EP0981337A4 - Activite anti-angiogenique amelioree des derives constamment charges d'hormones steroidiennes - Google Patents

Activite anti-angiogenique amelioree des derives constamment charges d'hormones steroidiennes

Info

Publication number
EP0981337A4
EP0981337A4 EP98903921A EP98903921A EP0981337A4 EP 0981337 A4 EP0981337 A4 EP 0981337A4 EP 98903921 A EP98903921 A EP 98903921A EP 98903921 A EP98903921 A EP 98903921A EP 0981337 A4 EP0981337 A4 EP 0981337A4
Authority
EP
European Patent Office
Prior art keywords
steroid hormones
angiogenic activity
enhanced anti
permanently charged
charged derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98903921A
Other languages
German (de)
English (en)
Other versions
EP0981337A2 (fr
Inventor
Anat Biegon
Marcus E Brewster
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmos Corp
Original Assignee
Pharmos Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL12018497A external-priority patent/IL120184A/xx
Priority claimed from US08/833,074 external-priority patent/US6083990A/en
Application filed by Pharmos Corp filed Critical Pharmos Corp
Publication of EP0981337A2 publication Critical patent/EP0981337A2/fr
Publication of EP0981337A4 publication Critical patent/EP0981337A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
EP98903921A 1997-02-09 1998-02-04 Activite anti-angiogenique amelioree des derives constamment charges d'hormones steroidiennes Withdrawn EP0981337A4 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US833074 1986-02-26
IL12018497 1997-02-09
IL12018497A IL120184A (en) 1997-02-09 1997-02-09 Pharmaceutical compositions comprising permanently charged derivatives of steroid agonists or antagonists for preventing angiogenesis
US08/833,074 US6083990A (en) 1997-04-02 1997-04-02 Enhanced anti-angiogenic activity of permanently charged derivatives of steroid hormones
PCT/US1998/002176 WO1998034583A2 (fr) 1997-02-09 1998-02-04 Activite anti-angiogenique amelioree des derives constamment charges d'hormones steroidiennes

Publications (2)

Publication Number Publication Date
EP0981337A2 EP0981337A2 (fr) 2000-03-01
EP0981337A4 true EP0981337A4 (fr) 2003-03-12

Family

ID=26323367

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98903921A Withdrawn EP0981337A4 (fr) 1997-02-09 1998-02-04 Activite anti-angiogenique amelioree des derives constamment charges d'hormones steroidiennes

Country Status (5)

Country Link
EP (1) EP0981337A4 (fr)
JP (1) JP2001511182A (fr)
AU (1) AU746007B2 (fr)
CA (1) CA2280181A1 (fr)
WO (1) WO1998034583A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3046792B1 (fr) * 2016-01-19 2018-02-02 Les Laboratoires Servier Nouveaux derives d'ammonium, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AU2017312499B2 (en) * 2016-08-19 2023-02-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Selective estrogen-receptor modulators (SERMs) confer protection against photoreceptor degeneration

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2914561A (en) * 1957-08-06 1959-11-24 Wm S Merrell Co Amine derivatives of triphenylethylene
US2971001A (en) * 1959-10-21 1961-02-07 Wm S Merrell Co Quaternary salts of triphenylethanols, -ethylenes, and -ethanes
US4536516A (en) * 1962-09-13 1985-08-20 Imperial Chemical Industries Plc Alkene derivatives
WO1994009764A1 (fr) * 1992-10-27 1994-05-11 Nippon Kayaku Kabushiki Kaisha Utilisation d'anti×strogenes non steroidiens pour traiter des maladies auto-immunes

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5650425A (en) * 1994-04-04 1997-07-22 Pharmos Corporation Permanently ionic derivatives of steroid hormones and their antagonists

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2914561A (en) * 1957-08-06 1959-11-24 Wm S Merrell Co Amine derivatives of triphenylethylene
US2971001A (en) * 1959-10-21 1961-02-07 Wm S Merrell Co Quaternary salts of triphenylethanols, -ethylenes, and -ethanes
US4536516A (en) * 1962-09-13 1985-08-20 Imperial Chemical Industries Plc Alkene derivatives
WO1994009764A1 (fr) * 1992-10-27 1994-05-11 Nippon Kayaku Kabushiki Kaisha Utilisation d'anti×strogenes non steroidiens pour traiter des maladies auto-immunes

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BIEGON ANAT ET AL: "A permanently charges tamoxifen derivative displays anticancer activity and improved tissue selectivity in rodents.", CANCER RESEARCH, vol. 56, no. 19, 1996, pages 4328 - 4331, XP001121764, ISSN: 0008-5472 *
BREWSTER M E ET AL: "Mechanisms of action of quaternary derivatives of tamoxifen.", ABSTRACTS OF PAPERS AMERICAN CHEMICAL SOCIETY, vol. 212, no. 1-2, 1996, 212th American Chemical Society National Meeting;Orlando, Florida, USA; August 25-29, 1996, pages MEDI 43, XP009003601, ISSN: 0065-7727 *
BREWSTER M E ET AL: "Tamoxifen methiodide-induced necrosis and fibrosis in implanted human breast tumors, an MRI study.", PHARMACEUTICAL RESEARCH (NEW YORK), vol. 13, no. 9 SUPPL., 1996, Annual Meeting of the American Association of Pharmaceutical Scientists;Seattle, Washington, USA; October 27-31, 1996, pages S492, XP009003325, ISSN: 0724-8741 *
FOLKMAN J: "WHAT IS THE EVIDENCE THAT TUMORS ARE ANGIOGENESIS DEPENDENT?", JOURNAL OF THE NATIONAL CANCER INSTITUTE, US DEPT. OF HEALTH, EDICATIONAND WELFARE, PUBLIC HEALTH, US, vol. 82, 3 January 1990 (1990-01-03), pages 4 - 6, XP000943514, ISSN: 0027-8874 *
GAGLIARDI A ET AL: "INHIBITION OF ANGIOGENESIS BY ANTIESTROGENS", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 53, 1 February 1993 (1993-02-01), pages 533 - 535, XP001121715, ISSN: 0008-5472 *
See also references of WO9834583A3 *
WEIDNER N ET AL: "TUMOR ANGIOGENESIS AND METASTASIS CORRELATION IN INVASIVE BREAST CARCINOMA", NEW ENGLAND JOURNAL OF MEDICINE, vol. 324, no. 1, 1991, pages 1 - 8, XP009003719, ISSN: 0028-4793 *

Also Published As

Publication number Publication date
WO1998034583A2 (fr) 1998-08-13
AU746007B2 (en) 2002-04-11
JP2001511182A (ja) 2001-08-07
EP0981337A2 (fr) 2000-03-01
WO1998034583A3 (fr) 1998-11-05
AU6056298A (en) 1998-08-26
CA2280181A1 (fr) 1998-08-13

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Legal Events

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Ipc: 7A 61P 17/06 B

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RTI1 Title (correction)

Free format text: USE OF PERMANENTLY CHARGED DERIVATIVES OF STEROID HORMONES FOR THE TREATMENT OF DISEASES ASSOCIATED WITH PATHOLOGICAL ANG

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Ipc: 7A 61K 31/135 B

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Ipc: 7A 61K 31/40 A

RIC1 Information provided on ipc code assigned before grant

Ipc: 7A 61P 43/00 B

Ipc: 7A 61P 17/06 B

Ipc: 7A 61P 27/02 B

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Owner name: PHARMOS CORPORATION

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Effective date: 20050816