BG60440B2 - Нови стероидни производни,фармацевтични състави,които ги съдържат,и метод за получаването им - Google Patents
Нови стероидни производни,фармацевтични състави,които ги съдържат,и метод за получаването им Download PDFInfo
- Publication number
- BG60440B2 BG60440B2 BG098269A BG9826993A BG60440B2 BG 60440 B2 BG60440 B2 BG 60440B2 BG 098269 A BG098269 A BG 098269A BG 9826993 A BG9826993 A BG 9826993A BG 60440 B2 BG60440 B2 BG 60440B2
- Authority
- BG
- Bulgaria
- Prior art keywords
- triene
- dione
- cyclic
- water
- tetrahydroxypregna
- Prior art date
Links
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- 229960000890 hydrocortisone Drugs 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000002329 infrared spectrum Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 229940098779 methanesulfonic acid Drugs 0.000 description 1
- 239000002395 mineralocorticoid Substances 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 239000003880 polar aprotic solvent Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 231100000683 possible toxicity Toxicity 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 150000003126 pregnane derivatives Chemical class 0.000 description 1
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 239000011877 solvent mixture Substances 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 125000003774 valeryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
- C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU891155A HU203769B (en) | 1989-03-09 | 1989-03-09 | Process for producing new steroide derivatives and pharmaceutical compositions containing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG60440B2 true BG60440B2 (bg) | 1995-03-31 |
Family
ID=10953084
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG098269A BG60440B2 (bg) | 1989-03-09 | 1993-12-02 | Нови стероидни производни,фармацевтични състави,които ги съдържат,и метод за получаването им |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5053404A (no) |
| EP (1) | EP0387090A3 (no) |
| JP (1) | JPH075629B2 (no) |
| KR (1) | KR930009446B1 (no) |
| CN (1) | CN1045397A (no) |
| AR (1) | AR245452A1 (no) |
| AU (1) | AU617929B2 (no) |
| BG (1) | BG60440B2 (no) |
| CA (1) | CA2011280A1 (no) |
| EG (1) | EG19166A (no) |
| FI (1) | FI901200A0 (no) |
| HU (1) | HU203769B (no) |
| IL (1) | IL93477A (no) |
| IN (1) | IN169862B (no) |
| NO (1) | NO177099C (no) |
| PH (1) | PH26685A (no) |
| PT (1) | PT93374A (no) |
| TW (1) | TW208020B (no) |
| ZA (1) | ZA901753B (no) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9100341D0 (sv) * | 1991-02-04 | 1991-02-04 | Astra Ab | Novel steroids |
| FR2675146A1 (fr) * | 1991-04-10 | 1992-10-16 | Roussel Uclaf | Nouveaux derives sterouides de la pregna-1,4-diene-3,20-dione, leur preparation, leur application a la preparation de derives 16,17-methylene dioxy substitues et nouveaux intermediaires. |
| WO1999061055A1 (en) | 1998-05-22 | 1999-12-02 | The Board Of Trustees Of The Leland Stanford Junior University | Bifunctional molecules and therapies based thereon |
| WO2006116718A2 (en) | 2005-04-28 | 2006-11-02 | Proteus Biomedical, Inc. | Pharma-informatics system |
| WO2007035716A2 (en) | 2005-09-16 | 2007-03-29 | Raptor Pharmaceutical Inc. | Compositions comprising receptor-associated protein (rap) variants specific for cr-containing proteins and uses thereof |
| ES2919563T3 (es) | 2009-02-20 | 2022-07-27 | Enhanx Biopharm Inc | Sistema de administración de medicamentos a base de glutatión |
| EA024559B1 (ru) | 2009-05-06 | 2016-09-30 | Лаборэтори Скин Кэа, Инк. | Композиции для нанесения на кератинизированную поверхность кожи млекопитающего и способ доставки |
