DE60019725D1 - Verwendung eines mit dem peptid "elagigiltv" assoziierten enterobakterien-proteins ompa zur behandlung von melanomen - Google Patents
Verwendung eines mit dem peptid "elagigiltv" assoziierten enterobakterien-proteins ompa zur behandlung von melanomenInfo
- Publication number
- DE60019725D1 DE60019725D1 DE60019725T DE60019725T DE60019725D1 DE 60019725 D1 DE60019725 D1 DE 60019725D1 DE 60019725 T DE60019725 T DE 60019725T DE 60019725 T DE60019725 T DE 60019725T DE 60019725 D1 DE60019725 D1 DE 60019725D1
- Authority
- DE
- Germany
- Prior art keywords
- melanoma
- ompa
- enterobakterial
- treatment
- protein associated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 201000001441 melanoma Diseases 0.000 title abstract 2
- POVNCJSPYFCWJR-USZUGGBUSA-N (4s)-4-[[(2s)-2-[[(2s)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]amino]-5-[(2s)-2-[[2-[(2s)-2-[[(2s)-1-[[(2s,3r)-1-[[(1s)-1-carboxy-2-methylpropyl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1- Chemical compound C([C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N1[C@@H](CCC1)C(=O)NCC(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(O)=O)C1=CC=C(O)C=C1 POVNCJSPYFCWJR-USZUGGBUSA-N 0.000 title 1
- SZKKRCSOSQAJDE-UHFFFAOYSA-N Schradan Chemical compound CN(C)P(=O)(N(C)C)OP(=O)(N(C)C)N(C)C SZKKRCSOSQAJDE-UHFFFAOYSA-N 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 241000588747 Klebsiella pneumoniae Species 0.000 abstract 1
- 108010079246 OMPA outer membrane proteins Proteins 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 231100000433 cytotoxic Toxicity 0.000 abstract 1
- 230000001472 cytotoxic effect Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
- 230000001173 tumoral effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/26—Klebsiella (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6068—Other bacterial proteins, e.g. OMP
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9901917A FR2789588B1 (fr) | 1999-02-17 | 1999-02-17 | Utilisation d'une proteine ompa d'enterobacterie associee a un antigene dans une composition pharmaceutique destinee a generer ou accroitre une reponse cytotoxique antivirale, antiparasitaire ou antitumorale |
PCT/FR2000/000394 WO2000048629A1 (fr) | 1999-02-17 | 2000-02-17 | UTILISATION D'UNE PROTEINE OmpA D'ENTEROBACTERIE ASSOCIEE AU PEPTIDE ELAGIGILTV POUR LE TRAITEMENT DES MELANOMES |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60019725D1 true DE60019725D1 (de) | 2005-06-02 |
Family
ID=9542129
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60019725T Expired - Lifetime DE60019725D1 (de) | 1999-02-17 | 2000-02-17 | Verwendung eines mit dem peptid "elagigiltv" assoziierten enterobakterien-proteins ompa zur behandlung von melanomen |
Country Status (11)
Country | Link |
---|---|
EP (2) | EP1150706A1 (de) |
JP (2) | JP2003506314A (de) |
CN (2) | CN1191089C (de) |
AT (1) | ATE293991T1 (de) |
AU (2) | AU777511B2 (de) |
BR (2) | BR0008307A (de) |
CA (2) | CA2362192A1 (de) |
DE (1) | DE60019725D1 (de) |
FR (1) | FR2789588B1 (de) |
WO (2) | WO2000048628A1 (de) |
ZA (2) | ZA200106725B (de) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2803302B1 (fr) * | 2000-01-04 | 2004-12-10 | Pf Medicament | Procede de preparation d'un polypeptide soluble en solvant aqueux en absence de detergent |
