BE637389A
(xx)
*
|
1962-09-13 |
|
|
|
GB1560274A
(en)
*
|
1977-02-28 |
1980-02-06 |
Ici Ltd |
Phenylbut 1-ene derivatives having antiostrogenicactivity
|
EP0002097B1
(en)
*
|
1977-08-22 |
1981-08-05 |
Imperial Chemical Industries Plc |
Triphenylalkene derivatives, process for their preparation and pharmaceutical compositions containing them
|
DE3046719C2
(de)
*
|
1980-12-11 |
1983-02-17 |
Klinge Pharma GmbH, 8000 München |
1,1,2-Triphenyl-but-1-en-Derivate, Verfahren zu ihrer Herstellung und Arzneimittel
|
DE3462398D1
(en)
*
|
1983-05-24 |
1987-04-02 |
Bristol Myers Co |
Process for the conversion of the e isomer of 1,2-diphenyl-1-(4-(2-dimethylaminoethoxy)-phenyl)-1-butene to tamoxifen hcl
|
US4666885A
(en)
*
|
1985-02-08 |
1987-05-19 |
Fernand Labrie |
Combination therapy for treatment of female breast cancer
|
US4760053A
(en)
*
|
1984-08-02 |
1988-07-26 |
Fernand Labrie |
Combination therapy for selected sex steroid dependent cancers
|
US4775660A
(en)
*
|
1984-08-02 |
1988-10-04 |
Fernand Labrie |
Treatment of breast cancer by combination therapy
|
US4806685A
(en)
*
|
1985-08-05 |
1989-02-21 |
Gyogyszerkutato Inteezet/Pharmaceutical Research Institute |
1,1,2-triphenylpropane and -propene derivatives
|
GB8604528D0
(en)
*
|
1986-02-24 |
1986-04-03 |
Ici Plc |
Therapeutic agents
|
CA1289570C
(en)
*
|
1986-06-16 |
1991-09-24 |
Tetsuji Asao |
1,1,2-triaryl-1-alkene derivatives
|
EP0287690B1
(de)
*
|
1987-04-21 |
1992-09-02 |
HEUMANN PHARMA GMBH & CO |
Stabile Lösungsmitteladdukte von Z-1-(p-beta-Dimethylamino-ethoxyphenyl)-1-(p-hydroxyphenyl)-2-phenylbut-1-en
|
DE3736682A1
(de)
*
|
1987-10-29 |
1989-05-11 |
Klinge Co Chem Pharm Fab |
Verfahren zur herstellung von trans-1,1,2-triphenyl-but-1-en-derivaten
|
US4895715A
(en)
*
|
1988-04-14 |
1990-01-23 |
Schering Corporation |
Method of treating gynecomastia
|
US5204337A
(en)
*
|
1988-10-31 |
1993-04-20 |
Endorecherche Inc. |
Estrogen nucleus derivatives for use in inhibition of sex steroid activity
|
US5364847A
(en)
*
|
1989-03-10 |
1994-11-15 |
Endorecherche |
Inhibitors of sex steroid biosynthesis and methods for their production and use
|
ZA924811B
(en)
*
|
1991-06-28 |
1993-12-29 |
Endorecherche Inc |
Controlled release systems and low dose androgens
|
US6515009B1
(en)
|
1991-09-27 |
2003-02-04 |
Neorx Corporation |
Therapeutic inhibitor of vascular smooth muscle cells
|
US5811447A
(en)
|
1993-01-28 |
1998-09-22 |
Neorx Corporation |
Therapeutic inhibitor of vascular smooth muscle cells
|
US5446203A
(en)
*
|
1992-08-25 |
1995-08-29 |
New York University |
Synthesis of haloenones and aryl or alkyl substituted enones or alkenes
|
US6251920B1
(en)
|
1993-05-13 |
2001-06-26 |
Neorx Corporation |
Prevention and treatment of cardiovascular pathologies
|
US5770609A
(en)
*
|
1993-01-28 |
1998-06-23 |
Neorx Corporation |
Prevention and treatment of cardiovascular pathologies
|
US5354861A
(en)
*
|
1992-11-04 |
1994-10-11 |
National University Of Singapore |
2-(benzyl)-3-arylbenzofurans as antitumour and hypocholesterolemic agents
|
US6491938B2
(en)
|
1993-05-13 |
2002-12-10 |
Neorx Corporation |
Therapeutic inhibitor of vascular smooth muscle cells
|
JPH08510451A
(ja)
*
|
1993-05-13 |
1996-11-05 |
ネオルックス コーポレイション |
異常増殖性平滑筋細胞に関連した病因の予防及び治療
|
ES2105525T3
(es)
*
|
1993-06-24 |
1997-10-16 |
Lilly Co Eli |
2-fenil-3-aroilbenzotiofenos antiestrogenicos como agentes hipoglicemicos.
