BE896453A - Farmacologisch aktieve bifosfonaten, werkwijze voor hun bereiding en farmaceutica met deze stoffen daarin. - Google Patents
Farmacologisch aktieve bifosfonaten, werkwijze voor hun bereiding en farmaceutica met deze stoffen daarin.Info
- Publication number
- BE896453A BE896453A BE2/60071A BE2060071A BE896453A BE 896453 A BE896453 A BE 896453A BE 2/60071 A BE2/60071 A BE 2/60071A BE 2060071 A BE2060071 A BE 2060071A BE 896453 A BE896453 A BE 896453A
- Authority
- BE
- Belgium
- Prior art keywords
- farmacologisch
- daarin
- bifosfonaten
- bereiding
- aktieve
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
- C07F9/3804—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
- C07F9/3804—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3856—Polyphosphonic acids containing halogen or nitro(so) substituents
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT8220781A IT1201087B (it) | 1982-04-15 | 1982-04-15 | Bifosfonati farmacologicamente attivi,procedimento per la loro preparazione e relative composizioni farmaceutiche |
Publications (1)
Publication Number | Publication Date |
---|---|
BE896453A true BE896453A (fr) | 1983-08-01 |
Family
ID=11171970
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE2/60071A BE896453A (fr) | 1982-04-15 | 1983-04-14 | Farmacologisch aktieve bifosfonaten, werkwijze voor hun bereiding en farmaceutica met deze stoffen daarin. |
Country Status (12)
Country | Link |
---|---|
US (1) | US4621077A (fr) |
JP (1) | JPS58189193A (fr) |
BE (1) | BE896453A (fr) |
CH (1) | CH661437A5 (fr) |
FR (1) | FR2525223B1 (fr) |
GB (1) | GB2118042B (fr) |
HK (1) | HK79390A (fr) |
IT (1) | IT1201087B (fr) |
LU (2) | LU84746A1 (fr) |
MX (1) | MX9203428A (fr) |
NL (5) | NL192562C (fr) |
SE (1) | SE463239B (fr) |
Families Citing this family (111)
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DE3540150A1 (de) * | 1985-11-13 | 1987-05-14 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
DE3623397A1 (de) * | 1986-07-11 | 1988-01-14 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
IL86951A (en) * | 1987-07-06 | 1996-07-23 | Procter & Gamble Pharma | Methylene phosphonoalkylphosphinates and pharmaceutical preparations containing them |
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TW237386B (fr) * | 1992-04-15 | 1995-01-01 | Ciba Geigy | |
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US5591730A (en) * | 1993-10-12 | 1997-01-07 | The Regents Of The University Of California | Inhibition of urinary calculi growth |
US5854227A (en) * | 1994-03-04 | 1998-12-29 | Hartmann; John F. | Therapeutic derivatives of diphosphonates |
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JP3411690B2 (ja) * | 1994-09-21 | 2003-06-03 | 帝人株式会社 | 局所投与用アレンドロン酸ナトリウム製剤 |
US6008206A (en) * | 1994-09-21 | 1999-12-28 | Merck & Co., Inc. | Sodium alendronate preparation for local administration |
WO1996025165A1 (fr) * | 1995-02-17 | 1996-08-22 | Merck & Co., Inc. | Procede de diminution des risques de fractures osseuses autres que les fractures vertebrales |
US20010051616A1 (en) * | 1995-02-17 | 2001-12-13 | David B. Karpf | Method of lessening the risk of vertebral fractures |
WO1996035407A1 (fr) * | 1995-05-12 | 1996-11-14 | Merck & Co., Inc. | Prevention des pertes de dnets par l'administration d'alendronate ou de ses sels |
PT833643E (pt) * | 1995-06-06 | 2005-06-30 | Merck & Co Inc | Formulacoes de sal anidro de alendronato |
CA2223450A1 (fr) | 1995-06-06 | 1996-12-12 | Merck & Co., Inc. | Composition a base de ciment de bisphosphonate permettant d'eviter le relachement aseptique des protheses orthopediques |
EP0837863A4 (fr) * | 1995-06-06 | 1999-06-16 | Merck & Co Inc | Preparations d'alendronate disodique |
EP1820497A3 (fr) * | 1996-05-17 | 2009-07-22 | Merck & Co., Inc. | Formulation de bisphosphonate effervescente |
EP1378234A1 (fr) * | 1996-05-17 | 2004-01-07 | MERCK & CO. INC. | Formulation de bisphosphonate effervescente |
JP2000511178A (ja) * | 1996-05-17 | 2000-08-29 | メルク エンド カンパニー インコーポレーテッド | 発泡性ビスホスホネート製剤 |
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JP2017512183A (ja) | 2014-02-13 | 2017-05-18 | リガンド・ファーマシューティカルズ・インコーポレイテッド | プロドラッグ化合物およびそれらの使用 |
PL407922A1 (pl) | 2014-04-16 | 2015-10-26 | Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną Odpowiedzialnością | Nowe bisfosfoniany i ich zastosowanie |
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US4275059A (en) * | 1977-03-28 | 1981-06-23 | The Procter & Gamble Company | Salicylate anti-inflammatory composition |
US4216211A (en) * | 1977-10-31 | 1980-08-05 | The Procter & Gamble Company | Therapeutic composition |
US4230700A (en) * | 1977-12-07 | 1980-10-28 | The Procter & Gamble Company | Methods for inhibiting mobilization of calcium phosphate in animal tissue |
US4330537A (en) * | 1977-12-07 | 1982-05-18 | The Procter & Gamble Company | Compositions for inhibiting mobilization of calcium phosphate in animal tissue |
US4216212A (en) * | 1978-06-08 | 1980-08-05 | The Procter & Gamble Company | Pyrazolidine anti-inflammatory composition and methods of use |
IT1097292B (it) * | 1978-06-27 | 1985-08-31 | Gentili Ist Spa | Composizione farmaceutica per la terapia dell'ittero ostruttivo non neoplastico |
US4282214A (en) * | 1978-07-31 | 1981-08-04 | The Procter & Gamble Company | Phenylacetate anti-inflammatory composition |
US4264582A (en) * | 1978-07-31 | 1981-04-28 | The Procter & Gamble Company | Isobutylphenylacetate anti-inflammatory composition |
US4254114A (en) * | 1979-01-02 | 1981-03-03 | The Proctor & Gamble Company | Control of pyrophosphate microorganisms with organophosphonates |
GB2043072B (en) * | 1979-02-13 | 1983-11-23 | Symphar Sa | Diphosphonate compounds |
GB2076889B (en) * | 1980-03-12 | 1983-10-26 | Cadbury Schweppes Transport | Feeding fuel and water emulsion i c engines |
DE3016289A1 (de) * | 1980-04-28 | 1981-10-29 | Henkel KGaA, 4000 Düsseldorf | Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren |
GB2079285B (en) * | 1980-07-09 | 1984-05-23 | Symphar Sa | Dipthosphonate derivatives and pahrmaceutical compositions containing them |
GB2082585A (en) * | 1980-08-27 | 1982-03-10 | Vysoka Skola Chem Tech | 6-amino-1-hydroxyhexylidene diphosphonic acid, salts thereof and a method of producing the acid and salts. |
JPS5759900A (en) * | 1980-09-29 | 1982-04-10 | Vysoka Skola Chem Tech | 6-amino-1-hydroxyhexylidene diphosphonic acid |
BE890453A (fr) * | 1980-10-07 | 1982-03-22 | Procter & Gamble | Procede d'inhibition des metastases de cellules tumorales |
