BG98470A - Метод за превръщане на липид-съдържащи бактериални капсуловани полизахариди в свободни от липид полизахариди - Google Patents

Метод за превръщане на липид-съдържащи бактериални капсуловани полизахариди в свободни от липид полизахариди

Info

Publication number
BG98470A
BG98470A BG98470A BG9847094A BG98470A BG 98470 A BG98470 A BG 98470A BG 98470 A BG98470 A BG 98470A BG 9847094 A BG9847094 A BG 9847094A BG 98470 A BG98470 A BG 98470A
Authority
BG
Bulgaria
Prior art keywords
lipide
polysaccharides
free
polysaccharide
capsules
Prior art date
Application number
BG98470A
Other languages
English (en)
Inventor
Ann Lee
Walter Manger
Mark Rienstra
Robert Sitrin
Original Assignee
Merck & Co. Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/909,346 external-priority patent/US5314811A/en
Application filed by Merck & Co. Inc. filed Critical Merck & Co. Inc.
Publication of BG98470A publication Critical patent/BG98470A/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • General Preparation And Processing Of Foods (AREA)

Abstract

По метода липидсъдържащи бактериални капсулирани полизахариди се превръщат в свободни от липид и отендотоксин полизахариди, например полирибозилриботолфосфат, чрез разтваряне на съдържащото полизахарид прахообразно вещество, получено от бактериалнакултура, например наеморнilus influеnzае, тип в, отцепване от полизахарида на ковалентно свързанитес него мастни киселини и отделяне на липидите и ендотоксина.
BG98470A 1991-08-16 1994-02-14 Метод за превръщане на липид-съдържащи бактериални капсуловани полизахариди в свободни от липид полизахариди BG98470A (bg)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74652391A 1991-08-16 1991-08-16
US07/909,346 US5314811A (en) 1992-07-13 1992-07-13 Process for converting lipid-containing bacterial capsular polysaccharide into lipid-free polysaccharide
PCT/US1992/006301 WO1993004183A1 (en) 1991-08-16 1992-07-29 Process for converting lipid-containing bacterial capsular polysaccharide into lipid-free polysaccharide

Publications (1)

Publication Number Publication Date
BG98470A true BG98470A (bg) 1994-12-02

Family

ID=27114616

Family Applications (1)

Application Number Title Priority Date Filing Date
BG98470A BG98470A (bg) 1991-08-16 1994-02-14 Метод за превръщане на липид-съдържащи бактериални капсуловани полизахариди в свободни от липид полизахариди

Country Status (18)

Country Link
EP (1) EP0528635B1 (bg)
JP (1) JPH05209002A (bg)
KR (1) KR930004473A (bg)
CN (1) CN1071699A (bg)
AT (1) ATE176929T1 (bg)
AU (1) AU2105492A (bg)
BG (1) BG98470A (bg)
CA (1) CA2075681C (bg)
CZ (1) CZ28694A3 (bg)
DE (1) DE69228454T2 (bg)
FI (1) FI940700A (bg)
HU (1) HU9400426D0 (bg)
IL (1) IL102763A0 (bg)
MX (1) MX9204721A (bg)
NZ (1) NZ243892A (bg)
SK (1) SK18594A3 (bg)
WO (1) WO1993004183A1 (bg)
YU (1) YU89692A (bg)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT897427E (pt) * 1996-02-14 2005-01-31 Merck & Co Inc Processo de precipitacao de polissacarideos
US6410025B1 (en) 1996-02-14 2002-06-25 Merck & Co., Inc. Polysaccharide precipitation process
SE0003958D0 (sv) 2000-10-31 2000-10-31 Biogaia Fermentation Ab Method for growth of microorganisms
MXPA03006561A (es) 2001-01-23 2004-10-15 Aventis Pasteur Vacuna del conjugado proteina-polisacarido meningococico, multivalente.
GB0115176D0 (en) 2001-06-20 2001-08-15 Chiron Spa Capular polysaccharide solubilisation and combination vaccines
KR100826963B1 (ko) * 2001-11-13 2008-05-02 주식회사 포스코 고로 노심온도 관리 방법
GB0408978D0 (en) * 2004-04-22 2004-05-26 Chiron Srl Meningococcal fermentation for preparing conjugate vaccines
EP2409994A3 (en) 2007-02-28 2012-08-15 Lipoxen Technologies Limited Reduction of endotoxin in polysialic acids
FR2918671B1 (fr) 2007-07-10 2010-10-15 Sanofi Pasteur Milieu de culture d'haemophilus influenzae type b.
CN101724085B (zh) * 2008-10-22 2011-09-21 上海生物制品研究所 一种荚膜多糖纯化方法
CN103059149B (zh) * 2011-10-19 2016-08-31 天士力制药集团股份有限公司 一种prp多糖提取方法
CN102660602B (zh) * 2012-04-17 2015-03-25 江苏康泰生物医学技术有限公司 快速纯化细菌荚膜多糖的方法
CN102731670B (zh) * 2012-06-29 2014-09-03 成都欧林生物科技股份有限公司 Hib荚膜多糖纯化工艺
BR102019021510A2 (pt) * 2019-10-14 2022-01-25 Instituto Butantan Processo de produção, recuperação e purificação de polissacarídeo capsular poliribosil-ribitol-fosfato (prp) e uso do mesmo

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2316964A1 (fr) * 1975-07-11 1977-02-04 Pasteur Institut Medicament contenant, a titre de principe actif, un produit a base de polysaccharides, notamment obtenu a partir de lipopolysaccharides bacteriens
NZ188211A (en) * 1977-10-28 1984-09-28 American Cyanamid Co Isolation of polyribosyl ribitol phosphate(prp)from haemophilus influenzae type b;vaccine comprising prp and bordetellapertussis antigens

Also Published As

Publication number Publication date
FI940700A0 (fi) 1994-02-15
EP0528635B1 (en) 1999-02-24
SK18594A3 (en) 1994-08-10
KR930004473A (ko) 1993-03-22
CN1071699A (zh) 1993-05-05
WO1993004183A1 (en) 1993-03-04
NZ243892A (en) 1994-06-27
HU9400426D0 (en) 1994-05-30
CA2075681A1 (en) 1993-02-17
JPH05209002A (ja) 1993-08-20
DE69228454D1 (de) 1999-04-01
MX9204721A (es) 1993-07-01
DE69228454T2 (de) 1999-07-15
FI940700A (fi) 1994-02-15
AU2105492A (en) 1993-02-18
YU89692A (sh) 1995-10-24
IL102763A0 (en) 1993-01-31
EP0528635A1 (en) 1993-02-24
CZ28694A3 (en) 1994-05-18
ATE176929T1 (de) 1999-03-15
CA2075681C (en) 2003-03-25

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