KR960704852A - 아졸 유도체 및 이의 약제학적 조성물 (Azole derivative and pharmaceutical composition thereof) - Google Patents
아졸 유도체 및 이의 약제학적 조성물 (Azole derivative and pharmaceutical composition thereof)Info
- Publication number
- KR960704852A KR960704852A KR1019960701595A KR19960701595A KR960704852A KR 960704852 A KR960704852 A KR 960704852A KR 1019960701595 A KR1019960701595 A KR 1019960701595A KR 19960701595 A KR19960701595 A KR 19960701595A KR 960704852 A KR960704852 A KR 960704852A
- Authority
- KR
- South Korea
- Prior art keywords
- group
- different
- same
- general formula
- lower alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
본 발명은 다음 일반식(Ⅰ)의 아졸 유도체, 이의 염, 이의 수화물 또는 이의 용매화물에 관한 것이다.
상기 식에서 R1및 R2는 동일하거나 서로 상이하며 각각 수소원자, 저급 알킬 그룹, 또는 할로겐 원자에 의해 치환될 수 있는 페닐 그룹이고, A,B 및 D는 동일하거나 서로 상이하며 각각 일반식의 그룹이거나 질소원자이고 X 및 Y는 동일하거나 서로 상이하며 각각 단일결합, 메틸렌 그룹, 산소원자, 일반식 S(O)n의 그루, 또는 일반식의 그룹이고 R3및 R4는 동일하거나 서로 상이하며 각각 수소원자 또는 저급알킬 그룹이고 n은 0,1 또는 2이다.
이 화합물은 스테로이드 17~20리아제를 억제하는 작용이있으며 전립선 암, 전립선 비대, 남성증, 유방암, 유선증, 자궁근종 및 자궁내막증의 예방 및 치료 제제로서 유용하다.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (8)
- 다음 일반식(Ⅰ)의 아졸 유도체, 이의 염, 이의 수화물 또는 이의 용매화물.상기 식에서 R1및 R2는 동일하거나 서로 상이하며 각각 수소원자, 저급 알킬 그룹, 또는 할로겐 원자에 의해 치환될 수 있는 페닐 그룹이고 A,B 및 D는 동일하거나 서로 상이하며 각각 일반식의 그룹이거나 질소원자이고 X 및 Y는 동일하거나 서로 상이하며 각각 단일결합, 메틸렌 그룹, 산소원자, 일반식 S(P)n의 그룹 또는 일반식의 그룹이고 R3및 R4는 동일하거나 서로 상이하며 각각 수소원자 또는 저급 알킬 그룹이고 n은 0,1또는 2이다.
- 제1항에 있어서 R1및 R2가 동일하거나 서로 상이하며 각각 수소원자 또는 저급 알킬 그룹이고 Z가 단일결합 또는 일반식 S(O)n의 그룹이고 Y가 메틸렌 그룹, 일반식 S(O)n의 그룹 또는 일반식의 그룹인 아졸 유도체 또는 이의 염.
- 제1항에 있어서 Z가 단일결합이고 Y가 메틸렌 그룹인 아졸 유도체 또는 이의염.
- 제1항에 있어서 1-「1-(9H-플루오렌-2-일)에틸」-1H-이미다졸인 아졸 유도체 또는 이의 염.
- 제1항의 아졸 유도체 또는 이의 약제학적으로 허용되는 염을 활성 성분으로서 포함하는 약제학적 조성물.
- 제1항의 아졸 유도체 또는 이의 약제학적으로 허용되는 염을 활성 성분으로서 함유하는 스테로이드 17~20 리아제 억제제.
- 제6항에 있어서 전립선 암, 전립선 비대, 남성증, 다모증, 유방암, 유선증, 자궁근종 및 자궁내막증의 예방/치료제인 스테로이드 17~20 리아제 억제제.
- 제6항 또는 제7항에 있어서 1-「1-(9H-플루오렌-2-일)에틸」-1H-이미다졸 또는 이의 약제학적으로 허용되는 염을 활성 성분으로서 포함하는 스테로이드 17~20 리아제 억제제.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP93-244944 | 1993-09-30 | ||
JP24494493 | 1993-09-30 | ||
PCT/JP1994/001593 WO1995009157A1 (fr) | 1993-09-30 | 1994-09-28 | Derive d'azole et composition pharmaceutique le contenant |
Publications (1)
Publication Number | Publication Date |
---|---|
KR960704852A true KR960704852A (ko) | 1996-10-09 |
Family
ID=17126291
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019960701595A KR960704852A (ko) | 1993-09-30 | 1994-09-28 | 아졸 유도체 및 이의 약제학적 조성물 (Azole derivative and pharmaceutical composition thereof) |
Country Status (12)
Country | Link |
---|---|
US (1) | US5807880A (ko) |
EP (1) | EP0721943A4 (ko) |
KR (1) | KR960704852A (ko) |
CN (1) | CN1131944A (ko) |
AU (1) | AU679119B2 (ko) |
CA (1) | CA2170874A1 (ko) |
FI (1) | FI961418A0 (ko) |
HU (1) | HUT75871A (ko) |
NO (1) | NO961274D0 (ko) |
NZ (1) | NZ273681A (ko) |
PL (1) | PL313769A1 (ko) |
WO (1) | WO1995009157A1 (ko) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA977103B (en) | 1996-08-09 | 1999-02-08 | Eisai Co Ltd | Benzopiperidine derivatives |
AU6229698A (en) | 1997-02-21 | 1998-09-09 | Takeda Chemical Industries Ltd. | Fused ring compounds, process for producing the same and use thereof |
US6559157B2 (en) | 1997-10-02 | 2003-05-06 | Daiichi Pharmaceutical Co., Ltd. | Dihydronaphthalene compounds |
WO1999018075A1 (fr) * | 1997-10-02 | 1999-04-15 | Yukijirushi Nyugyo Kabushiki Kaisha | Nouveaux composes a base de dihydronaphtalene et leur procede de production |
JP4546589B2 (ja) * | 1998-04-23 | 2010-09-15 | 武田薬品工業株式会社 | ナフタレン誘導体 |
ATE293102T1 (de) | 1998-04-23 | 2005-04-15 | Takeda Pharmaceutical | Naphthalene derivate ,ihre herstellung und verwendung |
EP1227086B1 (en) * | 1999-10-22 | 2006-03-29 | Takeda Pharmaceutical Company Limited | 1-substituted phenyl-1-(1h-imidazol-4-yl) alcohols, process for producing the same and use thereof |
JP4520012B2 (ja) * | 1999-10-22 | 2010-08-04 | 武田薬品工業株式会社 | 1−置換−1−(1h−イミダゾール−4−イル)メタノール類 |
PE20010781A1 (es) * | 1999-10-22 | 2001-08-08 | Takeda Chemical Industries Ltd | Compuestos 1-(1h-imidazol-4-il)-1-(naftil-2-sustituido)etanol, su produccion y utilizacion |
KR100725442B1 (ko) | 2000-11-17 | 2007-06-07 | 다케다 야쿠힌 고교 가부시키가이샤 | 신규 이미다졸 유도체, 이의 제조 방법 및 이의 용도 |
AU2002214320A1 (en) | 2000-11-20 | 2002-05-27 | Takeda Chemical Industries Ltd. | Imidazole derivatives, process for their preparation and their use |
AU2002221080A1 (en) | 2000-12-08 | 2002-06-18 | Masami Kusaka | Substituted thiazole derivatives bearing 3-pyridyl groups, process for preparingthe same and use thereof |
US20060177506A1 (en) * | 2003-03-17 | 2006-08-10 | Shigeo Yanai | Release control compositions |
WO2008021250A2 (en) * | 2006-08-10 | 2008-02-21 | Fred Hutchinson Cancer Research Center | Compositions and methods for modulating apoptosis in cells over-expressing bcl-2 family member proteins |
MY155570A (en) | 2009-06-26 | 2015-10-30 | Novartis Ag | 1, 3-disubstituted imidazolidin-2-one derivatives as inhibitors of cyp 17 |
WO2011041731A2 (en) | 2009-10-02 | 2011-04-07 | Fred Hutchinson Cancer Research Center | Method of inhibiting bcl-2-related survival proteins |
WO2011041737A2 (en) | 2009-10-02 | 2011-04-07 | Fred Hutchinson Cancer Research Center | Gain-of-function bcl-2 inhibitors |
WO2012018948A2 (en) | 2010-08-04 | 2012-02-09 | Pellficure Pharmaceuticals, Inc. | Novel treatment of prostate carcinoma |
WO2012035078A1 (en) | 2010-09-16 | 2012-03-22 | Novartis Ag | 17α-HYDROXYLASE/C17,20-LYASE INHIBITORS |
EP2651905B1 (en) * | 2010-12-13 | 2017-07-19 | Innocrin Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
EP2702052B1 (en) | 2011-04-28 | 2017-10-18 | Novartis AG | 17alpha-hydroxylase/c17,20-lyase inhibitors |
JP5990059B2 (ja) * | 2012-08-03 | 2016-09-07 | 花王株式会社 | StAR発現抑制剤 |
JP6275378B2 (ja) * | 2012-12-26 | 2018-02-07 | エヌ・イーケムキャット株式会社 | カルバゾール類の製造方法およびこの方法により製造されたカルバゾール類。 |
US20160022606A1 (en) | 2013-03-14 | 2016-01-28 | Pellficure Pharmaceuticals Inc. | Novel therapy for prostate carcinoma |
US10093620B2 (en) | 2014-09-12 | 2018-10-09 | Pellficure Pharmaceuticals, Inc. | Compositions and methods for treatment of prostate carcinoma |
EP3528799A1 (en) | 2016-10-24 | 2019-08-28 | Pellficure Pharmaceuticals, Inc. | Pharmaceutical compositions of 5-hydroxy-2-methylnaphthalene-1, 4-dione |
CN109748884B (zh) * | 2019-02-19 | 2022-06-24 | 成都恒昊创新科技有限公司 | 一种铁死亡抑制剂及其制备方法与应用 |
JP7433292B2 (ja) * | 2018-04-27 | 2024-02-19 | チョンドゥー ホンハオ インベストメント カンパニー リミテッド | 10h-フェノチアジン系フェロトーシス阻害剤、その製造方法、及び用途 |
WO2021098715A1 (zh) * | 2019-11-21 | 2021-05-27 | 成都恒昊投资有限公司 | 一种吩噻嗪类铁死亡抑制剂及其制备方法和用途 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ221729A (en) * | 1986-09-15 | 1989-07-27 | Janssen Pharmaceutica Nv | Imidazolyl methyl-substituted benzimidazole derivatives and pharmaceutical compositions |
DE3942227A1 (de) * | 1989-12-21 | 1991-06-27 | Bayer Ag | Triarylmethan-farbbildner |
GB9310635D0 (en) * | 1993-05-21 | 1993-07-07 | Glaxo Group Ltd | Chemical compounds |
WO1995004723A1 (fr) * | 1993-08-04 | 1995-02-16 | Yamanouchi Pharmaceutical Co., Ltd. | Derive d'imidazolylalkylamine et composition pharmaceutique contenant ledit derive |
-
1994
- 1994-09-28 WO PCT/JP1994/001593 patent/WO1995009157A1/ja not_active Application Discontinuation
- 1994-09-28 AU AU77071/94A patent/AU679119B2/en not_active Ceased
- 1994-09-28 EP EP94927788A patent/EP0721943A4/en not_active Withdrawn
- 1994-09-28 CA CA002170874A patent/CA2170874A1/en not_active Abandoned
- 1994-09-28 KR KR1019960701595A patent/KR960704852A/ko not_active Application Discontinuation
- 1994-09-28 US US08/619,629 patent/US5807880A/en not_active Expired - Fee Related
- 1994-09-28 HU HU9600813A patent/HUT75871A/hu unknown
- 1994-09-28 CN CN94193503A patent/CN1131944A/zh active Pending
- 1994-09-28 NZ NZ273681A patent/NZ273681A/en unknown
- 1994-09-28 PL PL94313769A patent/PL313769A1/xx unknown
-
1996
- 1996-03-29 FI FI961418A patent/FI961418A0/fi unknown
- 1996-03-29 NO NO961274A patent/NO961274D0/no unknown
Also Published As
Publication number | Publication date |
---|---|
FI961418A (fi) | 1996-03-29 |
PL313769A1 (en) | 1996-07-22 |
NO961274L (no) | 1996-03-29 |
HU9600813D0 (en) | 1996-05-28 |
NZ273681A (en) | 1996-09-25 |
AU7707194A (en) | 1995-04-18 |
EP0721943A4 (en) | 1996-09-04 |
FI961418A0 (fi) | 1996-03-29 |
AU679119B2 (en) | 1997-06-19 |
EP0721943A1 (en) | 1996-07-17 |
CN1131944A (zh) | 1996-09-25 |
WO1995009157A1 (fr) | 1995-04-06 |
CA2170874A1 (en) | 1995-04-06 |
HUT75871A (en) | 1997-05-28 |
NO961274D0 (no) | 1996-03-29 |
US5807880A (en) | 1998-09-15 |
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Legal Events
Date | Code | Title | Description |
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WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |