BG107502A - Непептидни ccr1 рецепторни антагонисти в комбинация с циклоспорин а за лечение на отхвърляне при сърдечна трансплантация - Google Patents
Непептидни ccr1 рецепторни антагонисти в комбинация с циклоспорин а за лечение на отхвърляне при сърдечна трансплантацияInfo
- Publication number
- BG107502A BG107502A BG107502A BG10750203A BG107502A BG 107502 A BG107502 A BG 107502A BG 107502 A BG107502 A BG 107502A BG 10750203 A BG10750203 A BG 10750203A BG 107502 A BG107502 A BG 107502A
- Authority
- BG
- Bulgaria
- Prior art keywords
- cyclosporin
- transplant rejection
- heart transplant
- treatment
- combination
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Transplantation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Изобретението се отнася до фармацевтичен състав, полезен при лечение на отхвърляне на сърдечен трансплантат при бозайници. Съставът включва фармацевтично приемлив пълнител, лечебно ефективно количество от непептиден CCR1 рецепторен антагонист и суб-нефротоксично количество от циклоспорин А.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22205300P | 2000-07-31 | 2000-07-31 | |
US23128200P | 2000-09-08 | 2000-09-08 | |
US09/915,411 US6740636B2 (en) | 2000-07-31 | 2001-07-25 | Non-peptide CCR1 receptor antagonists in combination with cyclosporin A for the treatment of heart transplant rejection |
PCT/US2001/023862 WO2002009762A2 (en) | 2000-07-31 | 2001-07-31 | Non-peptide ccr1 receptor antagonists in combination with cyclosporin a for the treatment of heart transplant rejection |
Publications (1)
Publication Number | Publication Date |
---|---|
BG107502A true BG107502A (bg) | 2003-07-31 |
Family
ID=27397025
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG107502A BG107502A (bg) | 2000-07-31 | 2003-01-27 | Непептидни ccr1 рецепторни антагонисти в комбинация с циклоспорин а за лечение на отхвърляне при сърдечна трансплантация |
Country Status (28)
Country | Link |
---|---|
US (1) | US6740636B2 (bg) |
EP (1) | EP1305047B1 (bg) |
JP (1) | JP2004530630A (bg) |
KR (1) | KR20030048000A (bg) |
CN (1) | CN1655818A (bg) |
AT (1) | ATE330634T1 (bg) |
AU (2) | AU7807301A (bg) |
BG (1) | BG107502A (bg) |
BR (1) | BR0113140A (bg) |
CA (1) | CA2417636A1 (bg) |
CY (1) | CY1105321T1 (bg) |
DE (1) | DE60120986T2 (bg) |
DK (1) | DK1305047T3 (bg) |
EE (1) | EE200300047A (bg) |
ES (1) | ES2261447T3 (bg) |
HR (1) | HRP20030121A2 (bg) |
HU (1) | HUP0300686A3 (bg) |
IL (1) | IL153933A0 (bg) |
LV (1) | LV13033B (bg) |
MX (1) | MXPA03000836A (bg) |
NO (1) | NO20030475L (bg) |
NZ (1) | NZ523688A (bg) |
PL (1) | PL364521A1 (bg) |
PT (1) | PT1305047E (bg) |
SI (1) | SI21123A (bg) |
SK (1) | SK1222003A3 (bg) |
WO (1) | WO2002009762A2 (bg) |
YU (1) | YU6703A (bg) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0413846A (pt) * | 2003-08-22 | 2006-10-24 | Schering Aktiengellschaft | derivados de piperazina inibidores de quimiocina e seu uso para tratar miocardite |
US10499828B2 (en) * | 2004-03-05 | 2019-12-10 | Lifescience Solutions, Llc | System and method for heart monitoring |
US7917195B2 (en) | 2004-03-05 | 2011-03-29 | Lifesciences Solutions LLC | Systems, methods and computer program products for heart monitoring |
US8103065B2 (en) * | 2006-01-05 | 2012-01-24 | Lifescience Solutions Llc | Assessment of medical conditions |
US20110009758A1 (en) * | 2009-07-10 | 2011-01-13 | Lifescience Solutions Llc | System and method for heart monitoring |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6323206B1 (en) | 1996-07-12 | 2001-11-27 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
PL335484A1 (en) | 1997-02-26 | 2000-04-25 | Pfizer | Derivatives of heteroarylhexamide, their production and application as selective inhibitors of mip-1a being assimilated by its ccr1 receptor |
US6207665B1 (en) * | 1997-06-12 | 2001-03-27 | Schering Aktiengesellschaft | Piperazine derivatives and their use as anti-inflammatory agents |
