PT1124577E - Utilizacao de uma proteina ompa de enterobacteria para o direccionamento especifico para as celulas apresentadoras de antigenios - Google Patents
Utilizacao de uma proteina ompa de enterobacteria para o direccionamento especifico para as celulas apresentadoras de antigeniosInfo
- Publication number
- PT1124577E PT1124577E PT99971719T PT99971719T PT1124577E PT 1124577 E PT1124577 E PT 1124577E PT 99971719 T PT99971719 T PT 99971719T PT 99971719 T PT99971719 T PT 99971719T PT 1124577 E PT1124577 E PT 1124577E
- Authority
- PT
- Portugal
- Prior art keywords
- protein
- ompa
- presenting cells
- enterobacteria
- utilization
- Prior art date
Links
- 210000000612 antigen-presenting cell Anatomy 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 241000305071 Enterobacterales Species 0.000 title 1
- SZKKRCSOSQAJDE-UHFFFAOYSA-N Schradan Chemical compound CN(C)P(=O)(N(C)C)OP(=O)(N(C)C)N(C)C SZKKRCSOSQAJDE-UHFFFAOYSA-N 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 108010079246 OMPA outer membrane proteins Proteins 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 241000588747 Klebsiella pneumoniae Species 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 229940088623 biologically active substance Drugs 0.000 abstract 1
- 210000004443 dendritic cell Anatomy 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6068—Other bacterial proteins, e.g. OMP
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9814007A FR2785542B1 (fr) | 1998-11-06 | 1998-11-06 | UTILISATION D'UNE PROTEINE OmpA D'ENTEROBACTERIE, POUR LE CIBLAGE SPECIFIQUE D'UNE SUBSTANCE BIOLOGIQUEMENT ACTIVE QUI LUI EST ASSOCIEE VERS LES CELLULES PRESENTATRICES D'ANTIGENES TELLES QUE LES CELLULES DENDRITIQUES HUMAINES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1124577E true PT1124577E (pt) | 2004-01-30 |
Family
ID=9532467
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT99971719T PT1124577E (pt) | 1998-11-06 | 1999-11-08 | Utilizacao de uma proteina ompa de enterobacteria para o direccionamento especifico para as celulas apresentadoras de antigenios |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP1124577B1 (pt) |
| JP (1) | JP2002529428A (pt) |
| CN (1) | CN1181890C (pt) |
| AT (1) | ATE247978T1 (pt) |
| AU (1) | AU764205B2 (pt) |
| BR (1) | BR9915071A (pt) |
| CA (1) | CA2350183A1 (pt) |
| DE (1) | DE69910809T2 (pt) |
| DK (1) | DK1124577T3 (pt) |
| ES (1) | ES2205946T3 (pt) |
| FR (1) | FR2785542B1 (pt) |
| PT (1) | PT1124577E (pt) |
| WO (1) | WO2000027432A1 (pt) |
| ZA (1) | ZA200103478B (pt) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2790960B1 (fr) * | 1999-03-15 | 2002-10-31 | Pf Medicament | Utilisation de fractions membranaires bacteriennes a activite immunostimulante dans le traitement de cancers, leurs procedes de preparation et les compositions pharmaceutiques les contenant |
| FR2790959B1 (fr) * | 1999-03-15 | 2003-06-27 | Pf Medicament | Utilisation de fractions membranaires bacteriennes a effet adjuvant, leurs procedes de preparation et composition pharmaceutique les contenant |
| AU6786600A (en) * | 1999-08-20 | 2001-03-19 | General Hospital Corporation, The | Outer membrane protein a, peptidoglycan-associated lipoprotein, and murein lipoprotein as therapeutic targets for treatment of sepsis |
