AU6928794A - Carbazole derivatives with 17,20-lyase-inhibiting activity - Google Patents

Carbazole derivatives with 17,20-lyase-inhibiting activity

Info

Publication number
AU6928794A
AU6928794A AU69287/94A AU6928794A AU6928794A AU 6928794 A AU6928794 A AU 6928794A AU 69287/94 A AU69287/94 A AU 69287/94A AU 6928794 A AU6928794 A AU 6928794A AU 6928794 A AU6928794 A AU 6928794A
Authority
AU
Australia
Prior art keywords
compound
formula
group
carbazole
fluoro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU69287/94A
Other languages
English (en)
Inventor
Peter Clive Cherry
John Derek Cocker
Andrew David Searle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of AU6928794A publication Critical patent/AU6928794A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU69287/94A 1993-05-21 1994-05-19 Carbazole derivatives with 17,20-lyase-inhibiting activity Abandoned AU6928794A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB939310635A GB9310635D0 (en) 1993-05-21 1993-05-21 Chemical compounds
GB9310635 1993-05-21
PCT/EP1994/001613 WO1994027989A1 (en) 1993-05-21 1994-05-19 Carbazole derivatives with 17,20-lyase-inhibiting activity

Publications (1)

Publication Number Publication Date
AU6928794A true AU6928794A (en) 1994-12-20

Family

ID=10736007

Family Applications (1)

Application Number Title Priority Date Filing Date
AU69287/94A Abandoned AU6928794A (en) 1993-05-21 1994-05-19 Carbazole derivatives with 17,20-lyase-inhibiting activity

Country Status (19)

Country Link
EP (1) EP0699196A1 (cg-RX-API-DMAC10.html)
JP (1) JPH08510455A (cg-RX-API-DMAC10.html)
CN (1) CN1126473A (cg-RX-API-DMAC10.html)
AU (1) AU6928794A (cg-RX-API-DMAC10.html)
BG (1) BG100154A (cg-RX-API-DMAC10.html)
CA (1) CA2162921A1 (cg-RX-API-DMAC10.html)
CZ (1) CZ305195A3 (cg-RX-API-DMAC10.html)
FI (1) FI955587A0 (cg-RX-API-DMAC10.html)
GB (1) GB9310635D0 (cg-RX-API-DMAC10.html)
HU (1) HUT73790A (cg-RX-API-DMAC10.html)
IL (1) IL109703A0 (cg-RX-API-DMAC10.html)
NO (1) NO954681L (cg-RX-API-DMAC10.html)
OA (1) OA10195A (cg-RX-API-DMAC10.html)
PE (1) PE31195A1 (cg-RX-API-DMAC10.html)
PL (1) PL311702A1 (cg-RX-API-DMAC10.html)
SK (1) SK142495A3 (cg-RX-API-DMAC10.html)
TW (1) TW279866B (cg-RX-API-DMAC10.html)
WO (1) WO1994027989A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA943494B (cg-RX-API-DMAC10.html)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ273681A (en) * 1993-09-30 1996-09-25 Yamanouchi Pharma Co Ltd Fluoroenylmethylazole derivatives (including tricyclic ring systems where the middle ring is heterosubstituted)
WO1996014090A1 (en) * 1994-11-07 1996-05-17 Janssen Pharmaceutica N.V. Compositions comprising carbazoles and cyclodextrins
EP0820989A4 (en) * 1995-03-01 1998-05-06 Yamanouchi Pharma Co Ltd IMIDAZOLE DERIVATIVES AND MEDICINAL COMPOSITION BASED ON SAID DERIVATIVES
US6420375B1 (en) * 1997-02-21 2002-07-16 Takeda Chemical Industries, Ltd. Fused ring compounds, process for producing the same and use thereof
AR034854A1 (es) 2000-11-17 2004-03-24 Takeda Chemical Industries Ltd Compuesto de imidazol condensado, prodroga del mismo, composición farmaceutica y agente para reducir androgenos que lo contienen ,metodo para producirlo, sal diastereomerica de dicho compuesto y metodo para producir un compuesto opticamente activo del compuesto
CA2429437A1 (en) 2000-11-20 2002-05-23 Takeda Chemical Industries, Ltd. Imidazole derivatives, process for their preparation and their use
EP1348706B1 (en) 2000-12-08 2009-08-19 Takeda Pharmaceutical Company Limited Substituted thiazole derivatives bearing 3-pyridyl groups, process for preparing the same and use thereof
DE602006012322D1 (de) * 2005-06-24 2010-04-01 Lilly Co Eli Als androgen-rezeptor-modulatoren verwendbare tetrahydrocarbazol-derivate
GB0525323D0 (en) 2005-12-13 2006-01-18 Sterix Ltd Compound
US8093279B2 (en) 2005-12-13 2012-01-10 Gillian Reed, legal representative Compound
CN100586932C (zh) * 2007-01-26 2010-02-03 中国医学科学院医药生物技术研究所 抗肿瘤化合物及其制备方法
NZ596488A (en) 2009-06-26 2012-11-30 Novartis Ag 1, 3-disubstituted imidazolidin-2-one derivatives as inhibitors of cyp 17
WO2011097496A1 (en) * 2010-02-04 2011-08-11 Radius Health, Inc. Selective androgen receptor modulators
MX342898B (es) 2010-05-12 2016-10-18 Radius Health Inc * Regimen terapéutico de la sal de diclorhidrato del (r) -6-(2-(etil (4-2(etilamino) etil) bencil) amino)-4-metoxifenil)-5, 6,7,8-tetrahidronaftaleno-2-ol.
EP2600855A2 (en) 2010-08-04 2013-06-12 Pellficure Pharmaceuticals, Inc. Combination therapy for the treatment of prostate carcinoma
US8946260B2 (en) 2010-09-16 2015-02-03 Novartis Ag 17α-hydroxylase/C17,20-lyase inhibitors
ES2550319T3 (es) 2010-09-28 2015-11-06 Radius Health, Inc Moduladores selectivos del receptor de andrógenos
EP2702052B1 (en) 2011-04-28 2017-10-18 Novartis AG 17alpha-hydroxylase/c17,20-lyase inhibitors
US9492460B2 (en) * 2013-02-27 2016-11-15 Bristol-Myers Squibb Company Carbazole compounds useful as bromodomain inhibitors
WO2014158875A1 (en) 2013-03-14 2014-10-02 Pellficure Pharmaceuticals Inc. Novel therapy for prostate carcinoma
SI3122426T1 (sl) 2014-03-28 2023-04-28 Duke University Zdravljenje raka dojk z uporabo selektivnih modulatorjev estrogenskih receptorjev
US9421264B2 (en) 2014-03-28 2016-08-23 Duke University Method of treating cancer using selective estrogen receptor modulators
WO2016040896A1 (en) 2014-09-12 2016-03-17 Pellficure Pharmaceuticals, Inc. Compositions and methods for treatment of prostate carcinoma
CA3027563C (en) 2016-06-22 2024-07-02 Ellipses Pharma Ltd AR+ METHODS FOR BREAST CANCER TREATMENT
AU2017350690A1 (en) 2016-10-24 2019-06-13 Pellficure Pharmaceuticals Inc. Pharmaceutical compositions of 5-hydroxy-2-methylnaphthalene-1, 4-dione
ES2981967T3 (es) 2017-01-05 2024-10-14 Radius Pharmaceuticals Inc Formas polimórficas de RAD1901-2HCl

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS229934B2 (en) * 1981-07-07 1984-07-16 Pfizer Production method subst.indolylacryte acid derivative
GB8518743D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Heterocyclic compounds

Also Published As

Publication number Publication date
NO954681D0 (no) 1995-11-20
GB9310635D0 (en) 1993-07-07
HU9503321D0 (en) 1996-01-29
IL109703A0 (en) 1994-08-26
CA2162921A1 (en) 1994-12-08
PL311702A1 (en) 1996-03-04
NO954681L (no) 1995-11-20
BG100154A (en) 1996-07-31
EP0699196A1 (en) 1996-03-06
CN1126473A (zh) 1996-07-10
SK142495A3 (en) 1996-06-05
TW279866B (cg-RX-API-DMAC10.html) 1996-07-01
CZ305195A3 (en) 1996-06-12
JPH08510455A (ja) 1996-11-05
FI955587A7 (fi) 1995-11-20
WO1994027989A1 (en) 1994-12-08
FI955587A0 (fi) 1995-11-20
HUT73790A (en) 1996-09-30
OA10195A (en) 1996-12-18
PE31195A1 (es) 1995-10-18
ZA943494B (en) 1995-01-23

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