BE896572A - Benzoazacycloalkyl-spiro-imidazolidines leur preparation et leur application en therapeutique - Google Patents
Benzoazacycloalkyl-spiro-imidazolidines leur preparation et leur application en therapeutiqueInfo
- Publication number
- BE896572A BE896572A BE0/210633A BE210633A BE896572A BE 896572 A BE896572 A BE 896572A BE 0/210633 A BE0/210633 A BE 0/210633A BE 210633 A BE210633 A BE 210633A BE 896572 A BE896572 A BE 896572A
- Authority
- BE
- Belgium
- Prior art keywords
- benzoazacycloalkyl
- imidazolidines
- spiro
- therapeutics
- preparation
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8207203A FR2525603A1 (fr) | 1982-04-27 | 1982-04-27 | Benzoazacycloalkyl-spiro-imidazolinines, leur preparation et leur application en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE896572A true BE896572A (fr) | 1983-10-26 |
Family
ID=9273425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE0/210633A BE896572A (fr) | 1982-04-27 | 1983-04-26 | Benzoazacycloalkyl-spiro-imidazolidines leur preparation et leur application en therapeutique |
Country Status (22)
| Country | Link |
|---|---|
| JP (1) | JPS5910584A (index.php) |
| KR (1) | KR840004428A (index.php) |
| AT (1) | ATA125383A (index.php) |
| AU (1) | AU1395383A (index.php) |
| BE (1) | BE896572A (index.php) |
| DD (1) | DD209833A5 (index.php) |
| DE (1) | DE3315106A1 (index.php) |
| DK (1) | DK183583A (index.php) |
| ES (1) | ES521895A0 (index.php) |
| FR (1) | FR2525603A1 (index.php) |
| GB (1) | GB2133401B (index.php) |
| GR (1) | GR78481B (index.php) |
| IL (1) | IL68497A0 (index.php) |
| IT (1) | IT1167123B (index.php) |
| LU (1) | LU84770A1 (index.php) |
| MA (1) | MA19783A1 (index.php) |
| NL (1) | NL8301476A (index.php) |
| NO (1) | NO831473L (index.php) |
| OA (1) | OA07412A (index.php) |
| PT (1) | PT76595B (index.php) |
| SE (1) | SE8302347L (index.php) |
| ZA (1) | ZA832927B (index.php) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU617541B2 (en) * | 1988-10-20 | 1991-11-28 | Wyeth | Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors |
| US4927831A (en) * | 1988-10-20 | 1990-05-22 | American Home Products | Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors |
| US6953787B2 (en) | 2002-04-12 | 2005-10-11 | Arena Pharmaceuticals, Inc. | 5HT2C receptor modulators |
| PL2332921T3 (pl) | 2003-06-17 | 2016-08-31 | Arena Pharm Inc | Chlorowodorek 8-chloro-1-metylo-2,3,4,5-tetrahydro-1H-3-benzazepiny |
| CN1805939B (zh) | 2003-06-17 | 2010-10-13 | 艾尼纳制药公司 | 用于治疗5ht2c受体相关病症的苯并氮杂卓衍生物 |
| KR101281919B1 (ko) | 2004-12-21 | 2013-07-03 | 아레나 파마슈티칼스, 인크. | (ｒ)-8-클로로-1-메틸-2,3,4,5-테트라히드로-1ｈ-3-벤즈아제핀 히드로클로라이드의 결정질 형태 |
| RS50997B (sr) | 2004-12-23 | 2010-10-31 | Arena Pharmaceuticals Inc. | Kompozicije 5ht2c receptor modulatora i postupci njihove upotrebe |
| CA2646044A1 (en) | 2006-04-03 | 2007-10-25 | Arena Pharmaceuticals, Inc. | Processes for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates related thereto |
| JP5404414B2 (ja) | 2006-12-05 | 2014-01-29 | アリーナ ファーマシューティカルズ， インコーポレイテッド | （ｒ）−８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンゾアゼピンおよびその中間体を調製するための方法 |
| EP2288585A1 (en) | 2008-03-04 | 2011-03-02 | Arena Pharmaceuticals, Inc. | Processes for the preparation of intermediates related to the 5-ht2c agonist (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine |
| US8952197B2 (en) | 2009-06-18 | 2015-02-10 | Arena Pharmaceuticals, Inc. | Processes for the preparation of 5-HT2C receptor agonists |