US4330530A (en) * | 1980-12-22 | 1982-05-18 | The Procter & Gamble Company | Anti-arthritic compositions and method using gold salts and organophosphonates |
IT1194748B (it) * | 1981-02-12 | 1988-09-28 | Gentili Ist Spa | Composizioni farmaceutiche per il trattamento di osteopatie |
-
1982
- 1982-04-15 IT IT8220781A patent/IT1201087B/it active Protection Beyond IP Right Term
-
1983
- 1983-03-25 CH CH1654/83A patent/CH661437A5/it not_active IP Right Cessation
- 1983-03-30 GB GB08308791A patent/GB2118042B/en not_active Expired
- 1983-04-11 FR FR8305858A patent/FR2525223B1/fr not_active Expired
- 1983-04-13 JP JP58065160A patent/JPS58189193A/ja active Granted
- 1983-04-13 LU LU84746A patent/LU84746A1/fr active Protection Beyond IP Right Term
- 1983-04-13 LU LU88714C patent/LU88714I2/fr unknown
- 1983-04-14 BE BE2/60071A patent/BE896453A/fr not_active IP Right Cessation
- 1983-04-15 NL NL8301324A patent/NL192562C/nl active Protection Beyond IP Right Term
- 1983-04-15 SE SE8302130A patent/SE463239B/sv not_active IP Right Cessation
-
1984
- 1984-06-08 US US06/618,578 patent/US4621077A/en not_active Expired - Lifetime
-
1990
- 1990-10-03 HK HK793/90A patent/HK79390A/xx not_active IP Right Cessation
-
1992
- 1992-06-25 MX MX9203428A patent/MX9203428A/es unknown
-
1997
- 1997-11-07 NL NL970038C patent/NL970038I2/nl unknown
-
1998
- 1998-01-09 NL NL980004C patent/NL980004I1/nl unknown
- 1998-01-26 NL NL980005C patent/NL980005I1/nl unknown
- 1998-03-03 NL NL980010C patent/NL980010I1/nl unknown
Also Published As
Publication number | Publication date |
---|---|
GB2118042B (en) | 1986-01-15 |
US4621077A (en) | 1986-11-04 |
NL980010I1 (nl) | 1998-05-06 |
GB8308791D0 (en) | 1983-05-11 |
NL192562C (nl) | 1997-10-03 |
NL8301324A (nl) | 1983-11-01 |
JPH0213645B2 (fr) | 1990-04-04 |
SE8302130D0 (sv) | 1983-04-15 |
FR2525223A1 (fr) | 1983-10-21 |
NL192562B (nl) | 1997-06-02 |
HK79390A (en) | 1990-10-12 |
IT1201087B (it) | 1989-01-27 |
NL970038I2 (nl) | 2000-11-01 |
MX9203428A (es) | 1992-07-01 |
GB2118042A (en) | 1983-10-26 |
NL980005I1 (nl) | 1998-04-01 |
NL970038I1 (nl) | 1998-01-05 |
LU84746A1 (fr) | 1983-11-17 |
JPS58189193A (ja) | 1983-11-04 |
SE463239B (sv) | 1990-10-29 |
FR2525223B1 (fr) | 1986-04-25 |
NL980004I1 (nl) | 1998-04-01 |
LU88714I2 (fr) | 1996-08-23 |
SE8302130L (sv) | 1983-10-16 |
CH661437A5 (it) | 1987-07-31 |
IT8220781A0 (it) | 1982-04-15 |
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Legal Events
Date | Code | Title | Description |
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CCPV | Grant of a supplementary protection certificate |
Free format text: 096C0027, EXPIRES:20080414 |
|
RE20 | Patent expired |
Owner name: ISTITUTO *GENTILI S.P.A. Effective date: 20030414 |
|
CCCH | Change of ownership of the supplementary protection certificate |
Owner name: MSD OVERSEAS MANUFACTURING CO. IRELAND Spc suppl protection certif: 96C0027 Filing date: 19961008 |
|
CCRE | Expiry of a supplementary protection certificate |
Free format text: PRODUCT NAME: NATRII ALENDRONAS EQ. ALENDRONAS; NAT. REGISTRATION NO/DATE: 922 IS 171 F 3 19960411;FIRST REGISTRATION: IT 029052014 19930716 Spc suppl protection certif: 96C0027 Filing date: 19960724 Expiry date: 20030414 Extension date: 20080414 Effective date: 20080414 |