| CN110078785A (zh) * | 2019-06-04 | 2019-08-02 | 博诺康源(北京)药业科技有限公司 | 一种布地奈德杂质ep-ze的合成方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3167545A (en) * | 1959-02-07 | 1965-01-26 | Syntex Corp | 16beta-methyl-16alpha, 17 alpha-dihydroxy pregnenes and the 16alpha, 17alpha-cyclic ketals and acetals thereof |
| US3345362A (en) * | 1961-07-27 | 1967-10-03 | Lilly Co Eli | Novel pregnenolone acetonides |
| US3798216A (en) * | 1969-03-07 | 1974-03-19 | Fabrication Des Antibiotique S | 9-fluoro-11beta,21-dihydroxy-16alpha,17-(2-propenylidenedioxy)-pregna-1,4-diene-3,20-dione and derivatives thereof |
| US3992534A (en) * | 1972-05-19 | 1976-11-16 | Ab Bofors | Compositions and method of treating with component B of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steriods |
| SE378109B (no) * | 1972-05-19 | 1975-08-18 | Bofors Ab | |
| SE8008524L (sv) * | 1980-12-04 | 1982-06-05 | Draco Ab | 4-pregnen-derivat, ett forfarande for deras framstellning, beredning och metod for behandling av inflammatoriska tillstand |
| DE3133631A1 (de) * | 1981-08-21 | 1983-03-03 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue kortikoide ihre herstellung und verwendung |
| HU182775B (en) * | 1981-10-15 | 1984-03-28 | Richter Gedeon Vegyeszet | Process for preparing new 3-chloro-pregnane derivatives |
| SE8501693D0 (sv) * | 1985-04-04 | 1985-04-04 | Draco Ab | Novel 16,17-acetalsubstituted androstane-17beta-carboxylic acid esters |
| SE8506015D0 (sv) * | 1985-12-19 | 1985-12-19 | Draco Ab | Novel 16,17-acetalsubstituted pregnane 21-oic acid derivatives |
-
1989
- 1989-03-09 HU HU891155A patent/HU203769B/hu not_active IP Right Cessation
-
1990
- 1990-02-21 IL IL9347790A patent/IL93477A/en not_active IP Right Cessation
- 1990-02-28 IN IN184/CAL/90A patent/IN169862B/en unknown
- 1990-03-01 CA CA002011280A patent/CA2011280A1/en not_active Abandoned
- 1990-03-06 PH PH40142A patent/PH26685A/en unknown
- 1990-03-07 ZA ZA901753A patent/ZA901753B/xx unknown
- 1990-03-08 PT PT93374A patent/PT93374A/pt not_active Application Discontinuation
- 1990-03-08 JP JP2055161A patent/JPH075629B2/ja not_active Expired - Lifetime
- 1990-03-08 AU AU50798/90A patent/AU617929B2/en not_active Ceased
- 1990-03-08 NO NO901102A patent/NO177099C/no unknown
- 1990-03-08 KR KR1019900003057A patent/KR930009446B1/ko not_active IP Right Cessation
- 1990-03-09 AR AR90316351A patent/AR245452A1/es active
- 1990-03-09 EP EP19900302543 patent/EP0387090A3/en not_active Ceased
- 1990-03-09 CN CN90101249A patent/CN1045397A/zh active Pending
- 1990-03-09 FI FI901200A patent/FI901200A0/fi not_active IP Right Cessation
- 1990-03-09 US US07/491,682 patent/US5053404A/en not_active Expired - Fee Related
- 1990-03-11 EG EG16190A patent/EG19166A/xx active
- 1990-03-19 TW TW079102129A patent/TW208020B/zh active
-
1993
- 1993-12-02 BG BG098269A patent/BG60440B2/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO177099C (no) | 1995-07-19 |
| TW208020B (no) | 1993-06-21 |
| AU5079890A (en) | 1990-09-20 |
| PT93374A (pt) | 1990-11-07 |
| EP0387090A2 (en) | 1990-09-12 |
| AR245452A1 (es) | 1994-01-31 |
| IL93477A (en) | 1994-07-31 |
| JPH075629B2 (ja) | 1995-01-25 |
| NO901102D0 (no) | 1990-03-08 |
| KR900014423A (ko) | 1990-10-23 |
| PH26685A (en) | 1992-09-15 |
| HU203769B (en) | 1991-09-30 |
| CN1045397A (zh) | 1990-09-19 |
| ZA901753B (en) | 1990-12-28 |
| EG19166A (en) | 1994-11-30 |
| JPH02279697A (ja) | 1990-11-15 |
| FI901200A0 (fi) | 1990-03-09 |
| IL93477A0 (en) | 1990-11-29 |
| NO901102L (no) | 1990-09-10 |
| CA2011280A1 (en) | 1990-09-09 |
| IN169862B (no) | 1992-01-04 |
| KR930009446B1 (ko) | 1993-10-04 |
| AU617929B2 (en) | 1991-12-05 |
| US5053404A (en) | 1991-10-01 |
| EP0387090A3 (en) | 1992-05-06 |
| NO177099B (no) | 1995-04-10 |
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