BG105784A - Триазоли с допамин-d3 рецепторен афинитет - Google Patents

Триазоли с допамин-d3 рецепторен афинитет

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Publication number
BG105784A
BG105784A BG105784A BG10578401A BG105784A BG 105784 A BG105784 A BG 105784A BG 105784 A BG105784 A BG 105784A BG 10578401 A BG10578401 A BG 10578401A BG 105784 A BG105784 A BG 105784A
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Bulgaria
Prior art keywords
dopamine
triazole compounds
receptor affinity
receptor
compounds
Prior art date
Application number
BG105784A
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English (en)
Other versions
BG65086B1 (bg
Inventor
Dorothea Starck
Hans-Joerg Treiber
Liliane Unger
- SCHULZ Barbara NEUMANN
Kai Blumbach
Dietmar Schoebel
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Abbott Gmbh & Co. Kg
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Application filed by Abbott Gmbh & Co. Kg filed Critical Abbott Gmbh & Co. Kg
Publication of BG105784A publication Critical patent/BG105784A/bg
Publication of BG65086B1 publication Critical patent/BG65086B1/bg

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Abstract

Изобретението се отнася до триазолово съединение с формула, в която R1, R2, A и В имат значенията, посочени в описанието. Съединенията, получени съгласно изобретението, имат висок афинитет към допамин-D3-рецептор и са подходящи за лечение на болести, които отговарят на влиянието на допамин-D3-рецепторни лиганди.
BG105784A 1999-01-12 2001-08-03 Триазоли с допамин-d3 рецепторен афинитет BG65086B1 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19900811 1999-01-12

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BG105784A true BG105784A (bg) 2002-02-28
BG65086B1 BG65086B1 (bg) 2007-02-28

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ID=7894006

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BG105783A BG65105B1 (bg) 1999-01-12 2001-08-03 Триазоли с допамин-d3 рецепторен афинитет
BG105784A BG65086B1 (bg) 1999-01-12 2001-08-03 Триазоли с допамин-d3 рецепторен афинитет

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BG105783A BG65105B1 (bg) 1999-01-12 2001-08-03 Триазоли с допамин-d3 рецепторен афинитет

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US (3) US6583166B1 (bg)
EP (3) EP1144405B1 (bg)
JP (3) JP2002534521A (bg)
KR (3) KR100687682B1 (bg)
CN (3) CN1267430C (bg)
AR (3) AR022228A1 (bg)
AT (3) ATE366729T1 (bg)
AU (3) AU2289700A (bg)
BG (2) BG65105B1 (bg)
BR (2) BR0007504A (bg)
CA (3) CA2359952A1 (bg)
CO (3) CO5150182A1 (bg)
CZ (2) CZ303926B6 (bg)
DE (3) DE50015802D1 (bg)
ES (2) ES2334326T3 (bg)
HK (1) HK1045311B (bg)
HR (1) HRP20010590A2 (bg)
HU (2) HUP0200709A3 (bg)
ID (2) ID29552A (bg)
IL (3) IL144137A0 (bg)
NO (2) NO20013443L (bg)
NZ (2) NZ512830A (bg)
PL (2) PL201889B1 (bg)
SK (2) SK9852001A3 (bg)
TR (2) TR200102026T2 (bg)
TW (1) TWI274750B (bg)
WO (3) WO2000042037A1 (bg)
ZA (2) ZA200106584B (bg)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9810876D0 (en) 1998-05-20 1998-07-22 Smithkline Beecham Plc Compounds
AR023681A1 (es) 1998-10-08 2002-09-04 Smithkline Beecham Plc Derivados de tetrahidrobenzazepinas, composiciones farmaceuticas y el uso de los mismos para la manufactura de un medicamento.
AR022228A1 (es) 1999-01-12 2002-09-04 Abbott Gmbh & Co Kg Compuestos de triazol, composicion farmaceutica que los comprende y uso de los mismos para la preparar dicha composicion
AU2001256733A1 (en) * 2000-05-16 2001-11-26 Takeda Chemical Industries Ltd. Melanin-concentrating hormone antagonist
PL362992A1 (en) * 2000-11-14 2004-11-15 Smithkline Beecham P.L.C. Tetrahydrobenzazepine derivatives useful as modulators of dopamine d3 receptors (antipsychotic agents)
HU227543B1 (en) * 2001-09-28 2011-08-29 Richter Gedeon Nyrt N-[4-(2-piperazin- and 2-piperidin-1-yl-ethyl)-cyclohexyl]-sulfon- and sulfamides, process for their preparation, their use and pharmaceutical compositions containing them
GB0130219D0 (en) * 2001-12-18 2002-02-06 Pfizer Ltd Compounds for the treatment of sexual dysfunction
JP2005518414A (ja) * 2001-12-21 2005-06-23 スミスクライン ビーチャム パブリック リミテッド カンパニー ドーパミン受容体のモジュレーターとしての7−スルホニル−3−ベンゾアゼピン誘導体およびcns障害の治療のためのその使用
US7314937B2 (en) * 2002-03-21 2008-01-01 Eli Lilly And Company Non-imidazole aryl alkylamines compounds as histamine H3 receptor antagonists, preparation and therapeutic uses
MY133587A (en) 2002-05-29 2007-11-30 Glaxo Group Ltd Aromatic sulfones and their medical use
DE10304870A1 (de) * 2003-02-06 2004-08-19 Abbott Gmbh & Co. Kg Triazolverbindungen und ihre therapeutische Verwendung
EP1606633B1 (en) * 2003-03-17 2008-06-04 Bayer HealthCare AG Diagnostics and therapeutics for diseases associated with dopamine receptor d3 (drd3)
US6919342B2 (en) 2003-06-05 2005-07-19 Abbott Gmbh & Co. Kg Triazole compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor
WO2005051945A1 (en) * 2003-11-20 2005-06-09 Eli Lilly And Company Heterocyclic compounds as modulators of peroxisome proliferator activated receptors, useful for the treatment and/or prevention of disorders modulated by a ppar
KR20050054084A (ko) * 2003-12-03 2005-06-10 한국전자통신연구원 수신 환경에 기반한 위성 상태 데이터 분배 기능을 가지는위성관제 시스템 및 그 방법
TW200538113A (en) 2004-02-23 2005-12-01 Glaxo Group Ltd Compounds
US20080139532A1 (en) * 2004-03-08 2008-06-12 Glaxo Group Limited Tetrahydrobenzazepine Derivatives as Modulators of Dopamine D3 Receptors (Antipsychotic Agents)
US7563905B2 (en) * 2004-03-12 2009-07-21 Wyeth Triazole derivatives and method of using the same to treat HIV infections
GB0412314D0 (en) 2004-06-02 2004-07-07 Glaxo Group Ltd Compounds
DE102004027358A1 (de) 2004-06-04 2005-12-29 Abbott Gmbh & Co. Kg Pyrimidinverbindungen und ihre Verwendung
GB0413879D0 (en) * 2004-06-21 2004-07-21 Glaxo Group Ltd Compounds
GB0414795D0 (en) * 2004-07-01 2004-08-04 Glaxo Group Ltd Compounds
DE602005018366D1 (de) * 2004-08-09 2010-01-28 Abbott Gmbh & Co Kg Zur behandlung von auf eine modulation des dopamin-d3-rezeptors ansprechende erkrankungen geeignete 4-piperazinylpyrimidinverbindungen
EP1784390A2 (en) * 2004-08-13 2007-05-16 Amgen Inc. Substituted benzofused heterocycles
CN101384263A (zh) 2004-12-02 2009-03-11 艾博特股份有限两合公司 适合治疗对多巴胺d3受体调节产生反应的疾病的三唑化合物
GB0507602D0 (en) 2005-04-14 2005-05-18 Glaxo Group Ltd Compounds
GB0507680D0 (en) 2005-04-15 2005-05-25 Glaxo Group Ltd Compounds
ATE484502T1 (de) * 2005-06-14 2010-10-15 Glaxo Group Ltd Neue verbindungen
US7662813B2 (en) 2005-08-18 2010-02-16 Synta Pharmaceuticals Corp. Triazole compounds that modulate HSP90 activity
US7799815B2 (en) 2005-08-22 2010-09-21 Glaxo Group Limited Triazole derivatives as modulators of dopamine D3 receptors
WO2007028145A2 (en) * 2005-09-02 2007-03-08 Dara Biosciences, Inc. Agents and methods for reducing protein tyrosine phosphatase 1b activity in the central nervous system
US20070293548A1 (en) * 2006-03-31 2007-12-20 Wang Eric Y Inhibitors of semicarbazide-sensitive amine oxidase (SSAO) and VAP-1 mediated adhesion useful for treatment and prevention of diseases
DK2118077T3 (en) * 2007-02-08 2015-03-09 Synta Pharmaceuticals Corp Triazole compounds that modulate HSP90 ACTIVITY
EP2323737A2 (en) * 2008-08-08 2011-05-25 Synta Pharmaceuticals Corp. Triazole compounds that modulate hsp90 activity
WO2010040274A1 (zh) 2008-10-10 2010-04-15 中国人民解放军军事医学科学院毒物药物研究所 新型多巴胺d3受体配体,其制备方法及其医药用途
US9227944B2 (en) 2008-10-10 2016-01-05 Institute Of Pharmacology And Toxicology Academy Of Military Science P.L.A. China Dopamine D3 receptor ligands and preparation and medical uses of the same
US9326955B2 (en) * 2008-10-31 2016-05-03 Loyola University Chicago Combination pharmaceuticals and methods thereof using proteinacious channels as treatments for medical conditions
MX2012007339A (es) * 2009-12-22 2012-07-20 Cephalon Inc Derivados triciclicos y su uso farmaceutico y composiciones.
WO2012124744A1 (ja) * 2011-03-14 2012-09-20 大正製薬株式会社 含窒素縮合複素環化合物
CA2868240A1 (en) * 2012-05-30 2013-12-05 F. Hoffmann-La Roche Ag Triazolo compounds as pde10 inhibitors
RU2561063C1 (ru) * 2014-07-01 2015-08-20 Общество с ограниченной ответственностью "Научно-производственное объединение "Фарматрон" (НПО "Фарматрон") Способ коррекции неврологических нарушений при хронической алкогольной интоксикации
WO2016034671A1 (en) 2014-09-03 2016-03-10 Ctxt Pty Ltd Aminoindane-, aminotetrahydronaphthalene- and aminobenzocyclobutane-derived prmt5-inhibitors
WO2016034673A1 (en) 2014-09-03 2016-03-10 Ctxt Pty Ltd Tetrahydroisoquinoline derived prmt5-inhibitors
GB201415573D0 (en) 2014-09-03 2014-10-15 Cancer Therapeutics Crc Pty Ltd Compounds
GB201604030D0 (en) 2016-03-09 2016-04-20 Ctxt Pty Ltd Compounds
GB201604031D0 (en) 2016-03-09 2016-04-20 Ctxt Pty Ltd Compounds
GB201604029D0 (en) 2016-03-09 2016-04-20 Ctxt Pty Ltd Compounds
GB201604027D0 (en) 2016-03-09 2016-04-20 Ctxt Pty Ltd Compounds
GB201604020D0 (en) 2016-03-09 2016-04-20 Ctxt Pty Ltd Compounds
GB201604022D0 (en) 2016-03-09 2016-04-20 Ctxt Pty Ltd Compounds
WO2018209267A2 (en) * 2017-05-12 2018-11-15 Board Of Trustees Of The Southern Illinois University On Behalf Of Southern Illinois University Edwardsville 3,4,5-trisubstituted-1,2,4-triazoles and 3,4,5-trisubstituted-3-thio-1,2,4-triazoles and uses thereof
US10941153B2 (en) * 2018-05-31 2021-03-09 Regents Of The University Of Minnesota Substituted phenethylamine derivatives
GB202117129D0 (en) * 2021-11-26 2022-01-12 Epidarex Exeed Ltd Compounds

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4408049A (en) 1980-09-17 1983-10-04 The Upjohn Company Substituted piperazinyl-1,2,4-triazoles
US4338453A (en) 1980-09-17 1982-07-06 The Upjohn Company Aminoalkyl-1,2,4-triazoles
US4577020A (en) * 1983-01-25 1986-03-18 The Upjohn Company Aminoalkyl and aminoalkenyl triazoles as anti-psychotic agents
FR2601952B1 (fr) * 1986-07-23 1988-11-25 Carpibem Nouveaux derives amino alkyl thio de triazolopyridine ou triazoloquinoline, leurs procedes de preparation, medicaments les contenant, utiles notamment comme antalgiques
AU644500B2 (en) * 1990-12-20 1993-12-09 Merrell Dow Pharmaceuticals Inc. 3-aryl-5-alkylthio-4h-1,2,4-triazoles for treatment of hyperreflexia due to spinal trauma
ES2103374T3 (es) 1991-05-20 1997-09-16 Upjohn Co Derivados de carboxamido-(1,2n)-carbociclo-2-aminotetralina.
CZ287406B6 (cs) 1991-11-05 2000-11-15 Smithkline Beecham Corporation Indanové a indenové deriváty, způsob jejich výroby a farmaceutické prostředky s jejich obsahem
FR2687146B1 (fr) 1992-02-12 1994-04-01 Adir Cie Nouveaux derives de pyrrolidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
ATE213156T1 (de) 1993-04-27 2002-02-15 Smithkline Beecham Corp Endothelin-rezeptor-antagonisten
DE4338396A1 (de) * 1993-11-10 1995-05-11 Basf Ag N-Substituierte Azabicycloalkan-Derivate, ihre Herstellung und Verwendung
FR2722194B1 (fr) 1994-07-06 1996-08-23 Adir Nouveaux derives de benzopyrane, leur procede de preparation et les compositions pharmacuetiques qui les contiennent
DE4425144A1 (de) * 1994-07-15 1996-01-18 Basf Ag Triazolverbindungen und deren Verwendung
CN1088062C (zh) * 1994-11-23 2002-07-24 纽罗根公司 某些4-氨基甲基-2-取代的咪唑衍生物2-氨基甲基-4-取代的咪唑衍生物新的一族多巴胺受体亚型特异性配体
WO1996030333A1 (en) 1995-03-27 1996-10-03 Smithkline Beecham Plc Bicyclic amine derivatives and their use as anti-psychotic agents
AU5272296A (en) * 1995-04-06 1996-10-23 Novo Nordisk A/S Benzopyranopyrrole compounds, their preparation and use
GB9518572D0 (en) 1995-09-12 1995-11-15 Smithkline Beecham Plc Compounds
JPH11515030A (ja) * 1995-11-10 1999-12-21 ノボ ノルディスク アクティーゼルスカブ シス−ベンズ[e]インドール化合物のエナンチオマー、これらの製造、及びドーパミン−D3受容体選択的医薬としての利用
FR2742149B1 (fr) * 1995-12-11 1998-02-13 Inst Nat Sante Rech Med Nouveaux derives de 2-naphtamides et leurs applications therapeutiques
DE19600934A1 (de) * 1996-01-12 1997-07-17 Basf Ag Substituierte Aza- und Diazacycloheptan- und Cyclooctanverbindungen und deren Verwendung
US5688950A (en) 1996-04-23 1997-11-18 Neurogen Corporation Tricyclic aminoalkylcarboxamides; novel dopamine D3 receptor subtype specific ligands
WO1997043262A1 (en) * 1996-05-11 1997-11-20 Smithkline Beecham P.L.C. Tetrahydroisoquinoline derivatives as modulators of dopamine d3 receptors
EP0923542B1 (en) * 1996-05-31 2003-08-20 PHARMACIA & UPJOHN COMPANY Aryl substituted cyclic amines as selective dopamine d3 ligands
GB9612153D0 (en) 1996-06-11 1996-08-14 Smithkline Beecham Plc Compounds
DE69704060T2 (de) 1996-08-14 2001-08-02 Smithkline Beecham Plc Tetrahydroisochinolinderivate und ihre pharmazeutische anwendung
JPH10195056A (ja) * 1996-11-12 1998-07-28 Takeda Chem Ind Ltd 縮合ベンゼン誘導体、その製造法および剤
DE69707497T2 (de) 1996-12-06 2002-07-11 Abbott Lab Benzopyranopyrrole und benzopyranopyridine mit alpha-1 adrenergische wirkung
FR2760014B1 (fr) * 1997-02-27 1999-04-09 Adir Nouveaux composes de 2-amino indane, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
GB9708694D0 (en) 1997-04-30 1997-06-18 Smithkline Beecham Plc Compounds
GB9708805D0 (en) * 1997-05-01 1997-06-25 Smithkline Beecham Plc Compounds
IL132631A0 (en) 1997-05-03 2001-03-19 Smithkline Beecham Plc Tetrahydroisoquinoline derivatives as modulators of dopamine d3 receptors
GB9709303D0 (en) 1997-05-09 1997-06-25 Smithkline Beecham Plc Compounds
GB9710366D0 (en) * 1997-05-20 1997-07-16 Biocompatibles Ltd Stent deployment device
FR2764890B1 (fr) 1997-06-24 1999-08-27 Adir Nouveaux derives chromeniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DE19728996A1 (de) 1997-07-07 1999-01-14 Basf Ag Triazolverbindungen und deren Verwendung
AR022228A1 (es) 1999-01-12 2002-09-04 Abbott Gmbh & Co Kg Compuestos de triazol, composicion farmaceutica que los comprende y uso de los mismos para la preparar dicha composicion

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