BG60270B2 - Метод за получаване на 5н-2,3-бензодиазепинови производни - Google Patents

Метод за получаване на 5н-2,3-бензодиазепинови производни Download PDF

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Publication number
BG60270B2
BG60270B2 BG45206A BG4520679A BG60270B2 BG 60270 B2 BG60270 B2 BG 60270B2 BG 45206 A BG45206 A BG 45206A BG 4520679 A BG4520679 A BG 4520679A BG 60270 B2 BG60270 B2 BG 60270B2
Authority
BG
Bulgaria
Prior art keywords
general formula
compound
group
hydrazine
methyl
Prior art date
Application number
BG45206A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG60270B1 (bg
Inventor
Jenoe Koeroesi
Tibor Lang
Jozsef Szerely
Ferenc Andrasi
Gabor Zolyomi
Jozsef Borsy
Katalin Goldschmidt
Tamas Hamori
Gabriella Szabo
Zsuzsa Meszaros
Erzsebet Miglecz
Original Assignee
Egyt Gyogyszervegyeszety Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszety Gyar filed Critical Egyt Gyogyszervegyeszety Gyar
Publication of BG60270B1 publication Critical patent/BG60270B1/bg
Publication of BG60270B2 publication Critical patent/BG60270B2/bg

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/76—Benzo[c]pyrans

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BG45206A 1978-10-19 1979-10-18 Метод за получаване на 5н-2,3-бензодиазепинови производни BG60270B2 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU78GO1426A HU179018B (en) 1978-10-19 1978-10-19 Process for producing new 5h-2,3-benzodiazepine derivatives

Publications (2)

Publication Number Publication Date
BG60270B1 BG60270B1 (bg) 1994-03-31
BG60270B2 true BG60270B2 (bg) 1994-03-31

Family

ID=10996876

Family Applications (1)

Application Number Title Priority Date Filing Date
BG45206A BG60270B2 (bg) 1978-10-19 1979-10-18 Метод за получаване на 5н-2,3-бензодиазепинови производни

Country Status (25)

