BG107161A - 5-alkylpyrido[2,3-d]pyrimidines tyrosine kinase inhibitors - Google Patents
5-alkylpyrido[2,3-d]pyrimidines tyrosine kinase inhibitorsInfo
- Publication number
- BG107161A BG107161A BG107161A BG10716102A BG107161A BG 107161 A BG107161 A BG 107161A BG 107161 A BG107161 A BG 107161A BG 10716102 A BG10716102 A BG 10716102A BG 107161 A BG107161 A BG 107161A
- Authority
- BG
- Bulgaria
- Prior art keywords
- so2nr4r5
- compounds
- hydrogen
- alkylpyrido
- pyrimidines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18712400P | 2000-03-06 | 2000-03-06 | |
PCT/US2001/002657 WO2001070741A1 (en) | 2000-03-06 | 2001-01-29 | 5-alkylpyrido[2,3-d]pyrimidines tyrosine kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BG107161A true BG107161A (en) | 2003-06-30 |
Family
ID=22687699
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG107161A BG107161A (en) | 2000-03-06 | 2002-10-02 | 5-alkylpyrido[2,3-d]pyrimidines tyrosine kinase inhibitors |
Country Status (36)
Country | Link |
---|---|
EP (1) | EP1268476A1 (ja) |
JP (1) | JP2003528101A (ja) |
KR (1) | KR20020075805A (ja) |
CN (1) | CN1422268A (ja) |
AP (1) | AP2002002643A0 (ja) |
AR (1) | AR034119A1 (ja) |
AU (1) | AU2001233028A1 (ja) |
BG (1) | BG107161A (ja) |
BR (1) | BR0109056A (ja) |
CA (1) | CA2401368A1 (ja) |
CO (1) | CO5280200A1 (ja) |
CR (1) | CR6736A (ja) |
CZ (1) | CZ20022929A3 (ja) |
DZ (1) | DZ3308A1 (ja) |
EA (1) | EA200200802A1 (ja) |
EE (1) | EE200200506A (ja) |
GT (1) | GT200100037A (ja) |
HN (1) | HN2001000040A (ja) |
HR (1) | HRP20020798A2 (ja) |
HU (1) | HUP0300136A2 (ja) |
IL (1) | IL151480A0 (ja) |
IS (1) | IS6524A (ja) |
MA (1) | MA26881A1 (ja) |
MX (1) | MXPA02008535A (ja) |
NO (1) | NO20024235L (ja) |
NZ (1) | NZ520962A (ja) |
OA (1) | OA12227A (ja) |
PA (1) | PA8513201A1 (ja) |
PE (1) | PE20011177A1 (ja) |
PL (1) | PL358271A1 (ja) |
SK (1) | SK12472002A3 (ja) |
SV (1) | SV2001000338A (ja) |
TN (1) | TNSN01036A1 (ja) |
WO (1) | WO2001070741A1 (ja) |
YU (1) | YU66502A (ja) |
ZA (1) | ZA200207110B (ja) |
Families Citing this family (83)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7053070B2 (en) * | 2000-01-25 | 2006-05-30 | Warner-Lambert Company | Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors |
US7235551B2 (en) | 2000-03-02 | 2007-06-26 | Smithkline Beecham Corporation | 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases |
JP4524072B2 (ja) | 2000-10-23 | 2010-08-11 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | 新規化合物 |
IL156872A0 (en) * | 2001-02-12 | 2004-02-08 | Hoffmann La Roche | 6-substituted pyrido-pyrimidines |
MXPA03007623A (es) * | 2001-02-26 | 2003-12-04 | Tanabe Seiyaku Co | Derivado de piridopirimidina o naftiridina. |
AU2002324450A1 (en) * | 2001-06-21 | 2003-01-08 | Ariad Pharmaceuticals, Inc. | Novel pyridopyrimidines and uses thereof |
EP1408985A4 (en) * | 2001-06-21 | 2006-03-22 | Ariad Pharma Inc | NEW PYRIDOPYRIMIDONE AND ITS USES |
DK1470124T3 (da) * | 2002-01-22 | 2006-04-18 | Warner Lambert Co | 2-(Pyridin-2-yl amino)-pyrido[2,3]pyrimidin-7-oner |
DE60315826T2 (de) | 2002-04-19 | 2008-05-21 | Smithkline Beecham Corp. | Neue verbindungen |
DE60313339T2 (de) | 2002-07-31 | 2008-01-03 | Critical Outcome Technologies, Inc. | Protein tyrosin kinase inhibitoren |
DE60318089T2 (de) | 2002-10-09 | 2008-12-04 | Critical Outcome Technologies, Inc. | Protein-tyrosine-kinase-inhibitoren |
MXPA05007503A (es) * | 2003-01-17 | 2005-09-21 | Warner Lambert Co | Heterociclicos 2-aminopiridina sustituidos como inhibidores de proliferacion celular. |
US6861422B2 (en) | 2003-02-26 | 2005-03-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions |
EP1663204B1 (en) | 2003-08-29 | 2014-05-07 | Exelixis, Inc. | C-kit modulators and methods of use |
PL1685131T3 (pl) | 2003-11-13 | 2007-08-31 | Hoffmann La Roche | Hydroksyalkilo-podstawione pirydo-7-pirymidyn-7-ony |
DE102004029784A1 (de) | 2004-06-21 | 2006-01-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue 2-Benzylaminodihydropteridinone, Verfahren zur deren Herstellung und deren Verwendung als Arzneimittel |
DE102004033670A1 (de) | 2004-07-09 | 2006-02-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Pyridodihydropyrazinone, Verfahren zu Ihrer Herstellung und Ihre Verwendung als Arzneimittel |
FR2873118B1 (fr) | 2004-07-15 | 2007-11-23 | Sanofi Synthelabo | Derives de pyrido-pyrimidine, leur application en therapeutique |
US7728134B2 (en) | 2004-08-14 | 2010-06-01 | Boehringer Ingelheim International Gmbh | Hydrates and polymorphs of 4[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament |
US7759485B2 (en) | 2004-08-14 | 2010-07-20 | Boehringer Ingelheim International Gmbh | Process for the manufacture of dihydropteridinones |
US20060074088A1 (en) | 2004-08-14 | 2006-04-06 | Boehringer Ingelheim International Gmbh | Dihydropteridinones for the treatment of cancer diseases |
US20060058311A1 (en) | 2004-08-14 | 2006-03-16 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation |
US20060035903A1 (en) | 2004-08-14 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Storage stable perfusion solution for dihydropteridinones |
EP1630163A1 (de) | 2004-08-25 | 2006-03-01 | Boehringer Ingelheim Pharma GmbH & Co.KG | Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
JP2008510770A (ja) * | 2004-08-26 | 2008-04-10 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Plk阻害剤としての新規プテリジノン |
DE102004058337A1 (de) | 2004-12-02 | 2006-06-14 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten |
AU2006204724A1 (en) | 2005-01-14 | 2006-07-20 | Millennium Pharmaceuticals, Inc. | Cinnamide and hydrocinnamide derivatives with raf-kinase inhibitory activity |
TW200724142A (en) | 2005-03-25 | 2007-07-01 | Glaxo Group Ltd | Novel compounds |
PE20061351A1 (es) | 2005-03-25 | 2007-01-14 | Glaxo Group Ltd | COMPUESTOS 8H-PIRIDO[2,3-d]PIRIMIDIN-7-ONA 2,4,8-TRISUSTITUIDOS COMO INHIBIDORES DE LA QUINASA CSBP/RK/p38 |
KR20080002865A (ko) | 2005-03-25 | 2008-01-04 | 글락소 그룹 리미티드 | 피리도[2,3-d]피리미딘-7-온 및3,4-디히드로피리미도[4,5-d]피리미딘-2(1h)-온유도체의 제조 방법 |
US20090137550A1 (en) | 2005-03-25 | 2009-05-28 | Glaxo Group Limited | Novel Compounds |
US7737155B2 (en) * | 2005-05-17 | 2010-06-15 | Schering Corporation | Nitrogen-containing heterocyclic compounds and methods of use thereof |
FR2887882B1 (fr) | 2005-07-01 | 2007-09-07 | Sanofi Aventis Sa | Derives de pyrido[2,3-d] pyrimidine, leur preparation, leur application en therapeutique |
US7642270B2 (en) | 2005-09-14 | 2010-01-05 | Janssen Pharmaceutica N.V. | 5-oxo-5,8-dihydro-pyrido-pyrimidine as inhibitors of c-fms kinase |
TW200800983A (en) | 2005-09-14 | 2008-01-01 | Janssen Pharmaceutica Nv | 5-oxo-5,8-dihydro-pyrido-pyrimidines as inhibitors of C-FMS kinase |
CN101395155A (zh) * | 2005-10-07 | 2009-03-25 | 埃克塞里艾克西斯公司 | PI3Kα的吡啶并嘧啶酮抑制剂 |
US8247408B2 (en) * | 2005-10-07 | 2012-08-21 | Exelixis, Inc. | Pyridopyrimidinone inhibitors of PI3Kα for the treatment of cancer |
FR2896246B1 (fr) | 2006-01-13 | 2008-08-15 | Sanofi Aventis Sa | Derives de pyrido-pyrimidone, leur preparation, leur application en therapeutique. |
US7439358B2 (en) | 2006-02-08 | 2008-10-21 | Boehringer Ingelheim International Gmbh | Specific salt, anhydrous and crystalline form of a dihydropteridione derivative |
MEP8009A (en) | 2006-09-15 | 2011-12-20 | Pyrido (2, 3-d) pyrimidin0ne compounds and their use as pi3 inhibitors | |
EP1914234A1 (en) | 2006-10-16 | 2008-04-23 | GPC Biotech Inc. | Pyrido[2,3-d]pyrimidines and their use as kinase inhibitors |
EP2084159A1 (en) * | 2006-10-16 | 2009-08-05 | GPC Biotech Inc. | Pyrido ý2, 3-d¨pyrimidines and their use as kinase inhibitors |
US20080114007A1 (en) * | 2006-10-31 | 2008-05-15 | Player Mark R | 5-oxo-5,8-dihydro-pyrido-pyrimidines as inhibitors of c-fms kinase |
FR2910813B1 (fr) | 2006-12-28 | 2009-02-06 | Sanofi Aventis Sa | Nouvelle utilisation therapeutique pour le traitement des leucemies |
WO2008124323A1 (en) * | 2007-04-03 | 2008-10-16 | Array Biopharma Inc. | Imidazo[1,2-a]pyridine compounds as receptor tyrosine kinase inhibitors |
CN101784551A (zh) | 2007-06-15 | 2010-07-21 | 万有制药株式会社 | 二环苯胺衍生物 |
WO2009019205A1 (en) | 2007-08-03 | 2009-02-12 | Boehringer Ingelheim International Gmbh | Crystalline form of a dihydropteridione derivative |
WO2009085185A1 (en) | 2007-12-19 | 2009-07-09 | Amgen Inc. | Fused pyridine, pyrimidine and triazine compounds as cell cycle inhibitors |
US8466151B2 (en) | 2007-12-26 | 2013-06-18 | Critical Outcome Technologies, Inc. | Compounds and method for treatment of cancer |
EP2100894A1 (en) * | 2008-03-12 | 2009-09-16 | 4Sc Ag | Pyridopyrimidines used as Plk1 (polo-like kinase) inhibitors |
US8389533B2 (en) | 2008-04-07 | 2013-03-05 | Amgen Inc. | Gem-disubstituted and spirocyclic amino pyridines/pyrimidines as cell cycle inhibitors |
EP2112150B1 (en) | 2008-04-22 | 2013-10-16 | Forma Therapeutics, Inc. | Improved raf inhibitors |
EP2318406B1 (en) | 2008-07-17 | 2016-01-27 | Critical Outcome Technologies, Inc. | Thiosemicarbazone inhibitor compounds and cancer treatment methods |
EP2350070A1 (en) | 2008-09-30 | 2011-08-03 | Exelixis, Inc. | Pyridopyrimidinone inhibitors of pi3k and mtor |
TW201100441A (en) | 2009-06-01 | 2011-01-01 | Osi Pharm Inc | Amino pyrimidine anticancer compounds |
WO2011044535A2 (en) * | 2009-10-09 | 2011-04-14 | Afraxis, Inc. | 8-ethyl-6-(aryl)pyrido[2,3-d]pyrimidin-7(8h)-ones for the treatment of cns disorders |
US8889696B2 (en) | 2009-12-18 | 2014-11-18 | Temple University—Of the Commonwealth System of Higher Education | Substituted pyrido[2,3-d]pyrimidin-7(8H)-ones and therapeutic uses thereof |
US8901137B2 (en) | 2010-02-09 | 2014-12-02 | Exelixis, Inc. | Methods of treating cancer using pyridopyrimidinone inhibitors of PI3K and mTOR in combination with autophagy inhibitors |
WO2011120153A1 (en) | 2010-04-01 | 2011-10-06 | Critical Outcome Technologies Inc. | Compounds and method for treatment of hiv |
JP5512894B2 (ja) * | 2010-08-05 | 2014-06-04 | テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション | 2−置換−8−アルキル−7−オキソ−7,8−ジヒドロピリド[2,3d]ピリミジン−6−カルボニトリル及びその使用 |
US8546566B2 (en) | 2010-10-12 | 2013-10-01 | Boehringer Ingelheim International Gmbh | Process for manufacturing dihydropteridinones and intermediates thereof |
US9358233B2 (en) | 2010-11-29 | 2016-06-07 | Boehringer Ingelheim International Gmbh | Method for treating acute myeloid leukemia |
PT2646448T (pt) | 2010-11-29 | 2017-10-04 | Osi Pharmaceuticals Llc | Inibidores macrocíclicos de cinases |
ES2620521T3 (es) | 2011-03-23 | 2017-06-28 | Amgen Inc. | Inhibidores duales tricíclicos condensados de CDK 4/6 y FLT3 |
SI2710005T1 (sl) * | 2011-05-17 | 2017-03-31 | Principia Biopharma Inc. | Zaviralci tirozinske kinaze |
US9370535B2 (en) | 2011-05-17 | 2016-06-21 | Boehringer Ingelheim International Gmbh | Method for treatment of advanced solid tumors |
US9718821B2 (en) | 2012-02-23 | 2017-08-01 | Abbvie Inc. | Pyridopyrimidinone inhibitors of kinases |
PL3431475T3 (pl) * | 2013-02-21 | 2021-09-13 | Pfizer Inc. | Stałe postacie selektywnego inhibitora CDK4/6 |
US20150031699A1 (en) | 2013-07-26 | 2015-01-29 | Boehringer Ingelheim International Gmbh | Treatment of myelodysplastic syndrome |
JP6631616B2 (ja) * | 2014-07-26 | 2020-01-15 | ノース・アンド・サウス・ブラザー・ファーマシー・インベストメント・カンパニー・リミテッド | CDK阻害剤としての2−アミノ−ピリド[2,3−d]ピリミジン−7(8H)−オン誘導体及びその使用 |
US9867831B2 (en) | 2014-10-01 | 2018-01-16 | Boehringer Ingelheim International Gmbh | Combination treatment of acute myeloid leukemia and myelodysplastic syndrome |
US10449195B2 (en) | 2016-03-29 | 2019-10-22 | Shenzhen Pharmacin Co., Ltd. | Pharmaceutical formulation of palbociclib and a preparation method thereof |
TWI646094B (zh) * | 2016-06-01 | 2019-01-01 | 大陸商貝達藥業股份有限公司 | Crystal form of inhibitory protein kinase active compound and application thereof |
HUE055978T2 (hu) | 2016-08-15 | 2022-01-28 | Pfizer | Piridopirimidinon CDK2/4/6 inhibitorok |
US11192890B2 (en) * | 2017-03-03 | 2021-12-07 | Auckland Uniservices Limited | FGFR kinase inhibitors and pharmaceutical uses |
US11174252B2 (en) | 2018-02-15 | 2021-11-16 | Nuvation Bio Inc. | Heterocyclic compounds as kinase inhibitors |
US20220024916A1 (en) * | 2018-12-07 | 2022-01-27 | Hangzhou Innogate Pharma Co., Ltd. | Heterocyclic comipound as cdk-hdac dual pathway inhibitor |
CN112759589B (zh) * | 2019-11-01 | 2022-04-08 | 暨南大学 | 嘧啶并吡啶酮类化合物及其应用 |
WO2021108803A1 (en) | 2019-11-26 | 2021-06-03 | Theravance Biopharma R&D Ip, Llc | Fused pyrimidine pyridinone compounds as jak inhibitors |
JP2024508901A (ja) * | 2021-03-08 | 2024-02-28 | 曁南大学 | ピリドピリミジン系化合物及びその使用 |
WO2024056091A1 (zh) * | 2022-09-16 | 2024-03-21 | 华东师范大学 | 作为rsk抑制剂的吡啶酮并嘧啶衍生物及其应用 |
WO2024099403A1 (zh) * | 2022-11-10 | 2024-05-16 | 北京普祺医药科技股份有限公司 | 一种具有软药性质的硫醚类化合物、药物组合物及其用途 |
WO2024107730A1 (en) * | 2022-11-14 | 2024-05-23 | Onconova Therapeutics, Inc. | Methods and compositions for treating cancer |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5620981A (en) * | 1995-05-03 | 1997-04-15 | Warner-Lambert Company | Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation |
ATE391719T1 (de) * | 1997-02-05 | 2008-04-15 | Warner Lambert Co | Pyrido (2,3-d) pyrimidine und 4-amino-primidine als inhibitoren der zellulären proliferation |
AU763839B2 (en) * | 1998-05-26 | 2003-07-31 | Warner-Lambert Company | Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation |
-
2001
- 2001-01-29 WO PCT/US2001/002657 patent/WO2001070741A1/en active IP Right Grant
- 2001-01-29 OA OA1200200281A patent/OA12227A/en unknown
- 2001-01-29 YU YU66502A patent/YU66502A/sh unknown
- 2001-01-29 AP APAP/P/2002/002643A patent/AP2002002643A0/en unknown
- 2001-01-29 NZ NZ520962A patent/NZ520962A/en unknown
- 2001-01-29 HU HU0300136A patent/HUP0300136A2/hu unknown
- 2001-01-29 BR BR0109056-9A patent/BR0109056A/pt not_active IP Right Cessation
- 2001-01-29 CZ CZ20022929A patent/CZ20022929A3/cs unknown
- 2001-01-29 AU AU2001233028A patent/AU2001233028A1/en not_active Abandoned
- 2001-01-29 CN CN01807590A patent/CN1422268A/zh active Pending
- 2001-01-29 MX MXPA02008535A patent/MXPA02008535A/es not_active Application Discontinuation
- 2001-01-29 SK SK1247-2002A patent/SK12472002A3/sk unknown
- 2001-01-29 KR KR1020027011627A patent/KR20020075805A/ko not_active Application Discontinuation
- 2001-01-29 CA CA002401368A patent/CA2401368A1/en not_active Abandoned
- 2001-01-29 EE EEP200200506A patent/EE200200506A/xx unknown
- 2001-01-29 JP JP2001568942A patent/JP2003528101A/ja not_active Abandoned
- 2001-01-29 EP EP01905114A patent/EP1268476A1/en not_active Withdrawn
- 2001-01-29 PL PL01358271A patent/PL358271A1/xx not_active Application Discontinuation
- 2001-01-29 EA EA200200802A patent/EA200200802A1/ru unknown
- 2001-01-29 IL IL15148001A patent/IL151480A0/xx unknown
- 2001-01-29 DZ DZ013308A patent/DZ3308A1/fr active
- 2001-03-02 TN TNTNSN01036A patent/TNSN01036A1/en unknown
- 2001-03-05 PA PA20018513201A patent/PA8513201A1/es unknown
- 2001-03-05 GT GT200100037A patent/GT200100037A/es unknown
- 2001-03-05 SV SV2001000338A patent/SV2001000338A/es not_active Application Discontinuation
- 2001-03-05 CO CO01017398A patent/CO5280200A1/es not_active Application Discontinuation
- 2001-03-05 PE PE2001000216A patent/PE20011177A1/es not_active Application Discontinuation
- 2001-03-05 HN HN2001000040A patent/HN2001000040A/es unknown
- 2001-03-05 AR ARP010101039A patent/AR034119A1/es unknown
-
2002
- 2002-08-23 IS IS6524A patent/IS6524A/is unknown
- 2002-08-23 CR CR6736A patent/CR6736A/es not_active Application Discontinuation
- 2002-09-04 MA MA26801A patent/MA26881A1/fr unknown
- 2002-09-04 ZA ZA200207110A patent/ZA200207110B/en unknown
- 2002-09-05 NO NO20024235A patent/NO20024235L/no not_active Application Discontinuation
- 2002-10-02 BG BG107161A patent/BG107161A/xx unknown
- 2002-10-04 HR HR20020798A patent/HRP20020798A2/xx not_active Application Discontinuation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BG107161A (en) | 5-alkylpyrido[2,3-d]pyrimidines tyrosine kinase inhibitors | |
GEP20063915B (en) | PYRROLOTRIAZINE COMPOUNDS USEFUL AS KINASE INHIBITORS AND USE THEREOF FOR TREATING p38 KINASE-ASSOCIATED CONDITIONS | |
TR200102001T2 (tr) | P38 kinaz inhibitörleri olarak sübstitüe edilmiş pirazoller | |
YU50402A (sh) | Pirido(2,3-d)pirimidin-2,7-diaminski inhibitori kinaze | |
NO308108B1 (no) | Pyrrolo[2,3-d]pyrimidiner og deres anvendelse for fremstilling av et medikament | |
TNSN07281A1 (en) | Pyrazole derivatives for the inhibition of cdk's and gsk's | |
YU73300A (sh) | Biciklični pirimidini i biciklični 3,4-dihidropirimidini kao inhibitori ćelijske proliferacije | |
BG104949A (en) | Pyrazolopyrimidinone cgmp pde5 inhibitors for the treatment of sexual dysfunction | |
UY27198A1 (es) | Nuevos compuestos antiinflamatorios de bencimidazol | |
BG107960A (en) | Ether derivatives useful as inhibitors of pde4 isozymes | |
MXPA02005844A (es) | Inhibidores de cinasas de proteina. | |
YU84603A (sh) | Novi inhibitori tirozin kinaze | |
PE20020305A1 (es) | 2-(4-PIRIDIL) AMINO-6-DIALCOXIFENIL-PIRIDO [2,3-d] PIRIMIDIN-7-ONAS COMO INHIBIDORES DE LA TIROSINA QUINASA | |
NZ591712A (en) | Imidazopyridazinecarbonitriles useful as kinase inhibitors | |
NO20000702L (no) | cGMP PDE-inhibitorer for behandling av erektil dysfunksjon | |
NZ533310A (en) | Benzimidazoles useful as protein kinase inhibitors | |
TW200504061A (en) | Pyrazolopyridine derivatives | |
PT1758860E (pt) | 3-piridil-benzocicloalquilmetil-aminas saturadas e insaturadas para utilização no tratamento da dor, depressões e estados de ansiedade | |
NZ333706A (en) | Benzenesulfone derivatives and medicaments | |
MY110191A (en) | 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents | |
HUP0303034A2 (hu) | Új 7-azaindol-származékok, foszfodiészteráz-4 inhibitorjakénti alkalmazásuk és eljárás az előállításukra | |
DE60311812D1 (de) | 3-furylanaloga von toxoflavin als kinaseinhibitoren | |
MXPA04000065A (es) | Derivados de aril(o ehteroaril)azolilcarbinoles para el tratamiento de la incontinencia urinaria. | |
UA87895C2 (en) | Substituted 5-phenyl pyrimidines i in therapy | |
MXPA05010975A (es) | Derivados de (6-(fenoxi)-pirido[3,4-d]pirimidin-2-il)-amina como inhibidores de p38 cinasa para el tratamiento de condiciones inflamatorias como artritis reumatoide. |