BG48811A3 - Method for preparing of 2- bromine- alpha- ergokryptins - Google Patents

Method for preparing of 2- bromine- alpha- ergokryptins

Info

Publication number
BG48811A3
BG48811A3 BG080325A BG8032587A BG48811A3 BG 48811 A3 BG48811 A3 BG 48811A3 BG 080325 A BG080325 A BG 080325A BG 8032587 A BG8032587 A BG 8032587A BG 48811 A3 BG48811 A3 BG 48811A3
Authority
BG
Bulgaria
Prior art keywords
ergokryptins
bromine
alpha
preparing
optionally
Prior art date
Application number
BG080325A
Other languages
Bulgarian (bg)
English (en)
Inventor
Gabor Megyeri
Tibor Keve
Lajos Kovacs
Bela Stefko
Erik Bogsch
Anna Kassai Zieger
Ferenc Trischler
Gabor Szepesi
Maria Gazdag
Original Assignee
Richter Gedeon Vegyeszeti Gyar Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar Rt. filed Critical Richter Gedeon Vegyeszeti Gyar Rt.
Publication of BG48811A3 publication Critical patent/BG48811A3/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/02—Ergot alkaloids of the cyclic peptide type

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
BG080325A 1986-06-27 1987-06-26 Method for preparing of 2- bromine- alpha- ergokryptins BG48811A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU862690A HU196394B (en) 1986-06-27 1986-06-27 Process for preparing 2-halogenated ergoline derivatives

Publications (1)

Publication Number Publication Date
BG48811A3 true BG48811A3 (en) 1991-05-15

Family

ID=10960659

Family Applications (1)

Application Number Title Priority Date Filing Date
BG080325A BG48811A3 (en) 1986-06-27 1987-06-26 Method for preparing of 2- bromine- alpha- ergokryptins

Country Status (19)

Country Link
US (1) US4816587A (ja)
EP (1) EP0251732B1 (ja)
JP (1) JPH085879B2 (ja)
AR (1) AR243194A1 (ja)
AT (1) ATE88705T1 (ja)
AU (1) AU597673B2 (ja)
BG (1) BG48811A3 (ja)
CA (1) CA1301163C (ja)
CS (1) CS264295B2 (ja)
DD (1) DD264430A5 (ja)
DE (1) DE3785613T2 (ja)
DK (1) DK328687A (ja)
ES (1) ES2054672T3 (ja)
FI (1) FI89048C (ja)
HU (1) HU196394B (ja)
PL (1) PL151562B1 (ja)
SU (1) SU1528320A3 (ja)
UA (1) UA5571A1 (ja)
YU (1) YU46557B (ja)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU196598B (en) * 1986-04-25 1988-12-28 Richter Gedeon Vegyeszet Process for producing 1- and/or 8-substituted 2-halogenated ergoline derivatives and pharmaceutics comprising such compounds
DE4033496A1 (de) * 1990-10-20 1992-04-23 Sandoz Ag Neue ergolinderivate, ihre herstellung und verwendung
NZ261259A (en) * 1993-01-12 1996-12-20 Biogen Inc Humanised recombinant anti-vla4 antibody and diagnostic compositions and medicaments
US20030157642A1 (en) * 1997-07-15 2003-08-21 Caldwell Robert M. Increasing production of proteins in gram-positive microorganisms
US6723550B1 (en) 1997-07-15 2004-04-20 Genencor International, Inc. Proteases from gram-positive organisms
US6521421B1 (en) * 1997-07-16 2003-02-18 Genencor International, Inc. Expression vectors encoding Bacillus subtilis disulfide bond isomerase and methods of secreting proteins in gram-positive microorganisms using the same
US6521440B1 (en) 1997-09-15 2003-02-18 Genencor International, Inc. Proteases from gram-positive organisms
US6316241B1 (en) * 1997-11-20 2001-11-13 Genencor International, Inc. Alpha/beta hydrolase-fold enzymes
FR2786099B1 (fr) * 1998-11-24 2000-12-29 Aventis Laboratoire Nouvelle application therapeutique de la 1,6-dimethyl-8beta- hydroxymethyl-10alpha-methoxyergoline
US20050176629A1 (en) * 2001-03-13 2005-08-11 Andrews William H. Telomerase expression repressor proteins and methods of using the same
EP1411962B1 (en) 2001-03-15 2011-01-19 Neogenix Oncology, Inc. Monoclonal antibody therapy for pancreas cancer
KR100924625B1 (ko) 2001-07-02 2009-11-02 세키스이 메디칼 가부시키가이샤 측정 시약용 담체 입자 라텍스 및 측정 시약
CA2478458A1 (en) * 2004-08-20 2006-02-20 Michael Panzara Treatment of pediatric multiple sclerosis
PL2558499T3 (pl) 2010-04-16 2017-10-31 Biogen Ma Inc Przeciwciała anty-VLA-4
US8889768B2 (en) 2010-06-11 2014-11-18 Basf Se Laser-transparent PBT with organic additives
JP5843852B2 (ja) 2010-06-11 2016-01-13 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ 有機添加剤を有する、レーザーに対して透過性のポリブチレンテレフタレート
CN105560244B (zh) * 2014-10-10 2019-01-11 上海交通大学 一种γ-分泌酶抑制剂及其应用
SG11201703237VA (en) 2014-11-19 2017-06-29 Axon Neuroscience Se Humanized tau antibodies in alzheimer's disease
ES2877797T3 (es) 2016-06-14 2021-11-17 Denka Company Ltd Portador de membrana para el kit de prueba de muestra líquida, kit de prueba de muestra líquida y método para producir el kit de prueba de muestra líquida
JP6978489B2 (ja) 2017-03-28 2021-12-08 デンカ株式会社 膜担体、並びにそれを用いた液体試料検査キット及びその製造方法
CN115453112A (zh) 2017-03-28 2022-12-09 电化株式会社 膜载体和使用其的液体试样检测试剂盒
EP3800999A4 (en) 2018-06-04 2022-06-01 Biogen MA Inc. ANTI-VLA-4 ANTIBODIES WITH REDUCED EFFECTOR FUNCTION
US20230365552A1 (en) * 2022-05-12 2023-11-16 The Florida State University Research Foundation, Inc. Lysergic acid derivatives and methods
US20240228479A1 (en) * 2022-12-31 2024-07-11 Ceruvia Lifesciences Llc Process for synthesizing 2-bromolysergic acid diethylamide via controlled bromination of lysergic acid

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3901894A (en) * 1974-06-06 1975-08-26 Lilly Co Eli 8-thiomethylergolines
US3992422A (en) * 1975-08-14 1976-11-16 Schering Corporation Process for the preparation of 21-halogeno-21-desoxy-17α-acyloxy-20-keto-pregnenes
US4098790A (en) * 1976-09-15 1978-07-04 Eli Lilly And Company Ergoline chlorination process
YU216177A (en) * 1977-09-09 1984-02-29 Rudolf Rucman Process for preparing 2-bromo ergosine
US4166182A (en) * 1978-02-08 1979-08-28 Eli Lilly And Company 6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds
YU39849B (en) * 1978-09-26 1985-04-30 Lek Tovarna Farmacevtskih Process for preparing 2-bromo-ergolene and 2-bromo-ergoline compounds
HU193317B (en) * 1985-06-12 1987-09-28 Richter Gedeon Vegyeszet Process for producing 2-bromo-alpha-ergochristin
HU193782B (en) * 1985-06-21 1987-11-30 Richter Gedeon Vegyeszet Process for producing 2-halogeno-nicergoline derivatives and acid additional salts thereof
HU193780B (en) * 1985-06-21 1987-11-30 Richter Gedeon Vegyeszet Process for producing 2-halogeno-6-methyl-ergol-9-ene derivatives and acid additional salts thereof
HU196598B (en) * 1986-04-25 1988-12-28 Richter Gedeon Vegyeszet Process for producing 1- and/or 8-substituted 2-halogenated ergoline derivatives and pharmaceutics comprising such compounds

Also Published As

Publication number Publication date
DD264430A5 (de) 1989-02-01
PL151562B1 (en) 1990-09-28
YU119987A (en) 1988-06-30
FI872852A0 (fi) 1987-06-26
JPS6314783A (ja) 1988-01-21
EP0251732A2 (en) 1988-01-07
YU46557B (sh) 1993-11-16
DE3785613D1 (de) 1993-06-03
SU1528320A3 (ru) 1989-12-07
DK328687A (da) 1987-12-28
CS479187A2 (en) 1988-09-16
CS264295B2 (en) 1989-06-13
FI89048B (fi) 1993-04-30
ATE88705T1 (de) 1993-05-15
EP0251732B1 (en) 1993-04-28
ES2054672T3 (es) 1994-08-16
PL266477A1 (en) 1988-07-21
FI89048C (fi) 1993-08-10
AU597673B2 (en) 1990-06-07
HUT44541A (en) 1988-03-28
JPH085879B2 (ja) 1996-01-24
AU7476387A (en) 1988-01-07
DK328687D0 (da) 1987-06-26
UA5571A1 (uk) 1994-12-28
CA1301163C (en) 1992-05-19
FI872852A (fi) 1987-12-28
EP0251732A3 (en) 1989-05-10
DE3785613T2 (de) 1993-08-12
HU196394B (en) 1988-11-28
AR243194A1 (es) 1993-07-30
US4816587A (en) 1989-03-28

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