BG100154A - Carbazole derivatibes having inhibiting effect to 17,20-lyase - Google Patents
Carbazole derivatibes having inhibiting effect to 17,20-lyaseInfo
- Publication number
- BG100154A BG100154A BG100154A BG10015495A BG100154A BG 100154 A BG100154 A BG 100154A BG 100154 A BG100154 A BG 100154A BG 10015495 A BG10015495 A BG 10015495A BG 100154 A BG100154 A BG 100154A
- Authority
- BG
- Bulgaria
- Prior art keywords
- group
- derivatibes
- lyase
- carbazole
- mean
- Prior art date
Links
- UJOBWOGCFQCDNV-UHFFFAOYSA-N 9H-carbazole Chemical compound C1=CC=C2C3=CC=CC=C3NC2=C1 UJOBWOGCFQCDNV-UHFFFAOYSA-N 0.000 title 2
- 102000001854 Steroid 17-alpha-Hydroxylase Human genes 0.000 title 1
- 108010015330 Steroid 17-alpha-Hydroxylase Proteins 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 239000003098 androgen Substances 0.000 abstract 1
- 229940030486 androgens Drugs 0.000 abstract 1
- 125000000609 carbazolyl group Chemical class C1(=CC=CC=2C3=CC=CC=C3NC12)* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical group 0.000 abstract 1
- 239000012453 solvate Chemical group 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939310635A GB9310635D0 (en) | 1993-05-21 | 1993-05-21 | Chemical compounds |
| PCT/EP1994/001613 WO1994027989A1 (en) | 1993-05-21 | 1994-05-19 | Carbazole derivatives with 17,20-lyase-inhibiting activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG100154A true BG100154A (en) | 1996-07-31 |
Family
ID=10736007
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG100154A BG100154A (en) | 1993-05-21 | 1995-11-21 | Carbazole derivatibes having inhibiting effect to 17,20-lyase |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0699196A1 (cg-RX-API-DMAC10.html) |
| JP (1) | JPH08510455A (cg-RX-API-DMAC10.html) |
| CN (1) | CN1126473A (cg-RX-API-DMAC10.html) |
| AU (1) | AU6928794A (cg-RX-API-DMAC10.html) |
| BG (1) | BG100154A (cg-RX-API-DMAC10.html) |
| CA (1) | CA2162921A1 (cg-RX-API-DMAC10.html) |
| CZ (1) | CZ305195A3 (cg-RX-API-DMAC10.html) |
| FI (1) | FI955587A7 (cg-RX-API-DMAC10.html) |
| GB (1) | GB9310635D0 (cg-RX-API-DMAC10.html) |
| HU (1) | HUT73790A (cg-RX-API-DMAC10.html) |
| IL (1) | IL109703A0 (cg-RX-API-DMAC10.html) |
| NO (1) | NO954681D0 (cg-RX-API-DMAC10.html) |
| OA (1) | OA10195A (cg-RX-API-DMAC10.html) |
| PE (1) | PE31195A1 (cg-RX-API-DMAC10.html) |
| PL (1) | PL311702A1 (cg-RX-API-DMAC10.html) |
| SK (1) | SK142495A3 (cg-RX-API-DMAC10.html) |
| TW (1) | TW279866B (cg-RX-API-DMAC10.html) |
| WO (1) | WO1994027989A1 (cg-RX-API-DMAC10.html) |
| ZA (1) | ZA943494B (cg-RX-API-DMAC10.html) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR960704852A (ko) * | 1993-09-30 | 1996-10-09 | 오노다 마사요시 | 아졸 유도체 및 이의 약제학적 조성물 (Azole derivative and pharmaceutical composition thereof) |
| WO1996014090A1 (en) * | 1994-11-07 | 1996-05-17 | Janssen Pharmaceutica N.V. | Compositions comprising carbazoles and cyclodextrins |
| AU702406B2 (en) * | 1995-03-01 | 1999-02-18 | Yamanouchi Pharmaceutical Co., Ltd. | Imidazole derivatives and medicinal composition thereof |
| CA2281598A1 (en) * | 1997-02-21 | 1998-08-27 | Tetsuya Aono | Fused ring compounds, process for producing the same and use thereof |
| MXPA03004347A (es) | 2000-11-17 | 2004-05-04 | Takeda Chemical Industries Ltd | Nuevos derivados de imidazol, metodo de produccion y uso de los mismos. |
| US6960586B2 (en) | 2000-11-20 | 2005-11-01 | Takeda Pharmaceutical Company Limited | Imidazole derivatives, process for their preparation and their use |
| EP1348706B1 (en) | 2000-12-08 | 2009-08-19 | Takeda Pharmaceutical Company Limited | Substituted thiazole derivatives bearing 3-pyridyl groups, process for preparing the same and use thereof |
| DK1902026T3 (da) | 2005-06-24 | 2010-04-26 | Lilly Co Eli | Tetrahydrocarbazol-derivater, der kan anvendes som androgen-receptor-modulatorer (SARM) |