| WO2011153206A1 (en) | 2010-06-02 | 2011-12-08 | Arena Pharmaceuticals, Inc. | Processes for the preparation of 5-ht2c receptor agonists |
| KR20180094131A (ko) | 2010-09-01 | 2018-08-22 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 신장 손상을 갖는 개체에 대한 로카세린의 투여 |
| JP6272695B2 (ja) | 2010-09-01 | 2018-01-31 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 体重管理のために有用な５−ｈｔ２ｃアゴニストの改変放出剤形 |
| WO2012030957A2 (en) | 2010-09-01 | 2012-03-08 | Arena Pharmaceuticals, Inc. | Non-hygroscopic salts of 5-ht2c agonists |
| CN103189359A (zh) | 2010-09-01 | 2013-07-03 | 艾尼纳制药公司 | 5-ht2c激动剂的光学活性酸盐 |
| AR088670A1 (es) | 2012-10-09 | 2014-06-25 | Arena Pharm Inc | Metodo de control del peso |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4209630A (en) * | 1976-10-18 | 1980-06-24 | Pfizer Inc. | Hydantoin derivatives as therapeutic agents |
| US4235911A (en) * | 1979-06-13 | 1980-11-25 | Pfizer Inc. | Hydantoin derivatives |
-
1982
- 1982-04-27 FR FR8207203A patent/FR2525603A1/fr active Granted
-
1983
- 1983-04-08 AT AT0125383A patent/ATA125383A/de not_active IP Right Cessation
- 1983-04-25 LU LU84770A patent/LU84770A1/fr unknown
- 1983-04-25 DD DD83250187A patent/DD209833A5/de unknown
- 1983-04-26 DK DK183583A patent/DK183583A/da not_active Application Discontinuation
- 1983-04-26 KR KR1019830001753A patent/KR840004428A/ko not_active Withdrawn
- 1983-04-26 BE BE0/210633A patent/BE896572A/fr not_active IP Right Cessation
- 1983-04-26 ZA ZA832927A patent/ZA832927B/xx unknown
- 1983-04-26 NO NO831473A patent/NO831473L/no unknown
- 1983-04-26 GR GR71214A patent/GR78481B/el unknown
- 1983-04-26 JP JP58073687A patent/JPS5910584A/ja active Pending
- 1983-04-26 IT IT48155/83A patent/IT1167123B/it active
- 1983-04-26 SE SE8302347A patent/SE8302347L/xx not_active Application Discontinuation
- 1983-04-26 IL IL68497A patent/IL68497A0/xx unknown
- 1983-04-26 NL NL8301476A patent/NL8301476A/nl not_active Application Discontinuation
- 1983-04-26 AU AU13953/83A patent/AU1395383A/en not_active Abandoned
- 1983-04-26 PT PT76595A patent/PT76595B/pt unknown
- 1983-04-27 MA MA20003A patent/MA19783A1/fr unknown
- 1983-04-27 GB GB08311508A patent/GB2133401B/en not_active Expired
- 1983-04-27 OA OA57984A patent/OA07412A/xx unknown
- 1983-04-27 ES ES521895A patent/ES521895A0/es active Granted
- 1983-04-27 DE DE19833315106 patent/DE3315106A1/de not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| ES8405796A1 (es) | 1984-06-16 |
| DK183583A (da) | 1983-10-28 |
| ATA125383A (de) | 1986-05-15 |
| FR2525603B1 (index.php) | 1984-09-14 |
| JPS5910584A (ja) | 1984-01-20 |
| GB2133401A (en) | 1984-07-25 |
| KR840004428A (ko) | 1984-10-15 |
| IT1167123B (it) | 1987-05-13 |
| OA07412A (fr) | 1984-11-30 |
| DK183583D0 (da) | 1983-04-26 |
| GB2133401B (en) | 1985-10-23 |
| ES521895A0 (es) | 1984-06-16 |
| AU1395383A (en) | 1983-11-03 |
| NO831473L (no) | 1983-10-28 |
| GB8311508D0 (en) | 1983-06-02 |
| NL8301476A (nl) | 1983-11-16 |
| PT76595B (fr) | 1986-01-21 |
| ZA832927B (en) | 1984-06-27 |
| SE8302347L (sv) | 1983-10-28 |
| MA19783A1 (fr) | 1983-12-31 |
| GR78481B (index.php) | 1984-09-27 |
| FR2525603A1 (fr) | 1983-10-28 |
| IT8348155A0 (it) | 1983-04-26 |
| DE3315106A1 (de) | 1983-11-03 |
| IL68497A0 (en) | 1983-07-31 |
| DD209833A5 (de) | 1984-05-23 |
| PT76595A (fr) | 1983-05-01 |
| SE8302347D0 (sv) | 1983-04-26 |
| LU84770A1 (fr) | 1984-11-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RE | Patent lapsed |
Owner name: ADIR Effective date: 19860430 |