BR0311222A - R-enantiÈmeros de derivados de piranoindol contra hepatite c, seu método de obtenção e composição farmacêutica compreendendo os mesmos - Google Patents

R-enantiÈmeros de derivados de piranoindol contra hepatite c, seu método de obtenção e composição farmacêutica compreendendo os mesmos

Info

Publication number
BR0311222A
BR0311222A BR0311222-5A BR0311222A BR0311222A BR 0311222 A BR0311222 A BR 0311222A BR 0311222 A BR0311222 A BR 0311222A BR 0311222 A BR0311222 A BR 0311222A
Authority
BR
Brazil
Prior art keywords
pharmaceutical composition
obtaining
enantiomers
against hepatitis
derivatives against
Prior art date
Application number
BR0311222-5A
Other languages
English (en)
Inventor
Ariamala Gopalsamy
John W Ellingboe
Tarek Suhayl Mansour
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of BR0311222A publication Critical patent/BR0311222A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"R-ENANTIÈMEROS DE DERIVADOS DE PIRANOINDOL CONTRA HEPATITE C, SEU MéTODO DE OBTENçãO E COMPOSIçãO FARMACêUTICA COMPREENDENDO OS MESMOS". A presente invenção refere-se a um composto e uma composição farmacêutica da fórmula: em que as substituições em R~ 1~, R~ 2~, R~ 3~ - R~ 12~ e Y são determinadas na especificação.
BR0311222-5A 2002-05-21 2003-05-21 R-enantiÈmeros de derivados de piranoindol contra hepatite c, seu método de obtenção e composição farmacêutica compreendendo os mesmos BR0311222A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38214802P 2002-05-21 2002-05-21
PCT/US2003/015823 WO2003099824A1 (en) 2002-05-21 2003-05-21 R-enantiomers of pyranoindole derivatives against hepatitis c

Publications (1)

Publication Number Publication Date
BR0311222A true BR0311222A (pt) 2005-03-01

Family

ID=29584365

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0311222-5A BR0311222A (pt) 2002-05-21 2003-05-21 R-enantiÈmeros de derivados de piranoindol contra hepatite c, seu método de obtenção e composição farmacêutica compreendendo os mesmos

Country Status (11)

Country Link
US (1) US6964979B2 (pt)
EP (1) EP1506201A1 (pt)
JP (1) JP2005533031A (pt)
CN (1) CN1653069A (pt)
AR (1) AR040088A1 (pt)
AU (1) AU2003229336A1 (pt)
BR (1) BR0311222A (pt)
CA (1) CA2486056A1 (pt)
MX (1) MXPA04011063A (pt)
TW (1) TW200400963A (pt)
WO (1) WO2003099824A1 (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20031471A1 (it) * 2003-07-18 2005-01-19 Chemi Spa Processo per la racemizzazione dell'acido etodolico
WO2005016932A1 (en) * 2003-08-14 2005-02-24 Wyeth Pyranobenzothiophene derivatives to treat infection with hepatitis c virus
EP2626354A1 (en) 2004-02-20 2013-08-14 Boehringer Ingelheim International GmbH Viral polymerase inhibitors
JP4143669B2 (ja) 2004-02-24 2008-09-03 日本たばこ産業株式会社 ４環縮合複素環化合物及びそのｈｃｖポリメラーゼ阻害剤としての利用
US20070049593A1 (en) 2004-02-24 2007-03-01 Japan Tobacco Inc. Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor
MXPA06009881A (es) * 2004-03-01 2007-11-20 Viropharma Inc Derivados de piranoindol y el uso de los mismos para el tratamiento de infeccion o enfermedad de virus de hepatitis c.
US7795247B2 (en) 2004-10-26 2010-09-14 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa Tetracyclic indole derivatives as antiviral agents
EP1807397A2 (en) * 2004-10-26 2007-07-18 Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. Tetracyclic indole derivatives as antiviral agents
US7473688B2 (en) * 2005-09-13 2009-01-06 Bristol-Myers Squibb Company Indolobenzazepine HCV NS5B inhibitors
GB0608928D0 (en) 2006-05-08 2006-06-14 Angeletti P Ist Richerche Bio Therapeutic agents
US20080182895A1 (en) * 2006-08-25 2008-07-31 Howe Anita Y M Identification and characterization of hcv replicon variants with reduced susceptibility to hcv-796, and methods related thereto
CA2686051A1 (en) 2007-05-04 2008-11-13 Vertex Pharmaceuticals Incorporated Combination therapy for the treatment of hcv infection
WO2009010785A1 (en) 2007-07-17 2009-01-22 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa Macrocyclic indole derivatives for the treatment of hepatitis c infections
US8124601B2 (en) * 2007-11-21 2012-02-28 Bristol-Myers Squibb Company Compounds for the treatment of Hepatitis C
TWI491606B (zh) 2009-07-13 2015-07-11 Gilead Sciences Inc 調節細胞凋亡信號之激酶的抑制劑
SI3110797T1 (sl) 2014-02-27 2018-11-30 Gruenenthal Gmbh Postopek za pripravo 5-fluorotriptofola
US9586933B2 (en) 2014-12-23 2017-03-07 Gilead Sciences, Inc. Processes for preparing ASK1 inhibitors
EP4126881A1 (en) * 2020-04-03 2023-02-08 Vertex Pharmaceuticals Incorporated Pyrano[4,3-b]l ndole derivatives as alpha-1 -antitrypsin modulators for treating alpha-1 -antitrypsin deficiency (aatd)
EP4326702A1 (en) * 2021-04-22 2024-02-28 XF Technologies Inc. Methods for synthesis of an advantageous n-heterocyclic carbene catalyst

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3843681A (en) 1971-06-01 1974-10-22 American Home Prod 1-carboxamido pyrano(thiopyrano)(3,4-6)indole derivatives
US3939178A (en) 1971-06-01 1976-02-17 American Home Products Corporation Certain pyrano [3,4-b]indoles and thiopyrano[3,4-b]indoles
US3974179A (en) 1971-06-01 1976-08-10 American Home Products Corporation 1,3,4,9-Tetrahydropyrano[3,4-b]indole-1-acetamides and derivatives
US3880853A (en) 1972-01-13 1975-04-29 Ayerst Mckenna & Harrison Pyrano-and thiopyranoindole
US4012417A (en) 1972-05-16 1977-03-15 American Home Products Corporation Process for preparing pyrano[3,4-b]indole or thio pyrano[3,4-b]indole derivatives
US4076831A (en) 1972-05-16 1978-02-28 American Home Products Corporation Pyrano[3,4-b]-indole derivatives, pharmaceutical compositions and methods of use
US4070371A (en) 1972-05-16 1978-01-24 American Home Products Corporation Derivatives of 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid
US4036842A (en) 1972-05-16 1977-07-19 American Home Products Corporation Process for preparing polycyclic heterocycles having a pyran ring
US4118394A (en) 1976-10-18 1978-10-03 Ayerst, Mckenna & Harrison Limited Pyrano- and thiopyranoindole derivatives
US4179503A (en) 1978-05-08 1979-12-18 American Home Products Corp. 1-Hydroxyalkanamine pyrano[3,4-b]indole derivatives
US4501899A (en) 1983-08-16 1985-02-26 American Home Products Corporation Resolution of (+)-1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid using cholesteryl aniline
US4515961A (en) 1983-08-16 1985-05-07 American Home Products Corporation Resolution of (±)-1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4,-b] indole-1-acetic acid using enrichment crystallization
US4520203A (en) 1983-08-16 1985-05-28 American Home Products Corporation Resolution of (±)-1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid using cinchonine
US4544757A (en) 1984-02-16 1985-10-01 American Home Products Corporation Process for the resolution of pyrano[3,4-b]indole-1-acetic acids
US4604469A (en) 1984-02-16 1986-08-05 American Home Products Corporation Process for the resolution of pyrano[3,4-b]indole-1-acetic acids
US4585877A (en) 1985-05-06 1986-04-29 American Home Products Corporation Process for preparing 1,8-diethyl-1,3,4,9-tetrahydropyrano(3,4-b)-indole-1-acetic acid, etodolac
US4670462A (en) 1986-03-11 1987-06-02 American Home Products Corporation Substituted 1,3,4,9-tetrahydropyrano(3,4-B)indole-1-acetic acids
US4686213A (en) 1986-08-15 1987-08-11 American Home Products Corporation Substituted 1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acids
CA1319695C (en) 1987-02-20 1993-06-29 Brian A. Mckittrick Substituted 1,3,4,9-tetrahydropyrano¬3,4-b|- indole-1-acetic acids
US4810699A (en) 1987-02-20 1989-03-07 American Home Products Corporation Substituted 1,3,4,9-tetrahydropyrano[3,4,-b]indole-1-acetic acids, pharmaceutical compositions containing them, and methods for treating inflammatory conditions and for analgesic purposes using them
US4822781A (en) 1987-10-08 1989-04-18 American Home Products Substituted-8-alkenyl-1,3,4,9-tetrahydropyrano-[3,4-b]indole-1-acetic acids
US4822893A (en) 1988-02-08 1989-04-18 American Home Products Production of substituted 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acids
