ES2056873T3 - Derivados de 1-acil-2,3-dihidro-4-(1h)-quinolinona-4-oxima, procedimiento para producirlos y uso de los mismos. - Google Patents

Derivados de 1-acil-2,3-dihidro-4-(1h)-quinolinona-4-oxima, procedimiento para producirlos y uso de los mismos.

Info

Publication number
ES2056873T3
ES2056873T3 ES88118167T ES88118167T ES2056873T3 ES 2056873 T3 ES2056873 T3 ES 2056873T3 ES 88118167 T ES88118167 T ES 88118167T ES 88118167 T ES88118167 T ES 88118167T ES 2056873 T3 ES2056873 T3 ES 2056873T3
Authority
ES
Spain
Prior art keywords
compounds
quinolinone
produce
present
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88118167T
Other languages
English (en)
Inventor
Ei Mochida
Akio Uemura
Kazuo Kato
Hiroki Tokunaga
Akinori Haga
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mochida Pharmaceutical Co Ltd
Original Assignee
Mochida Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mochida Pharmaceutical Co Ltd filed Critical Mochida Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2056873T3 publication Critical patent/ES2056873T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Quinoline Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

EL PRESENTE INVENTO RELATA A NUEVOS COMPONENTES ACIDOS 1- ACIL- 2,3DIHIDRO- 4(1H)- QUINOLIMONE- 4- OXIME- O- SULFONICO, PROCESO PARA PRODUCIR DICHOS COMPONENTES, COMPONENTES INTERMEDIOS PARA PRODUCIR DICHOS COMPONENTES Y COMPOSICIONES QUE CONTIENEN DICHOS COMPONENTES CON ACTIVIDAD DIURETICA POTENTE QUE PUEDE SER USADA PARA TRATAR Y/O PREVENIR HIPERTENSION, OEDEMA Y/O PARA QUITAR ASCITAS. EL PRESENTE INVENTO ESTA BASADO EN LA SELECCION DE COMPONENTES ACIDOS 1- 1CIL- 7- HALO- 2,3- DIHIDRO- 4(1H)- QUINOLIMONE- 4- OXIME- OSULFONICA, A SABER DERIVADOS CARBONIL HETEROCICLICO O HETEROCICLICO FUNDIDO EN POSICION 1. LOS COMPONENTES DEL PRESENTE INVENTO QUE CONTIENE ESOS SUSTITUYENTES QUE TENGAN HIPOTENSORES POTENTE, AUTOEDOMATOSO Y EFECTO DIURETICO COMO TAMBIEN UNA ACTIVIDAD PARA QUITAR ASCITES Y SON EXTREMADAMENTE UTIL PARA EL TRATAMIENTO DE MALES Y DESORDENES ANTES MENCIONADOS
ES88118167T 1987-10-31 1988-10-31 Derivados de 1-acil-2,3-dihidro-4-(1h)-quinolinona-4-oxima, procedimiento para producirlos y uso de los mismos. Expired - Lifetime ES2056873T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62276474A JP2602037B2 (ja) 1987-10-31 1987-10-31 １−アシル−２，３−ジヒドロ−４（１ｈ）−キノリノン−４−オキシム誘導体、その製法およびそれらを主成分とする利尿、降圧、抗浮腫および腹水除去用医薬組成物

Publications (1)

Publication Number Publication Date
ES2056873T3 true ES2056873T3 (es) 1994-10-16

Family

ID=17569953

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88118167T Expired - Lifetime ES2056873T3 (es) 1987-10-31 1988-10-31 Derivados de 1-acil-2,3-dihidro-4-(1h)-quinolinona-4-oxima, procedimiento para producirlos y uso de los mismos.

Country Status (8)

Country Link
US (1) US4968680A (es)
EP (1) EP0315115B1 (es)
JP (1) JP2602037B2 (es)
AT (1) ATE107287T1 (es)
AU (1) AU612422B2 (es)
CA (1) CA1339663C (es)
DE (1) DE3850215T2 (es)
ES (1) ES2056873T3 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU661159B2 (en) * 1992-07-15 1995-07-13 Sumitomo Chemical Company, Limited N-acyldihydroquinoline derivatives, a method for producing the same and their use as herbicides
US7553967B2 (en) * 2004-03-12 2009-06-30 Wyeth 1,2-Dihydroquinoline derivatives and method for using the same to treat HIV infections
JP5305704B2 (ja) * 2008-03-24 2013-10-02 富士フイルム株式会社 新規化合物、光重合性組成物、カラーフィルタ用光重合性組成物、カラーフィルタ、及びその製造方法、固体撮像素子、並びに、平版印刷版原版
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
CA2905242C (en) 2013-03-15 2016-11-29 Pfizer Inc. Indole compounds that activate ampk

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4013662A (en) * 1974-12-19 1977-03-22 Pfizer Inc. Alkyl and benzyl 6,7-dialkoxy-2-methyl-4-oxo-1,2,3,4-tetrahydroquinoline-1-carboxylates
US3976650A (en) * 1975-11-04 1976-08-24 Pfizer Inc. Process for preparing optically active 6,7-dimethoxy-2-methyl-4-oxo-1,2,3,4-tetrahydro-1-quinoline carboxylic acid ester analgesics
US4260764A (en) * 1976-12-22 1981-04-07 Pfizer Inc. 9-Hydroxyoctahydrobenzo [C] quinolines and intermediates therefor
GB2092130B (en) * 1980-07-28 1984-05-10 Hodogaya Chemical Co Ltd 4-oximino-1,2,3,4-tetrahydroquinoline derivatives
US4421919A (en) * 1980-07-28 1983-12-20 Hodogaya Chemical Co., Ltd. 4-Oximino-1,2,3,4-tetrahydroquinoline derivatives
US4440770A (en) * 1980-07-28 1984-04-03 Mochida Seiyaku Kabushiki Kaisha Diuretic, hypotensive and antiedemic quinoline oximes
GB2081091B (en) * 1980-07-28 1984-03-07 Mochida Pharm Co Ltd Hypotensive diuretic pharmaceutical compositions containing tetrahydroquinoline derivatives
US4521607A (en) * 1981-02-27 1985-06-04 Takeda Chemical Industries, Ltd. Chromanyl glycines
DE3416695A1 (de) * 1984-05-05 1985-11-07 Bayer Ag, 5090 Leverkusen Amidinohydrazone von tetralin-, chromon-, thiochromon- und tretrahydrochinolin-derivaten, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
PH21213A (en) * 1984-10-26 1987-08-21 Fujisawa Pharmaceutical Co Benzene- and pyrazole- fused heterocyclic compound and pharmaceutical composition comprising the same
EP0199672B1 (de) * 1985-04-12 1988-06-01 Ciba-Geigy Ag Oximsulfonate mit reaktiven Gruppen
US4839368A (en) * 1986-05-02 1989-06-13 Mochida Pharmaceutical Co., Ltd. 1-acyl-2,3-dihydro-4(1H)-quinolinone-4-oxime derivatives
JPH0446951A (ja) * 1990-06-14 1992-02-17 Matsushita Electric Works Ltd フエノール樹脂成形材料

Also Published As

Publication number Publication date
JPH01121269A (ja) 1989-05-12
US4968680A (en) 1990-11-06
JP2602037B2 (ja) 1997-04-23
ATE107287T1 (de) 1994-07-15
AU2454988A (en) 1989-05-04
EP0315115A2 (en) 1989-05-10
DE3850215D1 (de) 1994-07-21
CA1339663C (en) 1998-02-10
EP0315115B1 (en) 1994-06-15
AU612422B2 (en) 1991-07-11
DE3850215T2 (de) 1994-11-24
EP0315115A3 (en) 1991-02-27

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