MXPA03006969A - Abridores de canal de potasio. - Google Patents

Abridores de canal de potasio.

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Publication number
MXPA03006969A
MXPA03006969A MXPA03006969A MXPA03006969A MXPA03006969A MX PA03006969 A MXPA03006969 A MX PA03006969A MX PA03006969 A MXPA03006969 A MX PA03006969A MX PA03006969 A MXPA03006969 A MX PA03006969A MX PA03006969 A MXPA03006969 A MX PA03006969A
Authority
MX
Mexico
Prior art keywords
potassium channel
channel openers
potassium
opening
openers
Prior art date
Application number
MXPA03006969A
Other languages
English (en)
Inventor
W Holladay Mark
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of MXPA03006969A publication Critical patent/MXPA03006969A/es

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/40—Acylated substituent nitrogen atom
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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    • C07C233/83—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of an acyclic saturated carbon skeleton
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    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
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Abstract

Los compuestos de la Formula (I) son utiles para tratar enfermedades que se previenen o se mejoran con abridores del canal de potasio. Tambien se describen composiciones abridoras del canal de potasio y un metodo para abrir canales de potasio en un mamifero.
MXPA03006969A 2001-02-05 2002-01-17 Abridores de canal de potasio. MXPA03006969A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/777,217 US6645968B2 (en) 1999-08-03 2001-02-05 Potassium channel openers
PCT/US2002/005252 WO2002062762A2 (en) 2001-02-05 2002-01-17 Potassium channel openers

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JP (1) JP2005507362A (es)
AT (1) ATE401310T1 (es)
CA (1) CA2437405A1 (es)
DE (1) DE60227662D1 (es)
ES (1) ES2311594T3 (es)
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Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2328799T3 (es) 2001-05-24 2009-11-18 Leo Pharma A/S Compuestos de piridilcianoguanidina.
JP4753523B2 (ja) * 2002-09-03 2011-08-24 株式会社明治 子宮平滑筋弛緩用の医療用の剤
ITTO20030668A1 (it) 2003-09-02 2005-03-03 Rotta Res Lab S P A O Ra Rottapharm Derivati dell'adamantano dotati di attivita' neuroprotettiva, antidepressiva e anti-ischemica e procedimento per la loro preparazione.
CA2594508C (en) * 2004-12-22 2013-10-01 Leo Pharma A/S Cyanoguanidine compounds
WO2007015632A1 (en) * 2005-08-04 2007-02-08 Cgk Co., Ltd. Atm and atr inhibitor
EP1917244A2 (de) * 2005-08-24 2008-05-07 Abbott GmbH & Co. KG Hetaryl substituierte guanidinverbindungen und ihre verwendung als bindungspartner für 5-ht5-rezeptoren
US9260384B2 (en) 2010-05-14 2016-02-16 Chinese Pla General Hospital Urea compounds and use thereof for inhibiting apoptosis
EP3085690B1 (en) * 2013-12-20 2019-09-11 Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China New urea compound, manufacturing method and application thereof
CN113683535B (zh) * 2020-05-18 2022-08-30 中国药科大学 含氰胍结构的化合物及其制备方法与用途

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1363904A (fr) * 1963-01-31 1964-06-19 Bruneau & Cie Lab Dérivés d'hexahydro pyrimidines et leur préparation
CH513913A (de) * 1968-01-18 1971-10-15 Ciba Geigy Ag Verfahren zur Herstellung von neuen heterocyclischen, zweikernigen N,N'-Diglycidylverbindungen und ihre Verwendung
CH494771A (de) * 1968-01-18 1970-08-15 Ciba Geigy Verfahren zur Herstellung von neuen heterocyclischen, zweikernigen N,N'-Diglycidylverbindungen und ihre Verwendung
DE1912281C2 (de) * 1968-04-10 1983-03-24 CIBA-GEIGY AG, 4002 Basel Verfahren zur Herstellung von vorverlängerten, epoxidgruppenhaltigen Addukten aus Polyepoxidverbindungen und einkernigen difunktionellen N-heterocyclischen Verbindungen
CH500247A (de) * 1968-04-17 1970-12-15 Ciba Geigy Ag Verfahren zur Herstellung von neuen epoxidgruppenhaltigen Addukten aus Polyepoxidverbindungen und zweikernigen N-heterocyclischen Verbindungen
DE1810293A1 (de) 1968-11-22 1970-06-11 Bayer Ag N-Fluoracetylamino-methyl-harnstoffe und Verfahren zu ihrer Herstellung
GB1489879A (en) 1974-12-20 1977-10-26 Leo Pharm Prod Ltd N'-cyano-n'-3-pyridylguanidines
US4146646A (en) 1976-02-12 1979-03-27 Fisons Limited Bis-amide fungicidal compounds
DE3027582A1 (de) * 1980-07-21 1982-02-25 Bayer Ag, 5090 Leverkusen Triazolidin-3,5-dion-formaldehyd-amin-kondensate und verfahren zu ihrer herstellung
US5654301A (en) 1985-02-15 1997-08-05 Research Corporation Technologies, Inc. Amino acid derivative anticonvulsant
US5378729A (en) 1985-02-15 1995-01-03 Research Corporation Technologies, Inc. Amino acid derivative anticonvulsant
US5278169A (en) 1988-08-09 1994-01-11 E. R. Squibb & Sons, Inc. Method of treating or prevention of fibrillation of the heart
US5028519A (en) * 1988-12-06 1991-07-02 Fuji Photo Film Co., Ltd. Silver halide color photosensitive material
EP0381504A3 (en) 1989-02-03 1991-09-04 Eli Lilly And Company Improvements in and relating to guanidine derivatives
US5140031A (en) 1989-05-31 1992-08-18 E. R. Squibb & Sons, Inc. Pyranyl cyanoguanidine derivatives
EP0547178A4 (en) 1990-08-31 1994-07-06 Warner Lambert Co Novel cholecystokinin antagonists, their preparation and therapeutic use
JPH05294935A (ja) 1991-03-15 1993-11-09 Green Cross Corp:The アミノピリジン系化合物
JP3453741B2 (ja) 1993-07-08 2003-10-06 日本製紙株式会社 感熱記録体
US5547966A (en) 1993-10-07 1996-08-20 Bristol-Myers Squibb Company Aryl urea and related compounds
AU713247B2 (en) 1995-10-19 1999-11-25 Merck & Co., Inc. Fibrinogen receptor antagonists
AU740064B2 (en) 1997-06-18 2001-10-25 H. Lundbeck A/S Heterocyclic substituted piperidines and uses thereof
US6121323A (en) 1997-12-03 2000-09-19 3M Innovative Properties Company Bishydroxyureas
WO1999032495A1 (en) 1997-12-19 1999-07-01 Novo Nordisk A/S Pyrido 1,2,4-thiadiazine derivatives, their preparation and use
ATE373642T1 (de) * 1999-08-03 2007-10-15 Abbott Lab Kalium kanalaktivatoren
JP2001328979A (ja) * 2000-03-15 2001-11-27 Toyama Chem Co Ltd イソインドロン誘導体の製造法

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WO2002062762A3 (en) 2003-07-31
JP2005507362A (ja) 2005-03-17
CA2437405A1 (en) 2002-08-15
US6645968B2 (en) 2003-11-11
WO2002062762A2 (en) 2002-08-15
ES2311594T3 (es) 2009-02-16
US20020028836A1 (en) 2002-03-07
EP1392655A2 (en) 2004-03-03
EP1392655B1 (en) 2008-07-16
ATE401310T1 (de) 2008-08-15
DE60227662D1 (de) 2008-08-28

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