en) 1995-01-25 1995-03-15 King S College London Nucleoside phosphorothioate derivatives,synthesis and use thereof
US6096881A (en) * 1997-05-30 2000-08-01 Hybridon, Inc. Sulfur transfer reagents for oligonucleotide synthesis
GB9717158D0 (en) 1997-08-13 1997-10-22 King S College London Solution synthesis of oligonucleotides and their phosphorothioate analogues
GB9924285D0 (en) 1999-10-14 1999-12-15 Avecia Ltd Process

Also Published As

Publication number Publication date
JP2003525305A (ja) 2003-08-26
EP1272501B1 (en) 2004-05-06
HUP0204249A2 (hu) 2003-04-28
ATE266037T1 (de) 2004-05-15
GB0004889D0 (en) 2000-04-19
US7022833B2 (en) 2006-04-04
NZ520778A (en) 2004-05-28
US20030099981A1 (en) 2003-05-29
CN1406242A (zh) 2003-03-26
IL151238A0 (en) 2003-04-10
CN1262557C (zh) 2006-07-05
AU3576601A (en) 2001-09-12
NO20024155D0 (no) 2002-08-30
DE60103145D1 (de) 2004-06-09
ES2220721T3 (es) 2004-12-16
NO20024155L (no) 2002-10-24
KR20030032924A (ko) 2003-04-26
EP1272501A1 (en) 2003-01-08
HUP0204249A3 (en) 2004-08-30
DE60103145T2 (de) 2005-05-04
CA2401083A1 (en) 2001-09-07
PL362067A1 (en) 2004-10-18
WO2001064702A1 (en) 2001-09-07
DK1272501T3 (da) 2004-08-16
AU2001235766B2 (en) 2005-01-27
CZ20022930A3 (cs) 2002-11-13
MXPA02008530A (es) 2003-02-12

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6O, 7O E 8O ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2016 DE 25/08/2009