BE1002110A4 - Derives de l'isoquinoleine. - Google Patents
Derives de l'isoquinoleine. Download PDFInfo
- Publication number
- BE1002110A4 BE1002110A4 BE8700839A BE8700839A BE1002110A4 BE 1002110 A4 BE1002110 A4 BE 1002110A4 BE 8700839 A BE8700839 A BE 8700839A BE 8700839 A BE8700839 A BE 8700839A BE 1002110 A4 BE1002110 A4 BE 1002110A4
- Authority
- BE
- Belgium
- Prior art keywords
- radical
- compounds
- atom
- represent
- hydroxyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- -1 alkyl radical Chemical class 0.000 abstract 1
- 230000001093 anti-cancer Effects 0.000 abstract 1
- 125000006196 aroyl alkyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 150000004292 cyclic ethers Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical compound [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical compound [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 150000003254 radicals Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Composés de la formule (dans laquelle R1 et R2, qui peuvent être identiques ou différents, représentent chacun un atome d'hydrogène, un radical hydroxyle ou un radical -OP(O) (OH)(OR4) [où R4 représente un atome d'hydrogène ou un radical alkyle (éventuellement substitué par un groupe hydroxyle, alcoxy, éther cyclique ou cyclo-alkyle), alcényle, cycloalkyle, aryle, aralkyle, ou aroyl-alkyle], avec la condition qu'au moins l'un des symboles R1 et R2 représente un groupe -OP(O)(OH)(OR4); et R3 représente un atome d'hydrogène ou un atome d'halogène ou le radical méthyle); ainsi que les sels de ces composés. Les nouveaux composés manifestent une activité anti-cancéreuse.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB868618398A GB8618398D0 (en) | 1986-07-29 | 1986-07-29 | Chemical compounds |
GB878710608A GB8710608D0 (en) | 1987-05-05 | 1987-05-05 | Chemical compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
BE1002110A4 true BE1002110A4 (fr) | 1990-07-10 |
Family
ID=26291098
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE8700839A BE1002110A4 (fr) | 1986-07-29 | 1987-07-28 | Derives de l'isoquinoleine. |
Country Status (30)
Country | Link |
---|---|
US (1) | US4851399A (fr) |
JP (1) | JPH02187A (fr) |
KR (1) | KR880001652A (fr) |
CN (1) | CN1015059B (fr) |
AT (1) | ATA190987A (fr) |
AU (1) | AU604731B2 (fr) |
BE (1) | BE1002110A4 (fr) |
CH (1) | CH672489A5 (fr) |
DE (1) | DE3725185A1 (fr) |
DK (1) | DK392187A (fr) |
ES (1) | ES2007666A6 (fr) |
FI (1) | FI873289A (fr) |
FR (1) | FR2602233B1 (fr) |
GB (1) | GB2195636B (fr) |
GR (1) | GR871208B (fr) |
HK (1) | HK8491A (fr) |
HU (1) | HU201936B (fr) |
IL (1) | IL83335A0 (fr) |
IT (1) | IT1211683B (fr) |
LU (1) | LU86956A1 (fr) |
MY (1) | MY102457A (fr) |
NL (1) | NL8701768A (fr) |
NO (1) | NO872963L (fr) |
NZ (1) | NZ221238A (fr) |
PH (1) | PH25494A (fr) |
PL (1) | PL267063A1 (fr) |
PT (1) | PT85380B (fr) |
SE (1) | SE8702986L (fr) |
SG (1) | SG84490G (fr) |
SU (1) | SU1676445A3 (fr) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8800312D0 (en) * | 1988-01-07 | 1988-02-10 | Glaxo Group Ltd | Process |
AU6836200A (en) * | 1999-08-10 | 2001-03-05 | Glaxo Group Limited | Use of ep4 receptor ligands in the treatment of, inter alia, neuropathic pain and colon cancer |
KR20030062812A (ko) * | 2002-01-19 | 2003-07-28 | 한국과학기술원 | 금속주대용 플라스틱 자켓을 구비하는 인공보철물장치 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0161102A2 (fr) * | 1984-05-03 | 1985-11-13 | Glaxo Group Limited | Dérivés de l'isoquinoléine |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1087221A (en) * | 1963-03-16 | 1967-10-18 | Geigy Uk Ltd | 12-aminonaphthindolizinediones and processes for their manufacture |