FR2808445A1 (fr) * | 2000-05-04 | 2001-11-09 | Pf Medicament | Proteine omp associee a un lysat de cellules tumorales autologues et/ou heterologues |
FR2842812A1 (fr) * | 2002-07-26 | 2004-01-30 | Pf Medicament | Procede de solubilisation de peptides hydrophobes et leur utilisation pour generer une reponse de type ctl antitumorale ou anti-infectueuse |
WO2004011486A2 (fr) * | 2002-07-26 | 2004-02-05 | Pierre Fabre Medicament | Procede de solubilisation de peptides hydrophobes et leur utilisation pour generer une response de type ctl antitumorale ou anti-infectieuse |
FR2842811A1 (fr) * | 2002-07-26 | 2004-01-30 | Pf Medicament | Procede de solubilisation de peptides hydrophobes et leur utilisation pour generer une reponse de type ctl antitumorale ou anti-infectueuse |
JP5151349B2 (ja) * | 2006-09-26 | 2013-02-27 | 東レ株式会社 | 免疫誘導剤及びその用途 |
EP2377883A1 (de) * | 2010-04-15 | 2011-10-19 | Universite d'Auvergne Clermont I | Antagonisten zur Vorbeugung oder Behandlung von entzündlicher Darmerkrankung, speziell von Morbus Crohn |
US9314516B2 (en) * | 2010-05-04 | 2016-04-19 | Cassian Yee | Conditional superagonist CTL ligands for the promotion of tumor-specific CTL responses |
CN110559424B (zh) * | 2019-08-26 | 2021-08-20 | 君维安(武汉)生命科技有限公司 | 一种外膜蛋白在制备恶性肿瘤免疫治疗药物中的应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2726472B1 (fr) * | 1994-11-07 | 1997-01-31 | Pf Medicament | Proteine porteuse a effet adjuvant, complexe immunogene la contenant, leur procede de preparation, sequence nucleotidique et vaccin |
FR2748476B1 (fr) * | 1996-05-07 | 1998-08-14 | Pf Medicament | Complexe immunogene, son utilisation, son procede de preparation et vaccin le contenant |
-
1999
- 1999-02-17 FR FR9901917A patent/FR2789588B1/fr not_active Expired - Fee Related
-
2000
- 2000-02-17 CN CNB008039593A patent/CN1191089C/zh not_active Expired - Fee Related
- 2000-02-17 JP JP2000599418A patent/JP2003506314A/ja active Pending
- 2000-02-17 DE DE60019725T patent/DE60019725D1/de not_active Expired - Lifetime
- 2000-02-17 WO PCT/FR2000/000393 patent/WO2000048628A1/fr not_active Application Discontinuation
- 2000-02-17 BR BR0008307-0A patent/BR0008307A/pt not_active IP Right Cessation
- 2000-02-17 JP JP2000599419A patent/JP2003506315A/ja active Pending
- 2000-02-17 EP EP00906411A patent/EP1150706A1/de not_active Withdrawn
- 2000-02-17 AU AU28093/00A patent/AU777511B2/en not_active Ceased
- 2000-02-17 CA CA002362192A patent/CA2362192A1/fr not_active Abandoned
- 2000-02-17 AU AU28094/00A patent/AU776903B2/en not_active Ceased
- 2000-02-17 BR BR0008305-4A patent/BR0008305A/pt not_active IP Right Cessation
- 2000-02-17 WO PCT/FR2000/000394 patent/WO2000048629A1/fr active IP Right Grant
- 2000-02-17 CN CNB008050937A patent/CN1191090C/zh not_active Expired - Fee Related
- 2000-02-17 EP EP00906412A patent/EP1150707B1/de not_active Expired - Lifetime
- 2000-02-17 AT AT00906412T patent/ATE293991T1/de not_active IP Right Cessation
- 2000-02-17 CA CA002372059A patent/CA2372059A1/fr not_active Abandoned
-
2001
- 2001-08-15 ZA ZA200106725A patent/ZA200106725B/xx unknown
- 2001-08-17 ZA ZA200106800A patent/ZA200106800B/en unknown
