BR0012215A - Ditiepino[6,5-b]piridinas e composições e métodos relacionados - Google Patents

Ditiepino[6,5-b]piridinas e composições e métodos relacionados

Info

Publication number
BR0012215A
BR0012215A BR0012215-7A BR0012215A BR0012215A BR 0012215 A BR0012215 A BR 0012215A BR 0012215 A BR0012215 A BR 0012215A BR 0012215 A BR0012215 A BR 0012215A
Authority
BR
Brazil
Prior art keywords
pyridines
methods
dithiepin
related compositions
disorders
Prior art date
Application number
BR0012215-7A
Other languages
English (en)
Inventor
James L Bullington
John H Dodd
Daniel A Hall
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Publication of BR0012215A publication Critical patent/BR0012215A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Reproductive Health (AREA)
  • Vascular Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Immunology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"DITIEPINO[6,5-b]PIRIDINAS E COMPOSIçõES E MéTODOS RELACIONADOS". Esta invenção fornece novas ditiepino[6,5-b]piridinas de fórmulas (I) e (II). Estes compostos são comuns como antagonistas de canal de cálcio com atividade cardiovascular, antiasmática e antibroncoconstrição. Então, esta invenção também fornece composições farmacêuticas, bem como, métodos para prevenção e tratamento de desordens tais como hipersensividade, alergia, asma, broncoespasmo, dismenorréia, espasmo esofageal, glaucoma, trabalho de parto prematuro, desordem de trato urinário, desordens de motilidade gastrintestinal e disordens cardiovasculares.
BR0012215-7A 1999-06-14 2000-05-30 Ditiepino[6,5-b]piridinas e composições e métodos relacionados BR0012215A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13898799P 1999-06-14 1999-06-14
PCT/US2000/014715 WO2000077009A1 (en) 1999-06-14 2000-05-30 DITHIEPINO[6,5-b]PYRIDINES, AND RELATED COMPOSITIONS AND METHODS

Publications (1)

Publication Number Publication Date
BR0012215A true BR0012215A (pt) 2002-07-02

Family

ID=22484608

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0012215-7A BR0012215A (pt) 1999-06-14 2000-05-30 Ditiepino[6,5-b]piridinas e composições e métodos relacionados

Country Status (23)

Country Link
US (4) US6291454B1 (pt)
EP (1) EP1192163B1 (pt)
JP (1) JP2003502335A (pt)
KR (1) KR20020027350A (pt)
CN (1) CN1160359C (pt)
AR (1) AR029755A1 (pt)
AT (1) ATE250067T1 (pt)
AU (1) AU771033B2 (pt)
BR (1) BR0012215A (pt)
CA (1) CA2375878A1 (pt)
CZ (1) CZ20014518A3 (pt)
DE (1) DE60005349T2 (pt)
DK (1) DK1192163T3 (pt)
ES (1) ES2207523T3 (pt)
HK (1) HK1049485B (pt)
HU (1) HUP0201566A3 (pt)
IL (1) IL147128A0 (pt)
MX (1) MXPA01013008A (pt)
MY (1) MY128062A (pt)
PL (1) PL352909A1 (pt)
PT (1) PT1192163E (pt)
RU (1) RU2230746C2 (pt)
WO (1) WO2000077009A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0202265A3 (en) * 1999-07-12 2004-12-28 Ortho Mcneil Pharm Inc Oxathiepino [6,5-b] dihydropyridines, process for their preparation, pharmaceutical compositions containing them and an apparatus for administering the same
AU7102700A (en) 1999-09-22 2001-04-24 Ortho-Mcneil Pharmaceutical, Inc. Benzo-fused dithiepino[6,5-b]pyridines, and related compositions and methods
WO2001051493A1 (en) 2000-01-12 2001-07-19 Ortho-Mcneil Pharmaceutical, Inc. Benzosulfones with calcium antagonist activity
JP2003523360A (ja) 2000-01-27 2003-08-05 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド ベンズオキサチエピノ［３，４−ｂ］ピリジン誘導体、それらの製造法及び薬剤としてのそれらの使用
KR200451743Y1 (ko) * 2008-03-25 2011-01-10 이영수 줄넘기용 줄 길이 조절장치

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2397431A1 (fr) * 1977-07-12 1979-02-09 Ugine Kuhlmann Procede de fabrication de copolymeres greffes par polymerisation-greffage en emulsion-suspension
US4483985A (en) 1978-10-31 1984-11-20 Bayer Aktiengesellschaft Production of 1,4-dihydropyridinecarboxylic acids
US4285955A (en) 1978-10-31 1981-08-25 Bayer Aktiengesellschaft 1,4-Dihydropyridinecarboxylic acids
NZ201395A (en) 1981-07-30 1987-02-20 Bayer Ag Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines
JPS58201764A (ja) 1982-05-17 1983-11-24 Maruko Seiyaku Kk ジヒドロピリジン誘導体
JPS61293972A (ja) * 1985-06-24 1986-12-24 Nisshin Flour Milling Co Ltd １，４−ジヒドロピリジンスルホン誘導体およびその製法
US4845225A (en) 1986-04-09 1989-07-04 Ortho Pharmaceutical Corporation Substituted thiacycloalkeno [3,2-b] pyridines
IT1204948B (it) * 1987-03-13 1989-03-10 Boheringer Biochemia Robin S P 2-tiometil-sostituite-piridine, metodo per la loro preparazione e composizioni farmaceutiche che le contengono.
US4889866A (en) * 1987-06-11 1989-12-26 Syntex (U.S.A.) Inc. Arylsulfonyl dihydropyridine derivatives
US4879384A (en) 1988-06-15 1989-11-07 Ortho Pharmaceutical Corporation Preparation of thiocycloalkno [3,2-b] pyridines
US5075440A (en) 1990-05-03 1991-12-24 Ortho Pharmaceutical Corporation Novel pyrido[2,3-f](1,4)thiazepines and pyrido[3,2-b](1,5)benzothiazepines
DE19532320A1 (de) 1995-09-01 1997-03-06 Bayer Ag Verfahren zur Herstellung von optisch aktiven ortho-substituierten 4-Aryl-Dihydropyridinen

Also Published As

Publication number Publication date
PL352909A1 (en) 2003-09-22
DE60005349T2 (de) 2004-12-30
AU5447300A (en) 2001-01-02
AR029755A1 (es) 2003-07-16
HUP0201566A3 (en) 2004-03-01
US20020103376A1 (en) 2002-08-01
HK1049485A1 (en) 2003-05-16
DK1192163T3 (da) 2003-12-08
AU771033B2 (en) 2004-03-11
CN1370175A (zh) 2002-09-18
US6291454B1 (en) 2001-09-18
MY128062A (en) 2007-01-31
KR20020027350A (ko) 2002-04-13
WO2000077009A1 (en) 2000-12-21
CA2375878A1 (en) 2000-12-21
ATE250067T1 (de) 2003-10-15
HUP0201566A2 (en) 2002-08-28
JP2003502335A (ja) 2003-01-21
CZ20014518A3 (cs) 2003-02-12
US20020026051A1 (en) 2002-02-28
MXPA01013008A (es) 2003-06-24
CN1160359C (zh) 2004-08-04
PT1192163E (pt) 2004-01-30
EP1192163B1 (en) 2003-09-17
RU2230746C2 (ru) 2004-06-20
EP1192163A1 (en) 2002-04-03
US20020032332A1 (en) 2002-03-14
DE60005349D1 (de) 2003-10-23
IL147128A0 (en) 2002-08-14
HK1049485B (zh) 2005-04-29
ES2207523T3 (es) 2004-06-01

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A E 9A ANUIDADES

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2008 DE 30/06/2009.