BE902726A - Derives de l'acide glutamique et de l'acide aspartique ayant des activites antagonistes vis-a-vis de polypeptides bioactifs. - Google Patents
Derives de l'acide glutamique et de l'acide aspartique ayant des activites antagonistes vis-a-vis de polypeptides bioactifs.Info
- Publication number
- BE902726A BE902726A BE0/215244A BE215244A BE902726A BE 902726 A BE902726 A BE 902726A BE 0/215244 A BE0/215244 A BE 0/215244A BE 215244 A BE215244 A BE 215244A BE 902726 A BE902726 A BE 902726A
- Authority
- BE
- Belgium
- Prior art keywords
- derivatives
- respect
- glutamic acid
- aspartic acid
- acid
- Prior art date
Links
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title 1
- 235000003704 aspartic acid Nutrition 0.000 title 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 title 1
- 230000000975 bioactive effect Effects 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000006165 cyclic alkyl group Chemical group 0.000 abstract 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N glutamic acid Chemical class OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229960005181 morphine Drugs 0.000 abstract 1
- -1 morpholino, piperidino Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/66—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT67644/84A IT1178982B (it) | 1984-06-25 | 1984-06-25 | Derivati del acido gludamico aventi attivita antagonista su polipep tidi bioattivi e procedimento per la loro preparazione |
| IT68070/84A IT1196751B (it) | 1984-10-26 | 1984-10-26 | Alogeno e ciano derivati dell'acido glutammico ed aspartico ad attivita antagonista su polipeptidi bioattivi e procedimento per la loro preparazione |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE902726A true BE902726A (fr) | 1985-10-16 |
Family
ID=26329809
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE0/215244A BE902726A (fr) | 1984-06-25 | 1985-06-21 | Derives de l'acide glutamique et de l'acide aspartique ayant des activites antagonistes vis-a-vis de polypeptides bioactifs. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US4791215A (enExample) |
| AT (1) | AT390949B (enExample) |
| AU (1) | AU566601B2 (enExample) |
| BE (1) | BE902726A (enExample) |
| CA (1) | CA1325633C (enExample) |
| CH (1) | CH674203A5 (enExample) |
| DE (1) | DE3522506A1 (enExample) |
| DK (1) | DK285685A (enExample) |
| ES (1) | ES8604859A1 (enExample) |
| FR (1) | FR2566397B1 (enExample) |
| GB (1) | GB2160869B (enExample) |
| IE (1) | IE57892B1 (enExample) |
| NL (1) | NL8501829A (enExample) |
| NZ (1) | NZ212436A (enExample) |
| SE (1) | SE503111C2 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1215169B (it) * | 1985-12-17 | 1990-01-31 | Rotta Research Lab | Derivati alchil ossigenati degli acidi glutammico ed aspartico ad attivita antagonista su polipeptidi bioattivi e procedimento per la loro preparazione |
| IT1196849B (it) * | 1986-02-16 | 1988-11-25 | Rotta Research Lab | Nuovi derivati degli acidi 5 pentilammino 5 oxo pentaoico e 4 pentilammino 4 oxo butanoico ad attivita antagonista della colecistochinina e procedimento per la loro preparazione |
| US4880938A (en) * | 1986-06-16 | 1989-11-14 | Merck & Co., Inc. | Amino acid analogs |
| US5089638A (en) * | 1986-06-16 | 1992-02-18 | Merck & Co., Inc. | Amino acid analogs as CCK-antagonists |
| IT1217123B (it) * | 1987-02-05 | 1990-03-14 | Rotta Research Lab | Derivati otticamente attivi dell acido 5 pentilammino 5 oxo pentanoico r ad attivita antagonista della colecistochinina e procedimento per la loro preparazione |
| US4971978A (en) * | 1987-09-21 | 1990-11-20 | Nadzan Alex M | Derivatives of D-glutamic acid and D-aspartic acid |
| WO1990003399A1 (en) * | 1988-09-30 | 1990-04-05 | Australian Commercial Research & Development Limited | Amino acid transport proteins, amino acid analogues, assay apparatus, uses thereof for treatment and diagnosis of cancer |
| FR2643371B1 (fr) * | 1989-02-17 | 1993-11-05 | Roussel Uclaf | Nouveaux derives de l'acide 2-amino pentanedioique, leur procede de preparation et leur application comme medicaments |
| DE69017302T3 (de) * | 1989-08-04 | 1999-08-05 | Merck Sharp & Dohme Ltd., Hoddesdon, Hertfordshire | Zentrale Cholecystokinin-Antagonisten zur Behandlung von psychiatrischen Krankheiten. |
| IE912285A1 (en) * | 1990-07-12 | 1992-01-15 | Black James Foundation | Amino acid derivatives |
| IT1241029B (it) * | 1990-12-11 | 1993-12-27 | Rotta Research Lab | Derivati amidici biciclici e policiclici degli acidi glutammico, aspartico e 2-ammino adipico ad attivita' antigastrinica e procedimento per la loro preparazione |
| US5217957A (en) * | 1991-08-20 | 1993-06-08 | Warner-Lambert Company | Cholecystokinin antagonists useful for treating depression |
| US5153191A (en) * | 1991-08-20 | 1992-10-06 | Warner-Lambert Company | Cholecystokinin antagonists useful for treating depression |
| EP0617621A4 (en) * | 1991-12-20 | 1995-04-05 | Merck Sharp & Dohme | CENTRAL CHOLECYSTOKININE ANTAGONISTS WITH PHARMACEUTICAL EFFECTIVENESS. |
| US5716958A (en) * | 1994-10-27 | 1998-02-10 | Tobishi Pharmaceutical Co., Ltd. | Amino acid derivative having anti-CCK activity |
| GB9721746D0 (en) * | 1997-10-15 | 1997-12-10 | Panos Therapeutics Limited | Compositions |
| EP2491980A2 (en) * | 2003-11-27 | 2012-08-29 | Shiseido Company Limited | Parakeratosis inhibitor and skin preparation for external use |
| CN108912007B (zh) * | 2018-06-20 | 2021-02-26 | 中国农业科学院兰州畜牧与兽药研究所 | 一种右氯谷胺的制备方法 |
| WO2020093188A1 (zh) * | 2018-11-05 | 2020-05-14 | 黄华成 | 天门冬氨酸脂肪酰基衍生物在制备动物饲料添加剂中的应用 |
| EP3888471A4 (en) * | 2018-12-18 | 2021-12-22 | Peng, Xianfeng | USE OF A GLUTAMINE DERIVATIVE IN THE MANUFACTURE OF ANIMAL FEED ADDITIVE |
| CN113272273B (zh) * | 2019-08-15 | 2023-09-15 | 弗门尼舍有限公司 | 味道改良化合物及其用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2828327A (en) * | 1953-12-17 | 1958-03-25 | Monsanto Chemicals | Esters of n-aroylaspartic acids |
| US3551419A (en) * | 1964-07-31 | 1970-12-29 | Rotta Research Lab | Amino acid amides and process for their production |
| JPS5111608B2 (enExample) * | 1972-06-07 | 1976-04-13 |
-
1985
- 1985-06-17 IE IE1502/85A patent/IE57892B1/en not_active IP Right Cessation
- 1985-06-17 NZ NZ212436A patent/NZ212436A/xx unknown
- 1985-06-18 US US06/746,065 patent/US4791215A/en not_active Expired - Lifetime
- 1985-06-18 CA CA000484341A patent/CA1325633C/en not_active Expired - Fee Related
- 1985-06-19 GB GB08515555A patent/GB2160869B/en not_active Expired
- 1985-06-20 FR FR8509383A patent/FR2566397B1/fr not_active Expired
- 1985-06-20 CH CH2617/85A patent/CH674203A5/it not_active IP Right Cessation
- 1985-06-20 SE SE8503097A patent/SE503111C2/sv not_active IP Right Cessation
- 1985-06-21 BE BE0/215244A patent/BE902726A/fr not_active IP Right Cessation
- 1985-06-22 ES ES544462A patent/ES8604859A1/es not_active Expired
- 1985-06-24 DK DK285685A patent/DK285685A/da not_active Application Discontinuation
- 1985-06-24 AU AU44109/85A patent/AU566601B2/en not_active Ceased
- 1985-06-24 AT AT0186985A patent/AT390949B/de not_active IP Right Cessation
- 1985-06-24 DE DE19853522506 patent/DE3522506A1/de active Granted
- 1985-06-25 NL NL8501829A patent/NL8501829A/nl not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| FR2566397B1 (fr) | 1988-08-05 |
| GB2160869B (en) | 1988-03-16 |
| AU566601B2 (en) | 1987-10-22 |
| AU4410985A (en) | 1986-01-02 |
| DE3522506C2 (enExample) | 1988-03-10 |
| IE851502L (en) | 1985-12-22 |
| SE8503097L (sv) | 1985-12-26 |
| DE3522506A1 (de) | 1986-01-02 |
| DK285685A (da) | 1985-12-26 |
| AT390949B (de) | 1990-07-25 |
| GB8515555D0 (en) | 1985-07-24 |
| NZ212436A (en) | 1989-04-26 |
| DK285685D0 (da) | 1985-06-24 |
| ES544462A0 (es) | 1986-03-16 |
| CH674203A5 (enExample) | 1990-05-15 |
| NL8501829A (nl) | 1986-01-16 |
| CA1325633C (en) | 1993-12-28 |
| ES8604859A1 (es) | 1986-03-16 |
| US4791215A (en) | 1988-12-13 |
| ATA186985A (de) | 1990-01-15 |
| SE503111C2 (sv) | 1996-03-25 |
| IE57892B1 (en) | 1993-05-05 |
| FR2566397A1 (fr) | 1985-12-27 |
| SE8503097D0 (sv) | 1985-06-20 |
| GB2160869A (en) | 1986-01-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RE | Patent lapsed |
Owner name: *ROTTA RESEARCH LABORATORIUM S.P.A. Effective date: 20020630 |