BR0012742A - Oxazolidinonas e seus usos como antibiótico - Google Patents

Oxazolidinonas e seus usos como antibiótico

Info

Publication number
BR0012742A
BR0012742A BR0012742-6A BR0012742A BR0012742A BR 0012742 A BR0012742 A BR 0012742A BR 0012742 A BR0012742 A BR 0012742A BR 0012742 A BR0012742 A BR 0012742A
Authority
BR
Brazil
Prior art keywords
oxazolidinones
antibiotic
thiocarbonyl
alkylthio
aminothiocarbonyl
Prior art date
Application number
BR0012742-6A
Other languages
English (en)
Inventor
Mikhail F Gordeev
Dinesh V Patel
Gary W Luehr
Robert C Gadwood
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of BR0012742A publication Critical patent/BR0012742A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"OXAZOLIDINONAS E SEUS USOS COMO ANTIBIóTICO". Os compostos da fórmula ( 1 ) em que: R~ 6~ é tioacila substituída, aminocarbonila, alcóxi-carbonila, aminotiocarbonila, alcóxi-tiocarbonila, alquiltio ( carbonila ), ou alquiltio ( tiocarbonila ); R~ 7~ é arila ou heteroarila; e R~ 8~-R~ 9~ são substituintes específicos; são úteis no tratamento ou na prevenção de uma doença infecciosa em um indivíduo humano ou outro animal.
BR0012742-6A 1999-07-28 2000-07-26 Oxazolidinonas e seus usos como antibiótico BR0012742A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14601299P 1999-07-28 1999-07-28
PCT/US2000/020332 WO2001009107A1 (en) 1999-07-28 2000-07-26 Oxazolidinones and their use as antiinfectives

Publications (1)

Publication Number Publication Date
BR0012742A true BR0012742A (pt) 2002-06-11

Family

ID=22515530

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0012742-6A BR0012742A (pt) 1999-07-28 2000-07-26 Oxazolidinonas e seus usos como antibiótico

Country Status (13)

Country Link
US (2) US6441005B1 (pt)
EP (1) EP1200416A1 (pt)
JP (1) JP2003513885A (pt)
KR (1) KR20020022787A (pt)
CN (1) CN1367780A (pt)
AR (1) AR024968A1 (pt)
AU (1) AU773359B2 (pt)
BR (1) BR0012742A (pt)
CA (1) CA2374383A1 (pt)
IL (1) IL147503A0 (pt)
MX (1) MXPA02000985A (pt)
NZ (1) NZ516853A (pt)
WO (1) WO2001009107A1 (pt)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7002020B1 (en) * 1998-01-23 2006-02-21 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
EP1200416A1 (en) * 1999-07-28 2002-05-02 Pharmacia & Upjohn Company Oxazolidinones and their use as antiinfectives
ES2256318T3 (es) * 2000-10-17 2006-07-16 PHARMACIA & UPJOHN COMPANY LLC Metodos de produccion de compuestos de oxazolidinona.
YU52403A (sh) 2000-12-26 2006-03-03 Dr.Reddy's Research Foundation Heterociklična jedinjenja koja imaju antibakterijsko dejstvo, postupak za njihovo dobijanje i farmaceutske smeše koje ih sadrže
US7160912B2 (en) 2000-12-26 2007-01-09 Dr.Reddy's Laboratories Ltd. Heterocyclic compounds having antibacterial activity: process for their preparation and pharmaceutical compositions containing them
WO2003031443A1 (en) 2001-10-04 2003-04-17 Morphochem Aktiengesellschaft für kombinatorische Chemie Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety
US6914058B2 (en) * 2002-01-18 2005-07-05 Dr. Reddy's Laboratories, Limited Antibacterial compounds: process for their preparation and pharmaceutical compositions containing them
AU2002339721A1 (en) 2002-09-20 2004-04-08 Lupin Limited Oxazolidinone derivatives, process for their preperation and their use as antimycobacterial agents
AU2002357561A1 (en) * 2002-12-30 2004-07-22 Nanjing Chang'ao Pharmaceutical Science And Technology Limited Company Oxazolidine derivative, methods of preparation and uses
US7144911B2 (en) * 2002-12-31 2006-12-05 Deciphera Pharmaceuticals Llc Anti-inflammatory medicaments
MXPA05011654A (es) 2003-04-30 2005-12-15 Morphochem Ag Komb Chemie Uso de antibioticos hibridos de oxazolidinona-quinolina para el tratamiento del antrax y de otras infecciones.
WO2004101552A1 (en) * 2003-05-14 2004-11-25 Orchid Chemicals & Pharmaceuticals Ltd Oxazolidinone derivatives as antibacterial agents
US8324398B2 (en) * 2003-06-03 2012-12-04 Rib-X Pharmaceuticals, Inc. Process for the synthesis of biaryl oxazolidinones
TWI378092B (en) 2003-06-03 2012-12-01 Rib X Pharmaceuticals Inc Biaryl heterocyclic compounds and methods of making and using the same
DE10340485B4 (de) * 2003-09-03 2015-05-13 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden
US7687627B2 (en) * 2003-09-08 2010-03-30 Wockhardt Limited Substituted piperidino phenyloxazolidinones having antimicrobial activity with improved in vivo efficacy
WO2005061468A1 (en) * 2003-12-17 2005-07-07 Rib-X Pharmaceuticals, Inc. Halogenated biaryl heterocyclic compounds and methods of making and using the same
PL1709044T5 (pl) 2003-12-18 2014-03-31 Morphochem Aktiengesellschaft Fuer Komb Chemie Antybiotyki hybrydowe oksazolidynon-chinolon
US8158797B2 (en) 2003-12-18 2012-04-17 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
ATE496914T1 (de) 2005-06-08 2011-02-15 Rib X Pharmaceuticals Inc Verfahren zur synthese von triazolen
EP2181993A1 (en) * 2006-03-31 2010-05-05 Research Foundation Itsuu Laboratory Antimicrobial oxazolidinone derivatives
CN100395270C (zh) * 2006-05-25 2008-06-18 湖北大学 线型聚苯乙烯支载的(4s)-5,5-二取代基噁唑烷酮及其制备方法和用途
JPWO2009044777A1 (ja) 2007-10-02 2011-02-10 財団法人乙卯研究所 ７員ヘテロ環を有するオキサゾリジノン誘導体
CA2929787C (en) 2015-05-12 2021-09-14 The Toronto-Dominion Bank Resource allocation control based on connected devices
CN113018506B (zh) * 2021-03-19 2021-11-30 衡阳市建衡实业有限公司 一种复合聚丙烯酰胺水凝胶及其制备方法

