AR243194A1 - Un procedimiento para la preparacion de derivados de ergolina 2-halogenados - Google Patents

Un procedimiento para la preparacion de derivados de ergolina 2-halogenados

Info

Publication number
AR243194A1
AR243194A1 AR87307983A AR30798387A AR243194A1 AR 243194 A1 AR243194 A1 AR 243194A1 AR 87307983 A AR87307983 A AR 87307983A AR 30798387 A AR30798387 A AR 30798387A AR 243194 A1 AR243194 A1 AR 243194A1
Authority
AR
Argentina
Prior art keywords
halagenated
preparation
ergoline derivatives
ergoline
derivatives
Prior art date
Application number
AR87307983A
Other languages
English (en)
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Application granted granted Critical
Publication of AR243194A1 publication Critical patent/AR243194A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/02—Ergot alkaloids of the cyclic peptide type

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AR87307983A 1986-06-27 1987-06-26 Un procedimiento para la preparacion de derivados de ergolina 2-halogenados AR243194A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU862690A HU196394B (en) 1986-06-27 1986-06-27 Process for preparing 2-halogenated ergoline derivatives

Publications (1)

Publication Number Publication Date
AR243194A1 true AR243194A1 (es) 1993-07-30

Family

ID=10960659

Family Applications (1)

Application Number Title Priority Date Filing Date
AR87307983A AR243194A1 (es) 1986-06-27 1987-06-26 Un procedimiento para la preparacion de derivados de ergolina 2-halogenados

Country Status (19)

Country Link
US (1) US4816587A (es)
EP (1) EP0251732B1 (es)
JP (1) JPH085879B2 (es)
AR (1) AR243194A1 (es)
AT (1) ATE88705T1 (es)
AU (1) AU597673B2 (es)
BG (1) BG48811A3 (es)
CA (1) CA1301163C (es)
CS (1) CS264295B2 (es)
DD (1) DD264430A5 (es)
DE (1) DE3785613T2 (es)
DK (1) DK328687A (es)
ES (1) ES2054672T3 (es)
FI (1) FI89048C (es)
HU (1) HU196394B (es)
PL (1) PL151562B1 (es)
SU (1) SU1528320A3 (es)
UA (1) UA5571A1 (es)
YU (1) YU46557B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU196598B (en) * 1986-04-25 1988-12-28 Richter Gedeon Vegyeszet Process for producing 1- and/or 8-substituted 2-halogenated ergoline derivatives and pharmaceutics comprising such compounds
DE4033496A1 (de) * 1990-10-20 1992-04-23 Sandoz Ag Neue ergolinderivate, ihre herstellung und verwendung
DK0678122T3 (da) * 1993-01-12 2000-03-06 Biogen Inc Rekombinante anti-VLA4 antistofmolekyler
US20030157642A1 (en) * 1997-07-15 2003-08-21 Caldwell Robert M. Increasing production of proteins in gram-positive microorganisms
US6723550B1 (en) 1997-07-15 2004-04-20 Genencor International, Inc. Proteases from gram-positive organisms
US6521421B1 (en) * 1997-07-16 2003-02-18 Genencor International, Inc. Expression vectors encoding Bacillus subtilis disulfide bond isomerase and methods of secreting proteins in gram-positive microorganisms using the same
US6521440B1 (en) 1997-09-15 2003-02-18 Genencor International, Inc. Proteases from gram-positive organisms
US6316241B1 (en) * 1997-11-20 2001-11-13 Genencor International, Inc. Alpha/beta hydrolase-fold enzymes
FR2786099B1 (fr) * 1998-11-24 2000-12-29 Aventis Laboratoire Nouvelle application therapeutique de la 1,6-dimethyl-8beta- hydroxymethyl-10alpha-methoxyergoline
WO2002072787A2 (en) * 2001-03-13 2002-09-19 Sierra Sciences, Inc. Telomerase expression repressor proteins and methods of using the same
EP2295064B1 (en) 2001-03-15 2017-02-22 Precision Biologics, Inc. Monoclonal antibody therapy for pancreas cancer
KR100894947B1 (ko) 2001-07-02 2009-04-27 세키스이 메디칼 가부시키가이샤 측정 시약용 담체 입자 라텍스 및 측정 시약
CA2478458A1 (en) * 2004-08-20 2006-02-20 Michael Panzara Treatment of pediatric multiple sclerosis
US20140161794A1 (en) 2010-04-16 2014-06-12 Biogen Idec Ma Inc. Anti-vla-4 antibodies
US8889768B2 (en) 2010-06-11 2014-11-18 Basf Se Laser-transparent PBT with organic additives
KR101889111B1 (ko) 2010-06-11 2018-08-16 바스프 에스이 유기 첨가제를 포함하는 레이저-투명 ｐｂｔ
CN105560244B (zh) * 2014-10-10 2019-01-11 上海交通大学 一种γ-分泌酶抑制剂及其应用
RS61431B1 (sr) 2014-11-19 2021-03-31 Axon Neuroscience Se Humanizovana antitela na tau u alchajmerovoj bolesti
ES2877797T3 (es) 2016-06-14 2021-11-17 Denka Company Ltd Portador de membrana para el kit de prueba de muestra líquida, kit de prueba de muestra líquida y método para producir el kit de prueba de muestra líquida
JP6978489B2 (ja) 2017-03-28 2021-12-08 デンカ株式会社 膜担体、並びにそれを用いた液体試料検査キット及びその製造方法
WO2018181540A1 (ja) 2017-03-28 2018-10-04 デンカ株式会社 膜担体及びそれを用いた液体試料検査キット
CN112867394B (zh) 2018-06-04 2024-09-13 马萨诸塞州渤健公司 具有降低的效应功能的抗vla-4抗体
US20230365552A1 (en) * 2022-05-12 2023-11-16 The Florida State University Research Foundation, Inc. Lysergic acid derivatives and methods
WO2024145546A1 (en) * 2022-12-31 2024-07-04 Ceruvia Lifesciences Llc Process for synthesizing 2-bromolysergic acid diethylamide via controlled bromination of lysergic acid

