BR0008307A - Utilização de uma proteìna ompa de enterobactéria ou de um de seus fragmentos, e, composição farmacêutica - Google Patents

Utilização de uma proteìna ompa de enterobactéria ou de um de seus fragmentos, e, composição farmacêutica

Info

Publication number
BR0008307A
BR0008307A BR0008307-0A BR0008307A BR0008307A BR 0008307 A BR0008307 A BR 0008307A BR 0008307 A BR0008307 A BR 0008307A BR 0008307 A BR0008307 A BR 0008307A
Authority
BR
Brazil
Prior art keywords
pharmaceutical composition
fragments
protein
compounds
enterobacterium ompa
Prior art date
Application number
BR0008307-0A
Other languages
English (en)
Inventor
Toufic Renno
Jean-Yves Bonnefoy
Original Assignee
Pf Medicament
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pf Medicament filed Critical Pf Medicament
Publication of BR0008307A publication Critical patent/BR0008307A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/26—Klebsiella (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6068—Other bacterial proteins, e.g. OMP

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"UTILIZAçãO DE UMA PROTEìNA OmpA DE ENTEROBACTéRIA OU DE UM DE SEUS FRAGMENTOS, E, COMPOSIçãO FARMACêUTICA". A invenção refere-se à utilização de uma proteína de membrana OmpA de enterobactéria, notadamente de Klebsiella pneumoniae, associada a um antígeno ou um hapteno, para a preparação de uma composição farmacêutica destinada a gerar ou melhorar uma resposta T citotóxica dirigida contra um agente infeccioso ou uma célula tumoral. A invenção compreende a utilização destes compostos para a prevenção e o tratamento de infecção ou de câncer, notadamente os cânceres associados a um antígeno tumoral como o melanoma, assim como as composições farmacêuticas compreendendo alguns destes compostos.
BR0008307-0A 1999-02-17 2000-02-17 Utilização de uma proteìna ompa de enterobactéria ou de um de seus fragmentos, e, composição farmacêutica BR0008307A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9901917A FR2789588B1 (fr) 1999-02-17 1999-02-17 Utilisation d'une proteine ompa d'enterobacterie associee a un antigene dans une composition pharmaceutique destinee a generer ou accroitre une reponse cytotoxique antivirale, antiparasitaire ou antitumorale
PCT/FR2000/000393 WO2000048628A1 (fr) 1999-02-17 2000-02-17 UTILISATION D'UNE PROTEINE OmpA D'ENTEROBACTERIE ASSOCIEE A UN ANTIGENE POUR GENERER UNE REPONSE CYTOTOXIQUE ANTIVIRALE, ANTIPARASITAIRE OU ANTITUMORALE

Publications (1)

Publication Number Publication Date
BR0008307A true BR0008307A (pt) 2002-01-22

Family

ID=9542129

Family Applications (2)

Application Number Title Priority Date Filing Date
BR0008307-0A BR0008307A (pt) 1999-02-17 2000-02-17 Utilização de uma proteìna ompa de enterobactéria ou de um de seus fragmentos, e, composição farmacêutica
BR0008305-4A BR0008305A (pt) 1999-02-17 2000-02-17 Utilização de uma proteìna ompa de enterobactéria, ou de um de seus fragmentos e composição farmacêutica

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR0008305-4A BR0008305A (pt) 1999-02-17 2000-02-17 Utilização de uma proteìna ompa de enterobactéria, ou de um de seus fragmentos e composição farmacêutica

Country Status (11)

Country Link
EP (2) EP1150706A1 (pt)
JP (2) JP2003506315A (pt)
CN (2) CN1191089C (pt)
AT (1) ATE293991T1 (pt)
AU (2) AU776903B2 (pt)
BR (2) BR0008307A (pt)
CA (2) CA2372059A1 (pt)
DE (1) DE60019725D1 (pt)
FR (1) FR2789588B1 (pt)
WO (2) WO2000048628A1 (pt)
ZA (2) ZA200106725B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2803302B1 (fr) * 2000-01-04 2004-12-10 Pf Medicament Procede de preparation d'un polypeptide soluble en solvant aqueux en absence de detergent
FR2808445A1 (fr) * 2000-05-04 2001-11-09 Pf Medicament Proteine omp associee a un lysat de cellules tumorales autologues et/ou heterologues
FR2842811A1 (fr) * 2002-07-26 2004-01-30 Pf Medicament Procede de solubilisation de peptides hydrophobes et leur utilisation pour generer une reponse de type ctl antitumorale ou anti-infectueuse
FR2842812A1 (fr) * 2002-07-26 2004-01-30 Pf Medicament Procede de solubilisation de peptides hydrophobes et leur utilisation pour generer une reponse de type ctl antitumorale ou anti-infectueuse
WO2004011486A2 (fr) * 2002-07-26 2004-02-05 Pierre Fabre Medicament Procede de solubilisation de peptides hydrophobes et leur utilisation pour generer une response de type ctl antitumorale ou anti-infectieuse
JP5151349B2 (ja) * 2006-09-26 2013-02-27 東レ株式会社 免疫誘導剤及びその用途
EP2377883A1 (en) * 2010-04-15 2011-10-19 Universite d'Auvergne Clermont I Antagonists for the prevention or treatment of inflammatory bowel disease, and more particularly of Crohn's disease
WO2011140284A2 (en) * 2010-05-04 2011-11-10 Fred Hutchinson Cancer Research Center Conditional superagonist ctl ligands for the promotion of tumor-specific ctl responses
CN110559424B (zh) * 2019-08-26 2021-08-20 君维安(武汉)生命科技有限公司 一种外膜蛋白在制备恶性肿瘤免疫治疗药物中的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2726472B1 (fr) * 1994-11-07 1997-01-31 Pf Medicament Proteine porteuse a effet adjuvant, complexe immunogene la contenant, leur procede de preparation, sequence nucleotidique et vaccin
FR2748476B1 (fr) * 1996-05-07 1998-08-14 Pf Medicament Complexe immunogene, son utilisation, son procede de preparation et vaccin le contenant

Also Published As

Publication number Publication date
FR2789588A1 (fr) 2000-08-18
AU2809400A (en) 2000-09-04
AU777511B2 (en) 2004-10-21
CN1191090C (zh) 2005-03-02
JP2003506314A (ja) 2003-02-18
EP1150706A1 (fr) 2001-11-07
JP2003506315A (ja) 2003-02-18
WO2000048629A1 (fr) 2000-08-24
DE60019725D1 (de) 2005-06-02
AU2809300A (en) 2000-09-04
BR0008305A (pt) 2002-01-22
CA2372059A1 (fr) 2000-08-24
CN1341029A (zh) 2002-03-20
CA2362192A1 (fr) 2000-08-24
ZA200106800B (en) 2002-05-10
EP1150707A1 (fr) 2001-11-07
EP1150707B1 (fr) 2005-04-27
FR2789588B1 (fr) 2001-05-04
CN1191089C (zh) 2005-03-02
WO2000048628A1 (fr) 2000-08-24
ZA200106725B (en) 2002-04-24
CN1344166A (zh) 2002-04-10
ATE293991T1 (de) 2005-05-15
AU776903B2 (en) 2004-09-23

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A E 9A ANUIDADES

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 NA RPI2003 DE 26/05/2009.