Family Cites Families (28)

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Publication number Priority date Publication date Assignee Title
US4705799A (en) 1983-06-07 1987-11-10 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents
DE3884563T2 (de) 1987-10-21 1994-02-17 Du Pont Merck Pharma Aminomethyl-oxo-oxazolidinyl-ethenylbenzen-Derivate, nützlich als antibakterielles Mittel.
US4977173A (en) 1987-10-21 1990-12-11 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl ethenylbenzene derivatives useful as antibacterial agents
US4948801A (en) 1988-07-29 1990-08-14 E. I. Du Pont De Nemours And Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
US5225565A (en) 1988-09-15 1993-07-06 The Upjohn Company Antibacterial 3-(fused-ring substituted)phenyl-5β-amidomethyloxazolidin-2-ones
US5182403A (en) 1988-09-15 1993-01-26 The Upjohn Company Substituted 3(5'indazolyl) oxazolidin-2-ones
ATE201870T1 (de) 1988-09-15 2001-06-15 Upjohn Co 3-(stickstoff substituierte)phenyl-5-beta- amidomethyloxazoliden-2-one
SK283420B6 (sk) 1992-05-08 2003-07-01 Pharmacia & Upjohn Company Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny
JP3365067B2 (ja) * 1994-02-10 2003-01-08 ソニー株式会社 プラズマ装置およびこれを用いたプラズマ処理方法
DE4425609A1 (de) * 1994-07-20 1996-01-25 Bayer Ag Benzofuranyl- und Benzothienyloxazolidinone
HRP960159A2 (en) 1995-04-21 1997-08-31 Bayer Ag Benzocyclopentane oxazolidinones containing heteroatoms
DE19601264A1 (de) 1996-01-16 1997-07-17 Bayer Ag Pyrido-annellierte Thienyl- und Furanyl-Oxazolidinone
DE19601627A1 (de) 1996-01-18 1997-07-24 Bayer Ag Heteroatomhaltige Cyclopentanopyridyl-Oxazolidinone
DE19604223A1 (de) 1996-02-06 1997-08-07 Bayer Ag Neue substituierte Oxazolidinone
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AU729745B2 (en) 1997-07-11 2001-02-08 Pharmacia & Upjohn Company Thiadiazolyl and oxadiazolyl phenyl oxazolidinone antibacterial agents
DE19730847A1 (de) * 1997-07-18 1999-01-28 Bayer Ag Tricyclisch substituierte Oxazolidinone
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DE19805117A1 (de) * 1998-02-09 1999-08-12 Bayer Ag Neue Oxazolidinone mit azolhaltigen Tricyclen
JPH11322729A (ja) 1998-03-09 1999-11-24 Hokuriku Seiyaku Co Ltd ジチオカルバミド酸誘導体
JP2000204084A (ja) * 1998-11-11 2000-07-25 Hokuriku Seiyaku Co Ltd チオカルバミド酸誘導体
WO2000029396A1 (de) * 1998-11-17 2000-05-25 Bayer Aktiengesellschaft Neue substituierte phenyloxazolidon-derivate
WO2000029409A1 (de) 1998-11-17 2000-05-25 Bayer Aktiengesellschaft Neue heterocyclyl-substituierte oxazolidon-derivate
EP1200416A1 (en) * 1999-07-28 2002-05-02 Pharmacia & Upjohn Company Oxazolidinones and their use as antiinfectives

Also Published As

Publication number Publication date
CN1367780A (zh) 2002-09-04
NZ516853A (en) 2003-11-28
IL147503A0 (en) 2002-08-14
WO2001009107A1 (en) 2001-02-08
EP1200416A1 (en) 2002-05-02
US6441005B1 (en) 2002-08-27
AU6377900A (en) 2001-02-19
CA2374383A1 (en) 2001-02-08
MXPA02000985A (es) 2002-07-30
US6743811B2 (en) 2004-06-01
KR20020022787A (ko) 2002-03-27
AR024968A1 (es) 2002-10-30
AU773359B2 (en) 2004-05-20
JP2003513885A (ja) 2003-04-15
US20020169191A1 (en) 2002-11-14

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A, 8A E 9A ANUIDADES

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2008 DE 30/06/2009.