WO2002009651A3 - Fatty acid synthase inhibitors - Google Patents
Fatty acid synthase inhibitors Download PDFInfo
- Publication number
- WO2002009651A3 WO2002009651A3 PCT/US2001/024366 US0124366W WO0209651A3 WO 2002009651 A3 WO2002009651 A3 WO 2002009651A3 US 0124366 W US0124366 W US 0124366W WO 0209651 A3 WO0209651 A3 WO 0209651A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- fatty acid
- acid synthase
- synthase inhibitors
- inhibitors
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/20—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
- C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
- C07D257/06—Five-membered rings with nitrogen atoms directly attached to the ring carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Abstract
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2001284705A AU2001284705A1 (en) | 2000-08-02 | 2001-08-02 | Fatty acid synthase inhibitors |
JP2002515206A JP2004505030A (en) | 2000-08-02 | 2001-08-02 | Fatty acid synthase inhibitors |
EP01963783A EP1322331A2 (en) | 2000-08-02 | 2001-08-02 | Fatty acid synthase inhibitors |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22268300P | 2000-08-02 | 2000-08-02 | |
US60/222,683 | 2000-08-02 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002009651A2 WO2002009651A2 (en) | 2002-02-07 |
WO2002009651A3 true WO2002009651A3 (en) | 2002-03-28 |
Family
ID=22833247
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/024366 WO2002009651A2 (en) | 2000-08-02 | 2001-08-02 | Fatty acid synthase inhibitors |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1322331A2 (en) |
JP (1) | JP2004505030A (en) |
AU (1) | AU2001284705A1 (en) |
WO (1) | WO2002009651A2 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20160002188A1 (en) | 2013-03-13 | 2016-01-07 | Forma Therapeutics, Inc. | Novel compounds and compositions for inhibition of fasn |
TWI767148B (en) | 2018-10-10 | 2022-06-11 | 美商弗瑪治療公司 | Inhibiting fatty acid synthase (fasn) |
CN113382633A (en) | 2018-10-29 | 2021-09-10 | 福马治疗股份有限公司 | Solid forms of (4- (2-fluoro-4- (1-methyl-1H-benzo [ d ] imidazol-5-yl) benzoyl) piperazin-1-yl) (1-hydroxycyclopropyl) methanone |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES451822A1 (en) * | 1975-09-25 | 1977-12-16 | American Cyanamid Co | Hypolipemic {60 -aryloxy para substituted phenyl acetic acid compounds |
US4125732A (en) * | 1977-05-06 | 1978-11-14 | American Cyanamid Company | 2-Aryloxy-2-(phenoxyalkoxy)phenyl acetic acid and esters |
US4168385A (en) * | 1975-09-25 | 1979-09-18 | American Cyanamid Company | Hypolipemic phenylacetic acid derivatives |
US4496738A (en) * | 1978-10-23 | 1985-01-29 | Basf Aktiengesellschaft | Process for preparing 1,2,4-triazole derivatives |
JPS63307837A (en) * | 1986-09-08 | 1988-12-15 | Daicel Chem Ind Ltd | Optical active compound |
WO2000034254A1 (en) * | 1998-12-04 | 2000-06-15 | Astrazeneca Ab | Novel compounds |
-
2001
- 2001-08-02 JP JP2002515206A patent/JP2004505030A/en not_active Withdrawn
- 2001-08-02 EP EP01963783A patent/EP1322331A2/en not_active Withdrawn
- 2001-08-02 AU AU2001284705A patent/AU2001284705A1/en not_active Abandoned
- 2001-08-02 WO PCT/US2001/024366 patent/WO2002009651A2/en not_active Application Discontinuation
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES451822A1 (en) * | 1975-09-25 | 1977-12-16 | American Cyanamid Co | Hypolipemic {60 -aryloxy para substituted phenyl acetic acid compounds |
US4125729A (en) * | 1975-09-25 | 1978-11-14 | American Cyanamid Company | Hypolipemic α-aryloxy para substituted phenyl acetic acid compounds |
US4168385A (en) * | 1975-09-25 | 1979-09-18 | American Cyanamid Company | Hypolipemic phenylacetic acid derivatives |
US4125732A (en) * | 1977-05-06 | 1978-11-14 | American Cyanamid Company | 2-Aryloxy-2-(phenoxyalkoxy)phenyl acetic acid and esters |
US4496738A (en) * | 1978-10-23 | 1985-01-29 | Basf Aktiengesellschaft | Process for preparing 1,2,4-triazole derivatives |
JPS63307837A (en) * | 1986-09-08 | 1988-12-15 | Daicel Chem Ind Ltd | Optical active compound |
JP2562606B2 (en) * | 1986-09-08 | 1996-12-11 | ダイセル化学工業株式会社 | Optically active compound |
WO2000034254A1 (en) * | 1998-12-04 | 2000-06-15 | Astrazeneca Ab | Novel compounds |
Also Published As
Publication number | Publication date |
---|---|
AU2001284705A1 (en) | 2002-02-13 |
JP2004505030A (en) | 2004-02-19 |
EP1322331A2 (en) | 2003-07-02 |
WO2002009651A2 (en) | 2002-02-07 |
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