Also Published As
Publication number | Publication date |
---|---|
CA2372059A1 (fr) | 2000-08-24 |
CN1191089C (zh) | 2005-03-02 |
BR0008305A (pt) | 2002-01-22 |
WO2000048629A1 (fr) | 2000-08-24 |
CN1341029A (zh) | 2002-03-20 |
AU2809400A (en) | 2000-09-04 |
ZA200106725B (en) | 2002-04-24 |
ZA200106800B (en) | 2002-05-10 |
CN1191090C (zh) | 2005-03-02 |
FR2789588B1 (fr) | 2001-05-04 |
JP2003506315A (ja) | 2003-02-18 |
JP2003506314A (ja) | 2003-02-18 |
AU777511B2 (en) | 2004-10-21 |
EP1150707A1 (de) | 2001-11-07 |
FR2789588A1 (fr) | 2000-08-18 |
EP1150707B1 (de) | 2005-04-27 |
AU776903B2 (en) | 2004-09-23 |
AU2809300A (en) | 2000-09-04 |
CA2362192A1 (fr) | 2000-08-24 |
WO2000048628A1 (fr) | 2000-08-24 |
BR0008307A (pt) | 2002-01-22 |
ATE293991T1 (de) | 2005-05-15 |
EP1150706A1 (de) | 2001-11-07 |
CN1344166A (zh) | 2002-04-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MY136095A (en) | Use of human anti-ctla-4 antibodies for treatment of cancer | |
TR200301846T2 (tr) | Cripto bloke edici Antikorlar ve bu antikorların kullanımları. | |
IL147271A (en) | Isolated peptide ligands that bind to her2 | |
ATE397621T1 (de) | Hemmer der interaktion zwischen p53 und mdm2 | |
ID27788A (id) | Peptida-peptida antigen tumor yang diperoleh dari siklofilin b | |
HK1042479A1 (en) | 2-Amino-6-anilino-purines and their use as medicaments. | |
YU46097A (sh) | Nova klasa estara i njihove farmaceutske smeše | |
TW581808B (en) | Compounds for immunotherapy of prostate cancer and methods for their use | |
DE69427650D1 (de) | Verbindungen mit wachstumshormon-freisetzenden eigenschaften | |
TR199800012T1 (xx) | Piroloprimidinler ve preparasyon i�in tatbikler. | |
BR9808881A (pt) | Compostos para imunoterapia de câncer de próstata e métodos para seu uso | |
ATE256698T1 (de) | Biologisch aktive peptide und ihre zubereitungen und verwendungen | |
IL153680A0 (en) | Aplidine derivatives and methods for the preparation thereof | |
TR199901949T2 (xx) | Lemfositik t�m�rler i�in �areler. | |
YU21399A (sh) | Konjugati koji sadrže delove rastvorljive u vodi, njihova upotreba u proizvodnji leka korisnog za tretiranje raka prostate i farmaceutske kompozicije koje ih sadrže | |
DE60033649D1 (de) | Verbindungen und therapeutische methoden | |
YU68702A (sh) | Novi lhrh-antagonisti, njihova proizvodnja i upotreba kao leka | |
DE60019725D1 (de) | Verwendung eines mit dem peptid "elagigiltv" assoziierten enterobakterien-proteins ompa zur behandlung von melanomen | |
ATE325803T1 (de) | Glycokonjugate, glycoaminosäure, deren zwischenprodukte, und ihre verwendung | |
DE60143818D1 (de) | Alpha-fetoprotein-peptide und ihre verwendung | |
DE60123117D1 (de) | Verwendung von alpha-halogenacryloyl-distamycin derivaten zur herstellung eines medikaments zur behandlung von krebs | |
ATE536366T1 (de) | Peptidinhibitoren von hk2 und deren anwendung | |
DE50114335D1 (de) | Lh-rh-antagonisten, deren herstellung und verwendung als arzneimittel | |
AU2001235761A1 (en) | Diagnosis of breast cancer using bcmp-11 as marker | |
ATE419861T1 (de) | Peptide mit homing für lymphgefässtumor und ihre verwendung |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8332 | No legal effect for de |