BG61841B1 - Алкилови производни на тразодона - Google Patents

Алкилови производни на тразодона Download PDF

Info

Publication number
BG61841B1
BG61841B1 BG98896A BG9889694A BG61841B1 BG 61841 B1 BG61841 B1 BG 61841B1 BG 98896 A BG98896 A BG 98896A BG 9889694 A BG9889694 A BG 9889694A BG 61841 B1 BG61841 B1 BG 61841B1
Authority
BG
Bulgaria
Prior art keywords
formula
compound
alkyl
alk
chlorophenyl
Prior art date
Application number
BG98896A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG98896A (bg
Inventor
Leandro Baiocchi
Original Assignee
Angelini Ricerche Spa Societa'consortile
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Angelini Ricerche Spa Societa'consortile filed Critical Angelini Ricerche Spa Societa'consortile
Publication of BG98896A publication Critical patent/BG98896A/bg
Publication of BG61841B1 publication Critical patent/BG61841B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/067—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
BG98896A 1992-01-17 1994-07-08 Алкилови производни на тразодона BG61841B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI920084A IT1258790B (it) 1992-01-17 1992-01-17 Alchil derivati del trazodone
PCT/EP1993/000080 WO1993014091A1 (fr) 1992-01-17 1993-01-14 Derives alkyles de trazodone influant sur le systeme nerveux central

Publications (2)

Publication Number Publication Date
BG98896A BG98896A (bg) 1995-03-31
BG61841B1 true BG61841B1 (bg) 1998-07-31

Family

ID=11361589

Family Applications (1)

Application Number Title Priority Date Filing Date
BG98896A BG61841B1 (bg) 1992-01-17 1994-07-08 Алкилови производни на тразодона

Country Status (25)

Country Link
EP (1) EP0623131B1 (fr)
JP (1) JP2856912B2 (fr)
KR (1) KR100254690B1 (fr)
AT (1) ATE136307T1 (fr)
AU (1) AU671973B2 (fr)
BG (1) BG61841B1 (fr)
BR (1) BR9305752A (fr)
CA (1) CA2128202C (fr)
CZ (1) CZ282910B6 (fr)
DE (1) DE69302087T2 (fr)
DK (1) DK0623131T3 (fr)
ES (1) ES2088270T3 (fr)
FI (2) FI110186B (fr)
GE (1) GEP20001939B (fr)
GR (1) GR3020420T3 (fr)
HU (5) HU218678B (fr)
IT (1) IT1258790B (fr)
NO (2) NO302365B1 (fr)
NZ (1) NZ246598A (fr)
PL (1) PL170913B1 (fr)
RO (1) RO113465B1 (fr)
RU (1) RU2126801C1 (fr)
SK (1) SK280561B6 (fr)
WO (1) WO1993014091A1 (fr)
ZA (1) ZA93292B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU718075B2 (en) * 1993-07-01 2000-04-06 Angelini Ricerche S.P.A. Societa Consortile Intermediates for the preparation of pharmacologically active enantiomers of triazolone compounds
IT1268414B1 (it) * 1993-07-01 1997-02-27 Angelini Francesco Ist Ricerca Enantiomeri farmacologicamente attivi
TW200726765A (en) * 2005-06-17 2007-07-16 Bristol Myers Squibb Co Triazolopyridine cannabinoid receptor 1 antagonists
ITMI20051193A1 (it) 2005-06-24 2006-12-25 Acraf Uso farmaceutico di una 1-3-clorofenil-3-alchilpiperazina
WO2012072665A1 (fr) 2010-11-30 2012-06-07 Pharmaneuroboost N.V. Compositions comprenant de la pipampérone et des antagonistes/inhibiteurs de la recapture de la sérotonine
RU2706700C1 (ru) 2019-09-24 2019-11-20 Общество с ограниченной ответственностью "Научно-производственная компания "СКиФФ" Фармацевтическая композиция для коррекции поведения кошек и собак в стрессовых ситуациях

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US100505A (en) * 1870-03-08 Improvement in sash-bolt
IT1066857B (it) * 1965-12-15 1985-03-12 Acraf Derivati della s ipiazolo 4.3 a piridina e processi per la loro preparazione

