BE1003253A3 - Composition pour aerosols contenant la nitroglycerine comme ingredient actif. - Google Patents

Composition pour aerosols contenant la nitroglycerine comme ingredient actif. Download PDF

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Publication number
BE1003253A3
BE1003253A3 BE8900746A BE8900746A BE1003253A3 BE 1003253 A3 BE1003253 A3 BE 1003253A3 BE 8900746 A BE8900746 A BE 8900746A BE 8900746 A BE8900746 A BE 8900746A BE 1003253 A3 BE1003253 A3 BE 1003253A3
Authority
BE
Belgium
Prior art keywords
active ingredient
composition
component
nitroglycerin
aerosols containing
Prior art date
Application number
BE8900746A
Other languages
English (en)
Inventor
Margit Nee Kricsfalussy Nagy
Jozsef Kenderfi
Frigyes Goergenyi
Margit Csoergo
Lidia Fedina
Antal Mosonyi
Sandor Vajas
Attila Mandi
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Application granted granted Critical
Publication of BE1003253A3 publication Critical patent/BE1003253A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K3/00—Materials not provided for elsewhere
    • C09K3/30—Materials not provided for elsewhere for aerosols

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Physiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Materials Engineering (AREA)
  • Nutrition Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne une composition pour aérosols exempte de gaz propulsuer, contenant la nitroglycérine comme ingrédient actif. La composition selon l'invention se compose de 0,1 à 4% de nitroglycérine, 51 à 90% en poids d'un alcool aliphatique en C2-4(composant A), 1o à 49% en poids d'un polyalcoylèneglycol comportant 2 ou 3 atomes dans la portion alcoylène (composant B1) et/ou d'un alcool en C2-8 comportant deux ou trois groupes hydroxyle (composant B2) éventuellement conjointement avec un ou plusieurs véhicules et/ou diluants pharmaceutiquement acceptables.
BE8900746A 1988-07-08 1989-07-07 Composition pour aerosols contenant la nitroglycerine comme ingredient actif. BE1003253A3 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU883585A HU199678B (en) 1988-07-08 1988-07-08 Process for producing aerosols containing nitroglicerol

Publications (1)

Publication Number Publication Date
BE1003253A3 true BE1003253A3 (fr) 1992-02-11

Family

ID=10964655

Family Applications (1)

Application Number Title Priority Date Filing Date
BE8900746A BE1003253A3 (fr) 1988-07-08 1989-07-07 Composition pour aerosols contenant la nitroglycerine comme ingredient actif.

Country Status (15)

Country Link
US (1) US5047230A (fr)
JP (1) JPH0651620B2 (fr)
AT (1) AT401613B (fr)
BE (1) BE1003253A3 (fr)
BG (1) BG89108A (fr)
CH (1) CH679371A5 (fr)
CY (1) CY1761A (fr)
DE (1) DE3922650A1 (fr)
FR (1) FR2633933B1 (fr)
GB (1) GB2220949B (fr)
HU (1) HU199678B (fr)
IT (1) IT1230742B (fr)
NL (1) NL8901751A (fr)
RU (1) RU1837871C (fr)
UA (1) UA11237A (fr)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4007705C1 (fr) * 1990-03-10 1991-09-26 G. Pohl-Boskamp Gmbh & Co. Chemisch-Pharmazeutische Fabrik, 2214 Hohenlockstedt, De
DE4018919C2 (de) * 1990-06-13 1994-08-25 Sanol Arznei Schwarz Gmbh Nitroglycerin-Spray
US5370862A (en) * 1990-06-13 1994-12-06 Schwarz Pharma Ag Pharmaceutical hydrophilic spray containing nitroglycerin for treating angina
DE4026072A1 (de) * 1990-08-17 1992-02-20 Sanol Arznei Schwarz Gmbh Nitroglycerinhaltiger, hydrophiler, waessriger pumpspray
DE4038203A1 (de) * 1990-11-30 1992-06-04 Kali Chemie Pharma Gmbh Pharmazeutische spray-zubereitungen mit coronaraktiven wirkstoffen
WO1995032715A1 (fr) * 1994-05-27 1995-12-07 Neptune Pharmaceutical Corporation Composition donneuse d'oxyde nitrique et procede de traitement de troubles anaux
SK282468B6 (sk) * 1995-06-27 2002-02-05 Boehringer Ingelheim Kg Farmaceutický prostriedok na výrobu inhalovateľných aerosólov bez obsahu hnacieho plynu a jeho použitie
EP0910339B1 (fr) * 1996-04-12 2005-02-02 Novadel Pharma Inc. Aerosol buccal polaire
US20030077228A1 (en) * 1997-10-01 2003-04-24 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating endocrine disorders
US20030082107A1 (en) * 1997-10-01 2003-05-01 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating an infectious disease or cancer
US20040141923A1 (en) * 1997-10-01 2004-07-22 Dugger Harry A. Buccal, polar and non-polar spray containing alprazolam
US7632517B2 (en) * 1997-10-01 2009-12-15 Novadel Pharma Inc. Buccal, polar and non-polar spray containing zolpidem
US20040136913A1 (en) * 1997-10-01 2004-07-15 Dugger Harry A. Buccal, polar and non-polar spray containing sumatriptan
US20030077227A1 (en) * 1997-10-01 2003-04-24 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the central nervous system
US20050281752A1 (en) * 1997-10-01 2005-12-22 Dugger Harry A Iii Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the central nervous system
US20030095926A1 (en) * 1997-10-01 2003-05-22 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the gastrointestinal tract or urinary tract
US20040136914A1 (en) * 1997-10-01 2004-07-15 Dugger Harry A. Buccal, polar and non-polar spray containing ondansetron
US20050180923A1 (en) * 1997-10-01 2005-08-18 Dugger Harry A.Iii Buccal, polar and non-polar spray containing testosterone
ES2293875T3 (es) * 1997-10-01 2008-04-01 Novadel Pharma Inc. Aerosol bucal no polar.
US20030077229A1 (en) * 1997-10-01 2003-04-24 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing cardiovascular or renal drugs
US20040136915A1 (en) * 1997-10-01 2004-07-15 Dugger Harry A. Buccal, polar and non-polar spray containing atropine
US20030095925A1 (en) * 1997-10-01 2003-05-22 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating metabolic disorders
US20050002867A1 (en) * 1997-10-01 2005-01-06 Novadel Pharma Inc. Buccal, polar and non-polar sprays containing propofol
US20030185761A1 (en) 1997-10-01 2003-10-02 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating pain
US20090162300A1 (en) * 1997-10-01 2009-06-25 Dugger Iii Harry A Buccal, polar and non-polar spray containing alprazolam
US20050163719A1 (en) * 1997-10-01 2005-07-28 Dugger Harry A.Iii Buccal, polar and non-polar spray containing diazepam
US20030190286A1 (en) * 1997-10-01 2003-10-09 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating allergies or asthma
US20050287075A1 (en) * 1997-10-01 2005-12-29 Dugger Harry A Iii Buccal, polar and non-polar spray or capsule containing drugs for treating pain
US20030095927A1 (en) * 1997-10-01 2003-05-22 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating muscular and skeletal disorders
DE19855097A1 (de) * 1998-11-28 2000-05-31 Wella Ag Pigmenthaltiges, verschäumbares Gel
AU2879100A (en) * 1999-02-12 2000-08-29 Miles A. Libbey Iii Formulation and system for intra-oral delivery of pharmaceutical agents
US10004684B2 (en) 2001-02-14 2018-06-26 Gw Pharma Limited Pharmaceutical formulations
GB0417675D0 (en) * 2004-08-09 2004-09-08 Futura Medical Dev Ltd Composition for promoting vascular smooth muscle relaxation
US8097614B2 (en) * 2005-02-17 2012-01-17 Velcera Pharmaceuticals, Inc. Transmucosal administration of meloxicam compositions for treating and preventing disorders in non-human domesticated animals
GB0602224D0 (en) * 2006-02-03 2006-03-15 Futura Medical Dev Ltd Composition for promoting vascular smooth muscle relaxation
EP2015632B1 (fr) * 2006-04-19 2015-12-02 Mist Pharmaceuticals, LLC Formulations hydroalcooliques stables à pulvériser dans la cavité buccale et procédés associés
EP2124897A4 (fr) * 2006-12-22 2012-05-09 Novadel Pharma Inc Préparations antinauséeuses à pulvériser, à usage oral, stables, et méthodes associées
BRPI0811430A2 (pt) * 2007-05-10 2015-06-23 Novadel Pharma Inc Composições anti-insônia e processos
DE202008008079U1 (de) * 2008-06-16 2008-09-04 G. Pohl-Boskamp Gmbh & Co. Kg Pharmazeutische Zubereitung in Wasserdampf durchlässigen Behältern mit verbesserter Stabilität
WO2012016690A1 (fr) 2010-08-03 2012-02-09 G. Pohl-Boskamp Gmbh & Co. Kg Utilisation de trinitrate de glycéryle pour le traitement d'hématomes
US20130327676A1 (en) 2011-02-25 2013-12-12 G. Pohl-Boskamp Gmbh & Co. Kg Packaging of Solid Pharmaceutical Preparations Containing the Active Substance Glyceryl Trinitrate
ES2617494T3 (es) 2012-05-31 2017-06-19 G. Pohl-Boskamp Gmbh & Co. Kg Inducción de arteriogénesis con un donador de óxido nítrico tal como nitroglicerina
US9248099B2 (en) 2012-05-31 2016-02-02 Desmoid Aktiengesellschaft Use of stabilized granules containing glyceryl trinitrate for arteriogenesis
EP2878310B1 (fr) 2013-11-29 2017-01-11 G. Pohl-Boskamp GmbH & Co. KG Composition aqueuse pulvérisable comprenant du trinitrate de glycéryle
CN104984351B (zh) * 2015-06-15 2018-01-30 马应龙药业集团股份有限公司 一种硝酸甘油丙二醇溶液的制备方法
CN113125596B (zh) * 2021-04-07 2023-01-13 马应龙药业集团股份有限公司 一种高效液相色谱法测定硝酸甘油软膏中有关物质的方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0175671A1 (fr) * 1984-08-23 1986-03-26 Kuhlemann & Co. Préparation pharmaceutique et procédé pour l'administration de cette préparation pharmaceutique
EP0310910A1 (fr) * 1987-09-30 1989-04-12 Nippon Kayaku Kabushiki Kaisha Aérosol de nitroglycérine

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE632504A (fr) * 1962-05-24
US4001391A (en) * 1969-04-18 1977-01-04 Plough, Inc. Means for depositing aerosol sprays in buttery form
US4369173A (en) * 1974-11-27 1983-01-18 Wickhen Products, Inc. Antiperspirant compositions
IL61721A (en) * 1980-12-16 1984-03-30 Blank Izhak Nitroglycerin preparations
DE3109783A1 (de) * 1981-03-13 1982-10-07 Sanol Schwarz-Monheim Gmbh, 4019 Monheim Mit wasser zu einer etwa isotonischen nitroglycerinloesung aufloesbare zubereitung und derartige nitroglycerinloesung
US4440777A (en) * 1981-07-07 1984-04-03 Merck & Co., Inc. Use of eucalyptol for enhancing skin permeation of bio-affecting agents
DE3246081A1 (de) * 1982-12-13 1984-06-14 G. Pohl-Boskamp GmbH & Co Chemisch-pharmazeutische Fabrik, 2214 Hohenlockstedt Nitroglycerin-spray
US4885173A (en) * 1985-05-01 1989-12-05 University Of Utah Methods and compositions for noninvasive dose-to-effect administration of drugs with cardiovascular or renal vascular activities
DE3613187A1 (de) * 1986-04-18 1987-10-22 Mack Chem Pharm Verwendung einer carbonsaeure in zur topischen anwendung bestimmten pharmazeutischen zubereitungen
DE4018919C2 (de) * 1990-06-13 1994-08-25 Sanol Arznei Schwarz Gmbh Nitroglycerin-Spray

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0175671A1 (fr) * 1984-08-23 1986-03-26 Kuhlemann & Co. Préparation pharmaceutique et procédé pour l'administration de cette préparation pharmaceutique
EP0310910A1 (fr) * 1987-09-30 1989-04-12 Nippon Kayaku Kabushiki Kaisha Aérosol de nitroglycérine

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 63, no. 6, juin 1974, pages 907-911; A.M. CONTRACTOR et al.: "Development and evaluation of an inhalation aerosol of nitroglycerin" *

Also Published As

Publication number Publication date
GB8915632D0 (en) 1989-08-23
UA11237A (uk) 1996-12-25
GB2220949A (en) 1990-01-24
BG89108A (bg) 1993-12-24
GB2220949B (en) 1992-01-22
US5047230A (en) 1991-09-10
AT401613B (de) 1996-10-25
CH679371A5 (fr) 1992-02-14
IT1230742B (it) 1991-10-29
NL8901751A (nl) 1990-02-01
FR2633933B1 (fr) 1994-07-22
DE3922650A1 (de) 1990-01-11
ATA165489A (de) 1996-03-15
DE3922650C2 (fr) 1993-03-04
RU1837871C (ru) 1993-08-30
JPH02142726A (ja) 1990-05-31
FR2633933A1 (fr) 1990-01-12
IT8921118A0 (it) 1989-07-07
JPH0651620B2 (ja) 1994-07-06
HU199678B (en) 1990-03-28
CY1761A (en) 1994-07-15

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: EGIS GYOGYSZERGYAR

Effective date: 20000731