| FR2803302B1 (fr) * | 2000-01-04 | 2004-12-10 | Pf Medicament | Procede de preparation d'un polypeptide soluble en solvant aqueux en absence de detergent |
| FR2809014A1 (fr) * | 2000-05-16 | 2001-11-23 | Pf Medicament | Utilisation d'une proteine ompa d'enterobacterie comme agent antimicrobien |
| FR2822071B1 (fr) * | 2001-03-15 | 2005-07-01 | Pf Medicament | Utilisation d'une fraction membranaire de bacteries a gram negatif pour induire la maturation des cellules dendritiques |
| EP2377883A1 (en) * | 2010-04-15 | 2011-10-19 | Universite d'Auvergne Clermont I | Antagonists for the prevention or treatment of inflammatory bowel disease, and more particularly of Crohn's disease |
| CN102286106B (zh) * | 2011-07-11 | 2013-05-01 | 中国人民解放军军事医学科学院微生物流行病研究所 | 夹心外膜蛋白展示载体及应用其制备的大肠埃希菌疫苗 |
| KR20170011221A (ko) * | 2015-07-22 | 2017-02-02 | 이화여자대학교 산학협력단 | 클렙시엘라균 감염질환의 예방용 백신 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2726472B1 (fr) * | 1994-11-07 | 1997-01-31 | Pf Medicament | Proteine porteuse a effet adjuvant, complexe immunogene la contenant, leur procede de preparation, sequence nucleotidique et vaccin |
| US5853719A (en) * | 1996-04-30 | 1998-12-29 | Duke University | Methods for treating cancers and pathogen infections using antigen-presenting cells loaded with RNA |
| FR2748476B1 (fr) * | 1996-05-07 | 1998-08-14 | Pf Medicament | Complexe immunogene, son utilisation, son procede de preparation et vaccin le contenant |
-
1998
- 1998-11-06 FR FR9814007A patent/FR2785542B1/fr not_active Expired - Fee Related
-
1999
- 1999-11-08 DK DK99971719T patent/DK1124577T3/da active
- 1999-11-08 CA CA002350183A patent/CA2350183A1/fr not_active Abandoned
- 1999-11-08 JP JP2000580661A patent/JP2002529428A/ja not_active Withdrawn
- 1999-11-08 DE DE69910809T patent/DE69910809T2/de not_active Expired - Fee Related
- 1999-11-08 EP EP99971719A patent/EP1124577B1/fr not_active Expired - Lifetime
- 1999-11-08 CN CNB998134538A patent/CN1181890C/zh not_active Expired - Fee Related
- 1999-11-08 WO PCT/FR1999/002734 patent/WO2000027432A1/fr active IP Right Grant
- 1999-11-08 AT AT99971719T patent/ATE247978T1/de not_active IP Right Cessation
- 1999-11-08 AU AU11641/00A patent/AU764205B2/en not_active Ceased
- 1999-11-08 PT PT99971719T patent/PT1124577E/pt unknown
- 1999-11-08 BR BR9915071-9A patent/BR9915071A/pt not_active IP Right Cessation
- 1999-11-08 ES ES99971719T patent/ES2205946T3/es not_active Expired - Lifetime
-
2001
- 2001-04-30 ZA ZA200103478A patent/ZA200103478B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000027432A1 (fr) | 2000-05-18 |
| CN1181890C (zh) | 2004-12-29 |
| ZA200103478B (en) | 2002-02-12 |
| ATE247978T1 (de) | 2003-09-15 |
| FR2785542A1 (fr) | 2000-05-12 |
| FR2785542B1 (fr) | 2001-02-09 |
| BR9915071A (pt) | 2001-07-17 |
| AU764205B2 (en) | 2003-08-14 |
| JP2002529428A (ja) | 2002-09-10 |
| EP1124577B1 (fr) | 2003-08-27 |
| EP1124577A1 (fr) | 2001-08-22 |
| DE69910809D1 (de) | 2003-10-02 |
| AU1164100A (en) | 2000-05-29 |
| DE69910809T2 (de) | 2004-06-17 |
| ES2205946T3 (es) | 2004-05-01 |
| CA2350183A1 (fr) | 2000-05-18 |
| DK1124577T3 (da) | 2003-12-08 |
| CN1326360A (zh) | 2001-12-12 |
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