NO20024155L - Fremgangsmåte for fremstilling av fosforotioattriestere - Google Patents

Fremgangsmåte for fremstilling av fosforotioattriestere

Info

Publication number
NO20024155L
NO20024155L NO20024155A NO20024155A NO20024155L NO 20024155 L NO20024155 L NO 20024155L NO 20024155 A NO20024155 A NO 20024155A NO 20024155 A NO20024155 A NO 20024155A NO 20024155 L NO20024155 L NO 20024155L
Authority
NO
Norway
Prior art keywords
preparation
phosphorothioate esters
phosphonate
alcohol
phosphorothioate
Prior art date
Application number
NO20024155A
Other languages
English (en)
Norwegian (no)
Other versions
NO20024155D0 (no
Inventor
Colin Bernard Reese
Original Assignee
Avecia Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avecia Ltd filed Critical Avecia Ltd
Publication of NO20024155D0 publication Critical patent/NO20024155D0/no
Publication of NO20024155L publication Critical patent/NO20024155L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06Pyrimidine radicals
    • C07H19/10Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/16Esters of thiophosphoric acids or thiophosphorous acids
    • C07F9/165Esters of thiophosphoric acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16Purine radicals
    • C07H19/20Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Luminescent Compositions (AREA)
NO20024155A 2000-03-01 2002-08-30 Fremgangsmåte for fremstilling av fosforotioattriestere NO20024155L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0004889.2A GB0004889D0 (en) 2000-03-01 2000-03-01 Synthesis of oligonucleotides
PCT/GB2001/000764 WO2001064702A1 (en) 2000-03-01 2001-02-23 Process for the preparation of phosphorothioate triesters

Publications (2)

Publication Number Publication Date
NO20024155D0 NO20024155D0 (no) 2002-08-30
NO20024155L true NO20024155L (no) 2002-10-24

Family

ID=9886705

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20024155A NO20024155L (no) 2000-03-01 2002-08-30 Fremgangsmåte for fremstilling av fosforotioattriestere

Country Status (21)

Country Link
US (1) US7022833B2 (pt)
EP (1) EP1272501B1 (pt)
JP (1) JP2003525305A (pt)
KR (1) KR20030032924A (pt)
CN (1) CN1262557C (pt)
AT (1) ATE266037T1 (pt)
AU (2) AU3576601A (pt)
BR (1) BR0108771A (pt)
CA (1) CA2401083A1 (pt)
CZ (1) CZ20022930A3 (pt)
DE (1) DE60103145T2 (pt)
DK (1) DK1272501T3 (pt)
ES (1) ES2220721T3 (pt)
GB (1) GB0004889D0 (pt)
HU (1) HUP0204249A3 (pt)
IL (1) IL151238A0 (pt)
MX (1) MXPA02008530A (pt)
NO (1) NO20024155L (pt)
NZ (1) NZ520778A (pt)
PL (1) PL362067A1 (pt)
WO (1) WO2001064702A1 (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9717158D0 (en) * 1997-08-13 1997-10-22 King S College London Solution synthesis of oligonucleotides and their phosphorothioate analogues
AU2002339175A1 (en) * 2001-11-21 2003-06-10 Avecia Biotechnology Inc. Coupling reagent for h-phosphonate chemistry
EP1386925A1 (en) * 2002-07-31 2004-02-04 Girindus AG Method for preparing oligonucleotides
GB0229423D0 (en) * 2002-12-18 2003-01-22 Avecia Ltd Process
CA2744987C (en) 2008-12-02 2018-01-16 Chiralgen, Ltd. Method for the synthesis of phosphorus atom modified nucleic acids
AU2010270714B2 (en) 2009-07-06 2015-08-13 Wave Life Sciences Ltd. Novel nucleic acid prodrugs and methods use thereof
EP2620428B1 (en) 2010-09-24 2019-05-22 Wave Life Sciences Ltd. Asymmetric auxiliary group
SG10201700554VA (en) 2011-07-19 2017-03-30 Wave Life Sciences Pte Ltd Methods for the synthesis of functionalized nucleic acids
WO2014012081A2 (en) 2012-07-13 2014-01-16 Ontorii, Inc. Chiral control
SG11201500239VA (en) 2012-07-13 2015-03-30 Wave Life Sciences Japan Asymmetric auxiliary group
BR112015000723A2 (pt) 2012-07-13 2017-06-27 Shin Nippon Biomedical Laboratories Ltd adjuvante de ácido nucléico quiral
US10149905B2 (en) 2014-01-15 2018-12-11 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having antitumor effect and antitumor agent
JPWO2015108046A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤
EP3095461A4 (en) 2014-01-15 2017-08-23 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator
MX2016009290A (es) 2014-01-16 2017-02-28 Wave Life Sciences Ltd Diseño quiral.
WO2021243443A1 (en) * 2020-06-02 2021-12-09 The Royal Institution For The Advancement Of Learning/Mcgill University Method for the preparation of oligonucleotides

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9501465D0 (en) 1995-01-25 1995-03-15 King S College London Nucleoside phosphorothioate derivatives,synthesis and use thereof
US6096881A (en) * 1997-05-30 2000-08-01 Hybridon, Inc. Sulfur transfer reagents for oligonucleotide synthesis
GB9717158D0 (en) * 1997-08-13 1997-10-22 King S College London Solution synthesis of oligonucleotides and their phosphorothioate analogues
GB9924285D0 (en) * 1999-10-14 1999-12-15 Avecia Ltd Process

Also Published As

Publication number Publication date
NO20024155D0 (no) 2002-08-30
HUP0204249A2 (hu) 2003-04-28
IL151238A0 (en) 2003-04-10
BR0108771A (pt) 2002-11-26
CZ20022930A3 (cs) 2002-11-13
NZ520778A (en) 2004-05-28
CN1406242A (zh) 2003-03-26
CN1262557C (zh) 2006-07-05
DK1272501T3 (da) 2004-08-16
AU2001235766B2 (en) 2005-01-27
US7022833B2 (en) 2006-04-04
MXPA02008530A (es) 2003-02-12
ATE266037T1 (de) 2004-05-15
EP1272501A1 (en) 2003-01-08
EP1272501B1 (en) 2004-05-06
KR20030032924A (ko) 2003-04-26
PL362067A1 (en) 2004-10-18
CA2401083A1 (en) 2001-09-07
ES2220721T3 (es) 2004-12-16
HUP0204249A3 (en) 2004-08-30
GB0004889D0 (en) 2000-04-19
WO2001064702A1 (en) 2001-09-07
DE60103145D1 (de) 2004-06-09
AU3576601A (en) 2001-09-12
JP2003525305A (ja) 2003-08-26
DE60103145T2 (de) 2005-05-04
US20030099981A1 (en) 2003-05-29

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