BG106038A - Аминопиримидини като инхибитори на сорбитолдехидрогеназа - Google Patents
Аминопиримидини като инхибитори на сорбитолдехидрогеназаInfo
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- BG106038A BG106038A BG106038A BG10603801A BG106038A BG 106038 A BG106038 A BG 106038A BG 106038 A BG106038 A BG 106038A BG 10603801 A BG10603801 A BG 10603801A BG 106038 A BG106038 A BG 106038A
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- C07—ORGANIC CHEMISTRY
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- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
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- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
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- C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
- C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
- C04B35/632—Organic additives
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- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/10—Spiro-condensed systems
Abstract
Изобретението се отнася до съединения, инхибиторина сорбитолдехидрогеназа, с формула@@в която R1, R2 и R3 имат значения, посочени в описанието. Изобретението се отнася също до методи за лечение или профилактика на усложнения, предизвикани от диабет, по-специално диабетна невропатия, диабетна нефропатия, диабетна микроангиопатия, диабетна макроангиопатия и диабетна кардиомиопатия чрез прилагане на съединенията на бозайници, страдащи от диабет, при които съществува риск от развитие на усложнения. Изобретението се отнася и до фармацевтични състави, включващи комбинация от посоченото съединение,с инхибитор на алдозна редуктаза, и до методи за лечение или профилактика на усложнения вследствие диабет. Изобретението се отнася също до фармацевтични състави, включващи комбинация от съединението сNHE-1-инхибитор (инхибитор на натриево-водороден обмен), до методи за лечение на кардиомиопатия и други, свързани с нея, проблеми на сърцето, както идо някои междинни съединения, използвани при синтеза на посочените съединения и до методи за получаването им.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12743799P | 1999-04-01 | 1999-04-01 | |
PCT/IB2000/000296 WO2000059510A1 (en) | 1999-04-01 | 2000-03-16 | Aminopyrimidines as sorbitol dehydrogenase inhibitors |
Publications (1)
Publication Number | Publication Date |
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BG106038A true BG106038A (bg) | 2002-06-28 |
Family
ID=22430114
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG106038A BG106038A (bg) | 1999-04-01 | 2001-10-23 | Аминопиримидини като инхибитори на сорбитолдехидрогеназа |
Country Status (41)
Country | Link |
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US (5) | US6414149B1 (bg) |
EP (1) | EP1185275A1 (bg) |
JP (1) | JP3581103B2 (bg) |
KR (1) | KR20020005653A (bg) |
CN (1) | CN1351497A (bg) |
AP (2) | AP2001002281A0 (bg) |
AR (1) | AR020562A1 (bg) |
AU (1) | AU768720B2 (bg) |
BG (1) | BG106038A (bg) |
BR (1) | BR0009433A (bg) |
CA (1) | CA2366858A1 (bg) |
CR (1) | CR6471A (bg) |
CZ (1) | CZ20013465A3 (bg) |
DZ (1) | DZ3037A1 (bg) |
EA (1) | EA004656B1 (bg) |
EE (1) | EE200100509A (bg) |
GT (1) | GT200000038A (bg) |
HK (1) | HK1045461A1 (bg) |
HN (1) | HN2000000040A (bg) |
HR (1) | HRP20010716A2 (bg) |
HU (1) | HUP0201011A3 (bg) |
ID (1) | ID30489A (bg) |
IL (1) | IL145364A0 (bg) |
IS (1) | IS6076A (bg) |
MA (1) | MA26727A1 (bg) |
MX (1) | MXPA01009871A (bg) |
MY (1) | MY136039A (bg) |
NO (1) | NO20014642L (bg) |
NZ (1) | NZ514144A (bg) |
OA (1) | OA11856A (bg) |
PA (1) | PA8493201A1 (bg) |
PE (1) | PE20001601A1 (bg) |
PL (1) | PL350884A1 (bg) |
SK (1) | SK13532001A3 (bg) |
TN (1) | TNSN00065A1 (bg) |
TR (1) | TR200102810T2 (bg) |
UA (1) | UA71951C2 (bg) |
UY (1) | UY26089A1 (bg) |
WO (1) | WO2000059510A1 (bg) |
YU (1) | YU71101A (bg) |
ZA (1) | ZA200108039B (bg) |
Families Citing this family (71)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SK13532001A3 (sk) * | 1999-04-01 | 2003-02-04 | Pfizer Products Inc. | Aminopiridíny ako inhibítory sorbitoldehydrogenázy |
IL154927A0 (en) * | 2000-10-18 | 2003-10-31 | Pfizer Prod Inc | Combination of statins and sorbitol dehydrogenase inhibitors |
SE0003795D0 (sv) | 2000-10-20 | 2000-10-20 | Astrazeneca Ab | Pharmaceutically useful compounds |
IL155704A0 (en) * | 2000-11-30 | 2003-11-23 | Pfizer Prod Inc | Combination of gaba agonists and sorbitol dehydrogenase inhibitors |
US20040180925A1 (en) * | 2000-12-27 | 2004-09-16 | Kenji Matsuno | Dipeptidylpeptidase-IV inhibitor |
IL147696A0 (en) * | 2001-01-25 | 2002-08-14 | Pfizer Prod Inc | Combination therapy |
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