Country Link
US (1) US4322346A (zh)
JP (1) JPS5592377A (zh)
AT (1) AT373589B (zh)
AU (1) AU532079B2 (zh)
BE (1) BE879404A (zh)
BG (1) BG60270B2 (zh)
CA (1) CA1125749A (zh)
CH (1) CH643835A5 (zh)
CS (1) CS236456B2 (zh)
DD (1) DD146596A5 (zh)
DE (1) DE2940483A1 (zh)
DK (1) DK155327C (zh)
ES (1) ES485163A1 (zh)
FI (1) FI66604C (zh)
FR (1) FR2439189A1 (zh)
GB (1) GB2034706B (zh)
GR (1) GR74034B (zh)
HU (1) HU179018B (zh)
IT (1) IT1220947B (zh)
NL (1) NL190552C (zh)
NO (1) NO152048C (zh)
PL (1) PL124063B1 (zh)
SE (1) SE439919B (zh)
SU (1) SU1402258A3 (zh)
YU (1) YU41887B (zh)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU186760B (en) * 1981-03-12 1985-09-30 Gyogyszerkutato Intezet Process for preparing 3,4-dihydro-5h-2,3-aenzodiazepine derivatives
HU191702B (en) * 1984-06-27 1987-03-30 Gyogyszerkutato Intezet New process for preparing 1-aryl-5 h-2,3-benzodiazepines
HU191698B (en) * 1984-07-27 1987-03-30 Gyogyszerkutato Intezet Process for producing new 1-aryl-5h-2beta-benzodiazepines
HU195788B (en) * 1986-05-21 1988-07-28 Gyogyszerkutato Intezet Process for producing 1-/hydroxy-stiryl/-5h-2,3-benzobiazepines and pharmaceutical compositions containing them
JPH01311400A (ja) * 1988-06-09 1989-12-15 Kyocera Corp 発光標識体の点灯方法
JPH0251568U (zh) * 1988-10-07 1990-04-11
JPH0324693U (zh) * 1989-07-18 1991-03-14
HU207055B (en) * 1990-10-17 1993-03-01 Gyogyszerkutato Intezet Process for producing new 5h-2,3-benzodiazepine derivative and pharmaceutical compositions comprising same
HU208429B (en) * 1991-05-03 1993-10-28 Gyogyszerkutato Intezet Process for producing 1-/3-chloro-phenyl/-4-methyl-7,8-dimethoxy-5h-2,3-benzodiazepine of high purity
US5939412A (en) * 1992-06-26 1999-08-17 Smithkline Beecham Corporation Bicyclic fibrinogen antagonists
AU666318B2 (en) * 1991-06-28 1996-02-08 Smithkline Beecham Corporation Bicyclic fibrinogen antagonists
US6458784B1 (en) 1994-06-29 2002-10-01 Smithkline Beecham Corporation Vitronectin receptor antagonists
SK283859B6 (sk) * 1995-02-09 2004-03-02 EGIS Gyógyszergyár Rt. 1-[2'-(Substituovaný)vinyl]-5H-2,3-benzodiazepínové deriváty, spôsob ich prípravy a medziprodukty na ich prípravu, liečivá ich obsahujúce a ich použitie
HU224435B1 (hu) * 1995-02-09 2005-10-28 EGIS Gyógyszergyár Rt. Benzodiazepin-származékok, eljárás előállításukra, alkalmazásukra és ezeket tartalmazó gyógyászati készítmények
EP0726256A1 (en) * 1995-02-09 1996-08-14 Egis Gyogyszergyar Rt. 1-Arylvinyl-3,4-dihydro-5H-2,3-benzodiazepine derivatives useful for the treatment of central nervous system disorders
US5977101A (en) * 1995-06-29 1999-11-02 Smithkline Beecham Corporation Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity
DE19604920A1 (de) 1996-02-01 1997-08-07 Schering Ag Neue 2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel
ES2111493B1 (es) * 1996-02-08 1999-08-01 Egyt Gyogyszervegyeszeti Gyar Derivados de 1-(2- (vinilo substituido ) ) -5h-2,3-benzo-diazepina, procedimiento para su preparacion, composiciones farmaceuticas que los contienen y utilizaciones correspondientes.
ZA972746B (en) * 1996-04-04 1998-10-09 Egyt Gyogyszervegyeszeti Gyar Novel 2,3-benzodiazepine derivatives
HU9600871D0 (en) * 1996-04-04 1996-05-28 Gyogyszerkutato Intezet New 2,3-benzodiazepine derivatives
HUP9701284A3 (en) * 1997-07-24 2005-11-28 Egyt Gyogyszervegyeszeti Gyar Use of 2,3-benzodiazepine derivatives for producing pharmaceutical compositions for treating and prophylacting illnesses and conditions connected with the endogene opioide system
HU227128B1 (en) * 1999-07-07 2010-07-28 Egyt Gyogyszervegyeszeti Gyar New 2,3-benzodiazepine derivatives
FR2824065A1 (fr) * 2001-04-26 2002-10-31 Neuro3D Composes inhibiteurs des phosphodiesterases des nucleotides cycliques, preparation et utilisations
US6649607B2 (en) * 2001-05-18 2003-11-18 Vela Pharmaceuticals, Inc. Compositions and methods for treating or preventing convulsions or seizures
JP4630665B2 (ja) * 2002-09-13 2011-02-09 モタック・ニューロサイエンス・リミテッド ２，３−ベンゾジアゼピンによる基底核関連運動障害の治療
WO2004026299A1 (en) * 2002-09-17 2004-04-01 Motac Neuroscience Limited Treatment of dyskinesia
US7022700B2 (en) * 2002-12-03 2006-04-04 Vela Pharmaceuticals, Inc. Method of increasing neutrophil production using optically-pure (R)-2,3-benzodiazepines
EP1567161A4 (en) * 2002-12-03 2008-09-03 Vela Acquisition Corp PHARMACEUTICAL COMPOSITION OF 1- (3,4-DIMETHOXYPHENYL) -4-METHYL-5-ETHYL-7-METHOXY-8-HYDROXY-5H-2,3-BENZODIAZEPINE AND ITS USE
US6638928B1 (en) * 2002-12-03 2003-10-28 Vela Pharmaceuticals, Inc. Treatment of irritable bowel syndrome and nonulcer dyspepsia with substituted 2,3-benzodiazepines
JP2006514084A (ja) * 2002-12-03 2006-04-27 ヴェラ ファーマスーティカルズ インコーポレイテッド １−（３−ヒドロキシ−４−メトキシフェニル）−４−メチル−５−エチル−７，８−ジメトキシ−５ｈ−２，３−ベンゾジアゼピンの製薬組成物及びその用途
US6864251B2 (en) * 2002-12-03 2005-03-08 Vela Pharmaceuticals, Inc. Treatment of LTB4-mediated inflammatory disorders with optically-pure (R)-2,3-benzodiazepines
US20040162284A1 (en) * 2003-02-19 2004-08-19 Harris Herbert W. Method of lowering body temperature with (S) tofisopam
US20040224943A1 (en) * 2003-02-19 2004-11-11 Leventer Steven M. Method of lowering body temperature with (R) - 2,3-benzodiazepines
US20070021412A1 (en) * 2003-05-16 2007-01-25 Vela Pharmaceuticals, Inc. Treatment of gastrointestinal dysfunction and related stress with an enantiomerically-pure (S) 2,3-benzodiazepine
US20040229867A1 (en) * 2003-05-16 2004-11-18 Kucharik Robert F. Treatment of gastrointestinal dysfunction and related stress with an enantiomerically-pure (R) 2,3-benzodiazepine
US20040254173A1 (en) * 2003-06-13 2004-12-16 Leventer Steven M. Modulation of dopamine responses with substituted (S)-2,3-benzodiazepines
HUP0302449A3 (en) * 2003-08-04 2005-06-28 Egis Gyogyszergyar Nyilvanosan 8-chloro-2,3-benzodiazepine derivatives, pharmaceutical compositions containing them and process for producing them
US7541355B2 (en) * 2005-05-23 2009-06-02 Vela Acquisition Corporation Conversion process for 2,3-benzodiazepine enantiomers

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK118660B (da) * 1966-12-09 1970-09-21 Egyt Gyogyszervegyeszeti Gyar Analogifremgangsmåde til fremstilling af 1-(3',4'-dimethoxyphenyl)-3-methyl-4-ethyl-6,7-dimethoxy-isoquinolin-N-imid.
GB1202579A (en) * 1966-12-09 1970-08-19 Egyt Gyogyszervegyeszeti Gyar Pharmacologically active new isoquinoline derivative and process for preparing same
USRE30014E (en) 1966-12-09 1979-05-29 Egyesult Gyogyazer-es Tapozergyar 1-(3,4-Dimethoxy-phenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5H-2,3-benzodiazepine
ZA712798B (en) * 1970-11-06 1972-02-23 Egyt Gyogyszervegyeszeti Gyar New,pharmaceutically active 2,3-diazabicyclo(5.4.0)undecapentaene derivative and process for preparing same

Also Published As

Publication number Publication date
NL190552B (nl) 1993-11-16
SE439919B (sv) 1985-07-08
JPS5592377A (en) 1980-07-12
HU179018B (en) 1982-08-28
ES485163A1 (es) 1980-06-16
YU241079A (en) 1984-02-29
ATA647279A (de) 1983-06-15
SE7908481L (sv) 1980-04-20
BG60270B1 (bg) 1994-03-31
IT7926579A0 (it) 1979-10-18
CH643835A5 (de) 1984-06-29
NO152048C (no) 1985-07-24
BE879404A (fr) 1980-04-15
US4322346A (en) 1982-03-30
FI793209A (fi) 1980-04-20
PL124063B1 (en) 1982-12-31
SU1402258A3 (ru) 1988-06-07
FR2439189B1 (zh) 1984-11-30
DK155327B (da) 1989-03-28
CS236456B2 (en) 1985-05-15
GB2034706B (en) 1982-08-04
YU41887B (en) 1988-02-29
GR74034B (zh) 1984-06-06
DE2940483A1 (de) 1980-04-30
DE2940483C2 (zh) 1989-06-22
PL219034A1 (zh) 1980-12-01
AT373589B (de) 1984-02-10
NL7907692A (nl) 1980-04-22
IT1220947B (it) 1990-06-21
GB2034706A (en) 1980-06-11
NO793349L (no) 1980-04-22
CA1125749A (en) 1982-06-15
FR2439189A1 (fr) 1980-05-16
JPS6350354B2 (zh) 1988-10-07
FI66604C (fi) 1984-11-12
DK440179A (da) 1980-04-20
FI66604B (fi) 1984-07-31
AU532079B2 (en) 1983-09-15
DK155327C (da) 1989-08-21
DD146596A5 (de) 1981-02-18
NL190552C (nl) 1994-04-18
NO152048B (no) 1985-04-15

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