PT76595B - Procede de preparation de benzoazacycloalkyl-spiro-imidazolidines - Google Patents

Procede de preparation de benzoazacycloalkyl-spiro-imidazolidines

Info

Publication number
PT76595B
PT76595B PT76595A PT7659583A PT76595B PT 76595 B PT76595 B PT 76595B PT 76595 A PT76595 A PT 76595A PT 7659583 A PT7659583 A PT 7659583A PT 76595 B PT76595 B PT 76595B
Authority
PT
Portugal
Prior art keywords
benzoazacycloalkyl
imidazolidines
spiro
preparation
Prior art date
Application number
PT76595A
Other languages
English (en)
French (fr)
Portuguese (pt)
Other versions
PT76595A (fr
Inventor
Charles Malen
Jean-Louis Peglion
Jacques Duhault
Michelle Boulanger
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir filed Critical Adir
Publication of PT76595A publication Critical patent/PT76595A/pt
Publication of PT76595B publication Critical patent/PT76595B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
PT76595A 1982-04-27 1983-04-26 Procede de preparation de benzoazacycloalkyl-spiro-imidazolidines PT76595B (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8207203A FR2525603A1 (fr) 1982-04-27 1982-04-27 Benzoazacycloalkyl-spiro-imidazolinines, leur preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
PT76595A PT76595A (fr) 1983-05-01
PT76595B true PT76595B (fr) 1986-01-21

Family

ID=9273425

Family Applications (1)

Application Number Title Priority Date Filing Date
PT76595A PT76595B (fr) 1982-04-27 1983-04-26 Procede de preparation de benzoazacycloalkyl-spiro-imidazolidines

Country Status (22)

Country Link
JP (1) JPS5910584A (index.php)
KR (1) KR840004428A (index.php)
AT (1) ATA125383A (index.php)
AU (1) AU1395383A (index.php)
BE (1) BE896572A (index.php)
DD (1) DD209833A5 (index.php)
DE (1) DE3315106A1 (index.php)
DK (1) DK183583A (index.php)
ES (1) ES521895A0 (index.php)
FR (1) FR2525603A1 (index.php)
GB (1) GB2133401B (index.php)
GR (1) GR78481B (index.php)
IL (1) IL68497A0 (index.php)
IT (1) IT1167123B (index.php)
LU (1) LU84770A1 (index.php)
MA (1) MA19783A1 (index.php)
NL (1) NL8301476A (index.php)
NO (1) NO831473L (index.php)
OA (1) OA07412A (index.php)
PT (1) PT76595B (index.php)
SE (1) SE8302347L (index.php)
ZA (1) ZA832927B (index.php)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU617541B2 (en) * 1988-10-20 1991-11-28 Wyeth Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
US4927831A (en) * 1988-10-20 1990-05-22 American Home Products Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
US6953787B2 (en) 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
CA2888392A1 (en) 2003-06-17 2005-03-03 Arena Pharmaceuticals, Inc. Processes for preparing 3-benzazepines
EP1636191A2 (en) 2003-06-17 2006-03-22 Arena Pharmaceuticals, Inc. Benzazepine derivatives useful for the treatment of 5ht2c receptor associated diseases
US8168624B2 (en) 2004-12-21 2012-05-01 Arena Pharmaceuticals, Inc. Crystalline forms of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride
EA201100129A1 (ru) 2004-12-23 2011-10-31 Арена Фармасьютикалз, Инк. Композиции и способы применения модулятора рецептора 5ht-2c
EP2001852A2 (en) 2006-04-03 2008-12-17 Arena Pharmaceuticals, Inc. Processes for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates related thereto
ES2522587T3 (es) 2006-12-05 2014-11-17 Arena Pharmaceuticals, Inc. Procesos para preparar (R)-8-cloro-1-metil-2,3,4,5-tetrahidro-1H-3-benzacepina e intermedios de la misma
EP2288585A1 (en) 2008-03-04 2011-03-02 Arena Pharmaceuticals, Inc. Processes for the preparation of intermediates related to the 5-ht2c agonist (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine
CN102648170A (zh) 2009-06-18 2012-08-22 艾尼纳制药公司 制备5-ht2c受体激动剂的方法
US9045431B2 (en) 2010-06-02 2015-06-02 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-HT2C receptor agonists
MX2013002418A (es) 2010-09-01 2013-08-01 Arena Pharm Inc Administracion de lorcaserina a individuos con daño renal.
SG10201506870PA (en) 2010-09-01 2015-10-29 Arena Pharm Inc Salts of lorcaserin with optically active acids
MX2013002421A (es) 2010-09-01 2013-05-17 Arena Pharm Inc Sales no hidroscopicas de agonistas de 5-ht2c.
EP3485878A1 (en) 2010-09-01 2019-05-22 Arena Pharmaceuticals, Inc. Modified-release dosage forms of 5-ht2c agonists useful for weight management
CA2886875A1 (en) 2012-10-09 2014-04-17 Arena Pharmaceuticals, Inc. Method of weight management

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4209630A (en) * 1976-10-18 1980-06-24 Pfizer Inc. Hydantoin derivatives as therapeutic agents
US4235911A (en) * 1979-06-13 1980-11-25 Pfizer Inc. Hydantoin derivatives

Also Published As

Publication number Publication date
ATA125383A (de) 1986-05-15
ES8405796A1 (es) 1984-06-16
IT1167123B (it) 1987-05-13
FR2525603A1 (fr) 1983-10-28
GR78481B (index.php) 1984-09-27
GB2133401A (en) 1984-07-25
BE896572A (fr) 1983-10-26
SE8302347L (sv) 1983-10-28
GB8311508D0 (en) 1983-06-02
AU1395383A (en) 1983-11-03
LU84770A1 (fr) 1984-11-28
PT76595A (fr) 1983-05-01
SE8302347D0 (sv) 1983-04-26
DK183583D0 (da) 1983-04-26
KR840004428A (ko) 1984-10-15
GB2133401B (en) 1985-10-23
NO831473L (no) 1983-10-28
JPS5910584A (ja) 1984-01-20
DE3315106A1 (de) 1983-11-03
OA07412A (fr) 1984-11-30
DK183583A (da) 1983-10-28
IL68497A0 (en) 1983-07-31
IT8348155A0 (it) 1983-04-26
NL8301476A (nl) 1983-11-16
MA19783A1 (fr) 1983-12-31
DD209833A5 (de) 1984-05-23
ZA832927B (en) 1984-06-27
ES521895A0 (es) 1984-06-16
FR2525603B1 (index.php) 1984-09-14

Similar Documents

Publication Publication Date Title
FR2479187B1 (fr) Procede de preparation de n-octadienol
RO86698A (ro) Procedeu pentru prepararea unor (1-piperidinilalchil)-pirimidinone
RO81944A (ro) Procedeu de preparare a unor imidodisulfamide
FR2527615B1 (fr) Procede de preparation du 26,26,26,27,27,27-hexafluoro-1a,25-dihydroxycholesterol
PT76595A (fr) Procede de preparation de benzoazacycloalkyl-spiro-imidazolidines
RO86646A (ro) Procedeu pentru prepararea unor o0imeteri
FR2555575B1 (fr) Procede de preparation de 4-alcoxyanilines
RO88128A (ro) Procedeu pentru prepararea n-fosfanometilglicinei
FR2496660B1 (fr) Procede de preparation de n-acylcarnosine
FR2562070B1 (fr) Procede de preparation de 2-amino-s-triazines
FR2524316B1 (fr) Procede de photodecontamination
BE889546A (fr) Procede de preparation de n-cyclohexylbenzothiazole-2-sulfenamide
FR2534905B1 (fr) Procede de preparation de phenylcetones
RO88202A (ro) Procedeu pentru preparare unor spiro-3-heteroazelone
FR2550190B1 (fr) Procede de preparation de b-phenylserine
PT74559B (fr) Procede de preparation de trifluoromethylphenyl-tetrahydropyri-dines substituees
FR2528825B1 (fr) Procede de preparation de meta-chlorobenzotrifluorure
FR2529889B1 (fr) Procede de preparation des indoles
FR2527603B1 (fr) Procede catalytique de preparation de thio-bis-phenols
FR2526021B1 (fr) Procede de preparation de 3-hydroxy-benzodiazepinones
FR2537578B1 (fr) Procede de preparation de trichloromethyl-carbinols
FR2550790B1 (fr) Procede de preparation de la 4-methylionone
FR2493310B1 (fr) Procede de preparation de thymosine a1
FR2526790B1 (fr) Procede de preparation de la o-phenylenediamine
FR2521556B1 (fr) Procede de preparation de 3, 3'-diamino-diphenylsulfones