ATE88705T1 - Verfahren zur herstellung von 2-halogenierten ergolinderivaten. - Google Patents

Verfahren zur herstellung von 2-halogenierten ergolinderivaten.

Info

Publication number
ATE88705T1
ATE88705T1 AT87305716T AT87305716T ATE88705T1 AT E88705 T1 ATE88705 T1 AT E88705T1 AT 87305716 T AT87305716 T AT 87305716T AT 87305716 T AT87305716 T AT 87305716T AT E88705 T1 ATE88705 T1 AT E88705T1
Authority
AT
Austria
Prior art keywords
preparation
ergoline derivatives
halogenated
halogenated ergoline
derivatives
Prior art date
Application number
AT87305716T
Other languages
English (en)
Inventor
Gabor Megyeri
Tibor Keve
Lajos Kovacs
Bela Stefko
Erik Bogsch
Anna Kassai
Ferenc Trischler
Gabor Szepesi
Maria Gazdag
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Application granted granted Critical
Publication of ATE88705T1 publication Critical patent/ATE88705T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/02—Ergot alkaloids of the cyclic peptide type

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT87305716T 1986-06-27 1987-06-26 Verfahren zur herstellung von 2-halogenierten ergolinderivaten. ATE88705T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU862690A HU196394B (en) 1986-06-27 1986-06-27 Process for preparing 2-halogenated ergoline derivatives
EP87305716A EP0251732B1 (de) 1986-06-27 1987-06-26 Verfahren zur Herstellung von 2-halogenierten Ergolinderivaten

Publications (1)

Publication Number Publication Date
ATE88705T1 true ATE88705T1 (de) 1993-05-15

Family

ID=10960659

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87305716T ATE88705T1 (de) 1986-06-27 1987-06-26 Verfahren zur herstellung von 2-halogenierten ergolinderivaten.

Country Status (19)

Country Link
US (1) US4816587A (de)
EP (1) EP0251732B1 (de)
JP (1) JPH085879B2 (de)
AR (1) AR243194A1 (de)
AT (1) ATE88705T1 (de)
AU (1) AU597673B2 (de)
BG (1) BG48811A3 (de)
CA (1) CA1301163C (de)
CS (1) CS264295B2 (de)
DD (1) DD264430A5 (de)
DE (1) DE3785613T2 (de)
DK (1) DK328687A (de)
ES (1) ES2054672T3 (de)
FI (1) FI89048C (de)
HU (1) HU196394B (de)
PL (1) PL151562B1 (de)
SU (1) SU1528320A3 (de)
UA (1) UA5571A1 (de)
YU (1) YU46557B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU196598B (en) * 1986-04-25 1988-12-28 Richter Gedeon Vegyeszet Process for producing 1- and/or 8-substituted 2-halogenated ergoline derivatives and pharmaceutics comprising such compounds
DE4033496A1 (de) * 1990-10-20 1992-04-23 Sandoz Ag Neue ergolinderivate, ihre herstellung und verwendung
ATE182625T1 (de) * 1993-01-12 1999-08-15 Biogen Inc Rekombinante anti-vla4 antikörpermoleküle
US6723550B1 (en) 1997-07-15 2004-04-20 Genencor International, Inc. Proteases from gram-positive organisms
US20030157642A1 (en) * 1997-07-15 2003-08-21 Caldwell Robert M. Increasing production of proteins in gram-positive microorganisms
US6521421B1 (en) * 1997-07-16 2003-02-18 Genencor International, Inc. Expression vectors encoding Bacillus subtilis disulfide bond isomerase and methods of secreting proteins in gram-positive microorganisms using the same
US6521440B1 (en) 1997-09-15 2003-02-18 Genencor International, Inc. Proteases from gram-positive organisms
US6316241B1 (en) * 1997-11-20 2001-11-13 Genencor International, Inc. Alpha/beta hydrolase-fold enzymes
FR2786099B1 (fr) * 1998-11-24 2000-12-29 Aventis Laboratoire Nouvelle application therapeutique de la 1,6-dimethyl-8beta- hydroxymethyl-10alpha-methoxyergoline
US20050176629A1 (en) * 2001-03-13 2005-08-11 Andrews William H. Telomerase expression repressor proteins and methods of using the same
JP2004537976A (ja) 2001-03-15 2004-12-24 インターナショナル バイオイムン システムズ，インコーポレーテッド 膵癌のモノクローナル抗体治療
JP3708942B2 (ja) 2001-07-02 2005-10-19 積水化学工業株式会社 測定試薬用担体粒子ラテックス及び測定試薬
CA2478458A1 (en) * 2004-08-20 2006-02-20 Michael Panzara Treatment of pediatric multiple sclerosis
RU2274640C1 (ru) * 2004-09-15 2006-04-20 Всероссийский научно-исследовательский институт лекарственных и ароматических растений ("ВИЛАР") СПОСОБ БРОМИРОВАНИЯ α И β-ЭРГОКРИПТИНОВ
LT2558499T (lt) 2010-04-16 2017-07-25 Biogen Ma Inc. Antikūnai prieš vla-4
US8889768B2 (en) 2010-06-11 2014-11-18 Basf Se Laser-transparent PBT with organic additives
KR101889111B1 (ko) 2010-06-11 2018-08-16 바스프 에스이 유기 첨가제를 포함하는 레이저-투명 ｐｂｔ
CN105560244B (zh) * 2014-10-10 2019-01-11 上海交通大学 一种γ-分泌酶抑制剂及其应用
SI3221349T1 (sl) 2014-11-19 2021-02-26 Axon Neuroscience Se Humanizirano tau protitelo pri alzheimerjevi bolezni
JP6849678B2 (ja) 2016-06-14 2021-03-24 デンカ株式会社 液体試料検査キット用膜担体、液体試料検査キット及び液体試料検査キットの製造方法
CN110337589A (zh) 2017-03-28 2019-10-15 电化株式会社 膜载体以及使用其的液体试样检测试剂盒及其制造方法
KR102505285B1 (ko) 2017-03-28 2023-03-02 덴카 주식회사 막 담체 및 이를 이용한 액체 시료 검사 키트
US12037398B2 (en) 2018-06-04 2024-07-16 Biogen Ma Inc. Anti-VLA-4 antibodies having reduced effector function
US20230365552A1 (en) * 2022-05-12 2023-11-16 The Florida State University Research Foundation, Inc. Lysergic acid derivatives and methods
WO2024145546A1 (en) * 2022-12-31 2024-07-04 Ceruvia Lifesciences Llc Process for synthesizing 2-bromolysergic acid diethylamide via controlled bromination of lysergic acid

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3901894A (en) * 1974-06-06 1975-08-26 Lilly Co Eli 8-thiomethylergolines
US3992422A (en) * 1975-08-14 1976-11-16 Schering Corporation Process for the preparation of 21-halogeno-21-desoxy-17α-acyloxy-20-keto-pregnenes
US4098790A (en) * 1976-09-15 1978-07-04 Eli Lilly And Company Ergoline chlorination process
YU216177A (en) * 1977-09-09 1984-02-29 Rudolf Rucman Process for preparing 2-bromo ergosine
US4166182A (en) * 1978-02-08 1979-08-28 Eli Lilly And Company 6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds
YU39849B (en) * 1978-09-26 1985-04-30 Lek Tovarna Farmacevtskih Process for preparing 2-bromo-ergolene and 2-bromo-ergoline compounds
HU193317B (en) * 1985-06-12 1987-09-28 Richter Gedeon Vegyeszet Process for producing 2-bromo-alpha-ergochristin
HU193782B (en) * 1985-06-21 1987-11-30 Richter Gedeon Vegyeszet Process for producing 2-halogeno-nicergoline derivatives and acid additional salts thereof
HU193780B (en) * 1985-06-21 1987-11-30 Richter Gedeon Vegyeszet Process for producing 2-halogeno-6-methyl-ergol-9-ene derivatives and acid additional salts thereof
HU196598B (en) * 1986-04-25 1988-12-28 Richter Gedeon Vegyeszet Process for producing 1- and/or 8-substituted 2-halogenated ergoline derivatives and pharmaceutics comprising such compounds

Also Published As

Publication number Publication date
FI872852L (fi) 1987-12-28
HU196394B (en) 1988-11-28
YU119987A (en) 1988-06-30
JPH085879B2 (ja) 1996-01-24
CA1301163C (en) 1992-05-19
ES2054672T3 (es) 1994-08-16
DD264430A5 (de) 1989-02-01
BG48811A3 (bg) 1991-05-15
EP0251732A2 (de) 1988-01-07
AU7476387A (en) 1988-01-07
FI872852A0 (fi) 1987-06-26
FI89048B (fi) 1993-04-30
SU1528320A3 (ru) 1989-12-07
US4816587A (en) 1989-03-28
AR243194A1 (es) 1993-07-30
EP0251732A3 (en) 1989-05-10
JPS6314783A (ja) 1988-01-21
DK328687A (da) 1987-12-28
PL266477A1 (en) 1988-07-21
DK328687D0 (da) 1987-06-26
AU597673B2 (en) 1990-06-07
DE3785613T2 (de) 1993-08-12
HUT44541A (en) 1988-03-28
CS264295B2 (en) 1989-06-13
PL151562B1 (en) 1990-09-28
UA5571A1 (uk) 1994-12-28
DE3785613D1 (de) 1993-06-03
CS479187A2 (en) 1988-09-16
EP0251732B1 (de) 1993-04-28
YU46557B (sh) 1993-11-16
FI89048C (fi) 1993-08-10

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee