BR0013249A - Derivados de ascididemina e suas aplicações terapêuticas - Google Patents
Derivados de ascididemina e suas aplicações terapêuticasInfo
- Publication number
- BR0013249A BR0013249A BR0013249-7A BR0013249A BR0013249A BR 0013249 A BR0013249 A BR 0013249A BR 0013249 A BR0013249 A BR 0013249A BR 0013249 A BR0013249 A BR 0013249A
- Authority
- BR
- Brazil
- Prior art keywords
- ascididemine
- derivatives
- therapeutic applications
- compounds
- therapeutic
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title abstract 3
- BTAIBIXHXSXUFN-UHFFFAOYSA-N ascididemine Chemical class C1=CC=CC2=NC(C(=O)C=3C4=NC=CC=3)=C3C4=NC=CC3=C21 BTAIBIXHXSXUFN-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 229940041181 antineoplastic drug Drugs 0.000 abstract 1
- 230000001472 cytotoxic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/16—Peri-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
"DERIVADOS DE ASCIDIDEMINA E SUAS APLICAçõES TERAPêUTICAS". A presente invenção se refere a uma composição farmacêutica que compreende uma quantidade eficaz de um composto escolhido entre os compostos de fórmulas (I) e (Ia) nas quais R~ 1~, R~ 2~, R~ 3~, R~ 4~, R~ 5~, R~ 6~ e R~ 7~ são tais como definidos na reivindicação 1. Esses compostos possuem propriedades citotóxicas interessantes que levam a uma aplicação terapêutica como medicamentos antitumorais.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9910490A FR2797445B1 (fr) | 1999-08-13 | 1999-08-13 | Derives d'ascididemine et leurs applications therapeutiques |
FR0006652A FR2809399B1 (fr) | 2000-05-24 | 2000-05-24 | Nouveaux derives d'ascididemine et leurs applications therapeutiques |
PCT/FR2000/002312 WO2001012631A2 (fr) | 1999-08-13 | 2000-08-11 | Derives d'ascididemine et leurs applications therapeutiques |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0013249A true BR0013249A (pt) | 2002-04-16 |
Family
ID=26212422
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0013249-7A BR0013249A (pt) | 1999-08-13 | 2000-08-11 | Derivados de ascididemina e suas aplicações terapêuticas |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP1202992B1 (pt) |
JP (1) | JP2003507381A (pt) |
CN (1) | CN1195754C (pt) |
AT (1) | ATE276256T1 (pt) |
AU (1) | AU779932B2 (pt) |
BR (1) | BR0013249A (pt) |
CA (1) | CA2393965A1 (pt) |
CZ (1) | CZ2002528A3 (pt) |
DE (1) | DE60013849T2 (pt) |
DK (1) | DK1202992T3 (pt) |
ES (1) | ES2228602T3 (pt) |
HU (1) | HUP0202767A3 (pt) |
IL (1) | IL147900A0 (pt) |
MX (1) | MXPA02001512A (pt) |
NO (1) | NO20020668L (pt) |
NZ (1) | NZ516896A (pt) |
PL (1) | PL353453A1 (pt) |
PT (1) | PT1202992E (pt) |
SK (1) | SK1662002A3 (pt) |
WO (1) | WO2001012631A2 (pt) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3548486B1 (de) * | 2016-12-05 | 2021-10-27 | Merck Patent GmbH | Materialien für organische elektrolumineszenzvorrichtungen |
-
2000
- 2000-08-11 CA CA002393965A patent/CA2393965A1/fr not_active Abandoned
- 2000-08-11 DE DE60013849T patent/DE60013849T2/de not_active Expired - Fee Related
- 2000-08-11 BR BR0013249-7A patent/BR0013249A/pt not_active IP Right Cessation
- 2000-08-11 PT PT00958678T patent/PT1202992E/pt unknown
- 2000-08-11 IL IL14790000A patent/IL147900A0/xx unknown
- 2000-08-11 PL PL00353453A patent/PL353453A1/xx not_active Application Discontinuation
- 2000-08-11 NZ NZ516896A patent/NZ516896A/en unknown
- 2000-08-11 CZ CZ2002528A patent/CZ2002528A3/cs unknown
- 2000-08-11 JP JP2001517529A patent/JP2003507381A/ja active Pending
- 2000-08-11 WO PCT/FR2000/002312 patent/WO2001012631A2/fr active IP Right Grant
- 2000-08-11 AT AT00958678T patent/ATE276256T1/de not_active IP Right Cessation
- 2000-08-11 DK DK00958678T patent/DK1202992T3/da active
- 2000-08-11 EP EP00958678A patent/EP1202992B1/fr not_active Expired - Lifetime
- 2000-08-11 SK SK166-2002A patent/SK1662002A3/sk unknown
- 2000-08-11 MX MXPA02001512A patent/MXPA02001512A/es unknown
- 2000-08-11 ES ES00958678T patent/ES2228602T3/es not_active Expired - Lifetime
- 2000-08-11 AU AU70124/00A patent/AU779932B2/en not_active Ceased
- 2000-08-11 CN CNB008126569A patent/CN1195754C/zh not_active Expired - Fee Related
- 2000-08-11 HU HU0202767A patent/HUP0202767A3/hu unknown
-
2002
- 2002-02-11 NO NO20020668A patent/NO20020668L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP1202992A2 (fr) | 2002-05-08 |
PL353453A1 (en) | 2003-11-17 |
DE60013849D1 (de) | 2004-10-21 |
JP2003507381A (ja) | 2003-02-25 |
HUP0202767A2 (hu) | 2003-01-28 |
NO20020668L (no) | 2002-04-15 |
DE60013849T2 (de) | 2005-02-03 |
SK1662002A3 (en) | 2002-09-10 |
CZ2002528A3 (cs) | 2002-05-15 |
CA2393965A1 (fr) | 2001-02-22 |
MXPA02001512A (es) | 2002-07-02 |
WO2001012631A2 (fr) | 2001-02-22 |
NO20020668D0 (no) | 2002-02-11 |
AU779932B2 (en) | 2005-02-17 |
EP1202992B1 (fr) | 2004-09-15 |
HUP0202767A3 (en) | 2003-12-29 |
CN1373762A (zh) | 2002-10-09 |
AU7012400A (en) | 2001-03-13 |
WO2001012631A3 (fr) | 2001-07-19 |
ATE276256T1 (de) | 2004-10-15 |
CN1195754C (zh) | 2005-04-06 |
DK1202992T3 (da) | 2005-01-24 |
IL147900A0 (en) | 2002-08-14 |
ES2228602T3 (es) | 2005-04-16 |
NZ516896A (en) | 2004-02-27 |
PT1202992E (pt) | 2004-12-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A, 8A E 9A ANUIDADES |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2008 DE 30/06/2009. |