WO2002010164A3 - Dihydronaphthyridine- and dihydropyrrolopyridine-derivated compounds as potassium channel openers - Google Patents
Dihydronaphthyridine- and dihydropyrrolopyridine-derivated compounds as potassium channel openers Download PDFInfo
- Publication number
- WO2002010164A3 WO2002010164A3 PCT/US2001/023804 US0123804W WO0210164A3 WO 2002010164 A3 WO2002010164 A3 WO 2002010164A3 US 0123804 W US0123804 W US 0123804W WO 0210164 A3 WO0210164 A3 WO 0210164A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- dihydropyrrolopyridine
- dihydronaphthyridine
- derivated
- compounds
- potassium channel
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01963751A EP1307453A2 (en) | 2000-08-02 | 2001-07-27 | Dihydronaphthyridine- and dihydropyrrolopyridine-derivated compounds as potassium channel openers |
CA002385908A CA2385908A1 (en) | 2000-08-02 | 2001-07-27 | Dihydronaphthyridine- and dihydropyrrolopyridine-derivated compounds as potassium channel openers |
JP2002515893A JP2004505081A (en) | 2000-08-02 | 2001-07-27 | Dihydronaphthyridine potassium channel opener |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US63119300A | 2000-08-02 | 2000-08-02 | |
US09/631,193 | 2000-08-02 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002010164A2 WO2002010164A2 (en) | 2002-02-07 |
WO2002010164A3 true WO2002010164A3 (en) | 2002-04-25 |
Family
ID=24530165
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/023804 WO2002010164A2 (en) | 2000-08-02 | 2001-07-27 | Dihydronaphthyridine- and dihydropyrrolopyridine-derivated compounds as potassium channel openers |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1307453A2 (en) |
JP (1) | JP2004505081A (en) |
CA (1) | CA2385908A1 (en) |
WO (1) | WO2002010164A2 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060128710A1 (en) * | 2004-12-09 | 2006-06-15 | Chih-Hung Lee | Antagonists to the vanilloid receptor subtype 1 (VR1) and uses thereof |
JP2006232819A (en) * | 2005-01-25 | 2006-09-07 | Takeda Chem Ind Ltd | Method for producing cyanodihydropyridine compound |
DE102006026585A1 (en) * | 2006-06-07 | 2007-12-13 | Bayer Healthcare Aktiengesellschaft | Substituted 4-aryl-1,4-dihydro-1,6-naphthyridines and their use |
DE102006026583A1 (en) | 2006-06-07 | 2007-12-13 | Bayer Healthcare Aktiengesellschaft | Aryl-substituted hetero-bicyclic compounds and their use |
DE102007009494A1 (en) | 2007-02-27 | 2008-08-28 | Bayer Healthcare Ag | New 1,6-naphthyridine or 8-azaquinazoline derivatives useful for treating aldosteronism, hypertension, cardiac insufficiency, myocardial infarct sequelae, liver cirrhosis, renal insufficiency and stroke |
CN101619041B (en) * | 2008-07-02 | 2012-07-04 | 重庆华邦制药股份有限公司 | Method for synthesizing diketo nitrogen-containing compound and intermediates thereof |
WO2010094405A1 (en) | 2009-02-18 | 2010-08-26 | Bayer Schering Pharma Aktiengesellschaft | Bi- and tricyclic indazole-substituted 1,4-dihydropyridine derivatives and uses thereof |
CN109721536B (en) * | 2017-10-27 | 2020-11-24 | 广东东阳光药业有限公司 | Phenyl-substituted fused tricyclic compounds and application thereof |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3130041A1 (en) * | 1981-07-30 | 1983-02-17 | Bayer Ag, 5090 Leverkusen | Dihydropyridines having a positive inotropic effect, novel compounds, their use in medicaments, and processes for their preparation |
EP0111455A2 (en) * | 1982-12-10 | 1984-06-20 | Ciba-Geigy Ag | Unsaturated lactones |
EP0111453A1 (en) * | 1982-12-10 | 1984-06-20 | Ciba-Geigy Ag | Amide derivatives |
EP0133530A2 (en) * | 1983-07-30 | 1985-02-27 | Gödecke Aktiengesellschaft | 1,6-Naphthyridinone derivatives, process for their preparation, and medicaments containing them |
US4567268A (en) * | 1984-04-03 | 1986-01-28 | Merck & Co., Inc. | Process for preparation of certain tetrahydrofuro[3,4-b]pyridines |
-
2001
- 2001-07-27 WO PCT/US2001/023804 patent/WO2002010164A2/en not_active Application Discontinuation
- 2001-07-27 CA CA002385908A patent/CA2385908A1/en not_active Abandoned
- 2001-07-27 EP EP01963751A patent/EP1307453A2/en not_active Withdrawn
- 2001-07-27 JP JP2002515893A patent/JP2004505081A/en not_active Withdrawn
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3130041A1 (en) * | 1981-07-30 | 1983-02-17 | Bayer Ag, 5090 Leverkusen | Dihydropyridines having a positive inotropic effect, novel compounds, their use in medicaments, and processes for their preparation |
EP0111455A2 (en) * | 1982-12-10 | 1984-06-20 | Ciba-Geigy Ag | Unsaturated lactones |
EP0111453A1 (en) * | 1982-12-10 | 1984-06-20 | Ciba-Geigy Ag | Amide derivatives |
EP0133530A2 (en) * | 1983-07-30 | 1985-02-27 | Gödecke Aktiengesellschaft | 1,6-Naphthyridinone derivatives, process for their preparation, and medicaments containing them |
US4567268A (en) * | 1984-04-03 | 1986-01-28 | Merck & Co., Inc. | Process for preparation of certain tetrahydrofuro[3,4-b]pyridines |
Non-Patent Citations (1)
Title |
---|
J. D. MAYA ET AL.: "Effects of 3-chloro-phenyl-1,4-dihydropyridine derivatives on Trypanosome cruzi epimastigotes", COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY PART C, vol. 125, no. 1, 2000, pages 103 - 109, XP002188922 * |
Also Published As
Publication number | Publication date |
---|---|
EP1307453A2 (en) | 2003-05-07 |
JP2004505081A (en) | 2004-02-19 |
WO2002010164A2 (en) | 2002-02-07 |
CA2385908A1 (en) | 2002-02-07 |
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