US4029659A (en) * | 1971-03-29 | 1977-06-14 | Omnium Chimique Societe Anonyme | N-disubstituted aminoethyl esters of 11-methoxy-raubasinic acid |
US3894029A (en) * | 1971-08-26 | 1975-07-08 | Basf Ag | Production of camptothecin and camptothecin-like compounds |
GB1459137A (en) * | 1973-05-30 | 1976-12-22 | Sandoz Ltd | Naphthoquinone derivatives |
US4033966A (en) * | 1975-06-24 | 1977-07-05 | Kanebo, Ltd. | Novel berbine derivatives |
US4087426A (en) * | 1976-08-16 | 1978-05-02 | Research Corporation | Oxybisberberine and a process for its production |
FR2387229A1 (fr) * | 1977-04-13 | 1978-11-10 | Anvar | Dipyrido (4,3-b) (3,4-f) indoles, procede d'obtention, application therapeutique et compositions pharmaceutiques les contenant |
FR2436786A1 (fr) * | 1978-09-21 | 1980-04-18 | Anvar | Nouveaux derives des pyrido (4,3-b) carbazoles (ellipticines), substitues en position 1 par une chaine polyaminee, leur obtention et leur application a titre de medicaments |
US4399282A (en) * | 1979-07-10 | 1983-08-16 | Kabushiki Kaisha Yakult Honsha | Camptothecin derivatives |
DK158666C (da) * | 1982-11-04 | 1990-11-19 | Glaxo Group Ltd | Analogifremgangsmaade til fremstilling af 5,14-dihydrobenz-oe5,6aa-isoindolooe2,1-baa-isoquinolin-8,13-dion |
-
1987
- 1987-07-15 NO NO872963A patent/NO872963L/no unknown
- 1987-07-21 MY MYPI87001071A patent/MY102457A/en unknown
- 1987-07-22 PT PT85380A patent/PT85380B/pt not_active IP Right Cessation
- 1987-07-27 NL NL8701768A patent/NL8701768A/nl not_active Application Discontinuation
- 1987-07-27 IL IL83335A patent/IL83335A0/xx unknown
- 1987-07-28 HU HU873460A patent/HU201936B/hu unknown
- 1987-07-28 AU AU76203/87A patent/AU604731B2/en not_active Ceased
- 1987-07-28 AT AT0190987A patent/ATA190987A/de not_active Application Discontinuation
- 1987-07-28 CH CH2885/87A patent/CH672489A5/de not_active IP Right Cessation
- 1987-07-28 LU LU86956A patent/LU86956A1/fr unknown
- 1987-07-28 US US07/078,716 patent/US4851399A/en not_active Expired - Fee Related
- 1987-07-28 CN CN87105778A patent/CN1015059B/zh not_active Expired
- 1987-07-28 NZ NZ221238A patent/NZ221238A/xx unknown
- 1987-07-28 GB GB8717864A patent/GB2195636B/en not_active Expired - Fee Related
- 1987-07-28 GR GR871208A patent/GR871208B/el unknown
- 1987-07-28 ES ES8702210A patent/ES2007666A6/es not_active Expired
- 1987-07-28 SE SE8702986A patent/SE8702986L/xx not_active Application Discontinuation
- 1987-07-28 FI FI873289A patent/FI873289A/fi not_active Application Discontinuation
- 1987-07-28 SU SU874203501A patent/SU1676445A3/ru active
- 1987-07-28 DK DK392187A patent/DK392187A/da not_active Application Discontinuation
- 1987-07-28 PH PH35592A patent/PH25494A/en unknown
- 1987-07-28 BE BE8700839A patent/BE1002110A4/fr not_active IP Right Cessation
- 1987-07-28 IT IT8748237A patent/IT1211683B/it active
- 1987-07-29 DE DE19873725185 patent/DE3725185A1/de not_active Withdrawn
- 1987-07-29 FR FR878710763A patent/FR2602233B1/fr not_active Expired - Fee Related
- 1987-07-29 KR KR1019870008224A patent/KR880001652A/ko not_active Application Discontinuation
- 1987-07-29 PL PL1987267063A patent/PL267063A1/xx unknown
-
1989
- 1989-02-15 JP JP1033893A patent/JPH02187A/ja active Pending
-
1990
- 1990-10-22 SG SG844/90A patent/SG84490G/en unknown
-
1991
- 1991-01-24 HK HK84/91A patent/HK8491A/xx unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0161102A2 (fr) * | 1984-05-03 | 1985-11-13 | Glaxo Group Limited | Dérivés de l'isoquinoléine |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RE | Patent lapsed |
Owner name: GLAXO GROUP LTD Effective date: 19920731 |