BE1002110A4 - Derives de l'isoquinoleine. - Google Patents

Derives de l'isoquinoleine. Download PDF

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Publication number
BE1002110A4
BE1002110A4 BE8700839A BE8700839A BE1002110A4 BE 1002110 A4 BE1002110 A4 BE 1002110A4 BE 8700839 A BE8700839 A BE 8700839A BE 8700839 A BE8700839 A BE 8700839A BE 1002110 A4 BE1002110 A4 BE 1002110A4
Authority
BE
Belgium
Prior art keywords
radical
compounds
atom
represent
hydroxyl
Prior art date
Application number
BE8700839A
Other languages
English (en)
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB868618398A external-priority patent/GB8618398D0/en
Priority claimed from GB878710608A external-priority patent/GB8710608D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of BE1002110A4 publication Critical patent/BE1002110A4/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Composés de la formule (dans laquelle R1 et R2, qui peuvent être identiques ou différents, représentent chacun un atome d'hydrogène, un radical hydroxyle ou un radical -OP(O) (OH)(OR4) [où R4 représente un atome d'hydrogène ou un radical alkyle (éventuellement substitué par un groupe hydroxyle, alcoxy, éther cyclique ou cyclo-alkyle), alcényle, cycloalkyle, aryle, aralkyle, ou aroyl-alkyle], avec la condition qu'au moins l'un des symboles R1 et R2 représente un groupe -OP(O)(OH)(OR4); et R3 représente un atome d'hydrogène ou un atome d'halogène ou le radical méthyle); ainsi que les sels de ces composés. Les nouveaux composés manifestent une activité anti-cancéreuse.
BE8700839A 1986-07-29 1987-07-28 Derives de l'isoquinoleine. BE1002110A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB868618398A GB8618398D0 (en) 1986-07-29 1986-07-29 Chemical compounds
GB878710608A GB8710608D0 (en) 1987-05-05 1987-05-05 Chemical compounds

Publications (1)

Publication Number Publication Date
BE1002110A4 true BE1002110A4 (fr) 1990-07-10

Family

ID=26291098

Family Applications (1)

Application Number Title Priority Date Filing Date
BE8700839A BE1002110A4 (fr) 1986-07-29 1987-07-28 Derives de l'isoquinoleine.

Country Status (30)

Country Link
US (1) US4851399A (fr)
JP (1) JPH02187A (fr)
KR (1) KR880001652A (fr)
CN (1) CN1015059B (fr)
AT (1) ATA190987A (fr)
AU (1) AU604731B2 (fr)
BE (1) BE1002110A4 (fr)
CH (1) CH672489A5 (fr)
DE (1) DE3725185A1 (fr)
DK (1) DK392187A (fr)
ES (1) ES2007666A6 (fr)
FI (1) FI873289A (fr)
FR (1) FR2602233B1 (fr)
GB (1) GB2195636B (fr)
GR (1) GR871208B (fr)
HK (1) HK8491A (fr)
HU (1) HU201936B (fr)
IL (1) IL83335A0 (fr)
IT (1) IT1211683B (fr)
LU (1) LU86956A1 (fr)
MY (1) MY102457A (fr)
NL (1) NL8701768A (fr)
NO (1) NO872963L (fr)
NZ (1) NZ221238A (fr)
PH (1) PH25494A (fr)
PL (1) PL267063A1 (fr)
PT (1) PT85380B (fr)
SE (1) SE8702986L (fr)
SG (1) SG84490G (fr)
SU (1) SU1676445A3 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8800312D0 (en) * 1988-01-07 1988-02-10 Glaxo Group Ltd Process
US6861441B1 (en) * 1999-08-10 2005-03-01 Smithkline Beecham Corporation Use of EP4 receptor ligands in the treatment of neuropathic pain and colon cancer
KR20030062812A (ko) * 2002-01-19 2003-07-28 한국과학기술원 금속주대용 플라스틱 자켓을 구비하는 인공보철물장치

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0161102A2 (fr) * 1984-05-03 1985-11-13 Glaxo Group Limited Dérivés de l'isoquinoléine

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1087221A (en) * 1963-03-16 1967-10-18 Geigy Uk Ltd 12-aminonaphthindolizinediones and processes for their manufacture
US4029659A (en) * 1971-03-29 1977-06-14 Omnium Chimique Societe Anonyme N-disubstituted aminoethyl esters of 11-methoxy-raubasinic acid
US3894029A (en) * 1971-08-26 1975-07-08 Basf Ag Production of camptothecin and camptothecin-like compounds
US4042591A (en) * 1973-05-30 1977-08-16 Sandoz Ltd. Naphthoquinone compounds
US4033966A (en) * 1975-06-24 1977-07-05 Kanebo, Ltd. Novel berbine derivatives
US4087426A (en) * 1976-08-16 1978-05-02 Research Corporation Oxybisberberine and a process for its production
FR2387229A1 (fr) * 1977-04-13 1978-11-10 Anvar Dipyrido (4,3-b) (3,4-f) indoles, procede d'obtention, application therapeutique et compositions pharmaceutiques les contenant
FR2436786A1 (fr) * 1978-09-21 1980-04-18 Anvar Nouveaux derives des pyrido (4,3-b) carbazoles (ellipticines), substitues en position 1 par une chaine polyaminee, leur obtention et leur application a titre de medicaments
US4399282A (en) * 1979-07-10 1983-08-16 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives
DK158666C (da) * 1982-11-04 1990-11-19 Glaxo Group Ltd Analogifremgangsmaade til fremstilling af 5,14-dihydrobenz-oe5,6aa-isoindolooe2,1-baa-isoquinolin-8,13-dion

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0161102A2 (fr) * 1984-05-03 1985-11-13 Glaxo Group Limited Dérivés de l'isoquinoléine

Also Published As

Publication number Publication date
NL8701768A (nl) 1988-02-16
DE3725185A1 (de) 1988-02-04
FR2602233B1 (fr) 1990-08-17
US4851399A (en) 1989-07-25
IL83335A0 (en) 1987-12-31
DK392187A (da) 1988-01-30
SU1676445A3 (ru) 1991-09-07
PL267063A1 (en) 1988-09-01
FI873289A (fi) 1988-01-30
PH25494A (en) 1991-07-24
JPH02187A (ja) 1990-01-05
GB8717864D0 (en) 1987-09-03
GR871208B (en) 1987-11-30
KR880001652A (ko) 1988-04-25
PT85380B (pt) 1990-04-30
HUT46011A (en) 1988-09-28
ES2007666A6 (es) 1989-07-01
SE8702986D0 (sv) 1987-07-28
PT85380A (en) 1987-08-01
FR2602233A1 (fr) 1988-02-05
IT1211683B (it) 1989-11-03
NO872963D0 (no) 1987-07-15
NO872963L (no) 1988-02-01
GB2195636B (en) 1990-05-30
SG84490G (en) 1991-01-04
FI873289A0 (fi) 1987-07-28
NZ221238A (en) 1990-03-27
HU201936B (en) 1991-01-28
AU604731B2 (en) 1991-01-03
CN87105778A (zh) 1988-02-24
DK392187D0 (da) 1987-07-28
SE8702986L (sv) 1989-01-29
IT8748237A0 (it) 1987-07-28
AU7620387A (en) 1988-02-04
ATA190987A (de) 1991-04-15
LU86956A1 (fr) 1988-02-02
CN1015059B (zh) 1991-12-11
MY102457A (en) 1992-06-30
HK8491A (en) 1991-02-01
CH672489A5 (fr) 1989-11-30
GB2195636A (en) 1988-04-13

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: GLAXO GROUP LTD

Effective date: 19920731