HUP0101320A3 (en) | 1998-01-21 | 2002-11-28 | Kyowa Hakko Kogyo Kk | Benzo- and pyridobenzoxepine and -benzazepine derivatives and use thereof |
AU2335699A (en) | 1998-01-21 | 1999-08-09 | Kyowa Hakko Kogyo Co. Ltd. | Chemokine receptor antagonists and methods of use therefor |
TR200002248T2 (tr) | 1998-02-05 | 2000-12-21 | Pfizer Products Inc. | Yeni dihidroksiheksanoik asit türevleri |
EP1000626A1 (en) | 1998-09-18 | 2000-05-17 | Applied Research Systems ARS Holding N.V. | Chemokine receptor antagonist and cyclosporin in combined therapy |
WO2000044365A1 (en) | 1999-01-29 | 2000-08-03 | Millennium Pharmaceuticals, Inc. | Methods for preventing graft rejection and ischemia-reperfusion injury |
-
2001
- 2001-07-25 US US09/915,411 patent/US6740636B2/en not_active Expired - Fee Related
- 2001-07-31 NZ NZ523688A patent/NZ523688A/en unknown
- 2001-07-31 PL PL01364521A patent/PL364521A1/xx not_active Application Discontinuation
- 2001-07-31 SI SI200120045A patent/SI21123A/sl not_active IP Right Cessation
- 2001-07-31 YU YU6703A patent/YU6703A/sh unknown
- 2001-07-31 KR KR10-2003-7001483A patent/KR20030048000A/ko not_active Application Discontinuation
- 2001-07-31 AU AU7807301A patent/AU7807301A/xx active Pending
- 2001-07-31 EE EEP200300047A patent/EE200300047A/xx unknown
- 2001-07-31 PT PT01956035T patent/PT1305047E/pt unknown
- 2001-07-31 MX MXPA03000836A patent/MXPA03000836A/es unknown
- 2001-07-31 AT AT01956035T patent/ATE330634T1/de not_active IP Right Cessation
- 2001-07-31 HU HU0300686A patent/HUP0300686A3/hu unknown
- 2001-07-31 EP EP01956035A patent/EP1305047B1/en not_active Expired - Lifetime
- 2001-07-31 IL IL15393301A patent/IL153933A0/xx unknown
- 2001-07-31 CA CA002417636A patent/CA2417636A1/en not_active Abandoned
- 2001-07-31 SK SK122-2003A patent/SK1222003A3/sk unknown
- 2001-07-31 WO PCT/US2001/023862 patent/WO2002009762A2/en active IP Right Grant
- 2001-07-31 JP JP2002515314A patent/JP2004530630A/ja not_active Withdrawn
- 2001-07-31 CN CNA018138004A patent/CN1655818A/zh active Pending
- 2001-07-31 BR BR0113140-0A patent/BR0113140A/pt not_active IP Right Cessation
- 2001-07-31 DK DK01956035T patent/DK1305047T3/da active
- 2001-07-31 ES ES01956035T patent/ES2261447T3/es not_active Expired - Lifetime
- 2001-07-31 DE DE60120986T patent/DE60120986T2/de not_active Expired - Fee Related
- 2001-07-31 AU AU2001278073A patent/AU2001278073B2/en not_active Expired - Fee Related
-
2003
- 2003-01-27 BG BG107502A patent/BG107502A/bg unknown
- 2003-01-30 NO NO20030475A patent/NO20030475L/no not_active Application Discontinuation
- 2003-02-19 HR HR20030121A patent/HRP20030121A2/hr not_active Application Discontinuation
- 2003-02-28 LV LVP-03-25A patent/LV13033B/en unknown
-
2006
- 2006-09-05 CY CY20061101266T patent/CY1105321T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
IL153933A0 (en) | 2003-07-31 |
KR20030048000A (ko) | 2003-06-18 |
LV13033B (en) | 2004-02-20 |
SI21123A (sl) | 2003-08-31 |
CY1105321T1 (el) | 2010-03-03 |
EE200300047A (et) | 2004-10-15 |
ATE330634T1 (de) | 2006-07-15 |
NO20030475L (no) | 2003-03-28 |
US6740636B2 (en) | 2004-05-25 |
NZ523688A (en) | 2005-04-29 |
EP1305047A2 (en) | 2003-05-02 |
AU7807301A (en) | 2002-02-13 |
AU2001278073B2 (en) | 2005-06-30 |
HUP0300686A3 (en) | 2005-03-29 |
CA2417636A1 (en) | 2002-02-07 |
YU6703A (sh) | 2006-05-25 |
WO2002009762A3 (en) | 2003-01-09 |
HUP0300686A2 (hu) | 2003-08-28 |
ES2261447T3 (es) | 2006-11-16 |
CN1655818A (zh) | 2005-08-17 |
EP1305047B1 (en) | 2006-06-21 |
WO2002009762A2 (en) | 2002-02-07 |
DE60120986D1 (de) | 2006-08-03 |
PL364521A1 (en) | 2004-12-13 |
DE60120986T2 (de) | 2006-11-23 |
JP2004530630A (ja) | 2004-10-07 |
BR0113140A (pt) | 2003-06-24 |
MXPA03000836A (es) | 2003-06-06 |
SK1222003A3 (en) | 2003-09-11 |
US20020039997A1 (en) | 2002-04-04 |
DK1305047T3 (da) | 2006-10-23 |
NO20030475D0 (no) | 2003-01-30 |
PT1305047E (pt) | 2006-11-30 |
HRP20030121A2 (en) | 2005-02-28 |
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