|
GB9326255D0
(en)
*
|
1993-12-23 |
1994-02-23 |
Roussel Lab Ltd |
Medical device for the prevention and treatment of cancer
|
US5650425A
(en)
*
|
1994-04-04 |
1997-07-22 |
Pharmos Corporation |
Permanently ionic derivatives of steroid hormones and their antagonists
|
US5681835A
(en)
*
|
1994-04-25 |
1997-10-28 |
Glaxo Wellcome Inc. |
Non-steroidal ligands for the estrogen receptor
|
PL181304B1
(pl)
|
1994-07-22 |
2001-07-31 |
Lilly Co Eli |
Preparat farmaceutyczny do hamowania zmniejszania masy kosci PL PL PL PL PL PL PL PL PL PL
|
AU6277396A
(en)
|
1995-06-07 |
1996-12-30 |
Neorx Corporation |
Prevention and treatment of cardiovascular pathologies with tamoxifen analogues
|
DE19526146A1
(de)
*
|
1995-07-07 |
1997-01-09 |
Schering Ag |
Triphenylethylene, Verfahren zu deren Herstellung, diese Triphenylethylene enthaltene pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
|
EP0883587A1
(en)
|
1996-01-20 |
1998-12-16 |
Bradford University |
Tamoxifen and analogues thereof
|
HN1996000101A
(es)
|
1996-02-28 |
1997-06-26 |
Inc Pfizer |
Terapia combinada para la osteoporosis
|
EP0981337A4
(en)
*
|
1997-02-09 |
2003-03-12 |
Pharmos Corp |
IMPROVED ANTI-ANGIOGENIC ACTIVITY OF CONSTANTLY LOADED DERIVATIVES OF STEROID HORMONES
|
US6083990A
(en)
*
|
1997-04-02 |
2000-07-04 |
Pharmos Corporation |
Enhanced anti-angiogenic activity of permanently charged derivatives of steroid hormones
|
US5955466A
(en)
*
|
1997-02-27 |
1999-09-21 |
Pharmacia & Upjohn Company |
Tamoxifen as a therapy to reduce irinotecan hydrochloride-induced diarrhea
|
GB9715479D0
(en)
*
|
1997-07-23 |
1997-10-01 |
Univ Bradford |
Tamoxifen and analogues thereof
|
RU2214236C2
(ru)
|
1997-08-15 |
2003-10-20 |
Дьюк Юниверсити |
Способ профилактики или лечения эстрогензависимых заболеваний и расстройств
|
UA66370C2
(en)
*
|
1997-12-16 |
2004-05-17 |
Lilly Co Eli |
Arylpiperazines having activity to setotonin 1 receptors
|
GB9824207D0
(en)
*
|
1998-11-04 |
1998-12-30 |
Zeneca Ltd |
Neurological disorders
|
TW593256B
(en)
|
1999-11-16 |
2004-06-21 |
Hormos Medical Oy Ltd |
Triphenylalkene derivatives and their use as selective estrogen receptor modulators
|
US20020013327A1
(en)
*
|
2000-04-18 |
2002-01-31 |
Lee Andrew G. |
Compositions and methods for treating female sexual dysfunction
|
GB0012291D0
(en)
*
|
2000-05-23 |
2000-07-12 |
Astrazeneca Ab |
Pharmaceutical combination
|
US20040033267A1
(en)
*
|
2002-03-20 |
2004-02-19 |
Elan Pharma International Ltd. |
Nanoparticulate compositions of angiogenesis inhibitors
|
US6613083B2
(en)
|
2001-05-02 |
2003-09-02 |
Eckhard Alt |
Stent device and method
|
DE60334711D1
(de)
*
|
2002-07-30 |
2010-12-09 |
Karykion Inc |
Zusammensetzungen aus ezetimib und verfahren zur behandlung von mit cholesterin zusammenhängenden gutartigen und bösartigen tumoren
|
US7332525B2
(en)
*
|
2003-01-17 |
2008-02-19 |
Castle Erik P |
Method of treatment of prostate cancer and composition for treatment thereof
|
US20040248989A1
(en)
|
2003-06-05 |
2004-12-09 |
Risto Santti |
Method for the treatment or prevention of lower urinary tract symptoms
|
AU2004273658A1
(en)
*
|
2003-09-19 |
2005-03-31 |
Wisconsin Alumni Research Foundation (Warf) |
Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin D derivatives and an estrogen agonist/antagonist
|
WO2005051298A2
(en)
|
2003-11-19 |
2005-06-09 |
Metabasis Therapeutics, Inc. |
Novel phosphorus-containing thyromimetics
|
EP3006039B1
(en)
|
2004-03-02 |
2021-01-06 |
Acceleron Pharma Inc. |
Alk7 polypeptides for use in promoting fat loss
|
US20050203086A1
(en)
*
|
2004-03-04 |
2005-09-15 |
Pfizer Inc. |
Methods of treatment using an EP2 selective receptor agonist
|
AP2007003979A0
(en)
*
|
2004-11-23 |
2007-06-30 |
Warner Lambert Co |
7-(2h-pyrazol-3-yl)-3,5-dihyroxy-heptanoic acid derivatives as hmg co-a reductase inhibitors for thetreatment of lipidemia
|
JP5475235B2
(ja)
|
2005-01-21 |
2014-04-16 |
アステックス・セラピューティクス・リミテッド |
医薬化合物
|
SG164368A1
(en)
|
2005-07-18 |
2010-09-29 |
Bipar Sciences Inc |
Treatment of cancer
|
US7741317B2
(en)
|
2005-10-21 |
2010-06-22 |
Bristol-Myers Squibb Company |
LXR modulators
|
US7888376B2
(en)
|
2005-11-23 |
2011-02-15 |
Bristol-Myers Squibb Company |
Heterocyclic CETP inhibitors
|
WO2007135547A2
(en)
|
2006-05-22 |
2007-11-29 |
Hormos Medical Ltd. |
Selective estrogen receptor modulators or aromatase inhibitors for treating chronic nonbacterial prostatitis
|
WO2007143607A2
(en)
|
2006-06-02 |
2007-12-13 |
Pear Tree Women's Health Care |
Method of treating atrophic vaginitis
|
US20100160442A1
(en)
*
|
2006-07-18 |
2010-06-24 |
Ossovskaya Valeria S |
Formulations for cancer treatment
|
WO2008044045A1
(en)
|
2006-10-12 |
2008-04-17 |
Astex Therapeutics Limited |
Pharmaceutical combinations
|
US8916552B2
(en)
|
2006-10-12 |
2014-12-23 |
Astex Therapeutics Limited |
Pharmaceutical combinations
|
JP5498168B2
(ja)
|
2006-12-01 |
2014-05-21 |
ブリストル−マイヤーズ スクイブ カンパニー |
アテローム性動脈硬化および循環器疾患の治療のためのcetp阻害剤としてのn−((3−ベンジル)−2,2−(ビス−フェニル)−プロパン−1−アミン誘導体
|
CN101678107A
(zh)
|
2007-08-03 |
2010-03-24 |
萨米特公开有限公司 |
用于治疗杜兴型肌营养不良的药物组合物
|
GB0715087D0
(en)
|
2007-08-03 |
2007-09-12 |
Summit Corp Plc |
Drug combinations for the treatment of duchenne muscular dystrophy
|
JP5558358B2
(ja)
|
2007-10-16 |
2014-07-23 |
レプロス セラピューティクス インコーポレイティド |
メタボリック症候群用のtrans−クロミフェン
|
US20120046364A1
(en)
|
2009-02-10 |
2012-02-23 |
Metabasis Therapeutics, Inc. |
Novel Sulfonic Acid-Containing Thyromimetics, and Methods for Their Use
|
EP2809312A1
(en)
|
2012-01-31 |
2014-12-10 |
Novartis AG |
Combination of a rtk inhibitor with an anti - estrogen and use thereof for the treatment of cancer
|
CA2865234A1
(en)
|
2012-02-29 |
2013-09-06 |
Repros Therapeutics Inc. |
Combination therapy for treating androgen deficiency
|
CN104203961B
(zh)
|
2012-03-05 |
2017-05-17 |
泽维尔大学 |
作为用于治疗乳腺癌的基于硼的4‑羟基他莫昔芬和因多昔芬前药
|
CN103992234B
(zh)
*
|
2014-06-11 |
2016-05-18 |
扬子江药业集团江苏海慈生物药业有限公司 |
一种枸橼酸他莫昔芬e异构体的制备方法
|
AU2016352592B2
(en)
|
2015-11-10 |
2023-04-27 |
Paracrine Therapeutics Ab |
Treatment of ER-negative breast cancer with an PDGF-CC inhibitor and an anti estrogen
|
WO2017120204A2
(en)
|
2016-01-05 |
2017-07-13 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Combination of histone deacetylase inhibitor and immunotherapy
|
WO2017136342A1
(en)
|
2016-02-02 |
2017-08-10 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Fulvestrant for inducing immune-mediated cytotoxic lysis of cancer cells
|
EP3493794A4
(en)
|
2016-08-04 |
2020-05-06 |
University of Iowa Research Foundation |
USE OF SWELL1 INHIBITORS AND MODULATORS FOR TREATING TYPE 2 DIABETES AND ADIPOSITAS
|
JP7100019B2
(ja)
|
2016-08-19 |
2022-07-12 |
ザ ユナイテッド ステイツ オブ アメリカ, アズ リプレゼンテッド バイ ザ セクレタリー, デパートメント オブ ヘルス アンド ヒューマン サービシーズ |
選択的エストロゲン受容体モジュレーター(serm)は、光受容体の変性に対する保護を付与する
|
AU2019223014B2
(en)
|
2018-02-21 |
2024-10-17 |
AI Therapeutics, Inc. |
Combination therapy with apilimod and glutamatergic agents
|
CA3142931A1
(en)
*
|
2019-06-10 |
2020-12-17 |
University Of Iowa Research Foundation |
Swell 1 modulators for treatment of non-alcoholic fatty liver disease, immune deficiencies, male infertility and vascular diseases
|
CN114133334B
(zh)
*
|
2021-11-09 |
2024-07-19 |
北京京丰制药(山东)有限公司 |
枸橼酸他莫昔芬的工业化制备工艺
|
EP4230196A1
(en)
|
2022-02-21 |
2023-08-23 |
Som Innovation Biotech, S.A. |
Compounds for use in the treatment of dystrophinopathies
|
EP4311546A1
(en)
|
2022-07-26 |
2024-01-31 |
Dynacure |
Combination therapy for myopathies
|