| US8093279B2 (en) | 2005-12-13 | 2012-01-10 | Gillian Reed, legal representative | Compound |
| GB0525323D0 (en) * | 2005-12-13 | 2006-01-18 | Sterix Ltd | Compound |
| CN100586932C (zh) * | 2007-01-26 | 2010-02-03 | 中国医学科学院医药生物技术研究所 | 抗肿瘤化合物及其制备方法 |
| KR101360725B1 (ko) | 2009-06-26 | 2014-02-07 | 노파르티스 아게 | Ｃｙｐ17의 억제제로서의 1,3-이치환된 이미다졸리딘-2-온 유도체 |
| AU2011212813B2 (en) | 2010-02-04 | 2014-10-23 | Radius Health, Inc. | Selective androgen receptor modulators |
| CA2799183A1 (en) | 2010-05-12 | 2011-11-17 | Radius Health, Inc. | Therapeutic regimens |
| US9132105B2 (en) | 2010-08-04 | 2015-09-15 | Pellficure Pharmaceuticals, Inc. | Treatment of prostate carcinoma |
| US8946260B2 (en) | 2010-09-16 | 2015-02-03 | Novartis Ag | 17α-hydroxylase/C17,20-lyase inhibitors |
| US9133182B2 (en) | 2010-09-28 | 2015-09-15 | Radius Health, Inc. | Selective androgen receptor modulators |
| WO2012149413A1 (en) | 2011-04-28 | 2012-11-01 | Novartis Ag | 17α-HYDROXYLASE/C17,20-LYASE INHIBITORS |
| US9492460B2 (en) * | 2013-02-27 | 2016-11-15 | Bristol-Myers Squibb Company | Carbazole compounds useful as bromodomain inhibitors |
| US20160022606A1 (en) | 2013-03-14 | 2016-01-28 | Pellficure Pharmaceuticals Inc. | Novel therapy for prostate carcinoma |
| US9421264B2 (en) | 2014-03-28 | 2016-08-23 | Duke University | Method of treating cancer using selective estrogen receptor modulators |
| HRP20251500T1 (hr) | 2014-03-28 | 2026-01-02 | Duke University | Liječenje raka dojke pozitivnog na receptor estrogena uporabom selektivnih modulatora receptora estrogena |
| US10093620B2 (en) | 2014-09-12 | 2018-10-09 | Pellficure Pharmaceuticals, Inc. | Compositions and methods for treatment of prostate carcinoma |
| ES2913470T3 (es) | 2016-06-22 | 2022-06-02 | Ellipses Pharma Ltd | Métodos de tratamiento de cáncer de mama AR+ |
| CA3044812A1 (en) | 2016-10-24 | 2018-05-03 | Pellficure Pharmaceuticals Inc. | Pharmaceutical compositions of 5-hydroxy-2-methylnaphthalene-1,4-dione |
| AU2018205285C9 (en) | 2017-01-05 | 2024-05-23 | Radius Pharmaceuticals, Inc. | Polymorphic forms of RAD1901-2HCl |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CS229934B2 (en) * | 1981-07-07 | 1984-07-16 | Pfizer | Production method subst.indolylacryte acid derivative |
| GB8518743D0 (en) * | 1985-07-24 | 1985-08-29 | Glaxo Group Ltd | Heterocyclic compounds |
-
1993
- 1993-05-21 GB GB939310635A patent/GB9310635D0/en active Pending
-
1994
- 1994-05-02 ZA ZA943494A patent/ZA943494B/xx unknown
- 1994-05-17 TW TW083104441A patent/TW279866B/zh active
- 1994-05-19 HU HU9503321A patent/HUT73790A/hu unknown
- 1994-05-19 EP EP94917647A patent/EP0699196A1/en not_active Withdrawn
- 1994-05-19 CN CN94192683A patent/CN1126473A/zh active Pending
- 1994-05-19 JP JP7500181A patent/JPH08510455A/ja active Pending
- 1994-05-19 SK SK1424-95A patent/SK142495A3/sk unknown
- 1994-05-19 CZ CZ953051A patent/CZ305195A3/cs unknown
- 1994-05-19 WO PCT/EP1994/001613 patent/WO1994027989A1/en not_active Ceased
- 1994-05-19 CA CA002162921A patent/CA2162921A1/en not_active Abandoned
- 1994-05-19 PL PL94311702A patent/PL311702A1/xx unknown
- 1994-05-19 AU AU69287/94A patent/AU6928794A/en not_active Abandoned
- 1994-05-20 IL IL10970394A patent/IL109703A0/xx unknown
- 1994-11-18 PE PE1994255110A patent/PE31195A1/es not_active Application Discontinuation
-
1995
- 1995-11-17 OA OA60742A patent/OA10195A/en unknown
- 1995-11-20 FI FI955587A patent/FI955587A7/fi not_active Application Discontinuation
- 1995-11-20 NO NO954681A patent/NO954681D0/no unknown
- 1995-11-21 BG BG100154A patent/BG100154A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL311702A1 (en) | 1996-03-04 |
| FI955587A0 (fi) | 1995-11-20 |
| TW279866B (cg-RX-API-DMAC10.html) | 1996-07-01 |
| PE31195A1 (es) | 1995-10-18 |
| CA2162921A1 (en) | 1994-12-08 |
| AU6928794A (en) | 1994-12-20 |
| ZA943494B (en) | 1995-01-23 |
| SK142495A3 (en) | 1996-06-05 |
| NO954681L (no) | 1995-11-20 |
| WO1994027989A1 (en) | 1994-12-08 |
| CZ305195A3 (en) | 1996-06-12 |
| IL109703A0 (en) | 1994-08-26 |
| HUT73790A (en) | 1996-09-30 |
| OA10195A (en) | 1996-12-18 |
| GB9310635D0 (en) | 1993-07-07 |
| JPH08510455A (ja) | 1996-11-05 |
| NO954681D0 (no) | 1995-11-20 |
| HU9503321D0 (en) | 1996-01-29 |
| FI955587A7 (fi) | 1995-11-20 |
| CN1126473A (zh) | 1996-07-10 |
| EP0699196A1 (en) | 1996-03-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BG100154A (en) | Carbazole derivatibes having inhibiting effect to 17,20-lyase | |
| TW358808B (en) | Morpholine derivatives, preparation thereof and pharmaceutical composition containing the same | |
| PH23739A (en) | Piperidine derivative and pharmaceutical composition | |
| UA41251C2 (uk) | Гідровані азотвмісні гетероциклічні сполуки, похідні піперидину, фармацевтична композиція та спосіб пригнічення активності речовини р в організмі | |
| ES8303411A1 (es) | Un procedimiento para la preparacion de derivados de tiofilina o teobromina. | |
| IL108259A0 (en) | Piperazine derivates, their preparation and pharmaceutical compositions containing them | |
| NZ214787A (en) | Arylcyclobutylalkylamines and pharmaceutical compositions | |
| ES8506629A1 (es) | Un procedimiento para preparar derivados de piridina | |
| IL72475A0 (en) | 1,4-dihydropyridine derivatives and pharmaceutical compositions containing them | |
| DE3661913D1 (en) | Derivatives of 2,3-dihydro-benzofurane, processes for their preparation and pharmaceutical compositions containing them | |
| HUT62563A (en) | Process for producing 4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydroproin derivatives and pharmaceutical compositions comprising same | |
| HUT50327A (en) | Process for producing 2-square brackets open /piperidin-4-yl/-methyl square brackets closed-1,2,3,4-tetrahydro-isoquinoline derivatives and pharmaceutical compositions comprising same | |
| ES8203867A1 (es) | Procedimiento para la obtencion de derivados de benzotiazol | |
| YU48399B (sh) | Jedinjenja 7-acil-3-(supstituisanih karbamoiloksi) cefema i postupak za njihovo dobijanje | |
| EP0315434A3 (en) | Pyridoxal hydrazone derivatives their production and use and pharmaceutical compositions containing the same | |
| ES8801637A1 (es) | Un procedimiento para la preparacion de benzimidazoles. | |
| IL115085A (en) | Piperazine bicyclic carboxamide derivatives their preparation and pharmaceutical compositions containing them | |
| TW333525B (en) | New perhydroisoindole derivatives, their preparation and the pharmaceutical compositions which contain them the invention relates to perhydroisoindole derivatives of general formula (I), and their salts when they exist advantageously as neurokinin A antagonists. | |
| ES8406442A1 (es) | Un procedimiento para preparar compuestos de acido quinolilacetico | |
| IL92646A0 (en) | Imidazolyl and pyridyl derivatives of phenyl substituted 1,4-dihydropyridines,their preparation and pharmaceutical compositions containing them | |
| ES2009553A6 (es) | Procedimiento de preparacion de nuevos derivados del acido 2-(2,3-dihidrido-2-oxo-3-benzofuranil)-acetico. | |
| ES8105981A1 (es) | Procedimiento para la preparacion de derivados de 4-(nafta- leniloxi)piperidina | |
| DE3470039D1 (en) | 2-aminoethyl pyridine or pyrazine derivatives, their preparation and pharmaceutical compositions containing them | |
| ATE132858T1 (de) | 4-cinnolinon-derivate, ihre herstellung und ihre verwendung als arzneimittel | |
| GB1080496A (en) | Improvements in or relating to a new derivatives of 2,4,6-triiodo-3-hydroxy-benzene and process for preparing the same |