BG64941B1 - Инхибитори на фарнезил протеин трансфераза с in vivo чувствителност към радиосенсибилизиращи свойства - Google Patents
Инхибитори на фарнезил протеин трансфераза с in vivo чувствителност към радиосенсибилизиращи свойства Download PDFInfo
- Publication number
- BG64941B1 BG64941B1 BG105108A BG10510801A BG64941B1 BG 64941 B1 BG64941 B1 BG 64941B1 BG 105108 A BG105108 A BG 105108A BG 10510801 A BG10510801 A BG 10510801A BG 64941 B1 BG64941 B1 BG 64941B1
- Authority
- BG
- Bulgaria
- Prior art keywords
- alkyl
- hydrogen
- methyl
- formula
- alkyloxy
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98202257 | 1998-07-06 | ||
EP98204330 | 1998-12-18 |
Publications (2)
Publication Number | Publication Date |
---|---|
BG105108A BG105108A (en) | 2001-11-30 |
BG64941B1 true BG64941B1 (bg) | 2006-10-31 |
Family
ID=26150503
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG105108A BG64941B1 (bg) | 1998-07-06 | 2001-01-03 | Инхибитори на фарнезил протеин трансфераза с in vivo чувствителност към радиосенсибилизиращи свойства |
Country Status (31)
Country | Link |
---|---|
US (1) | US6545020B1 (fr) |
EP (1) | EP1094839B1 (fr) |
JP (1) | JP4530537B2 (fr) |
KR (1) | KR100591603B1 (fr) |
CN (1) | CN1152716C (fr) |
AP (1) | AP1599A (fr) |
AT (1) | ATE238811T1 (fr) |
AU (1) | AU762423B2 (fr) |
BG (1) | BG64941B1 (fr) |
BR (1) | BR9911861A (fr) |
CA (1) | CA2336624C (fr) |
CZ (1) | CZ300968B6 (fr) |
DE (1) | DE69907461T2 (fr) |
DK (1) | DK1094839T3 (fr) |
EA (1) | EA003877B1 (fr) |
EE (1) | EE04582B1 (fr) |
ES (1) | ES2199579T3 (fr) |
HK (1) | HK1034451A1 (fr) |
HR (1) | HRP20000903A2 (fr) |
HU (1) | HU229076B1 (fr) |
ID (1) | ID26987A (fr) |
IL (2) | IL140721A0 (fr) |
MY (1) | MY126519A (fr) |
NO (1) | NO328178B1 (fr) |
PL (1) | PL193464B1 (fr) |
PT (1) | PT1094839E (fr) |
SI (1) | SI1094839T1 (fr) |
SK (1) | SK284723B6 (fr) |
TR (1) | TR200003879T2 (fr) |
TW (1) | TW586937B (fr) |
WO (1) | WO2000001411A1 (fr) |
Families Citing this family (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA003510B1 (ru) | 1998-07-06 | 2003-06-26 | Янссен Фармацевтика Н.В. | Ингибиторы фарнезилпротеинтрансферазы, применяемые для лечения артропатий |
AP1599A (en) | 1998-07-06 | 2006-04-27 | Janssen Pharmaceutica Nv | Farnesyl protein transferase inhibitors with in vivo radiosensitizing properties. |
JP5491681B2 (ja) * | 2000-02-04 | 2014-05-14 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 乳ガンの治療のためのファルネシルタンパク質トランスフェラーゼ阻害剤 |
JO2361B1 (en) * | 2000-06-22 | 2006-12-12 | جانسين فارماسيوتيكا ان. في | Enaniumer 1,2-anylated quinoline inhibitor for the transporter - farnesyl |
WO2002024686A2 (fr) | 2000-09-25 | 2002-03-28 | Janssen Pharmaceutica N.V. | Derives de la quinoleine et de la quinazoline 6-heterocyclylmethyle inhibiteurs de la farnesyle transferase |
JP4974439B2 (ja) | 2000-09-25 | 2012-07-11 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ファルネシルトランスフェラーゼを阻害する6−ヘテロシクリルメチルキノリノン誘導体 |
AU2001293829A1 (en) | 2000-09-25 | 2002-04-02 | Janssen Pharmaceutica N.V. | Farnesyl transferase inhibiting 6-((substituted phenyl)methyl)-quinoline and quinazoline derivatives |
WO2002024682A1 (fr) | 2000-09-25 | 2002-03-28 | Janssen Pharmaceutica N.V. | Derives de quinoline et de quinazoline inhibant la farnesyl transferase comme inhibiteurs de farnesyl transferase |
ES2328225T3 (es) | 2000-11-21 | 2009-11-11 | Janssen Pharmaceutica Nv | Derivados benzoheterociclicos inhibidores de la farnesil-transferasa. |
DE60119383T2 (de) * | 2000-12-27 | 2007-04-19 | Janssen Pharmaceutica N.V. | Farnesyltransferasehemmende 4-heterocyclylchinolin- und chinazolinderivate |
