BG64309B1 - Средство за отваряне на калиевите канали - Google Patents

Средство за отваряне на калиевите канали Download PDF

Info

Publication number
BG64309B1
BG64309B1 BG104594A BG10459400A BG64309B1 BG 64309 B1 BG64309 B1 BG 64309B1 BG 104594 A BG104594 A BG 104594A BG 10459400 A BG10459400 A BG 10459400A BG 64309 B1 BG64309 B1 BG 64309B1
Authority
BG
Bulgaria
Prior art keywords
dioxide
thiopyrano
hexahydro
quinoline
pyridin
Prior art date
Application number
BG104594A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG104594A (en
Inventor
William A. Carrol
Mark W. Holladay
James P. Sullivan
Irene Drizin
Henry Q. Zhang
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/206,055 external-priority patent/US6265417B1/en
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of BG104594A publication Critical patent/BG104594A/xx
Publication of BG64309B1 publication Critical patent/BG64309B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C07C45/298—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with manganese derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Nutrition Science (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Glass Compositions (AREA)
  • Hydrogen, Water And Hydrids (AREA)
  • Quinoline Compounds (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Gyroscopes (AREA)
  • Toys (AREA)
  • Weting (AREA)
  • Feeding And Controlling Fuel (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Polyesters Or Polycarbonates (AREA)
BG104594A 1997-12-18 2000-07-11 Средство за отваряне на калиевите канали BG64309B1 (bg)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US99339297A 1997-12-18 1997-12-18
US09/206,055 US6265417B1 (en) 1997-12-18 1998-12-04 Potassium channel openers
PCT/US1998/026780 WO1999031059A1 (en) 1997-12-18 1998-12-16 Potassium channel openers

Publications (2)

Publication Number Publication Date
BG104594A BG104594A (en) 2001-03-30
BG64309B1 true BG64309B1 (bg) 2004-09-30

Family

ID=26901004

Family Applications (1)

Application Number Title Priority Date Filing Date
BG104594A BG64309B1 (bg) 1997-12-18 2000-07-11 Средство за отваряне на калиевите канали

Country Status (22)

Country Link
US (1) US20010036950A1 (zh)
EP (1) EP1040097B1 (zh)
JP (1) JP2002508354A (zh)
CN (1) CN1158259C (zh)
AT (1) ATE264303T1 (zh)
AU (1) AU756505B2 (zh)
BG (1) BG64309B1 (zh)
BR (1) BR9813634A (zh)
CA (1) CA2314948A1 (zh)
DE (1) DE69823227T2 (zh)
DK (1) DK1040097T3 (zh)
ES (1) ES2222000T3 (zh)
HK (1) HK1032583A1 (zh)
HU (1) HUP0100112A3 (zh)
IL (1) IL135985A0 (zh)
NO (1) NO317099B1 (zh)
NZ (1) NZ504371A (zh)
PL (1) PL341298A1 (zh)
PT (1) PT1040097E (zh)
SK (1) SK8732000A3 (zh)
TR (1) TR200001715T2 (zh)
WO (1) WO1999031059A1 (zh)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6265417B1 (en) 1997-12-18 2001-07-24 Abbott Laboratories Potassium channel openers
US6593335B1 (en) 1997-12-18 2003-07-15 Abbott Laboratories Potassium channel openers
US6191140B1 (en) * 1998-10-28 2001-02-20 Abbott Laboratories Pyrano, piperidino, and thiopyrano compounds and methods of use
WO2000024741A2 (en) * 1998-10-28 2000-05-04 Abbott Laboratories Dihydropyridine compounds and their use as potassium channel openers
US6642222B2 (en) * 1998-10-28 2003-11-04 Abbott Laboratories Pyrano, piperidino, and thiopyrano compounds and methods of use
US6518279B2 (en) * 1999-03-04 2003-02-11 Abbott Laboratories Cyclopentanone dihydropyridine compounds useful as potassium channel openers
WO2002006237A1 (fr) * 2000-07-18 2002-01-24 Yamanouchi Pharmaceutical Co., Ltd. Medicament comprenant un derive de dicyanopyridine
WO2003070678A1 (en) * 2002-02-19 2003-08-28 Abbott Laboratories Iodination of 4-fluoro-benzaldehyde

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2658804A1 (de) * 1976-12-24 1978-07-06 Bayer Ag Kreislaufbeeinflussende mittel
DE2747513A1 (de) * 1977-10-22 1979-05-03 Bayer Ag Dihydropyridine mit schwefelhaltigen estergruppierungen
US4777167A (en) * 1986-04-09 1988-10-11 Ortho Pharmaceutical Corporation Pharmaceutically useful substituted thiacycloalkeno [3,2-b]pyridines, compositions and method of use
US4879384A (en) * 1988-06-15 1989-11-07 Ortho Pharmaceutical Corporation Preparation of thiocycloalkno [3,2-b] pyridines
US5075440A (en) * 1990-05-03 1991-12-24 Ortho Pharmaceutical Corporation Novel pyrido[2,3-f](1,4)thiazepines and pyrido[3,2-b](1,5)benzothiazepines
CA2080949A1 (en) * 1991-10-21 1993-04-22 Cyrus John Ohnmacht Therapeutic agents
GB9318935D0 (en) * 1992-10-20 1993-10-27 Zeneca Ltd Heterocyclic derivatives
DE4424678A1 (de) * 1994-07-13 1996-01-18 Bayer Ag Dioxo-thiopyrano-pyridin-carbonsäure-derivate

