BG101803A - Използване на мелатонин за лечение на пациенти,страдащи от лекарствена зависимост - Google Patents

Използване на мелатонин за лечение на пациенти,страдащи от лекарствена зависимост

Info

Publication number
BG101803A
BG101803A BG101803A BG10180397A BG101803A BG 101803 A BG101803 A BG 101803A BG 101803 A BG101803 A BG 101803A BG 10180397 A BG10180397 A BG 10180397A BG 101803 A BG101803 A BG 101803A
Authority
BG
Bulgaria
Prior art keywords
melatonin
drug
patient
patients suffering
treating patients
Prior art date
Application number
BG101803A
Other languages
English (en)
Other versions
BG62876B1 (bg
Inventor
Nava Zisapel
Original Assignee
Neurim Pharmaceuticals (1991) Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/381,535 external-priority patent/US6469044B1/en
Application filed by Neurim Pharmaceuticals (1991) Ltd. filed Critical Neurim Pharmaceuticals (1991) Ltd.
Publication of BG101803A publication Critical patent/BG101803A/bg
Publication of BG62876B1 publication Critical patent/BG62876B1/bg

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Anesthesiology (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Изобретението се отнася до използване на мелатонин за предпазване и лечение на пациенти, страдащи от зависимост, устойчивост или привикване към бензодиазепинови лекарствени средства при прекомерната им употреба и до фармацевтичен състав, предназначен за такова лечение. Дневният режим на приложение е от 0,01 до 100 mg. В случай на предпазване на пациент, приемащ бензодиазепиново лекарство дневнотоколичество мелатонин е по-малко от 10 mg.
BG101803A 1995-02-01 1997-07-30 Използване на мелатонин за лечение на пациенти,страдащи от лекарствена зависимост BG62876B1 (bg)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/381,535 US6469044B1 (en) 1995-02-01 1995-02-01 Method for treating patients suffering from drug dependencies which lead to plasma melationin deficiencies
EP95303853A EP0724878B1 (en) 1995-02-01 1995-06-06 Use of melatonin for treating patients suffering from drug dependencies
PCT/IB1996/000082 WO1996023496A1 (en) 1995-02-01 1996-01-29 Use of melatonin for treating patients suffering from drug addiction

Publications (2)

Publication Number Publication Date
BG101803A true BG101803A (bg) 1998-04-30
BG62876B1 BG62876B1 (bg) 2000-10-31

Family

ID=26140195

Family Applications (1)

Application Number Title Priority Date Filing Date
BG101803A BG62876B1 (bg) 1995-02-01 1997-07-30 Използване на мелатонин за лечение на пациенти,страдащи от лекарствена зависимост

Country Status (22)

Country Link
JP (1) JP4516159B2 (bg)
CN (1) CN1083263C (bg)
AT (1) AT408188B (bg)
AU (1) AU695366B2 (bg)
BG (1) BG62876B1 (bg)
BR (1) BR9607169A (bg)
CZ (1) CZ291349B6 (bg)
DK (1) DK176081B1 (bg)
EE (1) EE03384B1 (bg)
FI (1) FI119586B (bg)
IS (1) IS1980B (bg)
LU (1) LU90118B1 (bg)
LV (1) LV11940B (bg)
MD (1) MD1716C2 (bg)
NO (1) NO312814B1 (bg)
NZ (1) NZ298878A (bg)
PL (1) PL183148B1 (bg)
SI (1) SI9620022A (bg)
SK (1) SK284521B6 (bg)
TR (1) TR199700723T1 (bg)
TW (1) TW483757B (bg)
WO (1) WO1996023496A1 (bg)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA004679B1 (ru) 2000-01-05 2004-06-24 Неурим Фармасьютикалс (1991) Лтд. Применение и состав для лечения невосприимчивости организма к гипотензивным средствам и связанных с ней состояний
IL149377A (en) * 2002-04-28 2012-10-31 Neurim Pharma 1991 Pharmaceutical formulation comprising melatonin for the potentiation of the effect of hypnotic compounds
US9119846B2 (en) 2003-04-29 2015-09-01 Neurim Pharmaceuticals (1991) Ltd. Method and composition for enhancing cognition in alzheimer's patients
IL155666A (en) 2003-04-29 2013-12-31 Neurim Pharma 1991 Insomnia treatment
US11918557B2 (en) 2012-01-26 2024-03-05 Vanda Pharmaceuticals Inc. Treatment of circadian rhythm disorders
SI2806863T1 (sl) * 2012-01-26 2017-12-29 Vanda Pharmaceuticals Inc. Zdravljenje motenj cirkadianega ritma
AU2013361459A1 (en) 2012-12-18 2015-07-02 Vanda Pharmaceuticals Inc. Treatment of circadian rhythm disorders
US11090285B2 (en) 2013-11-12 2021-08-17 Vanda Pharmaceuticals Inc Treatment of circadian rhythm disorders
US10376487B2 (en) 2013-11-12 2019-08-13 Vanda Pharmaceuticals Inc. Method of treatment
KR102167190B1 (ko) * 2016-10-31 2020-10-19 뉴림 파머슈티칼스(1991) 리미티드 멜라토닌 소형 정제 및 이의 제조방법

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE181670T1 (de) * 1991-05-09 1999-07-15 Neurim Pharma 1991 Melatonin enthaltende arzneimittel
IT1251544B (it) * 1991-05-13 1995-05-17 Gabriele Biella Composizioni farmaceutiche attive nella terapia dei disturbi del sonno comprendenti melatonina o un suo derivato in associazione con un derivato benzodiazepinico

Also Published As

Publication number Publication date
IS4532A (is) 1997-07-25
CN1172431A (zh) 1998-02-04
AT408188B (de) 2001-09-25
EE03384B1 (et) 2001-04-16
PL321630A1 (en) 1997-12-08
NO973531D0 (no) 1997-07-31
SK284521B6 (sk) 2005-05-05
SK103097A3 (en) 1998-01-14
JPH10513177A (ja) 1998-12-15
BR9607169A (pt) 1997-11-11
NO312814B1 (no) 2002-07-08
DK89697A (da) 1997-07-30
TW483757B (en) 2002-04-21
LU90118B1 (fr) 1997-11-13
MD1716B2 (en) 2001-08-31
DK176081B1 (da) 2006-04-18
SI9620022A (sl) 1998-10-31
EE9700166A (et) 1998-02-16
LV11940B (en) 1998-05-20
MX9705856A (es) 1998-07-31
NZ298878A (en) 1999-05-28
FI119586B (fi) 2009-01-15
JP4516159B2 (ja) 2010-08-04
ATA901396A (de) 2001-02-15
CZ291349B6 (cs) 2003-02-12
IS1980B (is) 2005-01-14
AU4457496A (en) 1996-08-21
TR199700723T1 (xx) 1998-02-21
PL183148B1 (pl) 2002-05-31
NO973531L (no) 1997-09-30
AU695366B2 (en) 1998-08-13
FI973185A (fi) 1997-09-30
LV11940A (lv) 1998-01-20
CN1083263C (zh) 2002-04-24
CZ240597A3 (cs) 1998-01-14
BG62876B1 (bg) 2000-10-31
MD970254A (en) 1999-05-31
MD1716C2 (ro) 2002-02-28
WO1996023496A1 (en) 1996-08-08
FI973185A0 (fi) 1997-07-31

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