MXPA02008530A - Proceso para la preparacion de triesteres de fosforotioato. - Google Patents

Proceso para la preparacion de triesteres de fosforotioato.

Info

Publication number
MXPA02008530A
MXPA02008530A MXPA02008530A MXPA02008530A MXPA02008530A MX PA02008530 A MXPA02008530 A MX PA02008530A MX PA02008530 A MXPA02008530 A MX PA02008530A MX PA02008530 A MXPA02008530 A MX PA02008530A MX PA02008530 A MXPA02008530 A MX PA02008530A
Authority
MX
Mexico
Prior art keywords
preparation
phosphorothioate triesters
alcohol
phosphorothioate
coupling
Prior art date
Application number
MXPA02008530A
Other languages
English (en)
Inventor
Colin Bernard Reese
Original Assignee
Avecia Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avecia Ltd filed Critical Avecia Ltd
Publication of MXPA02008530A publication Critical patent/MXPA02008530A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06Pyrimidine radicals
    • C07H19/10Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/16Esters of thiophosphoric acids or thiophosphorous acids
    • C07F9/165Esters of thiophosphoric acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16Purine radicals
    • C07H19/20Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Luminescent Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Se proporciona un procedimiento para la sintesis de un triester fosforotioato.. El procedimiento comprende el acoplamiento de un H-fosfonato con un alcohol en la presencia de una solucion que comprende tanto un agente de acoplamiento como un agente de transferencia de azufre. Preferiblemente, el H-fosfonato y el alcohol son nucleosidos u oligonucleotidos protegidos.
MXPA02008530A 2000-03-01 2001-02-23 Proceso para la preparacion de triesteres de fosforotioato. MXPA02008530A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0004889.2A GB0004889D0 (en) 2000-03-01 2000-03-01 Synthesis of oligonucleotides
PCT/GB2001/000764 WO2001064702A1 (en) 2000-03-01 2001-02-23 Process for the preparation of phosphorothioate triesters

Publications (1)

Publication Number Publication Date
MXPA02008530A true MXPA02008530A (es) 2003-02-12

Family

ID=9886705

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA02008530A MXPA02008530A (es) 2000-03-01 2001-02-23 Proceso para la preparacion de triesteres de fosforotioato.

Country Status (21)

Country Link
US (1) US7022833B2 (es)
EP (1) EP1272501B1 (es)
JP (1) JP2003525305A (es)
KR (1) KR20030032924A (es)
CN (1) CN1262557C (es)
AT (1) ATE266037T1 (es)
AU (2) AU2001235766B2 (es)
BR (1) BR0108771A (es)
CA (1) CA2401083A1 (es)
CZ (1) CZ20022930A3 (es)
DE (1) DE60103145T2 (es)
DK (1) DK1272501T3 (es)
ES (1) ES2220721T3 (es)
GB (1) GB0004889D0 (es)
HU (1) HUP0204249A3 (es)
IL (1) IL151238A0 (es)
MX (1) MXPA02008530A (es)
NO (1) NO20024155L (es)
NZ (1) NZ520778A (es)
PL (1) PL362067A1 (es)
WO (1) WO2001064702A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9717158D0 (en) * 1997-08-13 1997-10-22 King S College London Solution synthesis of oligonucleotides and their phosphorothioate analogues
WO2003045969A1 (en) * 2001-11-21 2003-06-05 Avecia Biotechnology Inc. Coupling reagent for h-phosphonate chemistry
EP1386925A1 (en) 2002-07-31 2004-02-04 Girindus AG Method for preparing oligonucleotides
GB0229423D0 (en) * 2002-12-18 2003-01-22 Avecia Ltd Process
CA2744987C (en) 2008-12-02 2018-01-16 Chiralgen, Ltd. Method for the synthesis of phosphorus atom modified nucleic acids
BR112012000828A8 (pt) 2009-07-06 2017-10-10 Ontorii Inc Novas pró-drogas de ácido nucleico e métodos de uso das mesmas
WO2012039448A1 (ja) 2010-09-24 2012-03-29 株式会社キラルジェン 不斉補助基
US9605019B2 (en) 2011-07-19 2017-03-28 Wave Life Sciences Ltd. Methods for the synthesis of functionalized nucleic acids
AU2013288048A1 (en) 2012-07-13 2015-01-22 Wave Life Sciences Ltd. Asymmetric auxiliary group
KR20220139425A (ko) 2012-07-13 2022-10-14 웨이브 라이프 사이언시스 리미티드 키랄 제어
KR101835401B1 (ko) 2012-07-13 2018-03-08 신 니뽄 바이오메디칼 라보라토리즈, 엘티디. 키랄 핵산 어쥬번트
US10322173B2 (en) 2014-01-15 2019-06-18 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent
EP3095461A4 (en) 2014-01-15 2017-08-23 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator
WO2015108048A1 (ja) 2014-01-15 2015-07-23 株式会社新日本科学 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
PT3094728T (pt) 2014-01-16 2022-05-19 Wave Life Sciences Ltd Desenho quiral

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9501465D0 (en) 1995-01-25 1995-03-15 King S College London Nucleoside phosphorothioate derivatives,synthesis and use thereof
US6096881A (en) 1997-05-30 2000-08-01 Hybridon, Inc. Sulfur transfer reagents for oligonucleotide synthesis
GB9717158D0 (en) * 1997-08-13 1997-10-22 King S College London Solution synthesis of oligonucleotides and their phosphorothioate analogues
GB9924285D0 (en) * 1999-10-14 1999-12-15 Avecia Ltd Process

Also Published As

Publication number Publication date
US20030099981A1 (en) 2003-05-29
WO2001064702A1 (en) 2001-09-07
KR20030032924A (ko) 2003-04-26
PL362067A1 (en) 2004-10-18
CN1406242A (zh) 2003-03-26
GB0004889D0 (en) 2000-04-19
DK1272501T3 (da) 2004-08-16
DE60103145D1 (de) 2004-06-09
EP1272501B1 (en) 2004-05-06
CA2401083A1 (en) 2001-09-07
NO20024155D0 (no) 2002-08-30
CN1262557C (zh) 2006-07-05
EP1272501A1 (en) 2003-01-08
NO20024155L (no) 2002-10-24
AU2001235766B2 (en) 2005-01-27
JP2003525305A (ja) 2003-08-26
CZ20022930A3 (cs) 2002-11-13
ATE266037T1 (de) 2004-05-15
HUP0204249A2 (hu) 2003-04-28
HUP0204249A3 (en) 2004-08-30
DE60103145T2 (de) 2005-05-04
BR0108771A (pt) 2002-11-26
AU3576601A (en) 2001-09-12
ES2220721T3 (es) 2004-12-16
IL151238A0 (en) 2003-04-10
US7022833B2 (en) 2006-04-04
NZ520778A (en) 2004-05-28

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal