HUP0204249A2 - Eljárás foszfortioát-triészterek előállítására - Google Patents

Eljárás foszfortioát-triészterek előállítására

Info

Publication number
HUP0204249A2
HUP0204249A2 HU0204249A HUP0204249A HUP0204249A2 HU P0204249 A2 HUP0204249 A2 HU P0204249A2 HU 0204249 A HU0204249 A HU 0204249A HU P0204249 A HUP0204249 A HU P0204249A HU P0204249 A2 HUP0204249 A2 HU P0204249A2
Authority
HU
Hungary
Prior art keywords
preparation
phosphonate
phosphorothioate
phosphorothioate triesters
alcohol
Prior art date
Application number
HU0204249A
Other languages
English (en)
Inventor
Colin Bernard Reese
Original Assignee
Avecia Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avecia Ltd. filed Critical Avecia Ltd.
Publication of HUP0204249A2 publication Critical patent/HUP0204249A2/hu
Publication of HUP0204249A3 publication Critical patent/HUP0204249A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/16—Esters of thiophosphoric acids or thiophosphorous acids
    • C07F9/165—Esters of thiophosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Luminescent Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

A találmány tárgya eljárás foszfortioát-triészterek előállítására,amelynek során egy H-foszfonátot kapcsolószer jelenlétében egyalkohollal kapcsolnak, és az így kapott H-foszfonát-diésztertkénátvivő szerrel reagáltatva foszfortioat-triészterré alakítják. Atalálmány értelmében a H-foszfonát és az alkohol kapcsolási reakciójáta kénátvivő szer jelenlétében hajtják végre. Ó
HU0204249A 2000-03-01 2001-02-23 Process for the preparation of phosphorothioate triesters HUP0204249A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0004889.2A GB0004889D0 (en) 2000-03-01 2000-03-01 Synthesis of oligonucleotides
PCT/GB2001/000764 WO2001064702A1 (en) 2000-03-01 2001-02-23 Process for the preparation of phosphorothioate triesters

Publications (2)

Publication Number Publication Date
HUP0204249A2 true HUP0204249A2 (hu) 2003-04-28
HUP0204249A3 HUP0204249A3 (en) 2004-08-30

Family

ID=9886705

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0204249A HUP0204249A3 (en) 2000-03-01 2001-02-23 Process for the preparation of phosphorothioate triesters

Country Status (21)

Country Link
US (1) US7022833B2 (hu)
EP (1) EP1272501B1 (hu)
JP (1) JP2003525305A (hu)
KR (1) KR20030032924A (hu)
CN (1) CN1262557C (hu)
AT (1) ATE266037T1 (hu)
AU (2) AU2001235766B2 (hu)
BR (1) BR0108771A (hu)
CA (1) CA2401083A1 (hu)
CZ (1) CZ20022930A3 (hu)
DE (1) DE60103145T2 (hu)
DK (1) DK1272501T3 (hu)
ES (1) ES2220721T3 (hu)
GB (1) GB0004889D0 (hu)
HU (1) HUP0204249A3 (hu)
IL (1) IL151238A0 (hu)
MX (1) MXPA02008530A (hu)
NO (1) NO20024155L (hu)
NZ (1) NZ520778A (hu)
PL (1) PL362067A1 (hu)
WO (1) WO2001064702A1 (hu)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9717158D0 (en) * 1997-08-13 1997-10-22 King S College London Solution synthesis of oligonucleotides and their phosphorothioate analogues
WO2003045969A1 (en) * 2001-11-21 2003-06-05 Avecia Biotechnology Inc. Coupling reagent for h-phosphonate chemistry
EP1386925A1 (en) 2002-07-31 2004-02-04 Girindus AG Method for preparing oligonucleotides
GB0229423D0 (en) * 2002-12-18 2003-01-22 Avecia Ltd Process
CA2744987C (en) 2008-12-02 2018-01-16 Chiralgen, Ltd. Method for the synthesis of phosphorus atom modified nucleic acids
BR112012000828A8 (pt) 2009-07-06 2017-10-10 Ontorii Inc Novas pró-drogas de ácido nucleico e métodos de uso das mesmas
WO2012039448A1 (ja) 2010-09-24 2012-03-29 株式会社キラルジェン 不斉補助基
US9605019B2 (en) 2011-07-19 2017-03-28 Wave Life Sciences Ltd. Methods for the synthesis of functionalized nucleic acids
AU2013288048A1 (en) 2012-07-13 2015-01-22 Wave Life Sciences Ltd. Asymmetric auxiliary group
KR20220139425A (ko) 2012-07-13 2022-10-14 웨이브 라이프 사이언시스 리미티드 키랄 제어
KR101835401B1 (ko) 2012-07-13 2018-03-08 신 니뽄 바이오메디칼 라보라토리즈, 엘티디. 키랄 핵산 어쥬번트
US10322173B2 (en) 2014-01-15 2019-06-18 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent
EP3095461A4 (en) 2014-01-15 2017-08-23 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator
WO2015108048A1 (ja) 2014-01-15 2015-07-23 株式会社新日本科学 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
PT3094728T (pt) 2014-01-16 2022-05-19 Wave Life Sciences Ltd Desenho quiral

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9501465D0 (en) 1995-01-25 1995-03-15 King S College London Nucleoside phosphorothioate derivatives,synthesis and use thereof
US6096881A (en) 1997-05-30 2000-08-01 Hybridon, Inc. Sulfur transfer reagents for oligonucleotide synthesis
GB9717158D0 (en) * 1997-08-13 1997-10-22 King S College London Solution synthesis of oligonucleotides and their phosphorothioate analogues
GB9924285D0 (en) * 1999-10-14 1999-12-15 Avecia Ltd Process

Also Published As

Publication number Publication date
US20030099981A1 (en) 2003-05-29
WO2001064702A1 (en) 2001-09-07
KR20030032924A (ko) 2003-04-26
PL362067A1 (en) 2004-10-18
CN1406242A (zh) 2003-03-26
GB0004889D0 (en) 2000-04-19
DK1272501T3 (da) 2004-08-16
DE60103145D1 (de) 2004-06-09
EP1272501B1 (en) 2004-05-06
CA2401083A1 (en) 2001-09-07
NO20024155D0 (no) 2002-08-30
CN1262557C (zh) 2006-07-05
MXPA02008530A (es) 2003-02-12
EP1272501A1 (en) 2003-01-08
NO20024155L (no) 2002-10-24
AU2001235766B2 (en) 2005-01-27
JP2003525305A (ja) 2003-08-26
CZ20022930A3 (cs) 2002-11-13
ATE266037T1 (de) 2004-05-15
HUP0204249A3 (en) 2004-08-30
DE60103145T2 (de) 2005-05-04
BR0108771A (pt) 2002-11-26
AU3576601A (en) 2001-09-12
ES2220721T3 (es) 2004-12-16
IL151238A0 (en) 2003-04-10
US7022833B2 (en) 2006-04-04
NZ520778A (en) 2004-05-28

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