AR245452A1 - Procedimiento para obtener nuevos derivados de esteroides - Google Patents
Procedimiento para obtener nuevos derivados de esteroidesInfo
- Publication number
- AR245452A1 AR245452A1 AR90316351A AR31635190A AR245452A1 AR 245452 A1 AR245452 A1 AR 245452A1 AR 90316351 A AR90316351 A AR 90316351A AR 31635190 A AR31635190 A AR 31635190A AR 245452 A1 AR245452 A1 AR 245452A1
- Authority
- AR
- Argentina
- Prior art keywords
- hydrogen
- formula
- delta
- processes
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
- C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA OBTENER NUEVOS ACETALES Y CETALES, CICLICOS, DERIVADOS DE DELTA 14-16 ALFA, 17-DIHIDROXI-PREGNANO, DE FORMULA (I) EN LA QUE: A ES HIDROGENO O HIDROXI; X ES HIDROGENO O HALOGENO, CON LA SALVEDAD DE QUE,CUANDO A ES HIDROGENO, X TAMBIEN ES HIDROGENO; R ES HIDROGENO, BENZOILO O ALCANOILO; R1 Y R2, HIDROGENO O ALQUILO,O BIEN UNO DE ELLOS ES HIDROGENO Y EL OTRO FENILO, O BIEN JUNTOS, SON ALQUILENO, Y QUE COMPRENDE: A) HACER REACCIONAR UN DERIVADO DE DELTA 14-16 ALFA, 17-DIHIDROXI-PREGNANO, DE FORMULA (II), CON UN COMPUESTO DE OXO, DE FORMULA (IV), EN PRESENCIA DE UN CATALIZADOR ACIDO, O B) HACER REACCIONAR UN ORTOESTER CICLICO DERIVADO DE DELTA 14-16 ALFA, 17-DIHIDROXI PREGNANO, DE FORMULA (III), EN LA QUE R3 METILO O ETILO, CON UN COMPUESTO DE OXO, DE FORMULA (IV) EN PRESENCIA DE UN CATALIZADOR ACIDO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU891155A HU203769B (en) | 1989-03-09 | 1989-03-09 | Process for producing new steroide derivatives and pharmaceutical compositions containing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR245452A1 true AR245452A1 (es) | 1994-01-31 |
Family
ID=10953084
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AR90316351A AR245452A1 (es) | 1989-03-09 | 1990-03-09 | Procedimiento para obtener nuevos derivados de esteroides |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5053404A (es) |
| EP (1) | EP0387090A3 (es) |
| JP (1) | JPH075629B2 (es) |
| KR (1) | KR930009446B1 (es) |
| CN (1) | CN1045397A (es) |
| AR (1) | AR245452A1 (es) |
| AU (1) | AU617929B2 (es) |
| BG (1) | BG60440B2 (es) |
| CA (1) | CA2011280A1 (es) |
| EG (1) | EG19166A (es) |
| FI (1) | FI901200A0 (es) |
| HU (1) | HU203769B (es) |
| IL (1) | IL93477A (es) |
| IN (1) | IN169862B (es) |
| NO (1) | NO177099C (es) |
| PH (1) | PH26685A (es) |
| PT (1) | PT93374A (es) |
| TW (1) | TW208020B (es) |
| ZA (1) | ZA901753B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9100341D0 (sv) * | 1991-02-04 | 1991-02-04 | Astra Ab | Novel steroids |
| FR2675146A1 (fr) * | 1991-04-10 | 1992-10-16 | Roussel Uclaf | Nouveaux derives sterouides de la pregna-1,4-diene-3,20-dione, leur preparation, leur application a la preparation de derives 16,17-methylene dioxy substitues et nouveaux intermediaires. |
| ATE473759T1 (de) | 1998-05-22 | 2010-07-15 | Univ Leland Stanford Junior | Bifunktionelle moleküle sowie darauf basierende therapien. |
| CN103259027A (zh) | 2005-04-28 | 2013-08-21 | 普罗透斯数字保健公司 | 药物信息系统 |
| JP2009508494A (ja) | 2005-09-16 | 2009-03-05 | ラプトール ファーマシューティカル インコーポレイテッド | Ｃｒを含むタンパク質に対して特異的な受容体−結合タンパク質（ｒａｐ）変異体を含む組成物およびその使用 |
| PT2398500T (pt) | 2009-02-20 | 2019-06-14 | 2 Bbb Medicines B V | Sistema de entrega de medicamentos à base de glutationas |
| TWI556839B (zh) | 2009-05-06 | 2016-11-11 | 研究室護膚股份有限公司 | 包含活性劑－磷酸鈣粒子複合物之皮膚遞送組成物及其使用方法 |
| CN110078785A (zh) * | 2019-06-04 | 2019-08-02 | 博诺康源(北京)药业科技有限公司 | 一种布地奈德杂质ep-ze的合成方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3167545A (en) * | 1959-02-07 | 1965-01-26 | Syntex Corp | 16beta-methyl-16alpha, 17 alpha-dihydroxy pregnenes and the 16alpha, 17alpha-cyclic ketals and acetals thereof |
| US3345362A (en) * | 1961-07-27 | 1967-10-03 | Lilly Co Eli | Novel pregnenolone acetonides |
| US3798216A (en) * | 1969-03-07 | 1974-03-19 | Fabrication Des Antibiotique S | 9-fluoro-11beta,21-dihydroxy-16alpha,17-(2-propenylidenedioxy)-pregna-1,4-diene-3,20-dione and derivatives thereof |
| US3992534A (en) * | 1972-05-19 | 1976-11-16 | Ab Bofors | Compositions and method of treating with component B of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steriods |
| SE378109B (es) * | 1972-05-19 | 1975-08-18 | Bofors Ab | |
| SE8008524L (sv) * | 1980-12-04 | 1982-06-05 | Draco Ab | 4-pregnen-derivat, ett forfarande for deras framstellning, beredning och metod for behandling av inflammatoriska tillstand |
| DE3133631A1 (de) * | 1981-08-21 | 1983-03-03 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue kortikoide ihre herstellung und verwendung |
| HU182775B (en) * | 1981-10-15 | 1984-03-28 | Richter Gedeon Vegyeszet | Process for preparing new 3-chloro-pregnane derivatives |
| SE8501693D0 (sv) * | 1985-04-04 | 1985-04-04 | Draco Ab | Novel 16,17-acetalsubstituted androstane-17beta-carboxylic acid esters |
| SE8506015D0 (sv) * | 1985-12-19 | 1985-12-19 | Draco Ab | Novel 16,17-acetalsubstituted pregnane 21-oic acid derivatives |
-
1989
- 1989-03-09 HU HU891155A patent/HU203769B/hu not_active IP Right Cessation
-
1990
- 1990-02-21 IL IL9347790A patent/IL93477A/en not_active IP Right Cessation
- 1990-02-28 IN IN184/CAL/90A patent/IN169862B/en unknown
- 1990-03-01 CA CA002011280A patent/CA2011280A1/en not_active Abandoned
- 1990-03-06 PH PH40142A patent/PH26685A/en unknown
- 1990-03-07 ZA ZA901753A patent/ZA901753B/xx unknown
- 1990-03-08 JP JP2055161A patent/JPH075629B2/ja not_active Expired - Lifetime
- 1990-03-08 KR KR1019900003057A patent/KR930009446B1/ko not_active IP Right Cessation
- 1990-03-08 PT PT93374A patent/PT93374A/pt not_active Application Discontinuation
- 1990-03-08 AU AU50798/90A patent/AU617929B2/en not_active Ceased
- 1990-03-08 NO NO901102A patent/NO177099C/no unknown
- 1990-03-09 EP EP19900302543 patent/EP0387090A3/en not_active Ceased
- 1990-03-09 US US07/491,682 patent/US5053404A/en not_active Expired - Fee Related
- 1990-03-09 AR AR90316351A patent/AR245452A1/es active
- 1990-03-09 CN CN90101249A patent/CN1045397A/zh active Pending
- 1990-03-09 FI FI901200A patent/FI901200A0/fi not_active IP Right Cessation
- 1990-03-11 EG EG16190A patent/EG19166A/xx active
- 1990-03-19 TW TW079102129A patent/TW208020B/zh active
-
1993
- 1993-12-02 BG BG098269A patent/BG60440B2/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT93374A (pt) | 1990-11-07 |
| EG19166A (en) | 1994-11-30 |
| PH26685A (en) | 1992-09-15 |
| IL93477A (en) | 1994-07-31 |
| US5053404A (en) | 1991-10-01 |
| JPH075629B2 (ja) | 1995-01-25 |
| NO177099B (no) | 1995-04-10 |
| EP0387090A3 (en) | 1992-05-06 |
| JPH02279697A (ja) | 1990-11-15 |
| NO901102L (no) | 1990-09-10 |
| IL93477A0 (en) | 1990-11-29 |
| HU203769B (en) | 1991-09-30 |
| KR900014423A (ko) | 1990-10-23 |
| BG60440B2 (bg) | 1995-03-31 |
| CA2011280A1 (en) | 1990-09-09 |
| AU617929B2 (en) | 1991-12-05 |
| CN1045397A (zh) | 1990-09-19 |
| EP0387090A2 (en) | 1990-09-12 |
| TW208020B (es) | 1993-06-21 |
| AU5079890A (en) | 1990-09-20 |
| ZA901753B (en) | 1990-12-28 |
| NO177099C (no) | 1995-07-19 |
| KR930009446B1 (ko) | 1993-10-04 |
| FI901200A0 (fi) | 1990-03-09 |
| IN169862B (es) | 1992-01-04 |
| NO901102D0 (no) | 1990-03-08 |
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