BG105761A - Заместени 2-арилимино хетероцикли и състави коитоги съдържат за използване като средства за свързване на прогестероновия рецептор - Google Patents

Заместени 2-арилимино хетероцикли и състави коитоги съдържат за използване като средства за свързване на прогестероновия рецептор

Info

Publication number
BG105761A
BG105761A BG105761A BG10576101A BG105761A BG 105761 A BG105761 A BG 105761A BG 105761 A BG105761 A BG 105761A BG 10576101 A BG10576101 A BG 10576101A BG 105761 A BG105761 A BG 105761A
Authority
BG
Bulgaria
Prior art keywords
arylimino
progesterone receptor
substituted
compositions containing
receptor binding
Prior art date
Application number
BG105761A
Other languages
English (en)
Inventor
Brian Dixon
Cedo Bagi
Catherine Brennan
David Brittelli
William Bullock
Jinshan Chen
William COLLIBEE
Robert Dally
Jeffrey Johnson
Harold Kluender
William LATHROP
Peiying Liu
Carol MASE
Aniko Redmann
William Scott
Klaus Urbahns
Donald Wolanin
Original Assignee
Bayer Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Corporation filed Critical Bayer Corporation
Publication of BG105761A publication Critical patent/BG105761A/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/18—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/42—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/28—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/54—Nitrogen and either oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
    • C07D279/06—1,3-Thiazines; Hydrogenated 1,3-thiazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Изобретението се отнася до 2-арилиминохетероцикли, включващи 2-арилимино-1,3-тиазолидини, 2-арилимино-2,3,4,5-тетрахидро-1,3-тиазини, 2-арилимино-1,3-тиазолидин-4-они, 2-арилимино-1,3-тиазолидин-5-они и 2-арилимино-1,3-оксазолидини, до тяхното използване за модулиране на процеси, медиирани от прогестероновия рецептор, както и до фармацевтични състави, които се използват при такава терапия.
BG105761A 1999-01-14 2001-08-01 Заместени 2-арилимино хетероцикли и състави коитоги съдържат за използване като средства за свързване на прогестероновия рецептор BG105761A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23190699A 1999-01-14 1999-01-14
PCT/US1999/029601 WO2000042031A2 (en) 1999-01-14 1999-12-14 Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents

Publications (1)

Publication Number Publication Date
BG105761A true BG105761A (bg) 2002-03-29

Family

ID=22871101

Family Applications (1)

Application Number Title Priority Date Filing Date
BG105761A BG105761A (bg) 1999-01-14 2001-08-01 Заместени 2-арилимино хетероцикли и състави коитоги съдържат за използване като средства за свързване на прогестероновия рецептор

Country Status (21)

Country Link
EP (1) EP1144396A2 (bg)
JP (1) JP2002534517A (bg)
KR (1) KR20010089831A (bg)
CN (1) CN1337955A (bg)
AR (1) AR022214A1 (bg)
AU (1) AU2708700A (bg)
BG (1) BG105761A (bg)
BR (1) BR9916999A (bg)
CA (1) CA2359562A1 (bg)
CO (1) CO5160338A1 (bg)
CZ (1) CZ20012530A3 (bg)
GT (1) GT200000003A (bg)
HU (1) HUP0105134A2 (bg)
ID (1) ID30514A (bg)
IL (1) IL144031A0 (bg)
NO (1) NO20013318L (bg)
SK (1) SK10032001A3 (bg)
SV (1) SV2002000005A (bg)
TR (1) TR200102041T2 (bg)
WO (1) WO2000042031A2 (bg)
ZA (1) ZA200105253B (bg)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0202429A3 (en) * 1999-08-31 2004-04-28 Schering Ag Use of mesoprogestins (progesterone receptor modulators) for the preparation of pharmaceutical compositions for the treatment and prevention of benign hormone dependent gynecological disorders
US8193252B1 (en) 1999-08-31 2012-06-05 Bayer Pharma AG Mesoprogestins (progesterone receptor modulators) for the treatment and prevention of benign hormone dependent gynecological disorders
CO5200773A1 (es) * 1999-08-31 2002-09-27 Jenapharm Gmbh And Co Kg Mesoprogestinas (moduladores de receptores para progestero- na) como componente de composiciones utilizadas para la terapia de sustitucion hormonal (trh)
DE60038687T2 (de) 1999-09-14 2009-05-28 Shionogi & Co., Ltd. 2-imino-1,3-thiazin-derivate
EP1277743A4 (en) * 2000-03-28 2005-03-23 Nippon Soda Co OXA DERIVED (THIA) ZOLIDINE AND ANTI-INFLAMMATORY DRUG
BR0107179A (pt) * 2000-09-07 2002-07-02 Bayer Ag Amidinas cìclicas e acìclicas e composições farmacêuticas contendo as mesmas para uso como agentes de ligação de receptor de progesterona
JP4188694B2 (ja) * 2001-03-08 2008-11-26 塩野義製薬株式会社 １，３−チアジン誘導体を含有する医薬組成物
US7189751B2 (en) 2001-06-25 2007-03-13 Nippon Soda Co., Ltd. Oxa(thia)zolidine compounds, process for preparation thereof and anti-inflammatory agents
ES2367539T3 (es) 2001-12-21 2011-11-04 X-Ceptor Therapeutics, Inc. Moduladores heterocíclicos de receptores nucleares.
EP1636167A2 (en) * 2003-06-10 2006-03-22 SmithKline Beecham Corporation 1-aminonaphthalenes as modulators of androgen, glucocorticoid, mineralocorticoid and progesterone receptors
CN103382158B (zh) * 2013-07-29 2015-11-18 张家港市大伟助剂有限公司 一种2-环戊基氨基乙醇的制备方法
KR20220034151A (ko) * 2019-07-10 2022-03-17 바이엘 악티엔게젤샤프트 2-(페닐이미노)-1,3-티아졸리딘-4-온의 제조 방법
CN114507143A (zh) * 2022-02-26 2022-05-17 江苏壹药新材料有限公司 一种2-乙基-1-氟-4-硝基苯的合成方法
CN114671828B (zh) * 2022-04-28 2024-05-31 蔚林新材料科技股份有限公司 一种3-甲基-2-噻唑硫酮的制备方法
CN114957288B (zh) * 2022-06-07 2024-02-13 苏州华道生物药业股份有限公司 一种盐酸四咪唑的合成方法
CN115925559A (zh) * 2022-11-11 2023-04-07 上海泰坦科技股份有限公司 一种1-氨基-1-环戊基甲醇的制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670754A1 (de) * 1966-09-27 1970-12-23 Bayer Ag Verfahren zur Herstellung von 2-Phenylimino-oxazolidinen
FR1510015A (fr) * 1966-12-05 1968-01-19 Aquitaine Petrole Préparation d'imino-thiazolidines
DE1767335A1 (de) * 1968-04-27 1971-09-02 Bayer Ag Anaesthetikum fuer Tiere
DE1963193A1 (de) * 1969-12-17 1971-06-24 Bayer Ag N-substituierte 2-Arylimino-oxazolidine,Verfahren zu ihrer Herstellung und ihre Verwendung als Ektoparasiticide
FR2117337A5 (en) * 1970-12-04 1972-07-21 Eastman Kodak Co Merocyanine dye sensitisers - contg basic and acidic gps for silver halide emulsions
US3787575A (en) * 1970-12-17 1974-01-22 Bayer Ag N-substituted-2-arylimino-oxazolidines used as acaricides
GB1342232A (en) * 1971-07-29 1974-01-03 Bayer Ag Aryliminothiazolidines a process for their preparation and their use as acaricides
CH614946A5 (bg) * 1975-05-07 1979-12-28 Ciba Geigy Ag
DE2658138A1 (de) * 1976-12-22 1978-07-06 Bayer Ag Substituierte 2-phenylimino-thiazolidine, verfahren zu ihrer herstellung sowie ihre verwendung als ektoparasitizide
DE2926771A1 (de) * 1979-07-03 1981-01-15 Hoechst Ag Thiazolidinderivate und verfahren zu ihrer herstellung
DE3049460A1 (de) * 1980-12-30 1982-07-29 Hoechst Ag, 6000 Frankfurt "thiazolinderivate, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen
DE3505432A1 (de) * 1985-02-16 1986-08-21 Hoechst Ag, 6230 Frankfurt Pflanzenschutz- und schaedlingsbekaempfungsmittel auf der basis von thiazolidinderivaten sowie neue thiazolidinderivate und verfahren zu ihrer herstellung
IL84175A0 (en) * 1986-10-17 1988-03-31 Stauffer Chemical Co Iminooxazolidines,their preparation and their use as herbicides
US4806653A (en) * 1986-10-17 1989-02-21 Stauffer Chemical Company Process for preparation of iminooxazolidines
ATE63907T1 (de) * 1986-11-04 1991-06-15 Duphar Int Res Substituierte 2-phenylimino-oxazolidin-derivate mit herbizider wirkung.
AU2717488A (en) * 1987-11-19 1989-06-14 Chevron Research Company Ectoparasiticides

Also Published As

Publication number Publication date
ID30514A (id) 2001-12-13
CA2359562A1 (en) 2000-07-20
CO5160338A1 (es) 2002-05-30
EP1144396A2 (en) 2001-10-17
HUP0105134A2 (hu) 2002-04-29
WO2000042031A3 (en) 2000-11-09
NO20013318D0 (no) 2001-07-04
TR200102041T2 (tr) 2001-12-21
WO2000042031A2 (en) 2000-07-20
NO20013318L (no) 2001-08-30
JP2002534517A (ja) 2002-10-15
BR9916999A (pt) 2001-10-30
AR022214A1 (es) 2002-09-04
ZA200105253B (en) 2002-09-05
GT200000003A (es) 2001-07-06
KR20010089831A (ko) 2001-10-08
SK10032001A3 (sk) 2002-05-09
SV2002000005A (es) 2002-07-16
IL144031A0 (en) 2002-04-21
CN1337955A (zh) 2002-02-27
CZ20012530A3 (cs) 2002-02-13
AU2708700A (en) 2000-08-01

Similar Documents

Publication Publication Date Title
BG105761A (bg) Заместени 2-арилимино хетероцикли и състави коитоги съдържат за използване като средства за свързване на прогестероновия рецептор
HUP0104795A3 (en) Azabicycloalkanes as ccr5 modulators, pharmaceutical compositions comprising thereof and their use
IL154981A0 (en) Substituted indoles, pharmaceutical compositions containing such indoles and their use as ppay-y-binding agents
WO2000006085A3 (en) Compounds and methods
EP1129089A4 (en) SPIRO-INDOLINS AS Y5 RECEPTOR ANTAGONISTS
BG102726A (bg) Фармацевтичен състав за комбинирана терапия на остеопороза и използване
YU13301A (sh) Muskarinski agonisti i antagonisti
TR200002896T2 (tr) Kalsilitik Bileşimler
BG106391A (bg) Приложение на cgrp-антагонисти и инхибитори на освобождаването на cgrp за лечение на горещи вълни при менопауза
EP1244452A4 (en) UROTENSIN II RECEPTOR ANTAGONISTS
SE9802937D0 (sv) Novel compounds
PT1235579E (pt) Composicoes farmaceuticas contendo trimegestona
MXPA03001455A (es) Compuestos de pirazol, composiciones farmaceuticas y metodos para modular o inhibir la actividad del amiloide-beta-peptido asociado a reticulo endoplasmico y l-3-hidroxiacil-coa-deshidrogenasa.
AP9801182A0 (en) Endothelin receptor antagonists.
EP1246619A4 (en) UROTENSIN II RECEPTOR ANTAGONISTS
IL140044A0 (en) Compounds with growth hormone releasing properties
IL128500A (en) SUBSTITUTED 1,2,3,4-TETRAHYDRO-2-DIBENZOFURANAMINES AND 2-AMINOCYCLOHEPTA[b] BENZOFURANS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
BG101849A (bg) Бициклични тахикининови антагонисти, тяхното приготовляване и използуване в фармацевтични състави
ZA984838B (en) Bacterial pheromones and uses therefor.
EP0778833A4 (en) ENDOTHELIN RECEPTOR ANTAGONISTS
HUT77250A (hu) Bitumenkompozíciók, valamint azok előállítása és alkalmazása
WO2002020526A3 (en) Cyclic and acyclic amidines and pharmaceutical compositions containing them for use as progesterone receptor binding agents
IL142579A0 (en) Compounds with growth hormone releasing properties
NZ333506A (en) Methanesulphonate salt of an arylpiperazine derived from tryptamine and its solvates for pharmaceutical use
UA32316A (uk) Спосіб лікування жінок з патологічним клімаксом