US4960902A (en) 1988-08-19 1990-10-02 American Home Products Corporation Trifluoromethoxy substituted 1,3,4,9-tetrahydropyrano-[3,4-b]indole-1-acetic acids
US5128363A (en) 1988-08-19 1992-07-07 American Home Products Corporation Trifluoromethoxy substituted 1,3,4,9-tetrahydropyrano-[3,4-b]indole-1-acetic acids
US5071853A (en) 1989-03-23 1991-12-10 Bigge Christopher F Polycyclic amines useful as cerebrovascular agents
DE4027278A1 (de) 1990-08-29 1992-03-05 Bayer Ag Heterocyclisch substituierte indolsulfonamide
AU3806393A (en) 1992-03-13 1993-10-05 Sepracor, Inc. Antipyretic and analgesic methods and compositions containing optically pure r-etodolac
CH685345A5 (it) 1993-01-14 1995-06-15 Applied Pharma Res Metodo per la preparazione di acido S-(+)-etodolico e di suoi derivati salini.
IT1278077B1 (it) 1995-05-25 1997-11-17 Angeletti P Ist Richerche Bio Metodologia per riprodurre in vitro le attivita' di rna polimerasi rna-dipendente e di nucleotidiltransferasi terminale codificate dal
US5599946A (en) 1995-05-30 1997-02-04 Teva Pharmaceutical Industries Ltd. 3-(2-trialkylsilyloxy)ethyl-7-ethyl-1H-indoles and method for their preparation
US5830905A (en) 1996-03-29 1998-11-03 Viropharma Incorporated Compounds, compositions and methods for treatment of hepatitis C
US5633388A (en) 1996-03-29 1997-05-27 Viropharma Incorporated Compounds, compositions and methods for treatment of hepatitis C
US5776967A (en) 1996-07-26 1998-07-07 American Home Products Corporation Pyranoindole inhibitors of COX--2
US5830911A (en) 1996-08-14 1998-11-03 American Home Products Corporation Pyranoindole and tetrahydrocarbazole inhibitors of COX-2
US6177440B1 (en) 1996-10-30 2001-01-23 Eli Lilly And Company Substituted tricyclics
US6110955A (en) 1997-03-11 2000-08-29 Beacon Laboratories, Inc. Metabolically stabilized oxyalkylene esters and uses thereof
US5939455A (en) 1997-03-11 1999-08-17 Beacon Laboratories, Inc. Therapeutic augmentation of oxyalkylene diesters and butyric acid derivatives
FR2764890B1 (fr) 1997-06-24 1999-08-27 Adir Nouveaux derives chromeniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6066741A (en) 1998-09-08 2000-05-23 A.M.S.A. Anonima Materie Sintetiche & Affini S.P.A. Process for the preparation of etodolac
EP1126838A4 (en) 1998-10-30 2005-02-16 Nitromed Inc NITROSIS AND NITROSYAL NON-STEROID ANTI-INFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE
US6331638B1 (en) 1999-10-04 2001-12-18 Ranbaxy Laboratories Limited Process for the preparation of 1,8-disubstituted-1,3,4,9-tetrahydropyrano (3,4-B)-indole-1-acetic acid esters
US6720001B2 (en) 1999-10-18 2004-04-13 Lipocine, Inc. Emulsion compositions for polyfunctional active ingredients
US6429223B1 (en) 2000-06-23 2002-08-06 Medinox, Inc. Modified forms of pharmacologically active agents and uses therefor
US6448281B1 (en) 2000-07-06 2002-09-10 Boehringer Ingelheim (Canada) Ltd. Viral polymerase inhibitors
US6410583B1 (en) 2000-07-25 2002-06-25 Merck Frosst Canada & Co. Cyclopentanoindoles, compositions containing such compounds and methods of treatment
US7122544B2 (en) 2000-12-06 2006-10-17 Signal Pharmaceuticals, Llc Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto
US7129242B2 (en) 2000-12-06 2006-10-31 Signal Pharmaceuticals, Llc Anilinopyrimidine derivatives as JNK pathway inhibitors and compositions and methods related thereto

Also Published As

Publication number Publication date
EP1506201A1 (en) 2005-02-16
CN1653069A (zh) 2005-08-10
JP2005533031A (ja) 2005-11-04
MXPA04011063A (es) 2005-02-14
WO2003099824A1 (en) 2003-12-04
US6964979B2 (en) 2005-11-15
CA2486056A1 (en) 2003-12-04
AU2003229336A1 (en) 2003-12-12
AR040088A1 (es) 2005-03-16
AU2003229336A2 (en) 2003-12-12
TW200400963A (en) 2004-01-16
US20040029947A1 (en) 2004-02-12

Similar Documents

Publication Publication Date Title
BR0311222A (pt) R-enantiÈmeros de derivados de piranoindol contra hepatite c, seu método de obtenção e composição farmacêutica compreendendo os mesmos
UY29007A1 (es) Derivados de 2-carbamida-4-feniltiazol, su preparacinn, y su aplicacinn en terapcutica
BR0316386A (pt) Benzoxazin-3-onas e seus derivados como inibidores de p13k
BRPI0512677A2 (pt) derivados de quinazolina
CY1119988T1 (el) Αναστολεις του ιου της ηπατιτιδας c
BRPI0510273A (pt) derivados de tetraazabenzo[e]azuleno e análogos destes
BRPI0517846A (pt) azaindolcarboxamidas
BRPI0412851A (pt) benzamidazóis de n-metila-substituìdos
BRPI0518898A2 (pt) composto, processo para sua preparaÇço, composiÇço farmacÊutica, mÉtodo para tratamento e uso do composto
BR0316470A (pt) Derivados de 3-amino-piperadina e métodos de preparação
BR0317268A (pt) Compostos ativadores da pirazina e da piridina glucoquinase 5-substituìda, composição farmacêutica, uso e processo de preparação dos mesmos
BR0307960A (pt) N-aminoacetil-pirrolidina-2-carbonitrilas e seu uso como inibidores de ddp-iv
BRPI0512938A (pt) derivados da quinazolinediona como inibidores parp
EA200870216A1 (ru) Амидо соединения и их применение в качестве лекарственных средств
BRPI0415449A (pt) combinações de compostos ativos fungicidas sinergìsticos
BRPI0606606A2 (pt) composições estáveis contendo prostaglandina
NO20076425L (no) Fremgangsmater for behandling av drug-resistent cancer
UY28917A1 (es) Derivados de tetrahidroisoquinolilsulfonamidas composiciones farmaceuticas y su uso terapeutico
UY29892A1 (es) Nuevos derivados de cromano, composiciones farmaceuticas conteniendolos, procesos de preparacion y aplicaciones
ATE302756T1 (de) Kristalline formen von fluvastatin sodium
BR0308765A (pt) Compostos (4,2-dissubstituìdo-tiazol-5-il)amina como inibidores de pde7
BRPI0407652A (pt) método para acentuar a eficácia de um agente ativo, composição e método para produzir a composição
BRPI0407968A (pt) derivados de oxamida úteis como inibidores de raf-quinase
BRPI0501769A (pt) Compostos de pirrolidina e tiazolidina, processo para sua preparação e composições farmacêuticas contendo os mesmos
BR0211903A (pt) Isoxazolopiridinonas

Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]