Also Published As

Publication number Publication date
SK280561B6 (sk) 2000-03-13
CZ282910B6 (cs) 1997-11-12
FI110186B (fi) 2002-12-13
HU9502179D0 (en) 1995-09-28
HUT71511A (en) 1995-12-28
FI20021652A (fi) 2002-09-16
NO974462D0 (no) 1997-09-26
FI113266B (fi) 2004-03-31
HU217968B (hu) 2000-05-28
NO302365B1 (no) 1998-02-23
HU217981B (hu) 2000-05-28
SK84694A3 (en) 1995-04-12
GEP20001939B (en) 2000-02-05
HUT70761A (en) 1995-10-30
RO113465B1 (ro) 1998-07-30
NO942668L (no) 1994-09-16
ES2088270T3 (es) 1996-08-01
HU9502178D0 (en) 1995-09-28
HU9502180D0 (en) 1995-09-28
RU2126801C1 (ru) 1999-02-27
ATE136307T1 (de) 1996-04-15
JPH07503000A (ja) 1995-03-30
WO1993014091A1 (fr) 1993-07-22
NO303686B1 (no) 1998-08-17
ZA93292B (en) 1993-08-19
ITMI920084A0 (it) 1992-01-17
DE69302087T2 (de) 1996-11-28
NZ246598A (en) 1997-08-22
CA2128202A1 (fr) 1993-07-22
JP2856912B2 (ja) 1999-02-10
HUT71513A (en) 1995-12-28
CA2128202C (fr) 2001-01-23
HU219493B (hu) 2001-04-28
CZ173294A3 (en) 1995-02-15
HU217982B (hu) 2000-05-28
AU3350493A (en) 1993-08-03
ITMI920084A1 (it) 1993-07-17
HUT71512A (en) 1995-12-28
EP0623131B1 (fr) 1996-04-03
IT1258790B (it) 1996-02-29
HU218678B (hu) 2000-10-28
FI943386A (fi) 1994-07-15
HU9502177D0 (en) 1995-09-28
NO974462L (no) 1994-09-16
DE69302087D1 (de) 1996-05-09
PL170913B1 (pl) 1997-02-28
RU94036769A (ru) 1997-04-20
NO942668D0 (no) 1994-07-15
GR3020420T3 (en) 1996-10-31
BR9305752A (pt) 1997-01-28
BG98896A (bg) 1995-03-31
HU9402119D0 (en) 1994-09-28
HUT72591A (en) 1996-05-28
KR100254690B1 (ko) 2000-05-01
EP0623131A1 (fr) 1994-11-09
DK0623131T3 (da) 1996-08-05
AU671973B2 (en) 1996-09-19
FI943386A0 (fi) 1994-07-15

Similar Documents

Publication Publication Date Title
KR880001374B1 (ko) 항우울증 치료제인 2-펜옥시알킬-1,2,4-트리아졸-3-온 및 그의 제조방법
EP0058146B1 (fr) Nouveaux acides 2-(4-(diphénylméthyl)-1-pipérazinyl)-acétiques et leurs amides, leurs procédés de préparation et compositions thérapeutiques
US5859246A (en) 1-phenyl-4-benzylpiperazines: dopamine receptor subtype specific ligands
FR2521561A1 (fr) Derives de benzisothiazole et benzisoxale piperazine
HUT71347A (en) Novel process for preparing chiral {[(2-bromoethyl)-amino]-methyl}-2-nitro-1h-imidazol-1-ethanol and related compounds
BG61841B1 (bg) Алкилови производни на тразодона
FR2613717A1 (fr) Derives d'acides pyrimidinecarboxyliques, a action therapeutique
US5543563A (en) Alkyl derivatives of trazodone with CNS activity
FR2528431A1 (fr) Nouveaux derives de la 1,4-dihydropyridine, leur preparation et leur utilisation comme medicaments
EP0161143B1 (fr) Nouvelles 1,2,4-thiadiazines et leurs sels, leur procédé et leurs intermédiaires de préparation, leur application à titre de médicaments et les compositions les renfermant
US4386091A (en) 2-Phenoxyalkyl-1,2,4-triazol-3-one antidepressants
EP0373061B1 (fr) Nouveaux dérivés de l'indole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
KR100306018B1 (ko) 약리학적 활성을 갖는 에난티오머
US4639453A (en) Substituted 1-(4-amino-6,7-dialkoxyquinazolinyl)-4 cyclohexenyl derivatives of piperazine and homopiperazine, processes for their preparation and their use, formulations containing these compounds and intermediates
US4105768A (en) Hypotensive substituted 1,2,4-triazoles
CZ292867B6 (cs) Způsob cyklizace anilinových derivátů