AR024968A1 - Compuestos de oxazolidinona, metodos de preparacion y composicion que los contiene - Google Patents
Compuestos de oxazolidinona, metodos de preparacion y composicion que los contieneInfo
- Publication number
- AR024968A1 AR024968A1 ARP000103894A ARP000103894A AR024968A1 AR 024968 A1 AR024968 A1 AR 024968A1 AR P000103894 A ARP000103894 A AR P000103894A AR P000103894 A ARP000103894 A AR P000103894A AR 024968 A1 AR024968 A1 AR 024968A1
- Authority
- AR
- Argentina
- Prior art keywords
- nrc
- heteroaryl
- aryl
- alkyl
- oxazolidinones
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compuestos de formula (1) donde R6 es tioacilo, aminocarbonilo, alcoxicarbonilo, aminotiocarbonilo, alcoxitiocarbonilo, alquiltio(carbonil), o alquiltio(tiocarbonil);R7 es arilo o heteroarilo; R8 es alquilo de C1-7, alquenilo de C1-7, alquinilo de C1-7, NR, O, S, C(=O)NR, NRC(=O), C(=O), C(=O)O, OC(=O), OC(=O)NR, NRC(=O)O, C(=S)NR, NRS(=O), C(=S), C(=S)O, OC(=S), OC(=S)NR, NRC(=S)O, S(=O), SO2, SO2NR, NRSO2, NRCONR, NRC(=S)NNR, o (CH2)nO, donde n = 0-6, y donde Ry R son independientemente H, alquilo, heteroalquilo, arilo, o heteroarilo, y R9 es hidrogeno, OH, OR, SR, NRR, alquilo, arilo, heteroalquilo oheteroarilo, y donde R y R son independientemente H, alquilo, heteroalquilo, arilo o heteroarilo. Se proporcionan oxazolidinonas y métodos para sussíntesis . Además se proporcionan métodos para preparar oxazolidinonas biologicamente activas así como también composiciones farmacéuticamente aceptables quecomprenden oxazolidinonas. Las oxazolidinonas como se revelan en la presente se puedensintetizar fácilmente y se usan en una variedad de aplicacionesincluyendo el uso como agentes antimicrobianos. En una realizacion, se proporciona una variedad de tioamidometiloxazolidinonas y métodos para sus síntesis.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14601299P | 1999-07-28 | 1999-07-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR024968A1 true AR024968A1 (es) | 2002-10-30 |
Family
ID=22515530
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP000103894A AR024968A1 (es) | 1999-07-28 | 2000-07-27 | Compuestos de oxazolidinona, metodos de preparacion y composicion que los contiene |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US6441005B1 (es) |
| EP (1) | EP1200416A1 (es) |
| JP (1) | JP2003513885A (es) |
| KR (1) | KR20020022787A (es) |
| CN (1) | CN1367780A (es) |
| AR (1) | AR024968A1 (es) |
| AU (1) | AU773359B2 (es) |
| BR (1) | BR0012742A (es) |
| CA (1) | CA2374383A1 (es) |
| IL (1) | IL147503A0 (es) |
| MX (1) | MXPA02000985A (es) |
| NZ (1) | NZ516853A (es) |
| WO (1) | WO2001009107A1 (es) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7002020B1 (en) * | 1998-01-23 | 2006-02-21 | Pharmacia & Upjohn Company | Oxazolidinone combinatorial libraries, compositions and methods of preparation |
| EP1200416A1 (en) * | 1999-07-28 | 2002-05-02 | Pharmacia & Upjohn Company | Oxazolidinones and their use as antiinfectives |
| ES2256318T3 (es) * | 2000-10-17 | 2006-07-16 | PHARMACIA & UPJOHN COMPANY LLC | Metodos de produccion de compuestos de oxazolidinona. |
| YU52403A (sh) | 2000-12-26 | 2006-03-03 | Dr.Reddy's Research Foundation | Heterociklična jedinjenja koja imaju antibakterijsko dejstvo, postupak za njihovo dobijanje i farmaceutske smeše koje ih sadrže |
| US7160912B2 (en) | 2000-12-26 | 2007-01-09 | Dr.Reddy's Laboratories Ltd. | Heterocyclic compounds having antibacterial activity: process for their preparation and pharmaceutical compositions containing them |
| WO2003031443A1 (en) | 2001-10-04 | 2003-04-17 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety |
| US6914058B2 (en) * | 2002-01-18 | 2005-07-05 | Dr. Reddy's Laboratories, Limited | Antibacterial compounds: process for their preparation and pharmaceutical compositions containing them |
| AU2002339721A1 (en) | 2002-09-20 | 2004-04-08 | Lupin Limited | Oxazolidinone derivatives, process for their preperation and their use as antimycobacterial agents |
| AU2002357561A1 (en) * | 2002-12-30 | 2004-07-22 | Nanjing Chang'ao Pharmaceutical Science And Technology Limited Company | Oxazolidine derivative, methods of preparation and uses |
| US7144911B2 (en) * | 2002-12-31 | 2006-12-05 | Deciphera Pharmaceuticals Llc | Anti-inflammatory medicaments |
| MXPA05011654A (es) | 2003-04-30 | 2005-12-15 | Morphochem Ag Komb Chemie | Uso de antibioticos hibridos de oxazolidinona-quinolina para el tratamiento del antrax y de otras infecciones. |
| WO2004101552A1 (en) * | 2003-05-14 | 2004-11-25 | Orchid Chemicals & Pharmaceuticals Ltd | Oxazolidinone derivatives as antibacterial agents |
| US8324398B2 (en) * | 2003-06-03 | 2012-12-04 | Rib-X Pharmaceuticals, Inc. | Process for the synthesis of biaryl oxazolidinones |
| TWI378092B (en) | 2003-06-03 | 2012-12-01 | Rib X Pharmaceuticals Inc | Biaryl heterocyclic compounds and methods of making and using the same |
| DE10340485B4 (de) * | 2003-09-03 | 2015-05-13 | Morphochem AG Aktiengesellschaft für kombinatorische Chemie | Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden |
| US7687627B2 (en) * | 2003-09-08 | 2010-03-30 | Wockhardt Limited | Substituted piperidino phenyloxazolidinones having antimicrobial activity with improved in vivo efficacy |
| WO2005061468A1 (en) * | 2003-12-17 | 2005-07-07 | Rib-X Pharmaceuticals, Inc. | Halogenated biaryl heterocyclic compounds and methods of making and using the same |
| PL1709044T5 (pl) | 2003-12-18 | 2014-03-31 | Morphochem Aktiengesellschaft Fuer Komb Chemie | Antybiotyki hybrydowe oksazolidynon-chinolon |
| US8158797B2 (en) | 2003-12-18 | 2012-04-17 | Morphochem Aktiengesellschaft Fur Kombinatorische Chemie | Oxazolidinone-quinolone hybrid antibiotics |
| ATE496914T1 (de) | 2005-06-08 | 2011-02-15 | Rib X Pharmaceuticals Inc | Verfahren zur synthese von triazolen |
| EP2181993A1 (en) * | 2006-03-31 | 2010-05-05 | Research Foundation Itsuu Laboratory | Antimicrobial oxazolidinone derivatives |
| CN100395270C (zh) * | 2006-05-25 | 2008-06-18 | 湖北大学 | 线型聚苯乙烯支载的(4s)-5,5-二取代基噁唑烷酮及其制备方法和用途 |
| JPWO2009044777A1 (ja) | 2007-10-02 | 2011-02-10 | 財団法人乙卯研究所 | ７員ヘテロ環を有するオキサゾリジノン誘導体 |
| CA2929787C (en) | 2015-05-12 | 2021-09-14 | The Toronto-Dominion Bank | Resource allocation control based on connected devices |
| CN113018506B (zh) * | 2021-03-19 | 2021-11-30 | 衡阳市建衡实业有限公司 | 一种复合聚丙烯酰胺水凝胶及其制备方法 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4705799A (en) | 1983-06-07 | 1987-11-10 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents |
| DE3884563T2 (de) | 1987-10-21 | 1994-02-17 | Du Pont Merck Pharma | Aminomethyl-oxo-oxazolidinyl-ethenylbenzen-Derivate, nützlich als antibakterielles Mittel. |
| US4977173A (en) | 1987-10-21 | 1990-12-11 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl ethenylbenzene derivatives useful as antibacterial agents |
| US4948801A (en) | 1988-07-29 | 1990-08-14 | E. I. Du Pont De Nemours And Company | Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents |
| US5225565A (en) | 1988-09-15 | 1993-07-06 | The Upjohn Company | Antibacterial 3-(fused-ring substituted)phenyl-5β-amidomethyloxazolidin-2-ones |
| US5182403A (en) | 1988-09-15 | 1993-01-26 | The Upjohn Company | Substituted 3(5'indazolyl) oxazolidin-2-ones |
| ATE201870T1 (de) | 1988-09-15 | 2001-06-15 | Upjohn Co | 3-(stickstoff substituierte)phenyl-5-beta- amidomethyloxazoliden-2-one |
| SK283420B6 (sk) | 1992-05-08 | 2003-07-01 | Pharmacia & Upjohn Company | Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny |
| JP3365067B2 (ja) * | 1994-02-10 | 2003-01-08 | ソニー株式会社 | プラズマ装置およびこれを用いたプラズマ処理方法 |
| DE4425609A1 (de) * | 1994-07-20 | 1996-01-25 | Bayer Ag | Benzofuranyl- und Benzothienyloxazolidinone |
| HRP960159A2 (en) | 1995-04-21 | 1997-08-31 | Bayer Ag | Benzocyclopentane oxazolidinones containing heteroatoms |
| DE19601264A1 (de) | 1996-01-16 | 1997-07-17 | Bayer Ag | Pyrido-annellierte Thienyl- und Furanyl-Oxazolidinone |
| DE19601627A1 (de) | 1996-01-18 | 1997-07-24 | Bayer Ag | Heteroatomhaltige Cyclopentanopyridyl-Oxazolidinone |
| DE19604223A1 (de) | 1996-02-06 | 1997-08-07 | Bayer Ag | Neue substituierte Oxazolidinone |
| HRP970049A2 (en) | 1996-02-06 | 1998-04-30 | Bayer Ag | New heteroaryl oxazolidinones |
| NZ501412A (en) | 1997-05-30 | 2001-11-30 | Upjohn Co | Oxazolidinone antibacterial agents having a thiocarbonyl functionality |
| AU729745B2 (en) | 1997-07-11 | 2001-02-08 | Pharmacia & Upjohn Company | Thiadiazolyl and oxadiazolyl phenyl oxazolidinone antibacterial agents |
| DE19730847A1 (de) * | 1997-07-18 | 1999-01-28 | Bayer Ag | Tricyclisch substituierte Oxazolidinone |
| WO1999012914A1 (fr) | 1997-09-11 | 1999-03-18 | Hokuriku Seiyaku Co., Ltd. | Derives de thiouree |
| DE19802235A1 (de) | 1998-01-22 | 1999-07-29 | Bayer Ag | Mit tricyclischen Indolen substituierte Oxazolidinone |
| DE19802239A1 (de) | 1998-01-22 | 1999-07-29 | Bayer Ag | Neue mit Bicyclen substituierte Oxazolidinone |
| BR9907183A (pt) | 1998-01-23 | 2003-06-10 | Versicor Inc | Colet neas combinatórias de oxazolidinona, composições e processos de preparação |
| DE19805117A1 (de) * | 1998-02-09 | 1999-08-12 | Bayer Ag | Neue Oxazolidinone mit azolhaltigen Tricyclen |
| JPH11322729A (ja) | 1998-03-09 | 1999-11-24 | Hokuriku Seiyaku Co Ltd | ジチオカルバミド酸誘導体 |
| JP2000204084A (ja) * | 1998-11-11 | 2000-07-25 | Hokuriku Seiyaku Co Ltd | チオカルバミド酸誘導体 |
| WO2000029396A1 (de) * | 1998-11-17 | 2000-05-25 | Bayer Aktiengesellschaft | Neue substituierte phenyloxazolidon-derivate |
| WO2000029409A1 (de) | 1998-11-17 | 2000-05-25 | Bayer Aktiengesellschaft | Neue heterocyclyl-substituierte oxazolidon-derivate |
| EP1200416A1 (en) * | 1999-07-28 | 2002-05-02 | Pharmacia & Upjohn Company | Oxazolidinones and their use as antiinfectives |
-
2000
- 2000-07-26 EP EP00950714A patent/EP1200416A1/en not_active Withdrawn
- 2000-07-26 WO PCT/US2000/020332 patent/WO2001009107A1/en not_active Application Discontinuation
- 2000-07-26 US US09/625,756 patent/US6441005B1/en not_active Expired - Fee Related
- 2000-07-26 KR KR1020027001195A patent/KR20020022787A/ko not_active Application Discontinuation
- 2000-07-26 CA CA002374383A patent/CA2374383A1/en not_active Abandoned
- 2000-07-26 MX MXPA02000985A patent/MXPA02000985A/es not_active Application Discontinuation
- 2000-07-26 IL IL14750300A patent/IL147503A0/xx unknown
- 2000-07-26 BR BR0012742-6A patent/BR0012742A/pt not_active IP Right Cessation
- 2000-07-26 NZ NZ516853A patent/NZ516853A/en unknown
- 2000-07-26 JP JP2001514310A patent/JP2003513885A/ja active Pending
- 2000-07-26 CN CN00809582A patent/CN1367780A/zh active Pending
- 2000-07-26 AU AU63779/00A patent/AU773359B2/en not_active Ceased
- 2000-07-27 AR ARP000103894A patent/AR024968A1/es unknown
-
2002
- 2002-06-27 US US10/183,198 patent/US6743811B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1367780A (zh) | 2002-09-04 |
| NZ516853A (en) | 2003-11-28 |
| IL147503A0 (en) | 2002-08-14 |
| WO2001009107A1 (en) | 2001-02-08 |
| EP1200416A1 (en) | 2002-05-02 |
| US6441005B1 (en) | 2002-08-27 |
| AU6377900A (en) | 2001-02-19 |
| CA2374383A1 (en) | 2001-02-08 |
| MXPA02000985A (es) | 2002-07-30 |
| US6743811B2 (en) | 2004-06-01 |
| BR0012742A (pt) | 2002-06-11 |
| KR20020022787A (ko) | 2002-03-27 |
| AU773359B2 (en) | 2004-05-20 |
| JP2003513885A (ja) | 2003-04-15 |
| US20020169191A1 (en) | 2002-11-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |