BE898946A - Nouveaux antagonistes des recepteurs de l'adenosine - Google Patents
Nouveaux antagonistes des recepteurs de l'adenosineInfo
- Publication number
- BE898946A BE898946A BE0/212418A BE212418A BE898946A BE 898946 A BE898946 A BE 898946A BE 0/212418 A BE0/212418 A BE 0/212418A BE 212418 A BE212418 A BE 212418A BE 898946 A BE898946 A BE 898946A
- Authority
- BE
- Belgium
- Prior art keywords
- receptor antagonists
- adenosine receptor
- xanthine
- dipropyl
- novel adenosine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
De nouvelles 8-phénylxanthines, comme la 1,3-dipropyl-8-(2-amino-4-chlorophényl)xanthine, la 1,3-dipropyl-8-(2,4-diaminophényl)xanthine, la 8-(2-amino-4-chlorophényl)théophylline et la 1,3-dipropyl-8-phényl-xanthine, sont de puissants antagonistes des récepteurs de l'adénosine. La très haute activité de ces composés permet de les utiliser en concentrations plus faibles que les xanthines déjà connues et ainsi d'atténuer les effets secondaires observés.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/467,894 US4593095A (en) | 1983-02-18 | 1983-02-18 | Xanthine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
BE898946A true BE898946A (fr) | 1984-06-18 |
Family
ID=23857582
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE0/212418A BE898946A (fr) | 1983-02-18 | 1984-02-17 | Nouveaux antagonistes des recepteurs de l'adenosine |
Country Status (10)
Country | Link |
---|---|
US (1) | US4593095A (fr) |
JP (1) | JPS59205377A (fr) |
BE (1) | BE898946A (fr) |
CA (1) | CA1234804A (fr) |
DE (1) | DE3406275A1 (fr) |
FR (1) | FR2541281B1 (fr) |
GB (2) | GB8403574D0 (fr) |
IT (1) | IT1196031B (fr) |
NL (1) | NL8400514A (fr) |
SE (1) | SE456680B (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4755517A (en) * | 1986-07-31 | 1988-07-05 | Warner-Lambert Company | Derivatives of xanthine, pharmaceutical compositions and methods of use therefor |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4769377A (en) * | 1983-02-18 | 1988-09-06 | The Johns Hopkins University | Adenosine receptor antagonists |
US4696932A (en) * | 1984-10-26 | 1987-09-29 | The United States Of America As Represented By The Department Of Health And Human Services | Biologically-active xanthine derivatives |
GB8510758D0 (en) * | 1985-04-27 | 1985-06-05 | Wellcome Found | Compounds |
US5017577A (en) * | 1986-04-25 | 1991-05-21 | Burroughs Wellcome Co. | Methods for treating viral infection |
US4772607A (en) * | 1986-05-20 | 1988-09-20 | Warner-Lambert Company | Dialkenyl derivatives of xanthine, pharmaceutical compositions and methods of use therefor |
US4783530A (en) * | 1986-11-13 | 1988-11-08 | Marion Laboratories, Inc. | 8-arylxanthines |
JPS63154687A (ja) * | 1986-11-13 | 1988-06-27 | マリオン・ラボラトリーズ・インコーポレーテッド | 8ーアリールキサンチン |
US5015647A (en) * | 1987-04-24 | 1991-05-14 | Burroughs Wellcome Co. | Method for treating viral infections |
US5032593A (en) * | 1988-07-01 | 1991-07-16 | Marion Merrell Dow Inc. | Method of treating bronchoconstriction with 1,3-unsymmetrical straight chain alkyl-substituted 8-phenylxanthines |
US5298508A (en) * | 1988-07-19 | 1994-03-29 | The United States Of America As Represented By The Department Of Health And Human Services | Irreversible inhibitors of adenosine receptors |
DE3843117A1 (de) * | 1988-12-22 | 1990-06-28 | Boehringer Ingelheim Kg | Neue xanthinderivate mit adenosin-antagonistischer wirkung |
GB8906792D0 (en) | 1989-03-23 | 1989-05-10 | Beecham Wuelfing Gmbh & Co Kg | Treatment and compounds |
US5047534A (en) * | 1990-03-26 | 1991-09-10 | Merrell Dow Pharmaceuticals Inc. | Selective adenosine receptor agents |
IL100088A (en) * | 1990-11-21 | 1995-07-31 | Smithkline Beecham Corp | FNT inhibitor preparations containing histogenic transducts converted at positions 1, 3, and 8 |
US5484920A (en) * | 1992-04-08 | 1996-01-16 | Kyowa Hakko Kogyo Co., Ltd. | Therapeutic agent for Parkinson's disease |
TW252044B (fr) * | 1992-08-10 | 1995-07-21 | Boehringer Ingelheim Kg | |
JP2613355B2 (ja) * | 1992-09-28 | 1997-05-28 | 協和醗酵工業株式会社 | パーキンソン氏病治療剤 |
US5877179A (en) * | 1992-09-29 | 1999-03-02 | The United States Of America As Represented By The Department Of Health And Human Services | Xanthines for identifying CFTR--binding compounds useful for activating chloride conductance in animal cells |
WO1994025462A1 (fr) * | 1993-05-03 | 1994-11-10 | The United States Of America, Represented By The | Derives de 1,3,7-trialkyl-xanthine substitues en position 8 utiles comme antagonistes de recepteurs d'adenosine a2 a selectivite |
US5504090A (en) * | 1994-03-30 | 1996-04-02 | Trustees Of The University Of Pennsylvania | Compositions and methods for the prevention and treatment of ischemia-reperfusion organ injury |
GB9415529D0 (en) * | 1994-08-01 | 1994-09-21 | Wellcome Found | Phenyl xanthine derivatives |
US6323201B1 (en) | 1994-12-29 | 2001-11-27 | The Regents Of The University Of California | Compounds for inhibition of ceramide-mediated signal transduction |
US6930101B1 (en) | 1999-05-17 | 2005-08-16 | The Regents Of The University Of California | Thiazolopyrimidines useful as TNFα inhibitors |
US6403567B1 (en) | 1999-06-22 | 2002-06-11 | Cv Therapeutics, Inc. | N-pyrazole A2A adenosine receptor agonists |
USRE47351E1 (en) | 1999-06-22 | 2019-04-16 | Gilead Sciences, Inc. | 2-(N-pyrazolo)adenosines with application as adenosine A2A receptor agonists |
ES2166270B1 (es) * | 1999-07-27 | 2003-04-01 | Almirall Prodesfarma Sa | Derivados de 8-fenil-6,9-dihidro-(1,2,4,)triazolo(3,4-i)purin-5-ona. |
US6815446B1 (en) | 1999-08-31 | 2004-11-09 | Vanderbilt University | Selective antagonists of A2B adenosine receptors |
DE60026559T2 (de) * | 1999-10-29 | 2006-12-14 | Kyowa Hakko Kogyo Co., Ltd. | Arzneimittel gegen essstörungen |
CA2439222C (fr) * | 2000-02-23 | 2009-07-14 | Cv Therapeutics, Inc. | Procede permettant d'identifier des agonistes partiels du recepteur a2a |
US20080318983A1 (en) * | 2001-11-09 | 2008-12-25 | Rao Kalla | A2b adenosine receptor antagonists |
US7317017B2 (en) | 2002-11-08 | 2008-01-08 | Cv Therapeutics, Inc. | A2B adenosine receptor antagonists |
US7125993B2 (en) * | 2001-11-09 | 2006-10-24 | Cv Therapeutics, Inc. | A2B adenosine receptor antagonists |
US6977300B2 (en) * | 2001-11-09 | 2005-12-20 | Cv Therapeutics, Inc. | A2B adenosine receptor antagonists |
CN100467469C (zh) | 2001-11-09 | 2009-03-11 | Cv医药有限公司 | A2b腺苷受体拮抗剂 |
BR0302965A (pt) * | 2002-02-01 | 2005-02-09 | King Pharmaceuticals Res & Dev | Composto e método de tratar doenças mediadas por receptores de adenosina a2b |
US8470801B2 (en) | 2002-07-29 | 2013-06-25 | Gilead Sciences, Inc. | Myocardial perfusion imaging methods and compositions |
US20050020915A1 (en) * | 2002-07-29 | 2005-01-27 | Cv Therapeutics, Inc. | Myocardial perfusion imaging methods and compositions |
US7683037B2 (en) * | 2002-07-29 | 2010-03-23 | Gilead Palo Alto, Inc. | Myocardial perfusion imaging method |
JP4929173B2 (ja) * | 2004-09-01 | 2012-05-09 | ギリアード・パロ・アルト・インコーポレイテッド | A2bアデノシンレセプターアンタゴニストを使用する創傷治癒の方法 |
US7655636B2 (en) | 2004-10-20 | 2010-02-02 | Gilead Palo Alto, Inc. | Use of A2A adenosine receptor agonists |
EP1989214B8 (fr) | 2006-02-03 | 2016-12-21 | Gilead Sciences, Inc. | Procede de preparation d'un agoniste de recepteur a2a-adenosine et ses polymorphes |
EP2056834B1 (fr) * | 2006-09-01 | 2012-08-29 | Gilead Sciences, Inc. | Méthodes et compositions permettant d'augmenter la tolérabilité de patients pendant des méthodes d'imagerie myocardique |
US20090081120A1 (en) * | 2006-09-01 | 2009-03-26 | Cv Therapeutics, Inc. | Methods and Compositions for Increasing Patient Tolerability During Myocardial Imaging Methods |
WO2008042796A2 (fr) * | 2006-09-29 | 2008-04-10 | Cv Therapeutics, Inc. | Procédés d'imagerie myocardique chez des patients ayant un historique de maladie pulmonaire |
WO2008086096A2 (fr) * | 2007-01-03 | 2008-07-17 | Cv Therapeutics, Inc. | Imagerie de perfusion myocardique |
MX2011003168A (es) * | 2008-09-29 | 2011-05-19 | Gilead Sciences Inc | Combinaciones de un agente de control de cantidad y un antagonista del receptor a-2-alfa para utilizarse en metodos de tomografia computarizada de detectores multiples. |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2840559A (en) * | 1954-06-22 | 1958-06-24 | Krantz Jr | Nuclearly substituted 8-theophyllines and method of making the same |
DE1091570B (de) * | 1958-10-23 | 1960-10-27 | Albert Ag Chem Werke | Verfahren zur Herstellung von in 8-Stellung substituierten 1, 3-Dialkylxanthinen |
GB982079A (en) * | 1962-05-01 | 1965-02-03 | Dresden Arzneimittel | Process for the production of xanthine derivatives |
NL297352A (fr) * | 1962-08-31 | |||
EP0011399A1 (fr) * | 1978-11-11 | 1980-05-28 | FISONS plc | Théophyllines-N-substituées, procédés pour leur préparation et compositions pharmaceutiques les contenant |
US4452788A (en) * | 1982-04-21 | 1984-06-05 | Warner-Lambert Company | Substituted 8-phenylxanthines |
-
1983
- 1983-02-18 US US06/467,894 patent/US4593095A/en not_active Expired - Fee Related
-
1984
- 1984-02-10 GB GB848403574A patent/GB8403574D0/en active Pending
- 1984-02-14 SE SE8400788A patent/SE456680B/sv not_active IP Right Cessation
- 1984-02-17 BE BE0/212418A patent/BE898946A/fr not_active IP Right Cessation
- 1984-02-17 DE DE19843406275 patent/DE3406275A1/de not_active Ceased
- 1984-02-17 NL NL8400514A patent/NL8400514A/nl not_active Application Discontinuation
- 1984-02-17 GB GB08404243A patent/GB2135311B/en not_active Expired
- 1984-02-17 IT IT19675/84A patent/IT1196031B/it active
- 1984-02-17 CA CA000447705A patent/CA1234804A/fr not_active Expired
- 1984-02-17 FR FR8402472A patent/FR2541281B1/fr not_active Expired
- 1984-02-18 JP JP59028010A patent/JPS59205377A/ja active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4755517A (en) * | 1986-07-31 | 1988-07-05 | Warner-Lambert Company | Derivatives of xanthine, pharmaceutical compositions and methods of use therefor |
Also Published As
Publication number | Publication date |
---|---|
CA1234804A (fr) | 1988-04-05 |
GB2135311A (en) | 1984-08-30 |
SE456680B (sv) | 1988-10-24 |
DE3406275A1 (de) | 1984-09-27 |
NL8400514A (nl) | 1984-09-17 |
GB8404243D0 (en) | 1984-03-21 |
FR2541281A1 (fr) | 1984-08-24 |
FR2541281B1 (fr) | 1988-01-29 |
GB2135311B (en) | 1986-11-05 |
SE8400788D0 (sv) | 1984-02-14 |
GB8403574D0 (en) | 1984-03-14 |
JPS59205377A (ja) | 1984-11-20 |
IT8419675A0 (it) | 1984-02-17 |
US4593095A (en) | 1986-06-03 |
IT1196031B (it) | 1988-11-10 |
SE8400788L (sv) | 1984-08-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RE | Patent lapsed |
Owner name: THE JOHNS HOPKINS UNIVERSITY Effective date: 19940228 |