BR0012287A - Polipeptìdeo hìbrido, polipeptìdeo núcleo, e, processo para intensificar, as propriedades farmacocinéticas de um polipeptìdeo núcleo - Google Patents
Polipeptìdeo hìbrido, polipeptìdeo núcleo, e, processo para intensificar, as propriedades farmacocinéticas de um polipeptìdeo núcleoInfo
- Publication number
- BR0012287A BR0012287A BR0012287-4A BR0012287A BR0012287A BR 0012287 A BR0012287 A BR 0012287A BR 0012287 A BR0012287 A BR 0012287A BR 0012287 A BR0012287 A BR 0012287A
- Authority
- BR
- Brazil
- Prior art keywords
- polypeptide
- core polypeptide
- core
- pharmacokinetic properties
- enhancing
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 16
- 229920001184 polypeptide Polymers 0.000 title abstract 12
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 12
- 230000002708 enhancing effect Effects 0.000 title abstract 3
- 239000003623 enhancer Substances 0.000 abstract 3
- 101710091045 Envelope protein Proteins 0.000 abstract 1
- 101710188315 Protein X Proteins 0.000 abstract 1
- 102100021696 Syncytin-1 Human genes 0.000 abstract 1
- 101800001690 Transmembrane protein gp41 Proteins 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 230000001177 retroviral effect Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1021—Tetrapeptides with the first amino acid being acidic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18522—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Reproductive Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Biotechnology (AREA)
- Pulmonology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"POLIPEPTìDEO HìBRIDO, POLIPEPTìDEO NúCLEO, E, PROCESSO PARA INTENSIFICAR AS PROPRIEDADES FARMACOCINéTICAS DE UM POLIPEPTìDEO NúCLEO". A presente invenção diz respeito a seq³ências de peptídeos intensificadoras originalmente derivadas de várias seq³ências de proteínas envoltórias retrovirais (gp41) que intensificam as propriedades farmacocinéticas de qualquer polipeptídeo núcleo a que elas estão ligadas. A invenção se baseia na verificação de que os polipeptídeos híbridos que compreendem as seq³ências de peptídeos intensificadoras ligadas a um polipeptídeo núcleo, possuem propriedades farmacocinéticas intensificadas, tais como a meia-vida aumentada. A invenção ainda diz respeito a processos para intensificar as propriedades farmacocinéticas de qualquer polipeptídeo núcleo através da articulação das seq³ências de peptídeo intensificadoras ao polipeptídeo núcleo. Os polipeptídeos núcleo a serem usados na prática da invenção podem incluir qualquer peptídeo farmacologicamente útil que possa ser usado, por exemplo, como um reagente terapêutico ou profilático.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/350,641 US6656906B1 (en) | 1998-05-20 | 1999-07-09 | Hybrid polypeptides with enhanced pharmacokinetic properties |
PCT/US2000/018772 WO2001003723A1 (en) | 1999-07-09 | 2000-07-10 | Hybrid polypeptides with enhanced pharmacokinetic properties |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0012287A true BR0012287A (pt) | 2002-04-02 |
Family
ID=23377584
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0012287-4A BR0012287A (pt) | 1999-07-09 | 2000-07-10 | Polipeptìdeo hìbrido, polipeptìdeo núcleo, e, processo para intensificar, as propriedades farmacocinéticas de um polipeptìdeo núcleo |
Country Status (22)
Country | Link |
---|---|
US (2) | US6656906B1 (pt) |
EP (1) | EP1206272A4 (pt) |
JP (1) | JP2003504344A (pt) |
KR (1) | KR100755418B1 (pt) |
CN (1) | CN1254271C (pt) |
AR (1) | AR024699A1 (pt) |
AU (1) | AU6082200A (pt) |
BR (1) | BR0012287A (pt) |
CA (1) | CA2377677A1 (pt) |
CZ (1) | CZ200288A3 (pt) |
HK (1) | HK1045259A1 (pt) |
HR (1) | HRP20020022A2 (pt) |
IL (1) | IL147331A0 (pt) |
MX (1) | MXPA02000012A (pt) |
NO (1) | NO20020087L (pt) |
NZ (1) | NZ516550A (pt) |
PL (1) | PL352685A1 (pt) |
RU (1) | RU2279883C2 (pt) |
TR (1) | TR200200766T2 (pt) |
TW (1) | TWI248364B (pt) |
WO (1) | WO2001003723A1 (pt) |
YU (1) | YU1402A (pt) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
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US6818740B1 (en) | 1997-04-17 | 2004-11-16 | Whitehead Institute For Biomedical Research | Inhibitors of HIV membrane fusion |
US6150088A (en) | 1997-04-17 | 2000-11-21 | Whitehead Institute For Biomedical Research | Core structure of gp41 from the HIV envelope glycoprotein |
US6841657B2 (en) | 1997-04-17 | 2005-01-11 | Whitehead Institute For Biomedical Research | Inhibitors of HIV membrane fusion |
US7960504B2 (en) | 1998-07-30 | 2011-06-14 | Whitehead Institute For Biomedical Research | Inhibitors of HIV membrane fusion |
US6747126B1 (en) | 1998-07-30 | 2004-06-08 | Whitehead Institute For Biomedical Research | Peptide inhibitors of HIV entry |
ES2296665T3 (es) | 1999-12-16 | 2008-05-01 | Whitehead Institute For Biomedical Research | Proteina cinco-helice. |
DE60229677D1 (de) | 2001-05-31 | 2008-12-11 | Conjuchem Biotechnologies Inc | Langwirkende Fusionspeptidinhibitoren gegen HIV-Infektion |
CN1255548C (zh) | 2001-06-15 | 2006-05-10 | 霍夫曼-拉罗奇有限公司 | gp41片段的乙酰化 |
WO2003074691A1 (fr) * | 2002-03-01 | 2003-09-12 | National Institute Of Advanced Industrial Science And Technology | Cellules et liposomes immobilises et procede d'immobilisation correspondant |
EP1545371B1 (en) * | 2002-08-01 | 2016-04-13 | Robert A. Levine | Cardiac devices and methods for minimally invasive repair of ischemic mitral regurgitation |
EP1542718B1 (en) * | 2002-09-24 | 2015-11-11 | Dong Xie | Peptide derivative fusion inhibitors of hiv infection |
US7556813B2 (en) * | 2002-09-27 | 2009-07-07 | Trimeris, Inc. | Antiviral peptide-polymer conjugate comprising a polymer covalently attached to two or more synthetic HIV gp41 HR1 and/or HR2 peptides |
CA2521393A1 (en) * | 2003-04-04 | 2004-10-14 | Universite De Lausanne | Peptabody for cancer treatment |
WO2004106364A1 (en) * | 2003-08-05 | 2004-12-09 | Cornell Research Foundation, Inc. | Stabilizing peptides and their use in the preparation of stabilized hiv inhibitors |
JP2007515965A (ja) | 2003-12-23 | 2007-06-21 | セントカー・インコーポレーテツド | 抗レトロウイルス性の剤、組成物、方法および用途 |
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KR101105610B1 (ko) | 2006-08-17 | 2012-01-18 | 에프. 호프만-라 로슈 아게 | Ccr5 에 대한 항체 및 항푸소제닉 펩타이드의 컨쥬게이트 |
TW200817438A (en) * | 2006-08-17 | 2008-04-16 | Hoffmann La Roche | A conjugate of an antibody against CCR5 and an antifusogenic peptide |
EP2125876A1 (en) * | 2007-03-12 | 2009-12-02 | Thomas Jefferson University | Tighter-binding c-peptide inhibitors of hiv-1 entry |
US20090143288A1 (en) | 2007-03-13 | 2009-06-04 | Roche Palo Alto Llc | Peptide-complement conjugates |
EP2139526A4 (en) * | 2007-04-03 | 2010-07-14 | Trimeris Inc | NEW FORMULATIONS TO RELEASE ANTIVIRAL PEPTIDE THERAPEUTICS |
WO2008144590A2 (en) * | 2007-05-16 | 2008-11-27 | Conjuchem Biotechnologies Inc. | Long lasting modified antifusogenic peptide for preventing hiv infection |
EP2170314B1 (en) * | 2007-05-24 | 2013-10-02 | The Board of Regents of The University of Texas System | Methods and compositions for treating phenylketonuria |
AR067584A1 (es) | 2007-07-20 | 2009-10-14 | Hoffmann La Roche | Un conjugado de un anticuerpo contra la cd4 y peptidos antifusogenicos |
WO2009030872A1 (en) * | 2007-09-07 | 2009-03-12 | Mats Axel Atterdag Persson | Materials and methods for the treatment of hepatitis c |
JP2010540528A (ja) * | 2007-09-25 | 2010-12-24 | トリメリス,インコーポレーテッド | 治療的抗ウイルス性ペプチドの新規合成方法 |
WO2009094634A1 (en) * | 2008-01-24 | 2009-07-30 | Esperance Pharmaceuticals | Lytic domain fusion constructs and methods of making and using same |
WO2011060352A1 (en) | 2009-11-16 | 2011-05-19 | Ipsen Pharma S.A.S. | Pharmaceutical compositions of melanocortin receptor ligands |
CA2797033C (en) | 2010-04-22 | 2021-10-19 | Longevity Biotech, Inc. | Highly active polypeptides and methods of making and using the same |
CN103108884A (zh) | 2010-09-14 | 2013-05-15 | 弗·哈夫曼-拉罗切有限公司 | Serpin-finger融合多肽 |
CN104136455B (zh) * | 2012-02-27 | 2017-05-17 | 中国人民解放军军事医学科学院毒物药物研究所 | 抗hiv‑1多肽及其用途 |
CN104039815A (zh) * | 2012-02-28 | 2014-09-10 | 中国人民解放军军事医学科学院毒物药物研究所 | 用于抑制hiv的多肽及其作用靶点 |
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EP2968469A4 (en) | 2013-03-15 | 2016-08-31 | Longevity Biotech Inc | PEPTIDES COMPRISING NON-ENDOGENIC AMINO ACIDS AND METHODS OF MAKING AND USING SAME |
US10919904B2 (en) | 2016-08-17 | 2021-02-16 | North Carolina State University | Northern-southern route to synthesis of bacteriochlorins |
WO2018081832A1 (en) * | 2016-10-31 | 2018-05-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Peptide fragments from filoviruses and their uses |
WO2018102252A1 (en) | 2016-11-30 | 2018-06-07 | North Carolina State University | Methods for making bacteriochlorin macrocycles comprising an annulated isocyclic ring and related compounds |
US20210154327A1 (en) * | 2017-08-29 | 2021-05-27 | Pharis Biotec Gmbh | Protransduzin-d - improved enhancer of gene transfer |
US20220283151A1 (en) * | 2021-03-05 | 2022-09-08 | Brigham Young University | Method for controlling protein dimerization using an intramolecular to intermolecular conformational switch |
CN116162136B (zh) * | 2021-11-24 | 2024-08-23 | 成都奥达生物科技有限公司 | 一种抗合胞病毒膜融合抑制剂 |
CN117186187B (zh) * | 2023-07-12 | 2024-05-31 | 中国医学科学院病原生物学研究所 | 一种抗呼吸道合胞病毒膜融合抑制剂及其药物用途 |
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US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
EP0272858A3 (en) | 1986-12-15 | 1989-07-12 | Repligen Corporation | Recombinant hiv envelope proteins produced in insect cells |
AU626797B2 (en) | 1987-09-08 | 1992-08-13 | Albany Medical College | Immunogenic composites capable of selectively inducing antibody production, pharmaceutical compositions employing the same and method of selectively inducing antibody production |
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CA1341285C (en) * | 1988-02-12 | 2001-08-14 | Chang Yi Wang | Synthetic peptides for the detection of antibodies to hiv gp120 envelope protein for diagnosis of aids and pre-aids conditions and as vaccines |
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DE741187T1 (de) * | 1995-05-05 | 1997-04-30 | Hoffmann La Roche | Rekombinante Obesitäts-(OB)-Proteine |
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FR2739621B1 (fr) | 1995-10-05 | 1997-12-05 | Centre Nat Rech Scient | Peptides utilisables comme vecteurs pour l'adressage intracellulaire de molecules actives |
US6258782B1 (en) * | 1998-05-20 | 2001-07-10 | Trimeris, Inc. | Hybrid polypeptides with enhanced pharmacokinetic properties |
US6469136B1 (en) * | 1999-07-07 | 2002-10-22 | Trimeris, Inc. | Methods and composition for peptide synthesis |
-
1999
- 1999-07-09 US US09/350,641 patent/US6656906B1/en not_active Expired - Fee Related
-
2000
- 2000-07-10 WO PCT/US2000/018772 patent/WO2001003723A1/en active IP Right Grant
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- 2000-07-10 CA CA002377677A patent/CA2377677A1/en not_active Abandoned
- 2000-07-10 BR BR0012287-4A patent/BR0012287A/pt not_active Application Discontinuation
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- 2000-07-10 KR KR1020027000311A patent/KR100755418B1/ko not_active IP Right Cessation
- 2000-07-10 YU YU1402A patent/YU1402A/sh unknown
- 2000-07-10 JP JP2001509199A patent/JP2003504344A/ja active Pending
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2002
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Also Published As
Publication number | Publication date |
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WO2001003723A9 (en) | 2002-07-25 |
TWI248364B (en) | 2006-02-01 |
MXPA02000012A (es) | 2003-07-21 |
WO2001003723A1 (en) | 2001-01-18 |
EP1206272A1 (en) | 2002-05-22 |
CA2377677A1 (en) | 2001-01-18 |
HRP20020022A2 (en) | 2004-02-29 |
CN1254271C (zh) | 2006-05-03 |
PL352685A1 (en) | 2003-09-08 |
EP1206272A4 (en) | 2003-01-02 |
AU6082200A (en) | 2001-01-30 |
US7297784B2 (en) | 2007-11-20 |
CZ200288A3 (cs) | 2002-06-12 |
JP2003504344A (ja) | 2003-02-04 |
AR024699A1 (es) | 2002-10-23 |
CN1373669A (zh) | 2002-10-09 |
KR100755418B1 (ko) | 2007-09-05 |
HK1045259A1 (zh) | 2002-11-22 |
RU2279883C2 (ru) | 2006-07-20 |
NO20020087L (no) | 2002-03-01 |
TR200200766T2 (tr) | 2002-10-21 |
US6656906B1 (en) | 2003-12-02 |
NO20020087D0 (no) | 2002-01-08 |
KR20020029667A (ko) | 2002-04-19 |
NZ516550A (en) | 2004-05-28 |
IL147331A0 (en) | 2002-08-14 |
US20030186874A1 (en) | 2003-10-02 |
YU1402A (sh) | 2004-11-25 |
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