PT1040097E - Agentes de abertura de canais de potassio - Google Patents

Agentes de abertura de canais de potassio

Info

Publication number
PT1040097E
PT1040097E PT98963249T PT98963249T PT1040097E PT 1040097 E PT1040097 E PT 1040097E PT 98963249 T PT98963249 T PT 98963249T PT 98963249 T PT98963249 T PT 98963249T PT 1040097 E PT1040097 E PT 1040097E
Authority
PT
Portugal
Prior art keywords
channels
potassio
opening agents
opening
potassium channel
Prior art date
Application number
PT98963249T
Other languages
English (en)
Inventor
William A Carroll
Irene Drizin
James P Sullivan
Mark W Holladay
Henry Q Zhang
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/206,055 external-priority patent/US6265417B1/en
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of PT1040097E publication Critical patent/PT1040097E/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D221/00Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04Ortho- or peri-condensed ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C07C45/298Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with manganese derivatives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36Sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nutrition Science (AREA)
  • Urology & Nephrology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Quinoline Compounds (AREA)
  • Toys (AREA)
  • Gyroscopes (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Weting (AREA)
  • Feeding And Controlling Fuel (AREA)
  • Hydrogen, Water And Hydrids (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Pyridine Compounds (AREA)
PT98963249T 1997-12-18 1998-12-16 Agentes de abertura de canais de potassio PT1040097E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99339297A 1997-12-18 1997-12-18
US09/206,055 US6265417B1 (en) 1997-12-18 1998-12-04 Potassium channel openers

Publications (1)

Publication Number Publication Date
PT1040097E true PT1040097E (pt) 2004-08-31

Family

ID=26901004

Family Applications (1)

Application Number Title Priority Date Filing Date
PT98963249T PT1040097E (pt) 1997-12-18 1998-12-16 Agentes de abertura de canais de potassio

Country Status (22)

Country Link
US (1) US20010036950A1 (pt)
EP (1) EP1040097B1 (pt)
JP (1) JP2002508354A (pt)
CN (1) CN1158259C (pt)
AT (1) ATE264303T1 (pt)
AU (1) AU756505B2 (pt)
BG (1) BG64309B1 (pt)
BR (1) BR9813634A (pt)
CA (1) CA2314948A1 (pt)
DE (1) DE69823227T2 (pt)
DK (1) DK1040097T3 (pt)
ES (1) ES2222000T3 (pt)
HK (1) HK1032583A1 (pt)
HU (1) HUP0100112A3 (pt)
IL (1) IL135985A0 (pt)
NO (1) NO317099B1 (pt)
NZ (1) NZ504371A (pt)
PL (1) PL341298A1 (pt)
PT (1) PT1040097E (pt)
SK (1) SK8732000A3 (pt)
TR (1) TR200001715T2 (pt)
WO (1) WO1999031059A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6265417B1 (en) 1997-12-18 2001-07-24 Abbott Laboratories Potassium channel openers
US6593335B1 (en) * 1997-12-18 2003-07-15 Abbott Laboratories Potassium channel openers
US6642222B2 (en) * 1998-10-28 2003-11-04 Abbott Laboratories Pyrano, piperidino, and thiopyrano compounds and methods of use
US6191140B1 (en) 1998-10-28 2001-02-20 Abbott Laboratories Pyrano, piperidino, and thiopyrano compounds and methods of use
AU1459500A (en) * 1998-10-28 2000-05-15 Abbott Laboratories Dihydropyridine compounds and methods of use
US6518279B2 (en) 1999-03-04 2003-02-11 Abbott Laboratories Cyclopentanone dihydropyridine compounds useful as potassium channel openers
CN1441783A (zh) * 2000-07-18 2003-09-10 山之内制药株式会社 含二氰基吡啶衍生物的药物
CA2476824A1 (en) * 2002-02-19 2003-08-28 Abbott Laboratories Iodination of 4-fluoro-benzaldehyde

