BG108498A - Нови производни на оксазолидинони като антибактериални средства - Google Patents

Нови производни на оксазолидинони като антибактериални средства

Info

Publication number
BG108498A
BG108498A BG108498A BG10849803A BG108498A BG 108498 A BG108498 A BG 108498A BG 108498 A BG108498 A BG 108498A BG 10849803 A BG10849803 A BG 10849803A BG 108498 A BG108498 A BG 108498A
Authority
BG
Bulgaria
Prior art keywords
oxazolidinones
antibacterial agents
new derivatives
general formula
new
Prior art date
Application number
BG108498A
Other languages
English (en)
Inventor
Marisabel Mancini
Juan CLODET
Jose Rodriguez
Castillo Juan Del
Original Assignee
Laboratorios Vita, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Vita, S.A. filed Critical Laboratorios Vita, S.A.
Publication of BG108498A publication Critical patent/BG108498A/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Изобретението се отнася до нови флуорохинолонови производни на оксазолидоните с обща формула, до методи за получаването им, до съответните фармацевтични състави и до тяхното използване за производство на лекарствено средство за лечение на микробиални инфекции. Тези нови съединения са приложими като антибактериални средства. Изобретението се отнася също до феналинов тип съединения с обща формула, в която заместителите имат значения, посочени в описанието. а
BG108498A 2001-06-27 2003-12-22 Нови производни на оксазолидинони като антибактериални средства BG108498A (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200101559A ES2186550B2 (es) 2001-06-27 2001-06-27 Nuevos derivados de oxazolidinonas como antibacterianos.

Publications (1)

Publication Number Publication Date
BG108498A true BG108498A (bg) 2005-03-31

Family

ID=8498288

Family Applications (1)

Application Number Title Priority Date Filing Date
BG108498A BG108498A (bg) 2001-06-27 2003-12-22 Нови производни на оксазолидинони като антибактериални средства

Country Status (29)

Country Link
US (1) US20040147545A1 (bg)
EP (1) EP1401834A1 (bg)
JP (1) JP2004521147A (bg)
KR (1) KR20040030712A (bg)
CN (1) CN1520412A (bg)
AP (1) AP2003002942A0 (bg)
AR (1) AR035254A1 (bg)
BG (1) BG108498A (bg)
BR (1) BR0210667A (bg)
CA (1) CA2450982A1 (bg)
CO (1) CO5540387A2 (bg)
CR (1) CR7195A (bg)
CZ (1) CZ2004101A3 (bg)
EA (1) EA200400086A1 (bg)
EE (1) EE200400004A (bg)
ES (1) ES2186550B2 (bg)
HR (1) HRP20031063A2 (bg)
HU (1) HUP0400370A2 (bg)
IL (1) IL159434A0 (bg)
IS (1) IS7088A (bg)
MA (1) MA27046A1 (bg)
MX (1) MXPA04000185A (bg)
NO (1) NO20035791L (bg)
NZ (1) NZ530206A (bg)
OA (1) OA12639A (bg)
PE (1) PE20030134A1 (bg)
PL (1) PL365476A1 (bg)
SK (1) SK572004A3 (bg)
WO (1) WO2003002560A1 (bg)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003031443A1 (en) 2001-10-04 2003-04-17 Morphochem Aktiengesellschaft für kombinatorische Chemie Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety
WO2004096221A1 (en) * 2003-04-30 2004-11-11 Morphochem Aktiengesellschaft für kombinatorische Chemie Use of oxazolidinone-quinoline hybrid antibiotics for the treatment of anthrax and other infections
DE10340485B4 (de) 2003-09-03 2015-05-13 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden
US7304050B2 (en) * 2003-09-16 2007-12-04 Pfizer Inc. Antibacterial agents
WO2005051933A1 (en) * 2003-11-28 2005-06-09 Ranbaxy Laboratories Limited An improved process for the synthesis of 4-(4-benzyloxy-carbonylamino-2-fluorophenyl)-piperazine-1-carboxylic acid tert-butyl ester, a key intermediate for oxazolidinone antimicrobials and compounds prepared thereby
US8158797B2 (en) 2003-12-18 2012-04-17 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
EP1709044B2 (en) * 2003-12-18 2013-11-20 Morphochem Aktiengesellschaft Für Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
EP1557416A1 (en) * 2004-01-23 2005-07-27 Morphochem Aktiengesellschaft Für Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
US20060105941A1 (en) * 2004-11-12 2006-05-18 Allergan, Inc. Mixed antibiotic codrugs
CN101460495B (zh) 2006-03-31 2013-08-14 财团法人乙卯研究所 具有杂环的化合物
EP2233484A3 (en) 2007-10-02 2012-04-04 Research Foundation Itsuu Laboratory Oxazolidinone derivatives having a 7-membered heterocyclic ring
MY156304A (en) * 2008-05-09 2016-01-29 Actelion Pharmaceuticals Ltd 5-hydroxymethyl-oxazolidin-2-one derivatives for treating bacterial intestinal diseases
US9993469B2 (en) 2013-05-28 2018-06-12 Morphochem Aktiengesellschaft Für Kombinatorishe Chemie Combination therapy comprising oxazolidinone-quinolones for use in treating bacterial infections
EP3517106A1 (en) 2013-05-28 2019-07-31 Morphochem Aktiengesellschaft für kombinatorische Chemie Oxazolidinone-quinolone hybrid antibacterials for the parenteral treatment or prophylaxis of bacterial diseases
CN107286111B (zh) * 2016-03-30 2020-06-19 广东赛法洛药业有限公司 一种噁唑烷酮化合物的制备方法
CN107286182A (zh) * 2016-04-12 2017-10-24 李靖 新型噁唑烷酮‑氟喹诺酮衍生物及用途
US10087171B2 (en) 2016-12-19 2018-10-02 Actelion Pharmaceuticals Ltd Crystalline forms of cadazolid
GB201708606D0 (en) * 2017-05-30 2017-07-12 King S College London Antibiotic resistance breakers
EP3717490B1 (en) * 2017-11-29 2023-05-24 Bugworks Research, Inc. Anti-bacterial heterocyclic compounds and their synthesis
CN111087409B (zh) * 2018-10-24 2021-06-08 江阴安博生物医药有限公司 一种喹诺酮类化合物及其制备方法和应用
CN112940038A (zh) * 2019-12-11 2021-06-11 华创合成制药股份有限公司 新型噁唑烷酮类化合物及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE444566B (sv) * 1977-09-20 1986-04-21 Bellon Labor Sa Roger 7-dialkylamin-6-halogen-4-oxo-1,4-dihydrokinolin-3-karboxylsyra, forfarande for framstellning derav och farmaceutiskt preparat derav
DE69019859T2 (de) * 1989-03-30 1995-10-05 Wakunaga Seiyaku Kk Chinolon-Derivate und deren Salze, Verfahren zu deren Herstellung und diese enthaltende antibakterielle Wirkstoffe.
SK283420B6 (sk) * 1992-05-08 2003-07-01 Pharmacia & Upjohn Company Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny
MY115155A (en) 1993-09-09 2003-04-30 Upjohn Co Substituted oxazine and thiazine oxazolidinone antimicrobials.
PT788498E (pt) * 1994-10-26 2002-02-28 Upjohn Co Compostos antimicrobianos de feniloxazolidinona
KR19990082201A (ko) * 1996-01-31 1999-11-25 가와무라 요시부미 에이즈 치료제 또는 예방제
CZ298060B6 (cs) * 1996-04-11 2007-06-06 Pharmacia & Upjohn Company Zpusob prípravy oxazolidinonu
GB9614236D0 (en) * 1996-07-06 1996-09-04 Zeneca Ltd Chemical compounds

Also Published As

Publication number Publication date
CN1520412A (zh) 2004-08-11
WO2003002560A1 (en) 2003-01-09
IL159434A0 (en) 2004-06-01
EE200400004A (et) 2004-02-16
US20040147545A1 (en) 2004-07-29
EP1401834A1 (en) 2004-03-31
NZ530206A (en) 2005-07-29
EA200400086A1 (ru) 2004-06-24
AP2003002942A0 (en) 2003-12-24
CO5540387A2 (es) 2005-07-29
BR0210667A (pt) 2004-10-05
AR035254A1 (es) 2004-05-05
OA12639A (en) 2006-06-15
NO20035791L (no) 2004-02-19
PE20030134A1 (es) 2003-04-04
ES2186550B2 (es) 2003-11-16
HUP0400370A2 (hu) 2004-08-30
CZ2004101A3 (cs) 2004-07-14
CA2450982A1 (en) 2003-01-09
ES2186550A1 (es) 2003-05-01
IS7088A (is) 2003-12-22
SK572004A3 (en) 2004-08-03
MXPA04000185A (es) 2004-03-18
PL365476A1 (en) 2005-01-10
HRP20031063A2 (en) 2004-04-30
KR20040030712A (ko) 2004-04-09
JP2004521147A (ja) 2004-07-15
CR7195A (es) 2004-03-05
MA27046A1 (fr) 2004-12-20

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