Also Published As

Publication number Publication date
US20010036950A1 (en) 2001-11-01
ATE264303T1 (de) 2004-04-15
NO20003104L (no) 2000-08-17
AU756505B2 (en) 2003-01-16
DE69823227D1 (de) 2004-05-19
PT1040097E (pt) 2004-08-31
IL135985A0 (en) 2001-05-20
EP1040097B1 (en) 2004-04-14
ES2222000T3 (es) 2005-01-16
CA2314948A1 (en) 1999-06-24
AU1830799A (en) 1999-07-05
JP2002508354A (ja) 2002-03-19
HK1032583A1 (en) 2001-07-27
PL341298A1 (en) 2001-04-09
TR200001715T2 (tr) 2000-12-21
HUP0100112A3 (en) 2004-05-28
DK1040097T3 (da) 2004-08-02
NO317099B1 (no) 2004-08-09
HUP0100112A2 (hu) 2001-08-28
DE69823227T2 (de) 2005-03-10
CN1158259C (zh) 2004-07-21
NO20003104D0 (no) 2000-06-16
EP1040097A1 (en) 2000-10-04
WO1999031059A1 (en) 1999-06-24
BG104594A (en) 2001-03-30
SK8732000A3 (en) 2000-11-07
BR9813634A (pt) 2000-10-17
NZ504371A (en) 2002-02-01
CN1282321A (zh) 2001-01-31

Similar Documents

Publication Publication Date Title
KR960012368B1 (ko) 비스-벤조 또는 벤조피리도 시클로 헵타 피페리덴, 피페리딜리덴 및 피페라진 화합물 및 조성물
KR950004004B1 (ko) 신규한 벤조피리도 피페리딘, 피페리딜리덴 및 피페라진 화합물, 조성물, 제조방법 및 이용방법
KR101923367B1 (ko) 이온 채널의 조절제로서의 피롤로피라진―스피로사이클릭 피페리딘 아미드
US6265417B1 (en) Potassium channel openers
US20110263588A1 (en) Tricyclic compounds as glutamate receptor modulators
JPH0678316B2 (ja) ベンゾ〔５，６〕シクロヘプタピリジン類、組成物および使用法
KR20100039339A (ko) Ｇａｂａ 조절제로서 유용한 융합 퀴놀린 유도체
US4636506A (en) 7-heterocyclic-1,4-dihydroquinolones
US6593335B1 (en) Potassium channel openers
WO1998011110A1 (de) 3-substituierte pyrido [4',3':4,5] thieno [2,3-d]pyrimidin-derivate, ihre herstellung und verwendung
BG64309B1 (bg) Средство за отваряне на калиевите канали
KR100760072B1 (ko) 고리 축합된 피라졸 유도체
US20020049223A1 (en) Quinoline and naphthyridine carboxylic acid antibacterials
EP0208855A1 (en) Process for preparing piperidylidene dihydrodibenzo(a,d)cycloheptenes and aza derivatives thereof, compounds obtained by such process and the use of such compounds for preparing useful pharmaceutical compositions
NO831562L (no) Analogifremgangsmaate for fremstilling av fysiologisk aktive kinolinderivater
US20020007065A1 (en) Cyclopentanone dihydropyridine compounds useful as potassium channel openers
NO316693B1 (no) Nye indanolforbindelser, fremgangsmate ved deres fremstilling og farmasoytiske sammensetninger inneholdende dem
CA2385908A1 (en) Dihydronaphthyridine- and dihydropyrrolopyridine-derivated compounds as potassium channel openers
BG105524A (bg) Пиранови, пиперидинови и тиопиранови съединения иметод за получаването им
CZ20002137A3 (cs) Látky otevírající draslíkové kanály
NO157578B (no) Analogifremgangsmaate ved fremstilling av terapeutisk aktive imidazo(1,2-a)kinolinderivater
EP3004118A1 (en) Use of condensed benzo[b]thiazine derivatives as cytoprotectants
EP0002512A1 (en) Imino-bridged benzocycloheptapyridines, process for their preparation and pharmaceutical composition thereof
NZ716609B2 (en) Fused piperidine amides as modulators of ion channels
CZ20004428A3 (cs) Cyklopentanon dihydropyridinové sloučeniny užitečné jako látky otevírající draslíkové kanály