BR9915071A - Utilização de uma proteìna ompa de enterobactéria ou de um de seus fragmentos - Google Patents

Utilização de uma proteìna ompa de enterobactéria ou de um de seus fragmentos

Info

Publication number
BR9915071A
BR9915071A BR9915071-9A BR9915071A BR9915071A BR 9915071 A BR9915071 A BR 9915071A BR 9915071 A BR9915071 A BR 9915071A BR 9915071 A BR9915071 A BR 9915071A
Authority
BR
Brazil
Prior art keywords
protein
fragments
ompa
enterobacterium
ompa protein
Prior art date
Application number
BR9915071-9A
Other languages
English (en)
Inventor
Jean-Yves Bonnefoy
Sybille Lecoanet
Jean-Pierre Aubry
Pascale Jeannin
Thierry Baussant
Original Assignee
Pf Medicament
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pf Medicament filed Critical Pf Medicament
Publication of BR9915071A publication Critical patent/BR9915071A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6068—Other bacterial proteins, e.g. OMP

Abstract

"UTILIZAçãO DE UMA PROTEìNA OmpA DE ENTEROBACTéRIA, OU DE UM DE SEUS FRAGMENTOS" A invenção refere-se à utilização de uma proteína OmpA de enterobactéria, preferivelmente a proteína P40 de Klebsiella pneumoniae, para a marcação específica de uma substância biologicamente ativa que é associada à mesma para células apresentadoras de antígenos, notadamente as células dendríticas humanas. A invenção tem igualmente por objeto a utilização da proteína OmpA para a preparação de uma composição farmacêutica destinada à prevenção e/ou o tratamento de doenças, notadamente os canceres associados a um antígeno tumoral, as doenças auto-imunes ou as doenças infecciosas.
BR9915071-9A 1998-11-06 1999-11-08 Utilização de uma proteìna ompa de enterobactéria ou de um de seus fragmentos BR9915071A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9814007A FR2785542B1 (fr) 1998-11-06 1998-11-06 UTILISATION D'UNE PROTEINE OmpA D'ENTEROBACTERIE, POUR LE CIBLAGE SPECIFIQUE D'UNE SUBSTANCE BIOLOGIQUEMENT ACTIVE QUI LUI EST ASSOCIEE VERS LES CELLULES PRESENTATRICES D'ANTIGENES TELLES QUE LES CELLULES DENDRITIQUES HUMAINES
PCT/FR1999/002734 WO2000027432A1 (fr) 1998-11-06 1999-11-08 UTILISATION D'UNE PROTEINE OmpA D'ENTEROBACTERIE, POUR LE CIBLAGE SPECIFIQUE VERS LES CELLULES PRESENTATRICES D'ANTIGENES

Publications (1)

Publication Number Publication Date
BR9915071A true BR9915071A (pt) 2001-07-17

Family

ID=9532467

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9915071-9A BR9915071A (pt) 1998-11-06 1999-11-08 Utilização de uma proteìna ompa de enterobactéria ou de um de seus fragmentos

Country Status (14)

Country Link
EP (1) EP1124577B1 (pt)
JP (1) JP2002529428A (pt)
CN (1) CN1181890C (pt)
AT (1) ATE247978T1 (pt)
AU (1) AU764205B2 (pt)
BR (1) BR9915071A (pt)
CA (1) CA2350183A1 (pt)
DE (1) DE69910809T2 (pt)
DK (1) DK1124577T3 (pt)
ES (1) ES2205946T3 (pt)
FR (1) FR2785542B1 (pt)
PT (1) PT1124577E (pt)
WO (1) WO2000027432A1 (pt)
ZA (1) ZA200103478B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2790959B1 (fr) * 1999-03-15 2003-06-27 Pf Medicament Utilisation de fractions membranaires bacteriennes a effet adjuvant, leurs procedes de preparation et composition pharmaceutique les contenant
FR2790960B1 (fr) * 1999-03-15 2002-10-31 Pf Medicament Utilisation de fractions membranaires bacteriennes a activite immunostimulante dans le traitement de cancers, leurs procedes de preparation et les compositions pharmaceutiques les contenant
WO2001013948A1 (en) * 1999-08-20 2001-03-01 The General Hospital Corporation Outer membrane protein a, peptidoglycan-associated lipoprotein, and murein lipoprotein as therapeutic targets for treatment of sepsis
FR2803302B1 (fr) * 2000-01-04 2004-12-10 Pf Medicament Procede de preparation d'un polypeptide soluble en solvant aqueux en absence de detergent
FR2809014A1 (fr) * 2000-05-16 2001-11-23 Pf Medicament Utilisation d'une proteine ompa d'enterobacterie comme agent antimicrobien
FR2822071B1 (fr) * 2001-03-15 2005-07-01 Pf Medicament Utilisation d'une fraction membranaire de bacteries a gram negatif pour induire la maturation des cellules dendritiques
EP2377883A1 (en) * 2010-04-15 2011-10-19 Universite d'Auvergne Clermont I Antagonists for the prevention or treatment of inflammatory bowel disease, and more particularly of Crohn's disease
CN102286106B (zh) * 2011-07-11 2013-05-01 中国人民解放军军事医学科学院微生物流行病研究所 夹心外膜蛋白展示载体及应用其制备的大肠埃希菌疫苗
KR20170011221A (ko) * 2015-07-22 2017-02-02 이화여자대학교 산학협력단 클렙시엘라균 감염질환의 예방용 백신

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2726472B1 (fr) * 1994-11-07 1997-01-31 Pf Medicament Proteine porteuse a effet adjuvant, complexe immunogene la contenant, leur procede de preparation, sequence nucleotidique et vaccin
US5853719A (en) * 1996-04-30 1998-12-29 Duke University Methods for treating cancers and pathogen infections using antigen-presenting cells loaded with RNA
FR2748476B1 (fr) * 1996-05-07 1998-08-14 Pf Medicament Complexe immunogene, son utilisation, son procede de preparation et vaccin le contenant

Also Published As

Publication number Publication date
DE69910809T2 (de) 2004-06-17
AU1164100A (en) 2000-05-29
CN1181890C (zh) 2004-12-29
ES2205946T3 (es) 2004-05-01
PT1124577E (pt) 2004-01-30
CA2350183A1 (fr) 2000-05-18
DK1124577T3 (da) 2003-12-08
DE69910809D1 (de) 2003-10-02
EP1124577B1 (fr) 2003-08-27
CN1326360A (zh) 2001-12-12
FR2785542B1 (fr) 2001-02-09
FR2785542A1 (fr) 2000-05-12
JP2002529428A (ja) 2002-09-10
ZA200103478B (en) 2002-02-12
EP1124577A1 (fr) 2001-08-22
AU764205B2 (en) 2003-08-14
ATE247978T1 (de) 2003-09-15
WO2000027432A1 (fr) 2000-05-18

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AO NAO RECOLHIMENTO DA 8A E 9A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 DE RPI 1999 DE 28/04/2009.