US7129356B2 (en) | 2000-12-27 | 2006-10-31 | Janssen Pharmaceutica N.V. | Farnesyl transferase inhibiting 4-substituted quinoline and quinazoline derivatives |
US6713462B2 (en) | 2001-06-21 | 2004-03-30 | Ariad Pharmaceuticals, Inc. | Quinolinones and uses thereof |
AU2002358677B2 (en) | 2001-12-19 | 2008-02-07 | Janssen Pharmaceutica N.V. | 1,8-annelated quinoline derivatives substituted with carbon-linked triazoles as farnesyl transferase inhibitors |
CA2478813C (fr) | 2002-03-22 | 2011-10-18 | Janssen Pharmaceutica N.V. | Derives de 2-quinoleine et de 2-quinazoline substitues par du benzylimidazole utilises en tant qu'inhibiteurs de farnesyl transferase |
US7511138B2 (en) | 2002-04-15 | 2009-03-31 | Janssen Pharmaceutica Nv | Farnesyl transferase inhibiting tricyclic quinazoline derivatives substituted with carbon-linked imidazoles or triazoles |
MXPA06005687A (es) * | 2003-11-20 | 2006-08-17 | Janssen Pharmaceutica Nv | 2-quinolinonas y 2-quinoxalinonas sustituidas con 6-alquenilo y 6-fenilalquilo como inhibidores de la poli(adenosin fosfato-ribosa)polimerasa. |
WO2005051392A1 (fr) | 2003-11-20 | 2005-06-09 | Children's Hospital Medical Center | Inhibiteurs de gtpase et procedes d'utilisation correspondants |
US20060106060A1 (en) * | 2004-03-18 | 2006-05-18 | The Brigham And Women's Hospital, Inc. | Methods for the treatment of synucleinopathies (Lansbury) |
US20050288298A1 (en) * | 2004-03-18 | 2005-12-29 | The Brigham And Women's Hospital, Inc. | Methods for the treatment of synucleinopathies |
US20070293539A1 (en) * | 2004-03-18 | 2007-12-20 | Lansbury Peter T | Methods for the treatment of synucleinopathies |
WO2005089502A2 (fr) * | 2004-03-18 | 2005-09-29 | The Brigham And Women's Hospital, Inc. | Traitement des synucleinopathies |
US20050272722A1 (en) * | 2004-03-18 | 2005-12-08 | The Brigham And Women's Hospital, Inc. | Methods for the treatment of synucleinopathies |
WO2005089518A2 (fr) * | 2004-03-18 | 2005-09-29 | The Brigham And Women's Hospital, Inc. | Expression de uch-l1 et cancerotherapie |
US20060194821A1 (en) * | 2005-02-18 | 2006-08-31 | The Brigham And Women's Hospital, Inc. | Compounds inhibiting the aggregation of superoxide dismutase-1 |
CA2617056A1 (fr) | 2005-07-29 | 2007-02-08 | Children's Hospital Medical Center | Inhibiteurs de gtpase et methodes d'utilisation et structure cristalline de la gtpase rac-1 |
US20070213366A1 (en) | 2005-12-23 | 2007-09-13 | Justman Craig J | Treatment of Synucleinopathies |
JP2010528034A (ja) * | 2007-05-23 | 2010-08-19 | アラーガン、インコーポレイテッド | 医薬としての((フェニル)イミダゾリル)メチルキノリニル化合物 |
WO2009151683A2 (fr) * | 2008-03-12 | 2009-12-17 | Link Medicine Corporation | Inhibiteurs de quinolinone farnésyl transférase pour le traitement de synucléinopathies et d'autres indications |
ATE555384T1 (de) | 2008-06-26 | 2012-05-15 | Spherotec Gmbh | Verfahren zum testen der reaktion von zellen auf die einwirkung von therapeutika |
US20110060005A1 (en) * | 2008-11-13 | 2011-03-10 | Link Medicine Corporation | Treatment of mitochondrial disorders using a farnesyl transferase inhibitor |
BRPI0920927A2 (pt) * | 2008-11-13 | 2019-09-24 | Link Medicine Corp | derivados de azaquinolinona e usos dos mesmos |
US20100331363A1 (en) * | 2008-11-13 | 2010-12-30 | Link Medicine Corporation | Treatment of mitochondrial disorders using a farnesyl transferase inhibitor |
WO2013166043A1 (fr) | 2012-05-02 | 2013-11-07 | Children's Hospital Medical Center | Rajeunissement de cellules précurseurs |
CN105209453B (zh) | 2012-10-16 | 2017-06-20 | 詹森药业有限公司 | ROR‑γ‑T的亚甲基连接的喹啉基调节剂 |
ES2619610T3 (es) | 2012-10-16 | 2017-06-26 | Janssen Pharmaceutica Nv | Moduladores de ROR-gamma-t de quinolinilo enlazado con heteroarilo |
CA2888485C (fr) | 2012-10-16 | 2021-01-26 | Janssen Pharmaceutica Nv | Modulateurs de ror-gamma-t de type quinolinyle a liaison phenyle |
US9328095B2 (en) | 2013-10-15 | 2016-05-03 | Janssen Pharmaceutica Nv | Heteroaryl linked quinolinyl modulators of RORgammat |
US9624225B2 (en) | 2013-10-15 | 2017-04-18 | Janssen Pharmaceutica Nv | Quinolinyl modulators of RORγt |
US9403816B2 (en) | 2013-10-15 | 2016-08-02 | Janssen Pharmaceutica Nv | Phenyl linked quinolinyl modulators of RORγt |
US9221804B2 (en) | 2013-10-15 | 2015-12-29 | Janssen Pharmaceutica Nv | Secondary alcohol quinolinyl modulators of RORγt |
US10555941B2 (en) | 2013-10-15 | 2020-02-11 | Janssen Pharmaceutica Nv | Alkyl linked quinolinyl modulators of RORγt |
US9346782B2 (en) | 2013-10-15 | 2016-05-24 | Janssen Pharmaceutica Nv | Alkyl linked quinolinyl modulators of RORγt |
US9284308B2 (en) | 2013-10-15 | 2016-03-15 | Janssen Pharmaceutica Nv | Methylene linked quinolinyl modulators of RORγt |
US10028503B2 (en) | 2014-06-18 | 2018-07-24 | Children's Hospital Medical Center | Platelet storage methods and compositions for same |
KR101885361B1 (ko) | 2015-08-17 | 2018-08-06 | 쿠라 온콜로지, 인크. | 파르네실전달효소 억제제를 이용하여 암환자를 치료하는 방법 |
WO2017184968A1 (fr) | 2016-04-22 | 2017-10-26 | Kura Oncology, Inc. | Méthodes de sélection de patients atteints de cancer pour le traitement avec des inhibiteurs de farnésyltransférase |
JP2019534290A (ja) | 2016-11-03 | 2019-11-28 | クラ オンコロジー, インコーポレイテッド | 癌の治療方法において使用するためのファルネシルトランスフェラーゼ阻害剤 |
TWI693074B (zh) | 2017-02-21 | 2020-05-11 | 美商庫拉腫瘤技術股份有限公司 | 以法呢基轉移酶(farnesyltransferase)抑制劑治療癌症之方法 |
US9956215B1 (en) | 2017-02-21 | 2018-05-01 | Kura Oncology, Inc. | Methods of treating cancer with farnesyltransferase inhibitors |
BR112020002591A2 (pt) | 2017-08-07 | 2020-07-28 | Kura Oncology, Inc. | método para o tratamento de câncer |
US10806730B2 (en) | 2017-08-07 | 2020-10-20 | Kura Oncology, Inc. | Methods of treating cancer with farnesyltransferase inhibitors |
WO2019113269A1 (fr) | 2017-12-08 | 2019-06-13 | Kura Oncology, Inc. | Méthodes de traitement de patients cancéreux avec des inhibiteurs de la farnésyltransférase |
AU2019372141A1 (en) | 2018-11-01 | 2021-05-27 | Kura Oncology, Inc. | Methods of treating cancer with farnesyltransferase inhibitors |
US20220142983A1 (en) | 2019-03-01 | 2022-05-12 | Kura Oncology, Inc. | Methods of treating cancer with farnesyltransferase inhibitors |
TW202108170A (zh) | 2019-03-15 | 2021-03-01 | 美商庫拉腫瘤技術股份有限公司 | 以法呢基轉移酶(farnesyltransferase)抑制劑治療癌症患者之方法 |
CA3134825A1 (fr) | 2019-03-29 | 2020-10-08 | Kura Oncology, Inc. | Procedes de traitement de carcinomes squameux par des inhibiteurs de farnesyltransferase |
WO2020205387A1 (fr) | 2019-04-01 | 2020-10-08 | Kura Oncology, Inc. | Méthodes de traitement du cancer à l'aide d'inhibiteurs de la farnésyltransférase |
US20220305001A1 (en) | 2019-05-02 | 2022-09-29 | Kura Oncology, Inc. | Methods of treating acute myeloid leukemia with farnesyltransferase inhibitors |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6083917A (en) * | 1990-04-18 | 2000-07-04 | Board Of Regents, The University Of Texas System | Methods and compositions for the identification, characterization and inhibition of farnesyltransferase |
US5141851A (en) * | 1990-04-18 | 1992-08-25 | Board Of Regents, The University Of Texas System | Isolated farnesyl protein transferase enzyme |