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2658804A1 (de) * 1976-12-24 1978-07-06 Bayer Ag Kreislaufbeeinflussende mittel
DE2747513A1 (de) * 1977-10-22 1979-05-03 Bayer Ag Dihydropyridine mit schwefelhaltigen estergruppierungen
US4777167A (en) * 1986-04-09 1988-10-11 Ortho Pharmaceutical Corporation Pharmaceutically useful substituted thiacycloalkeno [3,2-b]pyridines, compositions and method of use
US4879384A (en) * 1988-06-15 1989-11-07 Ortho Pharmaceutical Corporation Preparation of thiocycloalkno [3,2-b] pyridines
US5075440A (en) * 1990-05-03 1991-12-24 Ortho Pharmaceutical Corporation Novel pyrido[2,3-f](1,4)thiazepines and pyrido[3,2-b](1,5)benzothiazepines
ATE161531T1 (de) * 1991-10-21 1998-01-15 Zeneca Ltd Acridine-1,8-dionderivate als therapeutisches mittel
GB9318935D0 (en) * 1992-10-20 1993-10-27 Zeneca Ltd Heterocyclic derivatives
DE4424678A1 (de) * 1994-07-13 1996-01-18 Bayer Ag Dioxo-thiopyrano-pyridin-carbonsäure-derivate

Also Published As

Publication number Publication date
ATE264303T1 (de) 2004-04-15
WO1999031059A1 (en) 1999-06-24
BG104594A (en) 2001-03-30
EP1040097B1 (en) 2004-04-14
NZ504371A (en) 2002-02-01
DK1040097T3 (da) 2004-08-02
HUP0100112A2 (hu) 2001-08-28
PL341298A1 (en) 2001-04-09
DE69823227D1 (de) 2004-05-19
IL135985A0 (en) 2001-05-20
AU756505B2 (en) 2003-01-16
CN1282321A (zh) 2001-01-31
SK8732000A3 (en) 2000-11-07
CN1158259C (zh) 2004-07-21
DE69823227T2 (de) 2005-03-10
BG64309B1 (bg) 2004-09-30
JP2002508354A (ja) 2002-03-19
TR200001715T2 (tr) 2000-12-21
HUP0100112A3 (en) 2004-05-28
ES2222000T3 (es) 2005-01-16
BR9813634A (pt) 2000-10-17
US20010036950A1 (en) 2001-11-01
AU1830799A (en) 1999-07-05
NO317099B1 (no) 2004-08-09
NO20003104D0 (no) 2000-06-16
EP1040097A1 (en) 2000-10-04
NO20003104L (no) 2000-08-17
HK1032583A1 (en) 2001-07-27
CA2314948A1 (en) 1999-06-24

Similar Documents

Publication Publication Date Title
DE60019121D1 (de) Kaliumkanäleöffner
AU2291097A (en) Novel phenanthridines substituted in the 6 position
BG102425A (en) (methylsulphonyl)phenyl-2-(5h)-furanons as cyclooxygenase-2-inhibitors
AU7650294A (en) Aminocyclohexylesters and uses thereof
MX9804588A (es) Uso de composiciones que comprenden blanqueador de halogeno para suavidad mejorada a la piel.
AU2169200A (en) Transistor with notched gate
PL325403A1 (en) Gate openable by rising same
ZA200005161B (en) Anti-inflammatory, antibacterial benzyl phenol agents.
ATE373642T1 (de) Kalium kanalaktivatoren
PT1040097E (pt) Agentes de abertura de canais de potassio
TR200003202T1 (tr) Potasyum kanalı açıcılar olarak faydalı siklopentanon dihidropiridin bileşikleri
MXPA03006969A (es) Abridores de canal de potasio.
PT1259510E (pt) Agentes de abertura de canais de potassio de di-hidropirazolona triciclina e di-hidro-isoxazolona triciclina
MXPA03007071A (es) Aminaldionas como abridores del canal de potasio.
WO2000024741A3 (en) Dihydropyridine compounds and their use as potassium channel openers
MX9500228A (es) N-oxidos de 4-arilpiperazinas y 4-arilpiperidinas.
GB9407432D0 (en) Heterocyclic derivative
WO2001083480A3 (en) Dihydropyridine compounds and methods of use
ZA983298B (en) Methods for reducing fibrinogen.