EP0981337A4 - Enhanced anti-angiogenic activity of permanently charged derivatives of steroid hormones - Google Patents
Enhanced anti-angiogenic activity of permanently charged derivatives of steroid hormonesInfo
- Publication number
- EP0981337A4 EP0981337A4 EP98903921A EP98903921A EP0981337A4 EP 0981337 A4 EP0981337 A4 EP 0981337A4 EP 98903921 A EP98903921 A EP 98903921A EP 98903921 A EP98903921 A EP 98903921A EP 0981337 A4 EP0981337 A4 EP 0981337A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- steroid hormones
- angiogenic activity
- enhanced anti
- permanently charged
- charged derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Cardiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US833074 | 1986-02-26 | ||
IL12018497A IL120184A (en) | 1997-02-09 | 1997-02-09 | Pharmaceutical compositions comprising permanently charged derivatives of steroid agonists or antagonists for preventing angiogenesis |
IL12018497 | 1997-02-09 | ||
US08/833,074 US6083990A (en) | 1997-04-02 | 1997-04-02 | Enhanced anti-angiogenic activity of permanently charged derivatives of steroid hormones |
PCT/US1998/002176 WO1998034583A2 (en) | 1997-02-09 | 1998-02-04 | Enhanced anti-angiogenic activity of permanently charged derivatives of steroid hormones |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0981337A2 EP0981337A2 (en) | 2000-03-01 |
EP0981337A4 true EP0981337A4 (en) | 2003-03-12 |
Family
ID=26323367
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP98903921A Withdrawn EP0981337A4 (en) | 1997-02-09 | 1998-02-04 | Enhanced anti-angiogenic activity of permanently charged derivatives of steroid hormones |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0981337A4 (en) |
JP (1) | JP2001511182A (en) |
AU (1) | AU746007B2 (en) |
CA (1) | CA2280181A1 (en) |
WO (1) | WO1998034583A2 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR3046792B1 (en) * | 2016-01-19 | 2018-02-02 | Les Laboratoires Servier | NOVEL AMMONIUM DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
EP3484463B1 (en) * | 2016-08-19 | 2020-02-12 | The United States of America, as Represented by The Secretary, Department of Health and Human Services Office of Technology Transfer | Selective estrogen-receptor modulators (serms) confer protection against photoreceptor degeneration |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2914561A (en) * | 1957-08-06 | 1959-11-24 | Wm S Merrell Co | Amine derivatives of triphenylethylene |
US2971001A (en) * | 1959-10-21 | 1961-02-07 | Wm S Merrell Co | Quaternary salts of triphenylethanols, -ethylenes, and -ethanes |
US4536516A (en) * | 1962-09-13 | 1985-08-20 | Imperial Chemical Industries Plc | Alkene derivatives |
WO1994009764A1 (en) * | 1992-10-27 | 1994-05-11 | Nippon Kayaku Kabushiki Kaisha | Use of non steroidal anti estrogens for autoimmune diseases |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5650425A (en) * | 1994-04-04 | 1997-07-22 | Pharmos Corporation | Permanently ionic derivatives of steroid hormones and their antagonists |
-
1998
- 1998-02-04 WO PCT/US1998/002176 patent/WO1998034583A2/en not_active Application Discontinuation
- 1998-02-04 EP EP98903921A patent/EP0981337A4/en not_active Withdrawn
- 1998-02-04 JP JP53487698A patent/JP2001511182A/en not_active Abandoned
- 1998-02-04 AU AU60562/98A patent/AU746007B2/en not_active Ceased
- 1998-02-04 CA CA002280181A patent/CA2280181A1/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2914561A (en) * | 1957-08-06 | 1959-11-24 | Wm S Merrell Co | Amine derivatives of triphenylethylene |
US2971001A (en) * | 1959-10-21 | 1961-02-07 | Wm S Merrell Co | Quaternary salts of triphenylethanols, -ethylenes, and -ethanes |
US4536516A (en) * | 1962-09-13 | 1985-08-20 | Imperial Chemical Industries Plc | Alkene derivatives |
WO1994009764A1 (en) * | 1992-10-27 | 1994-05-11 | Nippon Kayaku Kabushiki Kaisha | Use of non steroidal anti estrogens for autoimmune diseases |
Non-Patent Citations (7)
Title |
---|
BIEGON ANAT ET AL: "A permanently charges tamoxifen derivative displays anticancer activity and improved tissue selectivity in rodents.", CANCER RESEARCH, vol. 56, no. 19, 1996, pages 4328 - 4331, XP001121764, ISSN: 0008-5472 * |
BREWSTER M E ET AL: "Mechanisms of action of quaternary derivatives of tamoxifen.", ABSTRACTS OF PAPERS AMERICAN CHEMICAL SOCIETY, vol. 212, no. 1-2, 1996, 212th American Chemical Society National Meeting;Orlando, Florida, USA; August 25-29, 1996, pages MEDI 43, XP009003601, ISSN: 0065-7727 * |
BREWSTER M E ET AL: "Tamoxifen methiodide-induced necrosis and fibrosis in implanted human breast tumors, an MRI study.", PHARMACEUTICAL RESEARCH (NEW YORK), vol. 13, no. 9 SUPPL., 1996, Annual Meeting of the American Association of Pharmaceutical Scientists;Seattle, Washington, USA; October 27-31, 1996, pages S492, XP009003325, ISSN: 0724-8741 * |
FOLKMAN J: "WHAT IS THE EVIDENCE THAT TUMORS ARE ANGIOGENESIS DEPENDENT?", JOURNAL OF THE NATIONAL CANCER INSTITUTE, US DEPT. OF HEALTH, EDICATIONAND WELFARE, PUBLIC HEALTH, US, vol. 82, 3 January 1990 (1990-01-03), pages 4 - 6, XP000943514, ISSN: 0027-8874 * |
GAGLIARDI A ET AL: "INHIBITION OF ANGIOGENESIS BY ANTIESTROGENS", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 53, 1 February 1993 (1993-02-01), pages 533 - 535, XP001121715, ISSN: 0008-5472 * |
See also references of WO9834583A3 * |
WEIDNER N ET AL: "TUMOR ANGIOGENESIS AND METASTASIS CORRELATION IN INVASIVE BREAST CARCINOMA", NEW ENGLAND JOURNAL OF MEDICINE, vol. 324, no. 1, 1991, pages 1 - 8, XP009003719, ISSN: 0028-4793 * |
Also Published As
Publication number | Publication date |
---|---|
JP2001511182A (en) | 2001-08-07 |
AU6056298A (en) | 1998-08-26 |
AU746007B2 (en) | 2002-04-11 |
WO1998034583A2 (en) | 1998-08-13 |
EP0981337A2 (en) | 2000-03-01 |
CA2280181A1 (en) | 1998-08-13 |
WO1998034583A3 (en) | 1998-11-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19990909 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20030124 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: 7A 61P 17/06 B Ipc: 7A 61P 35/04 B Ipc: 7A 61P 29/00 B Ipc: 7A 61P 27/02 B Ipc: 7A 61P 19/02 B Ipc: 7A 61P 15/00 B Ipc: 7A 61P 7/00 B Ipc: 7A 61P 5/32 B Ipc: 7A 61K 31/40 A |
|
17Q | First examination report despatched |
Effective date: 20030507 |
|
GRAP | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOSNIGR1 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: 7A 61K 31/135 B Ipc: 7A 61K 31/138 B Ipc: 7A 61K 31/00 B Ipc: 7A 61P 17/06 B Ipc: 7A 61P 35/04 B Ipc: 7A 61P 29/00 B Ipc: 7A 61P 27/02 B Ipc: 7A 61P 19/02 B Ipc: 7A 61P 15/00 B Ipc: 7A 61P 7/00 B Ipc: 7A 61P 5/32 B Ipc: 7A 61K 31/40 A |
|
RTI1 | Title (correction) |
Free format text: USE OF PERMANENTLY CHARGED DERIVATIVES OF STEROID HORMONES FOR THE TREATMENT OF DISEASES ASSOCIATED WITH PATHOLOGICAL ANG |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: 7A 61K 31/135 B Ipc: 7A 61K 31/138 B Ipc: 7A 61K 31/00 B Ipc: 7A 61P 17/06 B Ipc: 7A 61P 35/04 B Ipc: 7A 61P 29/00 B Ipc: 7A 61P 27/02 B Ipc: 7A 61P 19/02 B Ipc: 7A 61P 15/00 B Ipc: 7A 61P 7/00 B Ipc: 7A 61P 5/32 B Ipc: 7A 61K 31/40 A |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: 7A 61P 43/00 B Ipc: 7A 61P 17/06 B Ipc: 7A 61P 27/02 B Ipc: 7A 61P 19/02 B Ipc: 7A 61P 15/00 B Ipc: 7A 61P 7/00 B Ipc: 7A 61K 31/135 B Ipc: 7A 61K 31/138 A |
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RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: PHARMOS CORPORATION |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20050816 |