US5602184A (en) | 1993-03-03 | 1997-02-11 | The United States Of America As Represented By Department Of Health And Human Services | Monoterpenes, sesquiterpenes and diterpenes as cancer therapy |
TW349948B (en) * | 1995-10-31 | 1999-01-11 | Janssen Pharmaceutica Nv | Farnesyl transferase inhibiting 2-quinolone derivatives |
EP1162201B1 (fr) * | 1995-12-08 | 2006-03-29 | Janssen Pharmaceutica N.V. | Dérivés de la ( imidazol-5-yl)méthyl-2-quinoléinone comme inhibiteurs de la protéine farnésyle transférase |
US20020034725A1 (en) * | 1996-04-15 | 2002-03-21 | W. Gillies Mckenna | Sensitization of cells to radiation and and chemotherapy |
AU709409B2 (en) * | 1996-07-15 | 1999-08-26 | Bristol-Myers Squibb Company | Thiadioxobenzodiazepine inhibitors of farnesyl protein transferase |
TW591030B (en) | 1997-03-10 | 2004-06-11 | Janssen Pharmaceutica Nv | Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with N- or C-linked imidazoles |
AP1599A (en) | 1998-07-06 | 2006-04-27 | Janssen Pharmaceutica Nv | Farnesyl protein transferase inhibitors with in vivo radiosensitizing properties. |
HUP0105231A3 (en) * | 1999-02-11 | 2003-01-28 | Pfizer Prod Inc | Heteroaryl-substituted quinolin-2-one derivatives useful as anticancer agents and medicaments containing the compounds |
-
1999
- 1999-06-30 AP APAP/P/2001/002057A patent/AP1599A/en active
- 1999-06-30 CA CA002336624A patent/CA2336624C/fr not_active Expired - Lifetime
- 1999-06-30 AU AU47805/99A patent/AU762423B2/en not_active Expired
- 1999-06-30 WO PCT/EP1999/004545 patent/WO2000001411A1/fr active IP Right Grant
- 1999-06-30 SK SK1986-2000A patent/SK284723B6/sk not_active IP Right Cessation
- 1999-06-30 EA EA200100111A patent/EA003877B1/ru not_active IP Right Cessation
- 1999-06-30 BR BR9911861-0A patent/BR9911861A/pt not_active Application Discontinuation
- 1999-06-30 DK DK99931229T patent/DK1094839T3/da active
- 1999-06-30 EP EP99931229A patent/EP1094839B1/fr not_active Expired - Lifetime
- 1999-06-30 ES ES99931229T patent/ES2199579T3/es not_active Expired - Lifetime
- 1999-06-30 DE DE69907461T patent/DE69907461T2/de not_active Expired - Lifetime
- 1999-06-30 KR KR1020007014066A patent/KR100591603B1/ko not_active IP Right Cessation
- 1999-06-30 CN CNB998082678A patent/CN1152716C/zh not_active Expired - Lifetime
- 1999-06-30 CZ CZ20004777A patent/CZ300968B6/cs not_active IP Right Cessation
- 1999-06-30 SI SI9930332T patent/SI1094839T1/xx unknown
- 1999-06-30 AT AT99931229T patent/ATE238811T1/de active
- 1999-06-30 HU HU0103689A patent/HU229076B1/hu unknown
- 1999-06-30 PL PL99347979A patent/PL193464B1/pl unknown
- 1999-06-30 ID IDW20010020A patent/ID26987A/id unknown
- 1999-06-30 IL IL14072199A patent/IL140721A0/xx active IP Right Grant
- 1999-06-30 JP JP2000557857A patent/JP4530537B2/ja not_active Expired - Lifetime
- 1999-06-30 TR TR2000/03879T patent/TR200003879T2/xx unknown
- 1999-06-30 EE EEP200000794A patent/EE04582B1/xx unknown
- 1999-06-30 US US09/743,130 patent/US6545020B1/en not_active Expired - Lifetime
- 1999-06-30 PT PT99931229T patent/PT1094839E/pt unknown
- 1999-07-01 MY MYPI99002794A patent/MY126519A/en unknown
- 1999-07-05 TW TW088111346A patent/TW586937B/zh not_active IP Right Cessation
-
2000
- 2000-12-28 HR HR20000903A patent/HRP20000903A2/hr not_active Application Discontinuation
-
2001
- 2001-01-03 BG BG105108A patent/BG64941B1/bg unknown
- 2001-01-04 IL IL140721A patent/IL140721A/en not_active IP Right Cessation
- 2001-01-05 NO NO20010082A patent/NO328178B1/no not_active IP Right Cessation
- 2001-07-18 HK HK01105023A patent/HK1034451A1/xx not_active IP Right Cessation
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