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3901894A (en) * 1974-06-06 1975-08-26 Lilly Co Eli 8-thiomethylergolines
US3992422A (en) * 1975-08-14 1976-11-16 Schering Corporation Process for the preparation of 21-halogeno-21-desoxy-17α-acyloxy-20-keto-pregnenes
US4098790A (en) * 1976-09-15 1978-07-04 Eli Lilly And Company Ergoline chlorination process
YU216177A (en) * 1977-09-09 1984-02-29 Rudolf Rucman Process for preparing 2-bromo ergosine
US4166182A (en) * 1978-02-08 1979-08-28 Eli Lilly And Company 6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds
YU39849B (en) * 1978-09-26 1985-04-30 Lek Tovarna Farmacevtskih Process for preparing 2-bromo-ergolene and 2-bromo-ergoline compounds
HU193317B (en) * 1985-06-12 1987-09-28 Richter Gedeon Vegyeszet Process for producing 2-bromo-alpha-ergochristin
HU193782B (en) * 1985-06-21 1987-11-30 Richter Gedeon Vegyeszet Process for producing 2-halogeno-nicergoline derivatives and acid additional salts thereof
HU193780B (en) * 1985-06-21 1987-11-30 Richter Gedeon Vegyeszet Process for producing 2-halogeno-6-methyl-ergol-9-ene derivatives and acid additional salts thereof
HU196598B (en) * 1986-04-25 1988-12-28 Richter Gedeon Vegyeszet Process for producing 1- and/or 8-substituted 2-halogenated ergoline derivatives and pharmaceutics comprising such compounds

Also Published As

Publication number Publication date
SU1528320A3 (ru) 1989-12-07
AU7476387A (en) 1988-01-07
CS479187A2 (en) 1988-09-16
FI89048B (fi) 1993-04-30
YU119987A (en) 1988-06-30
FI872852A0 (fi) 1987-06-26
ATE88705T1 (de) 1993-05-15
DE3785613T2 (de) 1993-08-12
JPH085879B2 (ja) 1996-01-24
PL266477A1 (en) 1988-07-21
FI89048C (fi) 1993-08-10
DK328687D0 (da) 1987-06-26
CS264295B2 (en) 1989-06-13
DD264430A5 (de) 1989-02-01
DK328687A (da) 1987-12-28
CA1301163C (en) 1992-05-19
UA5571A1 (uk) 1994-12-28
HU196394B (en) 1988-11-28
YU46557B (sh) 1993-11-16
FI872852A (fi) 1987-12-28
EP0251732A3 (en) 1989-05-10
HUT44541A (en) 1988-03-28
AU597673B2 (en) 1990-06-07
ES2054672T3 (es) 1994-08-16
JPS6314783A (ja) 1988-01-21
PL151562B1 (en) 1990-09-28
DE3785613D1 (de) 1993-06-03
EP0251732A2 (en) 1988-01-07
US4816587A (en) 1989-03-28
EP0251732B1 (en) 1993-04-28
BG48811A3 (en) 1991-05-15

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