BG33888A3 - Method for producing crystal hydrate of sin- isomer of natrium salt of 3- acetoxymethyl ester of 7- making open mean bracket 2- (2- amino- 4- thiazolyl)- 2- methoxyimino- acetamido closing mean bracket- cef- 3- em- 4- carbonic acid - Google Patents

Method for producing crystal hydrate of sin- isomer of natrium salt of 3- acetoxymethyl ester of 7- making open mean bracket 2- (2- amino- 4- thiazolyl)- 2- methoxyimino- acetamido closing mean bracket- cef- 3- em- 4- carbonic acid

Info

Publication number
BG33888A3
BG33888A3 BG7942035A BG4203578A BG33888A3 BG 33888 A3 BG33888 A3 BG 33888A3 BG 7942035 A BG7942035 A BG 7942035A BG 4203578 A BG4203578 A BG 4203578A BG 33888 A3 BG33888 A3 BG 33888A3
Authority
BG
Bulgaria
Prior art keywords
bracket
mean
cef
methoxyimino
acetamido
Prior art date
Application number
BG7942035A
Other languages
Bulgarian (bg)
English (en)
Inventor
Amiard
Bormann
Duerckheimer
Jolly
Original Assignee
Roussell Uclaf,Fr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9194564&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG33888(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Roussell Uclaf,Fr filed Critical Roussell Uclaf,Fr
Publication of BG33888A3 publication Critical patent/BG33888A3/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BG7942035A 1977-08-17 1978-08-15 Method for producing crystal hydrate of sin- isomer of natrium salt of 3- acetoxymethyl ester of 7- making open mean bracket 2- (2- amino- 4- thiazolyl)- 2- methoxyimino- acetamido closing mean bracket- cef- 3- em- 4- carbonic acid BG33888A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7725142A FR2400519A1 (fr) 1977-08-17 1977-08-17 Forme cristalline du sel de sodium d'un derive oximine de l'acide 7-amino-thiazolyl acetamido cephalosporanique, son procede de preparation et son application comme medicament

Publications (1)

Publication Number Publication Date
BG33888A3 true BG33888A3 (en) 1983-05-16

Family

ID=9194564

Family Applications (2)

Application Number Title Priority Date Filing Date
BG7942035A BG33888A3 (en) 1977-08-17 1978-08-15 Method for producing crystal hydrate of sin- isomer of natrium salt of 3- acetoxymethyl ester of 7- making open mean bracket 2- (2- amino- 4- thiazolyl)- 2- methoxyimino- acetamido closing mean bracket- cef- 3- em- 4- carbonic acid
BG7840671A BG33887A3 (en) 1977-08-17 1978-08-15 Method for producing crystal hydrate of sin- isomer of natrium salt of 3- acetoxymethyl ester of 7- making open mean bracket 2- (2- amino- 4- thiazolyl)- 2- methoxyimino- acetamido closing mean bracket- cef- 3- em- 4- carbonic acid

Family Applications After (1)

Application Number Title Priority Date Filing Date
BG7840671A BG33887A3 (en) 1977-08-17 1978-08-15 Method for producing crystal hydrate of sin- isomer of natrium salt of 3- acetoxymethyl ester of 7- making open mean bracket 2- (2- amino- 4- thiazolyl)- 2- methoxyimino- acetamido closing mean bracket- cef- 3- em- 4- carbonic acid

Country Status (34)

Country Link
US (1) US4224371A (ru)
EP (1) EP0001024B1 (ru)
JP (1) JPS5441890A (ru)
AT (2) AT366049B (ru)
AU (1) AU520898B2 (ru)
BG (2) BG33888A3 (ru)
CA (1) CA1121343A (ru)
CS (2) CS207646B2 (ru)
DD (1) DD137588A5 (ru)
DE (1) DE2860358D1 (ru)
DK (2) DK152213C (ru)
EG (1) EG13520A (ru)
ES (1) ES472381A1 (ru)
FI (1) FI65433C (ru)
FR (1) FR2400519A1 (ru)
GE (2) GEP19960475B (ru)
GR (1) GR73661B (ru)
HR (1) HRP931395B1 (ru)
HU (1) HU181497B (ru)
IE (1) IE47230B1 (ru)
IL (1) IL55186A (ru)
IT (1) IT1107961B (ru)
MD (2) MD225C2 (ru)
MX (2) MX155976A (ru)
NO (1) NO156168C (ru)
NZ (1) NZ188163A (ru)
OA (1) OA06016A (ru)
PL (1) PL126619B1 (ru)
PT (1) PT68431A (ru)
RO (1) RO79999A (ru)
SI (1) SI7811917A8 (ru)
SU (2) SU799666A3 (ru)
YU (1) YU42166B (ru)
ZA (1) ZA784187B (ru)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60120886A (ja) * 1983-12-02 1985-06-28 Takeda Chem Ind Ltd セフェムカルボン酸のナトリウム塩の結晶
JPS60142987A (ja) * 1983-12-29 1985-07-29 Mochida Pharmaceut Co Ltd セフアロスポリン誘導体
DE150507T1 (de) * 1983-12-29 1987-02-26 Mochida Pharmaceutical Co., Ltd., Tokio/Tokyo Cephalosporinverbindungen, verfahren zu ihrer herstellung und pharmazeutishe praeparate.
US4840945A (en) * 1985-04-01 1989-06-20 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
US4937330A (en) * 1985-08-12 1990-06-26 The Upjohn Company Conversion of cephalosporin hydrohalide salt to alkali metal salt
US4880798A (en) * 1986-11-25 1989-11-14 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
JPS63132893A (ja) * 1986-11-25 1988-06-04 Mochida Pharmaceut Co Ltd 新規セフアロスポリン誘導体、その製法およびそれらを有効成分とする抗菌剤
RU2021274C1 (ru) 1991-05-17 1994-10-15 Польска Акадэмия Наук Институт Хэмии Органичнэй Способ получения аминотиазолильных производных цефалоспорина
US5318781A (en) * 1993-04-06 1994-06-07 Hoffmann-La Roche Inc. Absorption enhancement of antibiotics
US5574154A (en) * 1994-09-29 1996-11-12 Alnejma Bulk Pharmaceutical Co. A.B.P.C. Process for the preparation of cephalosporanic compounds
GB9423459D0 (en) * 1994-11-21 1995-01-11 Biochemie Gmbh Silylation process
AT402928B (de) * 1994-12-23 1997-09-25 Biochemie Gmbh Neues verfahren zur herstellung von cefotaxim
AU690482B2 (en) * 1996-03-18 1998-04-23 Ranbaxy Laboratories Limited Process for producing cephalosporin antibiotics
GB9717629D0 (en) * 1997-08-21 1997-10-22 Johnson Matthey Plc Removal of residual organic solvents
WO2001092254A1 (fr) * 2000-05-30 2001-12-06 Fujisawa Pharmaceutical Co., Ltd. Procede permettant de remplacer des solvants contenus dans des cristaux de type clathrates
WO2004063203A1 (en) * 2003-01-10 2004-07-29 Orchid Chemicals & Pharmaceuticals Ltd Process for the preparation of cefotaxime sodium
CN100361995C (zh) * 2004-10-27 2008-01-16 山东瑞阳制药有限公司 注射级无菌头孢噻肟钠的一步法制备工艺

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3970651A (en) * 1974-01-07 1976-07-20 Bristol-Myers Company Crystalline cephalosporin derivative
US3985747A (en) * 1974-05-24 1976-10-12 Bristol-Myers Company Crystalline sesquihydrate of 7-[D-α-amino-α-(p-hydroxyphenyl)acetamido]-3-(1,2,3-triazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid
DK154939C (da) * 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
US4006138A (en) * 1975-04-11 1977-02-01 Eli Lilly And Company Crystalline form of sodium O-formylcefamandole
SE440655B (sv) * 1976-01-23 1985-08-12 Roussel Uclaf Sett att framstella nya oximderivat av 7-amino-tiazolyl-acetamido-cefalosporansyra
DE2760123C2 (de) * 1976-01-23 1986-04-30 Roussel-Uclaf, Paris 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporansäuren, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen

Also Published As

Publication number Publication date
SU852175A3 (ru) 1981-07-30
YU42166B (en) 1988-06-30
OA06016A (fr) 1981-06-30
MD225B1 (ro) 1995-06-30
GR73661B (ru) 1984-03-28
NO156168C (no) 1987-08-19
CS207647B2 (en) 1981-08-31
AU520898B2 (en) 1982-03-04
IE47230B1 (en) 1984-01-25
PL126619B1 (en) 1983-08-31
FI782494A (fi) 1979-02-18
MD247C2 (ru) 1995-12-31
DD137588A5 (de) 1979-09-12
ZA784187B (en) 1979-09-26
FR2400519B1 (ru) 1980-05-16
HU181497B (en) 1983-07-28
DK361078A (da) 1979-02-18
DE2860358D1 (en) 1981-03-12
DK163514C (da) 1992-07-27
MX5448E (es) 1983-08-09
GEP19960476B (en) 1996-07-22
AU3896578A (en) 1980-02-21
CS207646B2 (en) 1981-08-31
YU191778A (en) 1983-02-28
ATA52280A (de) 1981-07-15
FI65433B (fi) 1984-01-31
JPS5441890A (en) 1979-04-03
EP0001024A1 (fr) 1979-03-07
NO156168B (no) 1987-04-27
DK159786A (da) 1986-04-09
MD225C2 (ru) 1995-12-31
HRP931395B1 (en) 1996-04-30
AT366049B (de) 1982-03-10
MD247B1 (ro) 1995-07-31
GEP19960475B (en) 1996-07-22
IT1107961B (it) 1985-12-02
PT68431A (fr) 1978-09-01
NZ188163A (en) 1981-10-19
US4224371A (en) 1980-09-23
DK152213C (da) 1988-07-11
IE781669L (en) 1979-02-17
DK152213B (da) 1988-02-08
DK163514B (da) 1992-03-09
DK159786D0 (da) 1986-04-09
IL55186A0 (en) 1978-09-29
RO79999A (ro) 1982-10-11
NO782782L (no) 1979-02-20
FR2400519A1 (fr) 1979-03-16
PL209080A1 (pl) 1979-06-04
FI65433C (fi) 1984-05-10
AT366050B (de) 1982-03-10
EP0001024B1 (fr) 1981-01-21
ATA563578A (de) 1981-07-15
IT7850648A0 (it) 1978-08-08
SU799666A3 (ru) 1981-01-23
JPS6145626B2 (ru) 1986-10-08
EG13520A (en) 1982-03-31
IL55186A (en) 1981-07-31
MX155976A (es) 1988-06-06
BG33887A3 (en) 1983-05-16
ES472381A1 (es) 1979-03-16
SI7811917A8 (en) 1997-12-31
CA1121343A (fr) 1982-04-06

Similar Documents

Publication Publication Date Title
BG33888A3 (en) Method for producing crystal hydrate of sin- isomer of natrium salt of 3- acetoxymethyl ester of 7- making open mean bracket 2- (2- amino- 4- thiazolyl)- 2- methoxyimino- acetamido closing mean bracket- cef- 3- em- 4- carbonic acid
JPS6425768A (en) 2-(2-amino-4-thiazolyl)-2-methoxyiminoacetic acid derivative and manufacture
JPS5430194A (en) Cephalosporin derivative and its preparation
YU41823B (en) Process for obtaining new derivatives of thiazolidine, thiazane or related carboxylic acid
HU178918B (en) Process for preparing heterocyclic derivatives of unsaturated 7-acylamido-3-cefem-4-carboxylic acid
GB2004552B (en) Process for the production of heterocyclic compounds
GB2027618B (en) Process for the treatment of aluminium salt slags
NL7801779A (nl) Werkwijze voor het bereiden van kristallen van natriumcarbonaatmonohydraat.
PT76880A (en) Process for preparing 2-(2-aminothiazol-4-yl)-glyoxylic acid derivatives or salts thereof and of intermediates therefor
GB2005663B (en) Basic esters of polyhydroxy compounds
JPS5692291A (en) Nnsubstituted thiazolyl derivative of oxyimino substituted cephalosporin
DE3260406D1 (en) Process for preparing alkyl esters of c-alkyl-tartronic or c-halogenalkyl-tartronic acids
YU297976A (en) Process for preparing the crystalline from of the cefacetrial sodium salt
BG32858A3 (en) Method for obtaining of crystal sodium cephamandolmethanol
GB2001985B (en) Process for the preparation of penicillanic and cephalosporanic acid derivatives
GB2048257B (en) Heterocylic thiomethylation of the 3-position of 7-aminocephalosporanic acids
GB1557771A (en) Process for the production of salts of poly-alphahydroxyacrylic acids
GB2011895B (en) Method for producing crystals of sorbic acid
PL239885A1 (en) Process for preparing novel heterocyclic derivatives of acetic acid
YU103880A (en) Process for preparing new thiazolidine derivatives of 7-aminodeacetoxy cephalosporanic acid
PT65298A (en) Process for preparing c-3 esters of cephalosporin compounds
JPS53145964A (en) Production of salt for tempra
PL239882A1 (en) Process for preparing novel heterocyclic derivatives of acetic acid
PT65297B (en) Process for preparing esters of cephalosporin compounds
PL239886A1 (en) Process for preparing novel derivatives of heterocyclic carboxylic acids